Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters

Journal of Pharmaceutical Sciences

Volumn 90, Issue 4, 2001, Pages 397-421

  Dresser, Mark J ^a   Leabman, Maya Kaushal ^a   Giacomini, Kathleen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug transporter; Kidney; OAT; OCT; Pharmacokinetics

Indexed keywords

ACEBUTOLOL; ACETYLSALICYLIC ACID; ACICLOVIR; ADEFOVIR; ADRENALIN; ALDOSTERONE; AMANTADINE; AMINOPTERIN; AMPHETAMINE; ANION; ATORVASTATIN; BETAINE; BUMETANIDE; CAPTOPRIL; CARBENICILLIN; CARPROFEN; CARRIER PROTEIN; CATION; CEFALEXIN; CEFAZOLIN; CEFEPIME; CEFOPERAZONE; CEFOSELIS; CEFSULODIN; CEFTAZIDIME; CYTARABINE; LEVACECARNINE; UNINDEXED DRUG; ZIDOVUDINE;

ANION TRANSPORT; CATION TRANSPORT; DRUG ELIMINATION; DRUG TRANSPORT; HUMAN; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SHORT SURVEY; TISSUE DISTRIBUTION;

EID: 0035066252     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200104)90:4<397::AID-JPS1000>3.0.CO;2-D     Document Type: Short Survey

References (118)

1. Renal drug transport: A review
2. Mechanisms mediating renal secretion of organic anions and cations
3. Renal organic anion transport system: Pharmacological, physiological, and biochemical aspects
4. Renal secretion of organic anions and cations
5. Renal transporters for organic anions and organic cations. Structural requirements for substrates
6. Role of organic cation transporters in drug absorption and elimination
7. Organic cation transporters in intestine, kidney, liver, and brain
8. Molecular pharmacology of organic cation transporters in kidney
9. Molecular and functional characteristics of cloned human organic cation transporters
10. The multi-specific organic anion transporter (OAT) family
11. Structure of renal organic anion and cation transporters
12. Inhibition of renal tubular transport of methotrexate by probenecid
13. Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy
14. Expression cloning and characterization of a novel multispecific organic anion transporter
15. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney
16. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
17. Cloning of a human renal p-aminohippurate transporter, hROAT1
18. Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C
19. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
20. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
21. Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells
22. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
23. Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene
24. Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney
25. The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
26. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes
27. Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1
28. Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs
29. Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1
30. Molecular cloning and characterization of a novel liver-specific transport protein
31. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
32. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
33. A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse
34. Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation
35. Molecular cloning and characterization of multi-specific organic anion transporter 4 expressed in the placenta
36. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney
37. mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules
38. Functional analysis of rat renal organic anion transporter OAT-K1: Bidirectional methotrexate transport in apical membrane
39. Trans-stimulation effects of folic acid derivatives on methotrexate transport by rat renal organic anion transporter, OAT-K1
40. Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1
41. Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney
42. Expression cloning of a rat liver Na(+)-independent organic anion transporter
43. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
44. Immunologic distribution of an organic anion transport protein in rat liver and kidney
45. The choroid plexus epithelium is the site of the organic anion transport protein in the brain
46. Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney
47. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells
48. Organic anion transporting polypeptide mediates organic anion/HCO3-exchange
49. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
50. The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein
51. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
52. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
53. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
54. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
55. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
56. Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver
57. Electrophysiologic characterization of an organic anion transporter cloned from winter flounder kidney (fROAT)
58. Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1
59. Drug excretion mediated by a new prototype of polyspecific transporter
60. The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters
61. Molecular cloning and functional expression of a rabbit renal organic cation transporter
62. Cloning and functional expression of a human liver organic cation transporter
63. Cloning and characterization of two human polyspecific organic cation transporters
64. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A)
65. Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain
66. Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs
67. Membrane localization of the electrogenic cation transporter rOCT1 in rat liver
68. Functional characterization of an organic cation transporter (hOCT1)in a transiently transfected human cell line (HeLa)
69. The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1
70. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1)
71. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2
72. Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells
73. Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus
74. Transport of monoamine transmitters by the organic cation transporter type 2, OCT2
75. Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
76. rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger
77. Role of organic cation transporters in the renal secretion of nucleosides
78. A transfected cell model for the renal toxin transporter, rOCT2
79. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
80. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter
81. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27
82. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney
83. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
84. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta
85. Novel membrane transporter OCTN1 mediates multi-specific, bidirectional, and pH-dependent transport of organic cations
86. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
87. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
88. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
89. Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
90. Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2
91. A reevaluation of substrate specificity of the rat cation transporter rOCT1
92. The multidrug resistance protein family
93. A family of drug transporters: The multidrug resistance-associated proteins
94. Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family
95. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2
96. Multidrug resistance protein Mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate
97. Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs
98. Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted
99. Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption
100. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
101. What have we learnt thus far from mice with disrupted P-glycoprotein genes?
102. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
103. Absence of the mdr1a P-glyco-protein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
104. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
105. Molecular cloning and functional characterization of a polyspecific organic anion transporter from Caenorhabditis elegans
106. Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter
107. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
108. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
109. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter
110. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1
111. Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes
112. Selective substrates for non-neuronal monoamine transporters
113. Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1
114. Catecholamine transport by the organic cation transporter type 1 (OCT 1)
115. Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1
116. Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system
117. Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2