Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

Pharmaceutical Research

Volumn 13, Issue 4, 1996, Pages 497-513

  Yamazaki, Masayo ^a   Suzuki, Hiroshi ^b   Sugiyama, Yuichi ^b  

^a TOHO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bile acid; Eisai hyperbilirubinemic rat; GS X pump; hepatic clearance; HMG CoA reductase; Multidrug resistance related protein; Organic anion; P glycoprotein; Primary active transport; TR rat

Indexed keywords

6 HYDROXY 5,7 DIMETHYL 2 METHYLAMINO 4 (3 PYRIDYLMETHYL)BENZOTHIAZOLE; CEFODIZIME; GLYCOPROTEIN P; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYMECROMONE; LEUKOTRIENE C4; LIPOXYGENASE INHIBITOR; LIQUIRITIGENIN; MEMBRANE PROTEIN; PRAVASTATIN; SIMVASTATIN; XENOBIOTIC AGENT;

ACTIVE TRANSPORT; ARTICLE; BILIARY EXCRETION; DETOXIFICATION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG TRANSPORT; HUMAN; LIVER BLOOD FLOW; LIVER CLEARANCE; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; URINARY EXCRETION;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BILE ACIDS AND SALTS; BILIARY TRACT; BIOLOGICAL TRANSPORT, ACTIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PRAVASTATIN; RATS; XENOBIOTICS;

EID: 0029926676     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016077517241     Document Type: Article

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