Molecular pharmacology of renal organic anion transporters

American Journal of Physiology - Renal Physiology

Volumn 279, Issue 2 48-2, 2000, Pages

  Van Aubel, Rémon A M H ^a   Masereeuw, Rosalinde ^a   Russel, Frans G M ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Drug excretion; Kidney; Multidrug resistance protein; Peptide transporter; Proximal tubule

Indexed keywords

4 AMINOHIPPURIC ACID; AMPICILLIN; ANION; BUMETANIDE; CARRIER PROTEIN; CEFOPERAZONE; CNT 1 PROTEIN; CNT 2 PROTEIN; DICARBOXYLIC ACID; ENALAPRIL; FORMYCIN B; FUROSEMIDE; INDOMETACIN; KETOPROFEN; MULTIDRUG RESISTANCE PROTEIN; NAPROXEN; NUCLEOSIDE; OAT 1 PROTEIN; PEPT 1 PROTEIN; PEPT 2 PROTEIN; PEPTIDE; PIROXICAM; PROBENECID; RIFAMPICIN; SAT 1 PROTEIN; SODIUM ION; SULFATE; TESTOSTERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; XENOBIOTIC AGENT;

ANIMAL CELL; ANION TRANSPORT; DRUG EXCRETION; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; MOLECULAR CLONING; MOUSE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVIEW; UNINDEXED SEQUENCE;

EID: 0033844773     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.279.2.f216     Document Type: Review

References (213)

1. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
2. Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane
3. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes
4. Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir
5. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins
6. Insights into chronic cyclosporine nephrotoxicity
7. Immunologic distribution of an organic onion transport protein in rat liver and kidney
8. Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes
9. Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter
10. Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors
11. Conventional and confocal epi-reflection and fluorescence microscopy of the rat kidney in vivo
12. A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse
13. Epithelial cell polarity: Molecular mechanisms
14. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
15. Immunohistological localization of ligandin in human tissues
16. PAH/alpha-KG countertransport stimulates PAH uptake and net secretion in isolated rabbit renal tubules
17. Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter
18. Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter
19. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
20. Multidrug resistance mediated by the ATP-binding cassette transport protein MRP
21. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
22. Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics
23. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
24. Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: The nephrotoxin can be reabsorbed in all nephron segments by different mechanisms
25. Cisplatin metabolites in plasma, a study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin
26. Cellular and molecular mechanisms of renal peptide transport
27. Biotransformation and membrane transport in nephrotoxicity
28. The role of ochratoxin A metabolism and biochemistry in animal and human nephrotoxicity
29. Hepatic, intestinal and renal transport of 1-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia
30. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications
31. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells
32. Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1
33. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
34. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
35. Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1 rat) by transient expression in cultured mammalian cells
36. Expression cloning of a mammalian proton-coupled oligopeptide transporter
37. +-dependent nucleoside transport in liver: Two different isoforms from the same gene family are expressed in liver cells
38. Tissue distribution of the multidrug resistance protein
39. Further characterization of adenosine transport in renal brush-border membranes
40. Identification of thyroid hormone transporters
41. Human MRP3 transporter: Identification of the 5'-flanking region, genomic organization and alternative splice variants
42. Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2
43. Valacyclovir: A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2
44. Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2
45. Inhibition of initial transport rate of basolateral organic anion carrier in renal PT by BK and phenylephrine
46. The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: Toxodynamic and toxokinetic aspects
47. Renal metabolism and excretion of drugs
48. Interaction of ligandin with radiographic contrast media
49. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
50. Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney
51. Studies on the orientation of brush-border membrane vesicles
52. Transport of sulphate in rat jejunal and rat proximal tubular basolateral membrane vesicles
53. Renal organic anion secretion: Evidence for dopaminergic and adrenergic regulation
54. 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter
55. Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation
56. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats
57. Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3)
58. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
59. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein
60. Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis
61. Differential localisation of UDP-glucuronosyltransferase in kidney during human embryonic and fetal development
62. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membranes
63. Transport of temocaprilat into rat hepatocytes: Role of organic anion transporting polypeptide
64. Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR)
65. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
66. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver
67. Expression cloning of a rat liver Na(+)-independent organic anion transporter
68. Transport of glutathione, glucuronate and sulfate conjugates by the MRP gene-encoded conjugate export pump
69. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
70. Transient expression of Oatp organic anion transporter in mammalian cells: Identification of candidate substrates
71. Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter
72. Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney
73. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
74. Expression and localisation of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
75. Molecular basis of ATP-dependent transport of anionic conjugates in kidney and liver
76. Structural and functional studies of ligandin, a major renal organic anion-binding protein
77. cDNA cloning and inducable expression of the human multidrug resistance-associated protein 3 (MRP3)
78. ATP-dependent transport for glucuronides in canalicular plasma membrane vesicles
79. Molecular pharmacology of organic cation transporters in kidney
80. A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells
81. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
82. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1) in human cancer cell lines
83. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
84. MRP3, an organic anion transporter able to transport anti-cancer drugs
85. Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles
86. Reduced folate derivatives are endogenous substrates for cMOAT in rats
87. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
88. Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells
89. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter
90. Peptide transporters in the intestine and the kidney
91. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
92. 4 and structurally related conjugates
93. 4 as a substrate for oatp1, the hepatic sinusoidal organic anion solute transporter
94. +/peptide cotransporter. Cloning, functional expression, and chromosomal localization
95. Ligandin: A hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions
96. Xenobiotic metabolizing enzymes of the kidney
97. ATP-dependent 17β-D-estradiol 17(β-D-glucuronide) transport by multidrug resistance protein (MRP)
98. 4 and chemotherapeutic agents in membrane vesicles
99. Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): Evidence for cotransport with reduced glutathione
100. 1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
101. Renal drug metabolism
102. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
103. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
104. Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C
105. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein
106. Transport function and hepatocellular localization of mrp6 in rat liver
107. Active lucifer yellow secretion in renal proximal tubule: Evidence for organic anion transport system crossover
108. Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy
109. Interaction of fluorescein with the dicarboxylate carrier in rat kidney cortex mitochondria
110. Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule
111. Characterization of fluorescein transport in isolated proximal tubular cells of the rat: Evidence for mitochondrial accumulation
112. Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney
113. Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats
114. Functional analysis of rat renal organic anion transporter OAT-K1: Bidirectional methotrexate transport in apical membrane
115. Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1
116. mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules
117. pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells
118. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
119. hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions
120. Protein kinase C regulation of organic anion transport in renal proximal tubule
121. Confocal microscopic analysis of fluorescein compartmentation within crab urinary bladder cells
122. Fluorescence imaging study of organic anion transport from renal proximal tubule cell to lumen
123. Nocodazole inhibition of organic anion secretion in teleost renal proximal tubules
124. Intracellular compartmentation of organic anions within renal cells
125. Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter
126. Distribution and properties of the glycylsarcosine-transport system in rabbit renal proximal tubule. Studies with isolated brush-border-membrane vesicles
127. Proton gradient-coupled uphill transport of glycylsarcosine in rabbit renal brush-border membrane vesicles
128. Renal transport processes and glutathione conjugate-mediated nephrotoxicity
129. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
130. Biliary and renal excretions of cefpiramide in eisai hyperbilirubinemic rats
131. Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent
132. Acetaminophen nephrotoxicity in the rat: Quantitation of renal metabolic activation in vivo
133. Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B
134. Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: Comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole glucuronide
135. The role of the canalicular multispecific organic anion transporter in the disposal of endo- and xenobiotics
136. +/nucleoside cotransporter from pig kidney, pkCNT1
137. The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein
138. Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies
139. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
140. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
141. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
142. Glutathione S-transferases: An evaluation of their role in renal organic anion transport
143. Tissue and cell distribution of the multidrug resistance-associated protein (MRP) on mouse intestine and kidney
144. Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C-4 transport mediated by MRP/GS-X pump
145. Intracellular alpha-ketoglutarate controls the efficacy of renal organic anion transport
146. Mechanisms mediating renal secretion of organic anions and cations
147. Renal sulfate transport at the basolateral membrane is mediated by anion exchange
148. Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes
149. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
150. Proton/peptide cotransporter (PEPT 2) from human kidney: Functional characterization and chromosomal localization
151. Cloning of a human renal p-aminohippurate transporter, hROAT1
152. +-nucleoside cotransporter (hCNT1)
153. +/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine
154. Renal transport of organic anions
155. Hepatocanalicular organic-anion transport is regulated by protein kinase C
156. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
157. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney
158. +/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine kidney
159. Molecular cloning and tissue distribution of rat peptide transporter PEPT2
160. - exchange
161. Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa)
162. Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules
163. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
164. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
165. Expression cloning characterization of a novel multispecific organic anion transporter
166. Evidence for two forms of ligandin (YaYa dimers of glutathione S-transferase) in rat liver and kidney
167. Cisplatin-induced renal toxicity: Possible reversal by N-acetylcysteine treatment
168. Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney
169. Subcellular distribution of key metabolites in isolated liver cells from fasted rats
170. + gradient-driven dipeptide reabsorption in proximal tubule of rat kidney. Studies in vivo and in vitro
171. Molecular cloning and characterization of a novel liver-specific transport protein
172. Distribution of metabolites between mitochondria and cytosol of perfused liver
173. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells
174. Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
175. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney
176. +/peptide cotransporters in rat renal brush-border membranes
177. Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells
178. Different biliary excretion systems for glucuronide and sulfate of a model compound; study using eisai hyperbilirubinemic rats
179. Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1
180. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
181. Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: A functional analysis using ACE inhibitors to determine the isoform of the transporter
182. 1 cells
183. Metabolite anion carriers mediate the uptake of the anionic drug fluorescein in renal cortical mitochondria
184. Kinetic evidence for a common transporter for glycylsarcosine and phenylalanylprolylalanine in renal brush-border membrane vesicles
185. Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney
186. Transport of ochratoxin A by renal multispecific organic anion transporter 1
187. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport
188. Renal transporters for organic anions and cations. Structural requirements for substrates
189. Luminal transport step of para-aminohippurate (PAH): Transport from PAH-loaded proximal tubular cells into the tubular lumen of the rat kidney in vivo
190. Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney
191. Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine
192. Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells
193. Multidrug resistance protein Mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate
194. Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells
195. Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines over-expressing multidrug resistance-associated protein
196. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
197. Electro-physiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain
198. Na(+)-dependent purine nucleoside transporter from human kidney: Cloning and functional characterization
199. Effect of alpha-ketoglutarate on organic anion transport in single rabbit renal proximal tubules
200. Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells
201. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
202. Multidrug resistance protein 5, a candidate multispecific organic anion transporter
203. Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage
204. Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles
205. Expression cloning and characterization of a renal organic anion transporter from winter flounder
206. Biliary excretion of pravastatin in rats: Contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter
207. Transport of the antiviral nucleoside analogs 3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes
208. Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes
209. High induction of phenol UDP-glucuronosyltransferase in the kidney medulla of beta-naphthoflavone-treated rats
210. Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
211. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump
212. Role of glutathione in the export of compounds from cells by the multidrug resistance-associated protein
213. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines