Replicative senescence revisited

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 57, Issue 7, 2002, Pages B257-B269

  Marcotte, Richard ^a   Wang, Eugenia ^b  

^a MCGILL UNIVERSITY   (Canada)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ACTIVITY; CELL CYCLE; CELL GROWTH; INFORMATION; MITOSIS; MITOSIS INHIBITION; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SENESCENCE; TELOMERE;

NON-PROGRAMMATIC;

ANIMALS; CELL AGING; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; HUMANS; RETINOBLASTOMA PROTEIN; TELOMERE; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036303995     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/57.7.B257     Document Type: Review

References (180)

1. The limited in vitro lifetime of human diploid cell strains
2. Limited lifespan in somatic cell hybrids and cybrids
3. Evidence for the recessive nature of cellular immortality
4. The Pexcoller lecture: Cancer cell cycles revisited
5. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
6. A role for both RB and p53 in the regulation of human cellular senescence
7. Quantification of the frequency of immortalization of normal human dipolid fibroblasts by SV40 large T-antigen
8. Alterations in the responsiveness of senescent cells to growth factors
9. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts
10. Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
11. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
12. Downregulation of cdc2 in senescent human and hamster cells
13. Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation
14. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
15. Altered regulation of G1 cyclins in cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-CDK2 and cyclin D1-Cdk2 complexes
16. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts
17. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
18. A cell cycle regulator potentially involved in genesis of many tumor types
19. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
20. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
21. Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence
22. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
23. Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: Relationship of dysfunction to immortality and neoplasia
24. Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells
25. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
26. Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells
27. p16/MTS1/INK4A suppresses prostate cancer by both pRb dependent and independent pathways
28. Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescent-like state
29. INK4a can initiate an autonomous senescence program
30. Induction of senescence in human malignant glioma cells by p16INK4A
31. Senescence delay of human diploid fibroblast induced by anti-sense p16INK4a expression
32. Overcoming cellular senescence in human cancer pathogenesis
33. pl6/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells
34. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
35. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
36. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
37. Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest
38. Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins
39. BRG-1 is required for RB-mediated cell cycle arrest
40. LKB1 Brgl and is necessary for Brgl-induced growth arrest
41. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
42. INK4a tumor suppressor versus other INK4 family members during mouse development and aging
43. ARF predisposes mice to tumorigenesis
44. p161NK4A and pl9ARF act in overlapping pathways in cellular immortalization
45. R24C mutation facilitates tumorigenesis and escape from cellular senescence
46. Invasive melanoma in Cdk4-targeted mice
47. Ablation of the retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions
48. Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
49. Molecular characterization of the retinoblastoma susceptibility gene
50. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
51. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
52. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
53. Id-1 delays senescence but does not immortalize keratinocytes
54. The oncogene and Polycomb-group gene bmi-I regulates cell proliferation and senescence through the ink4a locus
55. INK4a expression
56. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
57. Escape from senescence in human diploid fibroblasts induced directly by mutant p53
58. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
59. Enhanced proliferative potential in culture of cells from p53-deficient mice
60. Increased activity of p53 in senescing fibroblasts
61. WAF1, a potential mediator of p53 tumor suppression
62. Increased p53 protein associated with aging in human diploid fibroblasts
63. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
64. Waf1/Cip1/sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
65. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
66. Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin
67. Bypass of senescence after disruption of p21cip1/waf1 gene in normal diploid human fibroblasts
68. -/- mice
69. Expression of p21 is not required for senescence of human fibroblasts
70. Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts
71. Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1
72. Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
73. Microinjection of anti-p21 antibodies induces senescent Hs68 human fibroblasts to synthesize DNA but not to divide
74. Reconstitution of DNA synthetic capacity in senescent normal human fibroblasts by expressing cellular factors E2F and Mdsm2
75. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
76. Escape from premature senescence is not sufficient for oncogenic transformation by Ras
77. Effects of p21waf1/cip1/sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
78. Microarray analysis of replicative senescence
79. Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor
80. The candidate tumour suppressor p33ingl cooperates with p53 in cell growth control
81. ING1 mediates repair of UV-damaged DNA
82. ING1
83. Alternative reading frame of the INK4a tumor suppressor gene encodes two unrelated proteins capable of inducing cell cycle arrest
84. The Ink4a tumor suppressor gene product, p19ARF, interacts with MDM2 and neutralizes MDM2's inhibition of p53
85. The alternative product from the human CDKN2A locus, pI4(ARF), participates in a regulatory feedback loop with p53 and MDM2
86. pl9(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2
87. Nucleolar Arf sequesters Mdm2 and activates p53
88. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19arf
89. Interaction between the retinoblastoma protein and the oncoprotein MDM2
90. Regulation of a senescence checkpoint response by the E2FI transcription factor and p14ARF tumor suppressor
91. ARF in replicative and induced senescence of human fibroblasts
92. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
93. Postranslational modification of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
94. Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
95. Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway
96. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers
97. TBX-3, the gene mutated in ulnar-mammary syndrome, is a negative regulator of pl9ARF and inhibits senescence
98. PML interaction with p53 and its role in apoptosis and replicative senescence
99. PML is induced by oncogenic ras and promotes premature senescence
100. Role of PML in cell growth and the retinoic acid pathway
101. PML regulates p53 acetylation and premature senescence induced by oncogenic ras
102. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
103. INK4a
104. INK4c, cell cycle inhibitors in proliferation and tumor-igenesis
105. INK4b
106. Transforming growth factor β triggers two independent-senescence programs in cancer cells
107. INK4b
108. INK4b expression by Myc through association with Miz-1
109. Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells
110. KIPI in retinoblastoma protein-mediated senescence
111. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
112. Kip1
113. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
114. Putting the stress on senescence
115. Cellular senescence: Mitotic clock or culture shock?
116. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
117. The behavior in successive nuclear divisions of a chromosome broken at meiosis
118. The stability of broken ends of chromosomes in Zea mays
119. The fusion of broken ends of chromosomes following nuclear fission
120. Extension of life-span by introduction of telomerase into normal human cells
121. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
122. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
123. Analysis of genomic integrity and p53-dependent GI checkpoint in telomerase-induced extended-life-span human fibroblasts
124. INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
125. Both rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
126. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
127. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase
128. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
129. Telomerase activity is sufficient to allow transformed cells to escape from crisis
130. Mammalian telomeres end in a large duplex loop
131. Control of telomere length by the human telomeric protein TRFI
132. TRF2 protects human telomeres from end-to-end fusions
133. Protection of mammalian telomeres
134. Control of human telomere length by TRFI and TRF2
135. Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process
136. Human endothelial cell life extension by telomerase expression
137. Telomere states and cell fates
138. Senescence induced by altered telomere state, not telomere loss
139. Lack of replicative senescence in normal rodent glia
140. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells
141. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
142. P53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
143. Atm-deficient mice: A paradigm of ataxia telangiectasia
144. Colony-forming ability of ataxia-telangiectasia skin fibroblasts is an indicator of their early senescence and increased demand for growth factors
145. Dual roles of ATM in the cellular response to radiation and in cell growth control
146. ATM function and telomere stability
147. Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression
148. A critical role for Pin2/TRF1 in ATM-dependent regulation: Inhibition of Pin2/TRF1 function complements telomere shortening, the radiosensitivity and G2/M checkpoint defect ofAtaxia-telangiectasia cells
149. Telomeric protein Pin/TRF1 as an important ATM target in response to double strand DNA breaks
150. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase
151. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
152. DNA strand break-sensing molecule poly(ADP-ribose) polymerase cooperates with p53 in telomere function, chromosome stability and tumor suppression
153. Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability
154. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
155. Tankyrase promotes telomere elongation in human cells
156. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
157. Ku binds telomeric DNA in vitro
158. Ku acts in a unique way at the mammalian telomere to prevent end joining
159. The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
160. Mammalian Ku86 protein prevent telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
161. Analysis of ku80-mutant mice and cells with deficient levels of p53
162. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
163. Many ways to telomere dysfunction: In vivo studies using mouse models
164. Agents that cause DNA double strand breaks lead to p16ink4a enrichment and the premature senescence of normal fibroblasts
165. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cipl in normal human fibroblasts
166. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
167. Senescence of human fibrolasts induced by oncogenic Raf
168. Raf-l-induced cell cycle arrest in LNCaP human prostate cancer cells
169. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
170. Rapid induction of senescence in human cervical carcinoma cells
171. Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres
172. A survey of telomerase activity in human cancer
173. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
174. The free radical theory of aging matures
175. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
176. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent
177. Telomere length in fibroblasts and blood cells from healthy centenarians
178. p53 mutant mice that display early ageing-associated phenotypes
179. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
180. New ways not to make ends meet: Telomerase, DNA damage proteins and heterochromatin