Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

Molecular and Cellular Biology

Volumn 16, Issue 3, 1996, Pages 859-867

  Hara, Eiji ^a   Smith, Rosalind ^a   Parry, David ^a   Tahara, Hidetoshi ^b   Stone, Steven ^c   Peters, Gordon ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c Myriad Genetics Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

CYCLIN DEPENDENT KINASE; RETINOBLASTOMA PROTEIN; RNA; CARRIER PROTEIN; PROTEIN P16INK4A;

ARTICLE; CELL AGING; CELL CYCLE G1 PHASE; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME INHIBITION; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE; CELL LINE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; SIMIAN VIRUS 40; VIRUS CELL TRANSFORMATION;

BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; CELL TRANSFORMATION, VIRAL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FIBROBLASTS; G1 PHASE; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; MOLECULAR SEQUENCE DATA; RNA; SIMIAN VIRUS 40; TRANSCRIPTION, GENETIC;

EID: 0029670840     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.3.859     Document Type: Article

References (67)

1. lnk4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. Int. J. Cancer 61:115-120
2. 1/S transition by cyclins D2 and D3 in hematopoietic cells Proc. Natl. Acad. Sci. USA 90:9571-9575.
3. Baldin, V., J. Lukas, M. J. Marcotte, M. Pagano, and G. Draetta. 1993 Cyclin D1 is a nuclear protein required for cell cycle progression. Genes Dev 7:812-821.
4. Barrett, J. C., L. A. Annab, D. Alcorta, G. Preston, P. Vojta, and Y. Yin. 1994. Cellular senescence and cancer. Cold Spring Harbor Symp. Quant. Biol. 59:411-418.
5. Bates, S., L. Bonetta, D. MacAllan, D. Parry, A. Holder, C. Dickson, and G. Peters. 1994. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene 9:71-79.
6. Bates, S., D. Parry, L. Bonetta, K. Vousden, C. Dickson, and G. Peters. 1994. Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9:1633-1640.
7. Chomczynski, P., and N. Saachi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162:156-159.
8. Dimri, G. P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke, and J. Campisi. 1995. A novel biomarker identifies senescent human cells in culture and m aging skin in vivo. Proc. Natl. Acad. Sci. USA 92:9363-9367.
9. Draetta, G. 1994 Mammalian G1 cyclins. Curr. Opin. Cell Biol. 6:842-846.
10. 1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc. Natl Acad. Sci USA 90:11034-11038.
11. INK4/MTS1 gene transcript expressed in B-cell malignancies Oncogene 11:21-29
12. El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin ,W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAFI, a potential mediator of p53 tumor suppression. Cell 75:817-825.
13. Futreal, P. A., and J. C. Barrett. 1991 Failure of senescent cells to phosphorylate the RB protein. Oncogene 6:1109-1113.
14. INK4/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8:2939-2952.
15. Hamel, P. A., R. M. Gill, R. A. Phillips, and B. L. Gallie. 1992. Transcriptional repression of the E2-containing promoters EllaE, c-myc, and KB1 by the product of the RB1 gene. Mol. Cell. Biol. 12:3431-3438.
16. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature (London) 371:257-261.
17. Hara, E., T. Yamaguchi, H. Nojima, T. Ide, J. Campisi, H. Okayama, and K. Oda. 1994. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269:2139-2145.
18. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell 75:805-816.
19. Jen, J., J. W. Harper, S. H. Bigner, D. D. Bigner, N. Papadopoulos, S. Markowitz, J. K. V. Willson, K. W. Kinzler, and B. Vogelstein. 1994. Deletion of p16 and p15 genes in brain tumors. Cancer Res. 54:6353-6358.
20. Jiang, W., S. M. Kahn, P. Zhou, Y.-J. Zhang, A. M. Cacace, A. S. Infante, S. Doi, R. M. Santella, and I. B. Weinstein. 1993. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8:3447-3457
21. Johnson, M., D. Dimitrov, P. J. Vojta, J. C. Barrett, A. Noda, O. M. Pereria-Smith, and J. R. Smith. 1994. Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells. Mol. Carcinog. 11:59-64.
22. Kamb, A. 1995. Cell-cycle regulators and cancer. Trends Genet. 11:136-140.
23. Kamb, A., N. A. Gruis, J. Weaver-Feldhaus, Q. Liu, K. Harshman, S. V. Tavtigian, E. Stockert, R. S. Day III, B. E. Johnson, and M. H. Skolnick. 1994. A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436-440.
24. Koh, J., G. H. Enders, B. D. Dynlacht, and E. Harlow. 1995. Tumour-derived p16 alleles encoding proteins, defective in cell-cycle inhibition. Nature (London) 375:506-510
25. Li, Y., M. A. Nichols, J. W. Shay, and Y. Xiong. 1994. Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res. 54:6078-6082.
26. Liu, Q., S. Neuhausen, M. McClure, C. Frye, J. Weaver-Feldhaus, N. A. Gruis, K. Eddington, M. J. Allalunis-Turner, M. H. Skolnick, F. K. Fujimura, and A. Kamb. 1995. CDKN2 (MTS1) tumor suppressor gene mutations in human tumor cell lines. Oncogene 10:1061-1067.
27. Loughran, O., K. G. Edington, I. J. Berry, L. J. Clark, and E. K. Parkinson. 1994. Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes. Cancer Res. 54:5045-5049.
28. Lucibello, F. C., A. Sewing, S. Brüsselbach, C. Bürger, and R. Müller. 1993 Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J. Cell Sci. 165:123-133.
29. 1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell. Biol 15:2600-2611.
30. Lukas, J., H. Müller, D. Spitkovsky, A. A. Kjerulff, P. Jansen-Dürr, M. Strauss, and J. Bartek. 1994. DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J. Cell Biol. 125:625-638.
31. Lukas, J., D. Parry, L. Aagaard, D. J. Mann, J. Bartkova, M. Strauss, G. Peters, and J. Bartek. 1995 Retinoblastoma-protein-dependent cell cycle inhibition by the tumour suppressor p16. Nature (London) 375:503-506.
32. INK4A transcript. Cancer Res. 55:2995-2997.
33. Matsuo, M., K. Kaji, T. Utakoji, and K. Hosoda. 1982. Ploidy of human embryonic fibroblasts during in vitro aging. J. Gerentol. 37:33-37.
34. INK4 requires functional retinoblastoma protein. Proc Natl. Acad Sci. USA 92:6289-6293
35. 1 to complete the cell cycle. Proc. Natl. Acad Sci. USA 91:8022-8026
36. Nobori, T., K. Miura, D. J. Wu, A. Lois, K. Takabayashi, and D. A. Carson. 1994 Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (London) 368:753-756.
37. Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen Exp. Cell Res 211:90-98
38. Ohashi, M., S. Aizawa, H. Ooka, T. Ohsawa, K. Kaji, H. Kondo, T. Kobayashi, T. Noumura, M. Matsuo, Y. Mitsui, S. Murota, K. Yamamoto, H. Ho, H. Shimada, and T. Utakoji. 1980. A new human diploid cell strain, TIG-1, for the research on cellular aging. Exp. Gerontol. 15:121-133.
39. INK4 in human cancer. Proc Natl. Acad. Sci. USA 91:11045-11049.
40. INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene 9:3375-3378
41. INK4/MTS1 tumour suppressor gene product. EMBO J. 14:503-511
42. Peeper, D. S., A. J. van der Eb, and A. Zantema. 1994. The G1/S cell-cycle checkpoint in eukaryotic cells. Biochim. Biophys. Acta 1198:215-230.
43. Peters, G. 1994. The D-type cyclins and their role in tumorigenesis. J Cell Sci. Suppl. 18:89-96.
44. 1 phase in rodent fibroblasts. Genes Dev. 7:1559-1571
45. 1/S phase transition by expression of cyclins D1 and E with an inducible system Mol. Cell. Biol. 14:1669-1679.
46. 1-to-S transition. Mol. Cell Biol. 15:3463-3469.
47. INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol. Cell. Biol. 15:4745-4753.
48. INK4. Science 267:249-252.
49. Serrano, M., G. J. Hannon, and D. Beach. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (London) 366:704-707.
50. INK4 expression m primary lung cancers and cell lines. Cancer Res. 55:505-509.
51. Sheaff, R. J., and J. M. Roberts. 1995. Lessons in p16 from phylum Falconium. Curr. Biol. 5:28-31.
52. 1 cyclins. Cell 73:1059-1065.
53. Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79:551-555.
54. Smith, R., G. Peters, and C. Dickson. 1988. Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors. EMBO J. 7:1013-1022.
55. Stein, G. H., M. Beeson, and L. Gordon. 1990. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249: 666-669.
56. 1 arrest in senescent human fibroblasts. Bioessays 17:537-543.
57. Stone, S., P. Jiang, P. Dayanath, S. V. Tavtigian, H. Katcher, D. Parry, G. Peters, and A. Kamb. 1995. Complex structure and regulation of the P16 (MTS1) locus. Cancer Res. 55:2988-2994.
58. Tahara, H., E. Sato, A. Noda, and T. Ide. 1995. Increase in expression level of p21sdi1/erp1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene 10:835-840.
59. Ink4. Cancer Res 54:5816-5820
60. Tam, S. W., A. M. Theodoras, J. W. Shay, G. F. Draetta, and M. Pagano. 1994. Differential expression and regulation of cyclin D1 protein in normal and tumor cells: association with Cdk4 is required for cyclin D1 function in G1 progression. Oncogene 9:2663-2674.
61. Tsuyama, N., M. Miura, M. Kitahira, S. Ishibashi, and T. Ide. 1991. SV40 T-antigen is required for maintenance of immortal growth in SV40-transformed human fibroblasts. Cell Struct Funct 16:55-62.
62. Washimi, O., M. Nagatake, H. Osada, R. Ueda, T. Koshikawa, T. Seki, T. Takahashi, and T. Takahashi. 1995. In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers. Cancer Res. 55:514-517.
63. Weinberg, R. A. 1995 The retinoblastoma protein and cell cycle control. Cell 81:323-330.
64. Wright, W. E., and J. W. Shay. 1992. Telomere positional effects and the regulation of cellular senescence. Trends Genet. 8:193-197
65. Xiong, Y., G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993 p21 is a universal inhibitor of cyclin kinases. Nature (London) 356: 701-704
66. Xiong, Y., H. Zhang, and D. Beach. 1993. Suhunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev. 7:1572-1583.
67. Yeager, T., W. Stadler, C. Belair, J. Puthenveettil, O. Olopade, and C. Reznikoff. 1995. Increased p16 levels correlate with pRb alterations in human urothelial cells. Cancer Res 55:493-497.