Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras

Oncogene

Volumn 18, Issue 35, 1999, Pages 4974-4982

  Pantoja, Cristina ^a   Serrano, Manuel ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Cell cycle; p21; Ras; Senescence; Transformation

Indexed keywords

PROTEIN P16; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; FIBROBLAST; LIFESPAN; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; SENESCENCE;

3T3 CELLS; ANIMALS; CELL AGING; CELL CYCLE; CELL DIVISION; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DOXORUBICIN; FIBROBLASTS; GENE DELETION; GENE EXPRESSION; MICE; MICE, KNOCKOUT; ONCOGENE PROTEIN P21(RAS); SERIAL PASSAGE; TRANSDUCTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033517357     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202880     Document Type: Article

References (83)

1. Afshari CA, Vojta PJ, Annab LA, Futreal PA, Willard TB and Barrett JC. (1993). Exp. Cell Res., 209, 231-237.
2. Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D and Barrett JC. (1996). Proc. Natl. Acad. Sci. USA, 93, 13742-13747.
3. Atadja P, Wong H, Garkavtsev I, Veillette and Riabowol K. (1995). Proc. Natl. Acad. Sci. USA, 92, 8348-8352.
4. Bates S, Phillips AC, Clark PA, Stott F, Peters G, Ludwig RL and Vousden KH. (1998). Nature, 395, 124-125.
5. Blasco MA, Lee H-W, Hande P, Samper E, Lansdorp P, DePinho R and Greider CW. (1997). Cell, 91, 25-34.
6. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu C-P, Morin GB, Harley CB, Shay JW, Lichtsteiner S and Wright WE. (1998). Science, 279, 349-352.
7. Bond JA, Blaydes JP, Rowson J, Haughton MF, Smith JR, Wynford-Thomas D and Wyllie FS. (1995). Cancer Res., 55, 2404-2409.
8. Bond J, Haughton M, Blaydes J, Gire V, Wynford-Thomas and Wyllie F. (1996). Oncogene, 13, 2097-2104.
9. Brenner AJ, Stampfer MR and Aldaz CM. (1998). Oncogene, 17, 199-205.
10. Brown JP, Wei W and Sedivy JM. (1997). Science, 277, 831-834.
11. Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T and Hannon GJ. (1995). Nature, 377, 552-557.
12. Brugarolas J, Bronson RT and Jacks T. (1998). J. Cell Biol., 141, 503-514.
13. Buckbinder L, Talbott R, Velasco-Miguel S, Tanenaka I, Faha B, Seizinger BR and Kely N. (1995). Nature, 377, 646-649.
14. Carman TA, Afshari CA and Barrett JC. (1998). Exp. Cell Res., 244, 33-42.
15. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y and Wang X-F. (1995). Proc. Natl. Acad. Sci. USA, 92, 5545-5549.
16. de Stanchina E, McCurrach M, Zindy F, Shieh S-Y, Ferbeyre G, Samuelson AV, Prives C, Roussel MF, Sherr CJ and Lowe SW. (1998). Genes Dev., 12, 2434-2442.
17. Deng C, Zhang P, Harper JW, Elledge SJ and Leder P. (1995). Cell, 82, 675-684.
18. Di Leonardo A, Linke SP, Clarkin K and Wahl GM. (1994). Genes Dev., 8, 2540-2551.
19. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery Jr CA, Butel JS and Bradley A. (1992). Nature, 356, 215-221.
20. El-Deiry W, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelstein B. (1993). Cell, 75, 817-825.
21. Erickson S, Sangfelt O, Heyman M, Castro J, Einhorn S and Grandér D. (1998). Oncogene, 17, 595-602.
22. Foster SA, Wong DJ, Barrett MT and Galloway DA. (1998). Mol. Cell. Biol., 18, 1793-1801.
23. Gallimore PH, Lecane PS, Roberts S, Rookes SM, Grand RJA and Parkhill J. (1997). J. Virol., 71, 6629-6640.
24. Garkavtsev I, Hull C and Riabowol K. (1998). Exp. Gerontol., 33, 81-94.
25. Giaccia AJ and Kastan MB. (1998). Genes Dev., 12, 2973-2983.
26. Gire V and Wynford-Thomas D. (1998). Mol. Cell. Biol., 18, 1611-1621.
27. Goldstein S, Moerman EJ, Jones RA and Baxter RC. (1991). Proc. Natl. Acad. Sci. USA, 88, 9680-9684.
28. Haber DA. (1997). Cell, 91, 555-558.
29. Halevy O, Novitch B, Spicer D, Skapek S, Rhee J, Hannon G, Beach D and Lassar A. (1995). Science, 267, 1018-1021.
30. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ. (1993). Cell, 75, 805-816.
31. Harvey DM and Levine AJ. (1991). Genes Dev., 5, 2357-2385.
32. Harvey M, Sands AT, Weiss RS, Hegi ME, Wiseman RW, Pantazis P, Giovanella BC, Tainsky MA, Bradley A and Donehower LA. (1993). Oncogene, 8, 2457-2467.
33. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT and Weinberg RA. (1994). Curr. Biol., 4, 1-7.
34. Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM and Bradley A. (1996). Proc. Natl. Acad. Sci. USA, 93, 14106-14111.
35. Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G and Sherr CJ. (1997). Cell, 91, 649-659.
36. Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF and Sherr CJ. (1998). Proc. Natl. Acad. Sci. USA, 95, 8292-8297.
37. Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA and Klingelhutz AJ. (1998). Nature, 396, 84-88.
38. Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M and Lowe SW. (1998). Genes Dev., 12, 3008-3019.
39. Lloyd AC, Obermuller F, Staddon S, Barth CF, McMahon M and Land H. (1997). Genes Dev., 11, 663-677.
40. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B and Jacks T. (1995). Genes Dev., 9, 935-944.
41. Mazars GR and Jat PS. (1997). Proc. Natl. Acad. Sci. USA, 94, 151-156.
42. Medclaf ASC, Klein-Szanto AJP and Cristofalo VJ. (1996). Cancer Res., 56, 4582-4585.
43. Metz T, Harris AW and Adams JM. (1995). Cell, 82, 29-36.
44. Missero C, Di Cunto F, Hiyokaza H, Koff A, Dott GP. (1996). Genes Dev., 10, 3065-3075.
45. Morgenstern JP and Land H. (1990). Nucl. Acids Res., 18, 3587-3596.
46. Noda A, Ning Y, Venable SF, Pereira-Smith OM and Smith JR. (1994). Exp. Cell Res., 211, 90-98.
47. Olson MF, Paterson HF and Marshall CJ. (1998). Nature, 394, 295-299.
48. Palmero I, McConnell B, Parry D, Brookes S, Hara E, Bates S, Jat P and Peters G. (1997). Oncogene, 15, 495-503.
49. Palmero I, Pantoja C and Serrano M. (1998). Nature, 395, 125-126.
50. Pear WS, Nolan GP, Scott and Baltimore D. (1993). Proc. Natl. Acad. Sci. USA, 90, 8392-8396.
51. Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee H-W, Cordon-Cardo C and DePinho RA. (1998). Cell, 92, 713-723.
52. Prives C. (1998). Cell, 95, 5-8.
53. Pumiglia KM and Decker SJ. (1997). Proc. Natl. Acad. Sci. USA, 94, 448-452.
54. Reznikoff CA, Yeager TR, Belair CD, Savelieva E, Puthenveettil JA and Stadler WM. (1996). Cancer Res., 56, 2886-2890.
55. Rittling SR, Brooks KM, Cristofalo VJ and Baserga R. (1986). Proc. Natl. Acad. Sci. USA, 83, 3316-3320.
56. Rittling SR and Denhardt DT. (1992). Oncogene, 7, 935-942.
57. Rittling SR. (1996). Exp. Cell Res., 229, 7-13.
58. Rogan EM, Bryan TM, Hukku B, Maclean K, Chang AC-M, Moy EL, Englezou A, Warneford SG, Dalla-Pozza L and Reddel RR. (1995). Mol. Cell. Biol., 15, 4745-4753.
59. Russo I. Silver ARJ, Cuthbert AP, Griffin DK, Trott DA and Newbold RF. (1998). Oncogene, 17, 3417-3426.
60. Serrano M, Lee H-W, Chin L, Cordon-Cardo C, Beach D and DePinho RA. (1996). Cell, 85, 27-37.
61. Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW. (1997). Cell, 88, 593-602.
62. Sewing A, Wiseman B, Lloyd A and Land H. (1997). Mol. Cell. Biol., 17, 5588-5597.
63. Sherr CJ. (1998). Genes Dev., 12, 2984-2991.
64. Sherr CJ and Roberts JM. (1995). Genes Dev., 9, 1149-1163.
65. Stein GH and Dulic V. (1995). Bioessays, 17, 537-543.
66. Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH and Peters G. (1998). EMBO J., 17, 5001-5014.
67. Tahara H, Sato E, Noda A and Ide T. (1995). Oncogene, 10, 835-840.
68. Tanaka N, Ishihara M, Kitagawa M, Harada H, Kimura T, Matsuyama T, Lamphier MS, Aizawa S, Mak TW and Taniguchi T. (1994). Cell, 77, 829-839.
69. Todaro GJ and Green H. (1963). J. Cell. Biol., 17, 299-313.
70. Tsukada T, Tomooka Y, Takai S, Ueda Y, Nishikawa S, Yagi T, Tokunaga T, Takeda N, Suda Y, Abe S, Matsuo I, Ikawa Y and Aizawa S. (1993). Oncogene, 8, 3313-3322.
71. Votja PJ and Barrett JC. (1995). Biochim. Biophys. Acta, 1242, 29-41.
72. Wang YA, Elson A and Leder P. (1997). Proc. Natl. Acad. Sci. USA, 94, 14590-14595.
73. Watanabe Y, Lee SW, Detmar M, Ajioka I and Dvorak HF. (1997). Oncogene, 14, 2025-2032.
74. Weinberg RA. (1997). Cell, 88, 573-575.
75. Weinberg WC, Montano NE and Deng C. (1997). Oncogene, 15, 685-690.
76. Woods D, Parry D, Cherwinski H, Bosch E, Lees E and McMahon M. (1997). Mol. Cell. Biol., 17, 5598-5611.
77. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D. (1993). Nature, 366, 701-704.
78. Xu Y, Yang EM, Brugarolas J, Jacks T and Baltimore D. (1998). Mol. Cell. Biol., 7, 4385-4390.
79. Yan Y, Ouellette MM, Shay JW and Wright WE. (1996). Mol. Cell. Biol., 7, 975-983.
80. Zhang Y, Xiong Y and Yarbrough WG. (1998). Cell, 92, 725-734.
81. Zhu J, Woods D, McMahon M and Bishop JM. (1998). Genes Dev., 12, 2997-3007.
82. Zindy F, Quelle DE, Roussel MF and Sherr CJ. (1997). Oncogene, 15, 203-211.
83. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ and Roussel MF. (1998). Genes Dev., 12, 2424-2433.