메뉴 건너뛰기




Volumn 59, Issue 12, 1999, Pages 2957-2964

p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; RETINOBLASTOMA PROTEIN;

EID: 0033564106     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (141)

References (65)
  • 1
    • 0344622606 scopus 로고
    • The limited in vitro lifespan of human diploid cell strains
    • Hayflick, L. The limited in vitro lifespan of human diploid cell strains. Exp. Cell Res., 25: 585-621, 1965.
    • (1965) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1
  • 2
    • 0019973132 scopus 로고
    • Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens
    • Newbold, R. F., Overell, R. W., and Connell, J. R. Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens. Nature (Lond.), 299, 633-635, 1982.
    • (1982) Nature (Lond.) , vol.299 , pp. 633-635
    • Newbold, R.F.1    Overell, R.W.2    Connell, J.R.3
  • 3
    • 0030038104 scopus 로고    scopus 로고
    • Replicative senescence: Implications for in vivo aging and tumor suppression
    • Washington DC
    • Smith, J. R., and Pereira-Smith, O. M. Replicative senescence: implications for in vivo aging and tumor suppression. Science (Washington DC), 273: 63-67, 1996.
    • (1996) Science , vol.273 , pp. 63-67
    • Smith, J.R.1    Pereira-Smith, O.M.2
  • 7
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • Shay, J. W., Pereira-Smith, O. M., and Wright, W. E. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res., 196: 33-39, 1991.
    • (1991) Exp. Cell Res. , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 8
    • 0027333087 scopus 로고
    • Role of SV40 T antigen binding to pRB and p53 in multistep transformation in vitro of human uroepithelial cells
    • Lond.
    • Kao, C., Huang, J., Wu, S. Q., Hauser, P., and Reznikoff, C. A. Role of SV40 T antigen binding to pRB and p53 in multistep transformation in vitro of human uroepithelial cells. Carcinogenesis (Lond.), 14: 2297-2302, 1993.
    • (1993) Carcinogenesis , vol.14 , pp. 2297-2302
    • Kao, C.1    Huang, J.2    Wu, S.Q.3    Hauser, P.4    Reznikoff, C.A.5
  • 9
    • 0028088250 scopus 로고
    • Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells
    • Reznikoff, C. A., Belair, C., Savelieva, E., Zhai, Y., Pfeifer, K., Yeager, T., Thompson, K. J., DeVries, S., Bindley, C., and Newton, M. A. Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells. Genes Dev., 8: 2227-2240, 1994.
    • (1994) Genes Dev. , vol.8 , pp. 2227-2240
    • Reznikoff, C.A.1    Belair, C.2    Savelieva, E.3    Zhai, Y.4    Pfeifer, K.5    Yeager, T.6    Thompson, K.J.7    DeVries, S.8    Bindley, C.9    Newton, M.A.10
  • 11
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., and Barrett, J. C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA, 93: 13742-13747, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 12
    • 0029890863 scopus 로고    scopus 로고
    • Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells
    • Reznikoff, C. A., Yeager, T. R., Belair, C. D., Savelieva, E., Puthenveettil, J. A., and Stadler, W. M. Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. Cancer Res., 56: 2886-2890, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 2886-2890
    • Reznikoff, C.A.1    Yeager, T.R.2    Belair, C.D.3    Savelieva, E.4    Puthenveettil, J.A.5    Stadler, W.M.6
  • 13
    • 0028946009 scopus 로고
    • Increase in expression level of p21/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts
    • Tahara, H., Sato, E., Noda, A., and Ide, T. Increase in expression level of p21/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene, 10: 835-840, 1995.
    • (1995) Oncogene , vol.10 , pp. 835-840
    • Tahara, H.1    Sato, E.2    Noda, A.3    Ide, T.4
  • 15
    • 0029997010 scopus 로고    scopus 로고
    • Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping
    • Cher, M. L., Bova, G. S., Moore, D. H., Small, E. J., Carroll, P. R., Pin, S. S., Epstein, J. I., Isaacs, W. B., and Jensen, R. H. Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cancer Res., 56: 3091-3102, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 3091-3102
    • Cher, M.L.1    Bova, G.S.2    Moore, D.H.3    Small, E.J.4    Carroll, P.R.5    Pin, S.S.6    Epstein, J.I.7    Isaacs, W.B.8    Jensen, R.H.9
  • 16
    • 0028836691 scopus 로고
    • Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas
    • Brooks, J. D., Bova, G. S., and Isaacs, W. B. Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas. Prostate, 26: 35-39, 1995.
    • (1995) Prostate , vol.26 , pp. 35-39
    • Brooks, J.D.1    Bova, G.S.2    Isaacs, W.B.3
  • 18
    • 0028179999 scopus 로고
    • Immunohistochemical determination of p53 protein nuclear accumulation in prostatic adenocarcinoma
    • Aprikian, A. G., Sarkis, A. S., Fair, W. R., Zhang, Z. F., Fuks, Z., and Cordon-Cardo, C. Immunohistochemical determination of p53 protein nuclear accumulation in prostatic adenocarcinoma. J. Urol., 151: 1276-1280, 1994.
    • (1994) J. Urol. , vol.151 , pp. 1276-1280
    • Aprikian, A.G.1    Sarkis, A.S.2    Fair, W.R.3    Zhang, Z.F.4    Fuks, Z.5    Cordon-Cardo, C.6
  • 20
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 22
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
    • Hara, E., Tsurui, H., Shinozaki, A., Nakada, S., and Oda, K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun., 179: 528-534, 1991.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 528-534
    • Hara, E.1    Tsurui, H.2    Shinozaki, A.3    Nakada, S.4    Oda, K.5
  • 23
    • 0029024691 scopus 로고
    • Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SKI1/WAF1
    • Bond, J. A., Blaydes, J. P., Rowson, J., Haughton, M. F., Smith, J. R., Wynford-Thomas, D., and Wyllie, F. S. Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SKI1/WAF1. Cancer Res., 55: 2404-2409, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 2404-2409
    • Bond, J.A.1    Blaydes, J.P.2    Rowson, J.3    Haughton, M.F.4    Smith, J.R.5    Wynford-Thomas, D.6    Wyllie, F.S.7
  • 26
    • 0025150387 scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Washington DC
    • Stein, G. H., Beeson, M., and Gordon, L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science (Washington DC), 249: 666-669, 1990.
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 27
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366: 704-707, 1993.
    • (1993) Nature (Lond.) , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 28
    • 0029670840 scopus 로고    scopus 로고
    • Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
    • Hara, E., Smith, R., Parry, D., Tahara, H., Stone, S., and Peters, G. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell. Biol., 16: 859-867, 1996.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2    Parry, D.3    Tahara, H.4    Stone, S.5    Peters, G.6
  • 29
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki, K., Ono, Y., Henson, J. W., Efird, J. T., von Deimling, A., and Louis, D. N. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res., 56: 150-153, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.W.3    Efird, J.T.4    Von Deimling, A.5    Louis, D.N.6
  • 30
    • 0028172926 scopus 로고
    • Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB
    • Otterson, G. A., Kratzke, R. A., Coxon, A., Kim, Y. W., and Kaye, F. J. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene, 9: 3375-3378, 1994.
    • (1994) Oncogene , vol.9 , pp. 3375-3378
    • Otterson, G.A.1    Kratzke, R.A.2    Coxon, A.3    Kim, Y.W.4    Kaye, F.J.5
  • 32
    • 0032517341 scopus 로고    scopus 로고
    • The p16/CDKN2 tumor suppressor gene and its relatives
    • Ruas, M., and Peters, G. The p16/CDKN2 tumor suppressor gene and its relatives. Biochim. Biophys. Acta, 1378: F115-F117, 1998.
    • (1998) Biochim. Biophys. Acta , vol.1378
    • Ruas, M.1    Peters, G.2
  • 33
    • 0030967596 scopus 로고    scopus 로고
    • p53, bcl-2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate
    • Theodorescu, D., Broder, S. R., Boyd, J. C., Mills, S. E., and Frierson, H. F., Jr. p53, bcl-2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate. J. Urol., 158: 131-137, 1997.
    • (1997) J. Urol. , vol.158 , pp. 131-137
    • Theodorescu, D.1    Broder, S.R.2    Boyd, J.C.3    Mills, S.E.4    Frierson H.F., Jr.5
  • 34
    • 0022653673 scopus 로고
    • Serum-free growth of adult human prostatic epithelial cells
    • Peehl, D. M., and Stamey, T. A. Serum-free growth of adult human prostatic epithelial cells. In Vitro Cell. Dev. Biol., 22: 82-90, 1986.
    • (1986) In Vitro Cell. Dev. Biol. , vol.22 , pp. 82-90
    • Peehl, D.M.1    Stamey, T.A.2
  • 35
    • 0023795190 scopus 로고
    • Clonal growth characteristics of adult human prostatic epithelial cells
    • Peehl, D. M., Wong, S. T., and Stamey, T. A. Clonal growth characteristics of adult human prostatic epithelial cells. In Vitro Cell. Dev. Biol., 24: 530-536, 1988.
    • (1988) In Vitro Cell. Dev. Biol. , vol.24 , pp. 530-536
    • Peehl, D.M.1    Wong, S.T.2    Stamey, T.A.3
  • 36
    • 0020980109 scopus 로고
    • Growth and characterization of normal human urothelium in vitro
    • Reznikoff, C. A., Johnson, M. D., Norback, D. H., and Bryan, G. T. Growth and characterization of normal human urothelium in vitro. In Vitro, 19: 326-343, 1983.
    • (1983) In Vitro , vol.19 , pp. 326-343
    • Reznikoff, C.A.1    Johnson, M.D.2    Norback, D.H.3    Bryan, G.T.4
  • 39
    • 0026024632 scopus 로고
    • The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
    • Halbert, C. L., Demers, G. W., and Galloway, D. A. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J. Virol., 65: 473-478, 1991.
    • (1991) J. Virol. , vol.65 , pp. 473-478
    • Halbert, C.L.1    Demers, G.W.2    Galloway, D.A.3
  • 40
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., and Sidransky, D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 44
    • 0032528231 scopus 로고    scopus 로고
    • On the statistical analysis of allelic-loss data
    • Newton, M. A., Gould, M. N., Reznikoff, C. A., and Haag, J. D. On the statistical analysis of allelic-loss data. Stat. Med., 17: 1425-1445, 1998.
    • (1998) Stat. Med. , vol.17 , pp. 1425-1445
    • Newton, M.A.1    Gould, M.N.2    Reznikoff, C.A.3    Haag, J.D.4
  • 45
    • 0027972462 scopus 로고
    • Multidirectional differentiation in the normal, hyperplastic, and neoplastic human prostate: Simultaneous demonstration of cell-specific epithelial markers
    • Bonkhoff, H., Stein, U., and Remberger, K. Multidirectional differentiation in the normal, hyperplastic, and neoplastic human prostate: simultaneous demonstration of cell-specific epithelial markers. Hum. Pathol., 25: 42-46, 1994.
    • (1994) Hum. Pathol. , vol.25 , pp. 42-46
    • Bonkhoff, H.1    Stein, U.2    Remberger, K.3
  • 47
    • 0027263711 scopus 로고
    • E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts
    • Shay, J. W., Wright, W. E., Brasiskyte, D., and Van der Haegen, B. A. E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene, 8: 1407-1413, 1993.
    • (1993) Oncogene , vol.8 , pp. 1407-1413
    • Shay, J.W.1    Wright, W.E.2    Brasiskyte, D.3    Van Der Haegen, B.A.4
  • 48
    • 0029283913 scopus 로고
    • Regulation of the cell cycle by viral oncoproteins
    • Vousden, K. H. Regulation of the cell cycle by viral oncoproteins. Semin. Cancer Biol., 6: 109-116, 1995.
    • (1995) Semin. Cancer Biol. , vol.6 , pp. 109-116
    • Vousden, K.H.1
  • 50
    • 0025940113 scopus 로고
    • Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles
    • Isaacs, W. B., Carter, B. S., and Ewing, C. M. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. Cancer Res., 51: 4716-4720, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4716-4720
    • Isaacs, W.B.1    Carter, B.S.2    Ewing, C.M.3
  • 55
    • 0029818858 scopus 로고    scopus 로고
    • Expression of p21 is not required for senescence of human fibroblasts
    • Medcalf, A. S., Klein-Szanto, A. J., and Cristofalo, V. J. Expression of p21 is not required for senescence of human fibroblasts. Cancer Res., 56: 4582-4585, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4582-4585
    • Medcalf, A.S.1    Klein-Szanto, A.J.2    Cristofalo, V.J.3
  • 60
    • 0030838976 scopus 로고    scopus 로고
    • Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization
    • Nishizaki, T., DeVries, S., Chew, K., Goodson, W. H., III, Ljung, B. M., Thor, A., and Waldman, F. M. Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization. Genes Chromosomes Cancer, 19: 267-272, 1997.
    • (1997) Genes Chromosomes Cancer , vol.19 , pp. 267-272
    • Nishizaki, T.1    DeVries, S.2    Chew, K.3    Goodson W.H. III4    Ljung, B.M.5    Thor, A.6    Waldman, F.M.7
  • 62
    • 0031456031 scopus 로고    scopus 로고
    • Telomerase activity: A biomarker of cell proliferation, not malignant transformation
    • Belair, C. D., Yeager, T. R., Lopez, P. M., and Reznikoff, C. A. Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc. Natl. Acad. Sci. USA, 94: 13677-13682, 1997.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13677-13682
    • Belair, C.D.1    Yeager, T.R.2    Lopez, P.M.3    Reznikoff, C.A.4
  • 64
    • 0030024671 scopus 로고    scopus 로고
    • Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas
    • Ittmann, M. M., and Wieczorek, R. Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas. Hum. Pathol., 27, 28-34, 1996.
    • (1996) Hum. Pathol. , vol.27 , pp. 28-34
    • Ittmann, M.M.1    Wieczorek, R.2
  • 65
    • 0028869884 scopus 로고
    • Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product
    • Parry, D., Bates, S., Mann, D. J., and Peters, G. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. EMBO J., 14: 503-511, 1995.
    • (1995) EMBO J. , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3    Peters, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.