-
1
-
-
0028988245
-
Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines
-
Aagaard, L., J. Lukas, J. Bartkova, A. A. Kjerulff, M. Strauss, and J. Bartek. 1995. Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. Int. J. Cancer 61:115-120.
-
(1995)
Int. J. Cancer
, vol.61
, pp. 115-120
-
-
Aagaard, L.1
Lukas, J.2
Bartkova, J.3
Kjerulff, A.A.4
Strauss, M.5
Bartek, J.6
-
2
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta, D. A., Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J. C. Barrett. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA 93:13742-13747.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
3
-
-
0029111404
-
Increased activity of p53 in senescing fibroblasts
-
Atadja, P., H. Wong, I. Garkavtsev, C. Veillette, and K. Riabowol. 1995. Increased activity of p53 in senescing fibroblasts. Proc. Natl. Acad. Sci. USA 92:8348-8352.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8348-8352
-
-
Atadja, P.1
Wong, H.2
Garkavtsev, I.3
Veillette, C.4
Riabowol, K.5
-
4
-
-
0029043839
-
Direct transcriptional repression by pRB and its reversal by specific cyclins
-
Bremner, R., B. L. Cohen, M. Sopta, P. A. Hamel, C. J. Ingles, B. L. Gallie, and R. A. Phillips. 1995. Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol. Cell. Biol. 15:3256-3265.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3256-3265
-
-
Bremner, R.1
Cohen, B.L.2
Sopta, M.3
Hamel, P.A.4
Ingles, C.J.5
Gallie, B.L.6
Phillips, R.A.7
-
5
-
-
0004168813
-
-
Academic Press, New York, N.Y.
-
Campisi, J., G. Dimiri, and E. Hara. 1996. Handbook of the biology of aging, 4th ed. Academic Press, New York, N.Y.
-
(1996)
Handbook of the Biology of Aging, 4th Ed.
-
-
Campisi, J.1
Dimiri, G.2
Hara, E.3
-
6
-
-
0030025660
-
Replicative senescence: An old lives' tale?
-
Campisi, J. 1996. Replicative senescence: an old lives' tale? Cell 84:497-500.
-
(1996)
Cell
, vol.84
, pp. 497-500
-
-
Campisi, J.1
-
7
-
-
0033176887
-
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
-
Carrano, A. C., E. Eytan, A. Hershko, and M. Pagano. 1999. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1:193-199.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 193-199
-
-
Carrano, A.C.1
Eytan, E.2
Hershko, A.3
Pagano, M.4
-
8
-
-
0031865232
-
Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
-
Castano, E., Y. Kleyner, and B. D. Dynlacht. 1998. Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor. Mol. Cell. Biol. 18:5380-5391.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5380-5391
-
-
Castano, E.1
Kleyner, Y.2
Dynlacht, B.D.3
-
9
-
-
0023392945
-
High-efficiency transformation of mammalian cells by plasmid DNA
-
Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 2745-2752
-
-
Chen, C.1
Okayama, H.2
-
10
-
-
0032578795
-
pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F
-
Chew, Y. P., M. Ellis, S. Wilkie, and S. Mittnacht. 1998. pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F. Oncogene 17:2177-2186.
-
(1998)
Oncogene
, vol.17
, pp. 2177-2186
-
-
Chew, Y.P.1
Ellis, M.2
Wilkie, S.3
Mittnacht, S.4
-
11
-
-
0028143074
-
p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107
-
Claudio, P. P., C. M. Howard, A. Baldi, A. De Luca, Y. Fu, G. Condorelli, Y. Sun, N. Colburn, B. Calabretta, and A. Giordano. 1994. p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res. 54:5556-5560.
-
(1994)
Cancer Res.
, vol.54
, pp. 5556-5560
-
-
Claudio, P.P.1
Howard, C.M.2
Baldi, A.3
De Luca, A.4
Fu, Y.5
Condorelli, G.6
Sun, Y.7
Colburn, N.8
Calabretta, B.9
Giordano, A.10
-
12
-
-
0029664461
-
Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
-
Coats, S., W. M. Flanagan, J. Nourse, and J. M. Roberts. 1996. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272:877-880.
-
(1996)
Science
, vol.272
, pp. 877-880
-
-
Coats, S.1
Flanagan, W.M.2
Nourse, J.3
Roberts, J.M.4
-
13
-
-
0033602278
-
A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells
-
Coats, S., P. Whyte, M. L. Fero, S. Lacy, G. Chung, E. Randel, E. Firpo, and J. M. Roberts. 1999. A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr. Biol. 9:163-173.
-
(1999)
Curr. Biol.
, vol.9
, pp. 163-173
-
-
Coats, S.1
Whyte, P.2
Fero, M.L.3
Lacy, S.4
Chung, G.5
Randel, E.6
Firpo, E.7
Roberts, J.M.8
-
14
-
-
0034698170
-
Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1
-
Collado, M., R. Medema, I. Garcia-Cao, M. Dubuisson, M. Barradas, J. Glassford, C. Rivas, B. Burgering, M. Serrano, and E. Lam. 2000. Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J. Biol. Chem. 275:21960-21968.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21960-21968
-
-
Collado, M.1
Medema, R.2
Garcia-Cao, I.3
Dubuisson, M.4
Barradas, M.5
Glassford, J.6
Rivas, C.7
Burgering, B.8
Serrano, M.9
Lam, E.10
-
15
-
-
0034704848
-
p16 INK4a can initiate an autonomous senescence program
-
Dai, C., and G. Enders. 2000. p16 INK4a can initiate an autonomous senescence program. Oncogene 19:1613-1622.
-
(2000)
Oncogene
, vol.19
, pp. 1613-1622
-
-
Dai, C.1
Enders, G.2
-
16
-
-
0033979731
-
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
-
Dickson, M. A., W. C. Hahn, Y. Ino, V. Ronfard, J. Y. Wu, R. A. Weinberg, D. N. Louis, F. P. Li, and J. G. Rheinwald. 2000. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell. Biol. 20:1436-1447.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 1436-1447
-
-
Dickson, M.A.1
Hahn, W.C.2
Ino, Y.3
Ronfard, V.4
Wu, J.Y.5
Weinberg, R.A.6
Louis, D.N.7
Li, F.P.8
Rheinwald, J.G.9
-
17
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri, G. P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke, and J. Campisi. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
Peacocke, M.11
Campisi, J.12
-
18
-
-
0033816629
-
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
-
Dulic, V., G. Beney, G. Frebourg, L. Drullinger, and G. Stein. 2000. Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol. Cell. Biol. 20:6741-6754.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6741-6754
-
-
Dulic, V.1
Beney, G.2
Frebourg, G.3
Drullinger, L.4
Stein, G.5
-
19
-
-
0032146274
-
The regulation of E2F by pRB-family proteins
-
Dyson, N. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245-2262.
-
(1998)
Genes Dev.
, vol.12
, pp. 2245-2262
-
-
Dyson, N.1
-
20
-
-
0028294605
-
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
-
el-Deiry, W. S., J. W. Harper, P. M. O'Connor, V. E. Velculescu, C. E. Canman, J. Jackman, J. A. Pietenpol, M. Burrell, D. E. Hill, Y. Wang, et al. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1169-1174.
-
(1994)
Cancer Res.
, vol.54
, pp. 1169-1174
-
-
El-Deiry, W.S.1
Harper, J.W.2
O'Connor, P.M.3
Velculescu, V.E.4
Canman, C.E.5
Jackman, J.6
Pietenpol, J.A.7
Burrell, M.8
Hill, D.E.9
Wang, Y.10
-
21
-
-
0025145238
-
Replicative senescence: The human fibroblast comes of age
-
Goldstein, S. 1990. Replicative senescence: the human fibroblast comes of age. Science 249:1129-1133.
-
(1990)
Science
, vol.249
, pp. 1129-1133
-
-
Goldstein, S.1
-
22
-
-
0026058874
-
The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
-
Goodrich, D. W., N. P. Wang, Y. W. Qian, E. Y. Lee, and W. H. Lee. 1991. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67:293-302.
-
(1991)
Cell
, vol.67
, pp. 293-302
-
-
Goodrich, D.W.1
Wang, N.P.2
Qian, Y.W.3
Lee, E.Y.4
Lee, W.H.5
-
23
-
-
0033019840
-
Telomerase activity is sufficient to allow transformed cells to escape from crisis
-
Halvorsen, T., G. Leibowitz, and F. Levine. 1999. Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol. Cell. Biol. 19:1864-1870.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1864-1870
-
-
Halvorsen, T.1
Leibowitz, G.2
Levine, F.3
-
24
-
-
0027496935
-
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
-
Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Keyomarsi, K.4
Elledge, S.J.5
-
25
-
-
0344622606
-
The serial cultivation of human diploid strains
-
Hayflick, L., and P. S. Moorhead. 1961. The serial cultivation of human diploid strains. Exp. Cell Res. 25:585-621.
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
26
-
-
0029670477
-
Translational control of p27Kip1 accumulation during the cell cycle
-
Hengst, L., and S. I. Reed. 1996. Translational control of p27Kip1 accumulation during the cell cycle. Science 271:1861-1864.
-
(1996)
Science
, vol.271
, pp. 1861-1864
-
-
Hengst, L.1
Reed, S.I.2
-
27
-
-
0029808318
-
TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein
-
Herrera, R. E., T. P. Makela, and R. A. Weinberg. 1996. TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein. Mol. Biol. Cell 7:1335-1342.
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 1335-1342
-
-
Herrera, R.E.1
Makela, T.P.2
Weinberg, R.A.3
-
28
-
-
0026802989
-
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
-
Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006.
-
(1992)
Cell
, vol.70
, pp. 993-1006
-
-
Hinds, P.W.1
Mittnacht, S.2
Dulic, V.3
Arnold, A.4
Reed, S.I.5
Weinberg, R.A.6
-
29
-
-
0025894713
-
p53 mutations in human cancers
-
Hollstein, M., D. Sidransky, B. Vogelstein, and C. C. Harris. 1991. p53 mutations in human cancers. Science 253:49-53.
-
(1991)
Science
, vol.253
, pp. 49-53
-
-
Hollstein, M.1
Sidransky, D.2
Vogelstein, B.3
Harris, C.C.4
-
30
-
-
15444353328
-
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
-
Hurford, R. K., Jr., D. Cobrinik, M. H. Lee, and N. Dyson. 1997. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11:1447-1463.
-
(1997)
Genes Dev.
, vol.11
, pp. 1447-1463
-
-
Hurford R.K., Jr.1
Cobrinik, D.2
Lee, M.H.3
Dyson, N.4
-
31
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N., M. Piatyszek, K. Prowse, C. Harley, M. West, P. Ho, G. Coviello, W. Wright, S. Weinrich, and J. Shay. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.1
Piatyszek, M.2
Prowse, K.3
Harley, C.4
West, M.5
Ho, P.6
Coviello, G.7
Wright, W.8
Weinrich, S.9
Shay, J.10
-
32
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono, T., S. A. Foster, J. I. Koop, J. K. McDougall, D. A. Galloway, and A. J. Klingelhutz. 1998. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396:84-88.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
33
-
-
0025734356
-
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
-
Koff, A., F. Cross, A. Fisher, J. Schumacher, K. Leguellec, M. Philippe, and J. M. Roberts. 1991. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66:1217-1228.
-
(1991)
Cell
, vol.66
, pp. 1217-1228
-
-
Koff, A.1
Cross, F.2
Fisher, A.3
Schumacher, J.4
Leguellec, K.5
Philippe, M.6
Roberts, J.M.7
-
34
-
-
0026656853
-
Wild-type p53 is a cell cycle checkpoint determinant following irradiation
-
Kuerbitz, S. J., B. S. Plunkett, W. V. Walsh, and M. B. Kastan. 1992. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89:7491-7495.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 7491-7495
-
-
Kuerbitz, S.J.1
Plunkett, B.S.2
Walsh, W.V.3
Kastan, M.B.4
-
35
-
-
0029941446
-
Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases
-
Latham, K. M., S. W. Eastman, A. Wong, and P. W. Hinds. 1996. Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases. Mol. Cell. Biol. 16:4445-4455.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4445-4455
-
-
Latham, K.M.1
Eastman, S.W.2
Wong, A.3
Hinds, P.W.4
-
36
-
-
0028845639
-
Cyclin dependent kinase regulation
-
Lees, E. 1995. Cyclin dependent kinase regulation. Curr. Opin. Cell Biol. 7:773-780.
-
(1995)
Curr. Opin. Cell Biol.
, vol.7
, pp. 773-780
-
-
Lees, E.1
-
37
-
-
0031239985
-
S-phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation
-
Leng, X., L. Connell-Crowley, D. Goodrich, and J. W. Harper. 1997. S-phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr. Biol. 7:709-712.
-
(1997)
Curr. Biol.
, vol.7
, pp. 709-712
-
-
Leng, X.1
Connell-Crowley, L.2
Goodrich, D.3
Harper, J.W.4
-
38
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin, A. W., M. Barradas, J. C. Stone, L. van Aelst, M. Serrano, and S. W. Lowe. 1998. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12: 3008-3019.
-
(1998)
Genes Dev.
, vol.12
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
Van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
39
-
-
0028983491
-
Growth suppression by p16ink4 requires functional retinoblastoma protein
-
Medema, R. H., R. E. Herrera, F. Lam, and R. A. Weinberg. 1995. Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. USA 92:6289-6293.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 6289-6293
-
-
Medema, R.H.1
Herrera, R.E.2
Lam, F.3
Weinberg, R.A.4
-
40
-
-
0033864096
-
A U-rich element in the 5′ untranslated region is necessary for the translation of p27 mRNA
-
Millard, S., A. Vidal, M. Markus, and A. Koff. 2000. A U-rich element in the 5′ untranslated region is necessary for the translation of p27 mRNA. Mol. Cell. Biol. 20:5947-5959.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5947-5959
-
-
Millard, S.1
Vidal, A.2
Markus, M.3
Koff, A.4
-
41
-
-
0025318790
-
A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells
-
Morgenstern, J. P., and H. Land. 1990. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res. 18:1068.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 1068
-
-
Morgenstern, J.P.1
Land, H.2
-
42
-
-
0029024015
-
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
-
Pagano, M., S. W. Tam, A. M. Theodoras, P. Beer-Romero, G. Del Sal, V. Chau, P. R. Yew, G. F. Draetta, and M. Rolfe. 1995. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685.
-
(1995)
Science
, vol.269
, pp. 682-685
-
-
Pagano, M.1
Tam, S.W.2
Theodoras, A.M.3
Beer-Romero, P.4
Del Sal, G.5
Chau, V.6
Yew, P.R.7
Draetta, G.F.8
Rolfe, M.9
-
43
-
-
0028869884
-
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product
-
Parry, D., S. Bates, D. J. Mann, and G. Peters. 1995. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. EMBO J. 14:503-511.
-
(1995)
EMBO J.
, vol.14
, pp. 503-511
-
-
Parry, D.1
Bates, S.2
Mann, D.J.3
Peters, G.4
-
44
-
-
0028176483
-
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
-
Polyak, K., M. H. Lee, H. Erdjument-Bromage, A. Koff, J. M. Roberts, P. Tempst, and J. Massague. 1994. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59-66.
-
(1994)
Cell
, vol.78
, pp. 59-66
-
-
Polyak, K.1
Lee, M.H.2
Erdjument-Bromage, H.3
Koff, A.4
Roberts, J.M.5
Tempst, P.6
Massague, J.7
-
45
-
-
0000299214
-
Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
-
Rohme, D. 1981. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc. Natl. Acad. Sci. USA 78:5009-5013.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 5009-5013
-
-
Rohme, D.1
-
46
-
-
0031930466
-
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
-
Sellers, W. R., B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. B. Lassar, and W. G. Kaelin, Jr. 1998. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 12:95-106.
-
(1998)
Genes Dev.
, vol.12
, pp. 95-106
-
-
Sellers, W.R.1
Novitch, B.G.2
Miyake, S.3
Heith, A.4
Otterson, G.A.5
Kaye, F.J.6
Lassar, A.B.7
Kaelin W.G., Jr.8
-
47
-
-
0029612231
-
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
-
Sellers, W. R., J. W. Rodgers, and W. G. Kaelin, Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. USA 92:11544-11548.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11544-11548
-
-
Sellers, W.R.1
Rodgers, J.W.2
Kaelin W.G., Jr.3
-
48
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano, M., A. W. Lin, M. E. McCurrach, D. Beach, and S. W. Lowe. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
49
-
-
0028961521
-
Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines
-
Shapiro, G. I., C. D. Edwards, L. Kobzik, J. Godleski, W. Richards, D. J. Sugarbaker, and B. J. Rollins. 1995. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res. 55:505-509.
-
(1995)
Cancer Res.
, vol.55
, pp. 505-509
-
-
Shapiro, G.I.1
Edwards, C.D.2
Kobzik, L.3
Godleski, J.4
Richards, W.5
Sugarbaker, D.J.6
Rollins, B.J.7
-
50
-
-
0026523778
-
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
-
Shaw, P., R. Bovey, S. Tardy, R. Sahli, B. Sordat, and J. Costa. 1992. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA 89:4495-4499.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4495-4499
-
-
Shaw, P.1
Bovey, R.2
Tardy, S.3
Sahli, R.4
Sordat, B.5
Costa, J.6
-
52
-
-
0023276258
-
Cellular senescence revisited: A review
-
Stanulis-Praeger, B. M. 1987. Cellular senescence revisited: a review. Mech. Ageing Dev. 38:1-48.
-
(1987)
Mech. Ageing Dev.
, vol.38
, pp. 1-48
-
-
Stanulis-Praeger, B.M.1
-
53
-
-
0029896193
-
Transcriptional repression and growth suppression by the p107 pocket protein
-
Starostik, P., K. N. Chow, and D. C. Dean. 1996. Transcriptional repression and growth suppression by the p107 pocket protein. Mol. Cell. Biol. 16:3606-3614.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 3606-3614
-
-
Starostik, P.1
Chow, K.N.2
Dean, D.C.3
-
54
-
-
0033174070
-
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
-
Sutterluty, H., E. Chatelain, A. Marti, C. Wirbelauer, M. Senften, U. Muller, and W. Krek. 1999. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat. Cell Biol. 1:207-214.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 207-214
-
-
Sutterluty, H.1
Chatelain, E.2
Marti, A.3
Wirbelauer, C.4
Senften, M.5
Muller, U.6
Krek, W.7
-
55
-
-
0028169994
-
p53-dependent apoptosis suppresses tumor growth and progression in vivo
-
Symonds, H., L. Krall, L. Remington, M. Saenz-Robles, S. Lowe, T. Jacks, and T. Van Dyke. 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78:703-711.
-
(1994)
Cell
, vol.78
, pp. 703-711
-
-
Symonds, H.1
Krall, L.2
Remington, L.3
Saenz-Robles, M.4
Lowe, S.5
Jacks, T.6
Van Dyke, T.7
-
56
-
-
0034175616
-
Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
-
Takahashi, Y., J. B. Rayman, and B. D. Dynlacht. 2000. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 14:804-816.
-
(2000)
Genes Dev.
, vol.14
, pp. 804-816
-
-
Takahashi, Y.1
Rayman, J.B.2
Dynlacht, B.D.3
-
57
-
-
0026329868
-
Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering
-
Templeton, D. J., S. H. Park, L. Lanier, and R. A. Weinberg. 1991. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sci. USA 88:3033-3037.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 3033-3037
-
-
Templeton, D.J.1
Park, S.H.2
Lanier, L.3
Weinberg, R.A.4
-
58
-
-
0032481314
-
Induction of DNA synthesis and apoptosis by regulated inactivation of a temperature-sensitive retinoblastoma protein
-
Tiemann, F., and P. W. Hinds. 1998. Induction of DNA synthesis and apoptosis by regulated inactivation of a temperature-sensitive retinoblastoma protein. EMBO J. 17:1040-1052.
-
(1998)
EMBO J.
, vol.17
, pp. 1040-1052
-
-
Tiemann, F.1
Hinds, P.W.2
-
59
-
-
0028363519
-
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
-
Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78:67-74.
-
(1994)
Cell
, vol.78
, pp. 67-74
-
-
Toyoshima, H.1
Hunter, T.2
-
60
-
-
0033578073
-
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
-
Tsvetkov, L. M., K. H. Yeh, S. J. Lee, H. Sun, and H. Zhang. 1999. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol. 9:661-664.
-
(1999)
Curr. Biol.
, vol.9
, pp. 661-664
-
-
Tsvetkov, L.M.1
Yeh, K.H.2
Lee, S.J.3
Sun, H.4
Zhang, H.5
-
61
-
-
0028902381
-
Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members
-
Vairo, G., D. M. Livingston, and D. Ginsberg. 1995. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev. 9:869-881.
-
(1995)
Genes Dev.
, vol.9
, pp. 869-881
-
-
Vairo, G.1
Livingston, D.M.2
Ginsberg, D.3
-
62
-
-
0027742184
-
Distinct roles for cyclin-dependent kinases in cell cycle control
-
van den Heuvel, S., and E. Harlow. 1993. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262:2050-2054.
-
(1993)
Science
, vol.262
, pp. 2050-2054
-
-
Van Den Heuvel, S.1
Harlow, E.2
-
63
-
-
0032567967
-
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
-
Vaziri, H., and S. Benchimol. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8:279-282.
-
(1998)
Curr. Biol.
, vol.8
, pp. 279-282
-
-
Vaziri, H.1
Benchimol, S.2
-
64
-
-
0031052563
-
Retinoblastoma protein in growth suppression and death protection
-
Wang, J. 1997. Retinoblastoma protein in growth suppression and death protection. Curr. Opin. Genet. Dev. 7:39-45.
-
(1997)
Curr. Opin. Genet. Dev.
, vol.7
, pp. 39-45
-
-
Wang, J.1
-
65
-
-
0029043782
-
Mechanism of active transcriptional repression by the retinoblastoma protein
-
Weintraub, S. J., K. N. Chow, R. X. Luo, S. H. Zhang, S. He, and D. C. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
-
(1995)
Nature
, vol.375
, pp. 812-815
-
-
Weintraub, S.J.1
Chow, K.N.2
Luo, R.X.3
Zhang, S.H.4
He, S.5
Dean, D.C.6
-
66
-
-
0029023065
-
Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity
-
Wright, W. E., J. W. Shay, and M. A. Piatyszek. 1995. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res. 23:3794-3795.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 3794-3795
-
-
Wright, W.E.1
Shay, J.W.2
Piatyszek, M.A.3
-
67
-
-
9844232032
-
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
-
Xu, H. J., Y. Zhou, W. Ji, G. S. Perng, R. Kruzelock, C. T. Kong, R. C. Bast, G. B. Mills, J. Li, and S. X. Hu. 1997. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene 15:2589-2596.
-
(1997)
Oncogene
, vol.15
, pp. 2589-2596
-
-
Xu, H.J.1
Zhou, Y.2
Ji, W.3
Perng, G.S.4
Kruzelock, R.5
Kong, C.T.6
Bast, R.C.7
Mills, G.B.8
Li, J.9
Hu, S.X.10
-
68
-
-
0028911406
-
Increased p16 levels correlate with pRb alterations in human urothelial cells
-
Yeager, T., W. Stadler, C. Belair, J. Puthenveettil, O. Olopade, and C. Reznikoff. 1995. Increased p16 levels correlate with pRb alterations in human urothelial cells. Cancer Res. 55:493-497.
-
(1995)
Cancer Res.
, vol.55
, pp. 493-497
-
-
Yeager, T.1
Stadler, W.2
Belair, C.3
Puthenveettil, J.4
Olopade, O.5
Reznikoff, C.6
-
69
-
-
0032192153
-
Senescence of human fibroblasts induced by oncogenic raf
-
Zhu, J., D. Woods, M. McMahon, and J. M. Bishop. 1998. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 12:2997-3007.
-
(1998)
Genes Dev.
, vol.12
, pp. 2997-3007
-
-
Zhu, J.1
Woods, D.2
McMahon, M.3
Bishop, J.M.4
-
70
-
-
0028983384
-
p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
-
Zhu, L., E. Harlow, and B. D. Dynlacht. 1995. p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9:1740-1752.
-
(1995)
Genes Dev.
, vol.9
, pp. 1740-1752
-
-
Zhu, L.1
Harlow, E.2
Dynlacht, B.D.3
-
71
-
-
0027313470
-
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein
-
Zhu, L., S. van den Heuvel, K. Helin, A. Fattacy, M. Ewen, D. Livingston, N. Dyson, and E. Harlow. 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7:1111-1125.
-
(1993)
Genes Dev.
, vol.7
, pp. 1111-1125
-
-
Zhu, L.1
Van Den Heuvel, S.2
Helin, K.3
Fattacy, A.4
Ewen, M.5
Livingston, D.6
Dyson, N.7
Harlow, E.8
|