-
1
-
-
0026460896
-
Telomere length predicts replicative capacity of human fibroblasts
-
Allsopp, R. C., H. Vaziri, C. Patterson, S. Goldstein, E. V. Younglai, A. B. Futcher, C. W. Greider, and C. B. Harley. 1992. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA 89: 10114-10118.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 10114-10118
-
-
Allsopp, R.C.1
Vaziri, H.2
Patterson, C.3
Goldstein, S.4
Younglai, E.V.5
Futcher, A.B.6
Greider, C.W.7
Harley, C.B.8
-
2
-
-
0032576733
-
Reconstitution of human telomerase activity in vitro
-
Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 1998. Reconstitution of human telomerase activity in vitro. Curr. Biol. 8:177-180.
-
(1998)
Curr. Biol.
, vol.8
, pp. 177-180
-
-
Beattie, T.L.1
Zhou, W.2
Robinson, M.O.3
Harrington, L.4
-
3
-
-
0017166058
-
Specific chromosome alterations in senescent fibroblast cell lines derived from human embryos
-
Benn, P. 1976. Specific chromosome alterations in senescent fibroblast cell lines derived from human embryos. Am. J. Hum. Genet. 28:465-473.
-
(1976)
Am. J. Hum. Genet.
, vol.28
, pp. 465-473
-
-
Benn, P.1
-
4
-
-
0003893137
-
-
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
Blackburn, E. H., and C. W. Greider. 1995. Telomeres. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
(1995)
Telomeres
-
-
Blackburn, E.H.1
Greider, C.W.2
-
5
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar, A. G., M. Ouelletle, M. Frolkis, S. E. Holt, C. Chiu, G. B. Morin, C. B. Harley, J. W. Shay, S. Lichtsteiner, and W. E. Wright. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouelletle, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
6
-
-
0029586089
-
A human telomeric protein
-
Chong, L., B. van Steensel, D. Broccoli, H. Erdjument, J. Hanish, P. Tempst, and T. de Lange. 1995. A human telomeric protein. Science 270:1663-1667.
-
(1995)
Science
, vol.270
, pp. 1663-1667
-
-
Chong, L.1
Van Steensel, B.2
Broccoli, D.3
Erdjument, H.4
Hanish, J.5
Tempst, P.6
De Lange, T.7
-
7
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter, C. M., A. A. Avilion, C. E. LeFeuvre, N. G. Stewart, C. W. Greider, C. B. Harley, and S. Bacchetti. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921-1929.
-
(1992)
EMBO J.
, vol.11
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
LeFeuvre, C.E.3
Stewart, N.G.4
Greider, C.W.5
Harley, C.B.6
Bacchetti, S.7
-
8
-
-
0029096515
-
RNA component of human telomerase
-
Feng, J., W. D. Funk, S. Wang, S. L. Weinrich, A. A. Avilion, C. Chiu, R. R. Adams, E. Chang, R. C. Allsopp, J. Yu, L. Siyuan, M. D. West, C. B. Harley, W. H. Andrews, C. W. Greider, and B. Villeponteau. 1995. RNA component of human telomerase. Science 269:1236-1241.
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.3
Weinrich, S.L.4
Avilion, A.A.5
Chiu, C.6
Adams, R.R.7
Chang, E.8
Allsopp, R.C.9
Yu, J.10
Siyuan, L.11
West, M.D.12
Harley, C.B.13
Andrews, W.H.14
Greider, C.W.15
Villeponteau, B.16
-
9
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
-
Greider, C. W., and E. H. Blackburn. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413.
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
10
-
-
0025787643
-
Telomere loss: Mitotic clock or genetic time bomb?
-
Harley, C. B. 1991. Telomere loss: mitotic clock or genetic time bomb? Mutat. Res. 256:271-282.
-
(1991)
Mutat. Res.
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
11
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
12
-
-
0026628668
-
The telomere hypothesis of cellular aging
-
Harley, C. B., H. Vaziri, C. M. Counter, and R. C. Allsopp. 1992. The telomere hypothesis of cellular aging. Exp. Gerontol. 27:375-382.
-
(1992)
Exp. Gerontol.
, vol.27
, pp. 375-382
-
-
Harley, C.B.1
Vaziri, H.2
Counter, C.M.3
Allsopp, R.C.4
-
13
-
-
0030668722
-
Human telomerase contains evolutionarily conserved catalytic and structural subunits
-
Harrington, L., W. Zhou, T. McPhail, R. Oulton, D. S. Yeung, V. Mar, M. B. Bass, and M. O. Robinson. 1997. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 11:3109-3115.
-
(1997)
Genes Dev.
, vol.11
, pp. 3109-3115
-
-
Harrington, L.1
Zhou, W.2
McPhail, T.3
Oulton, R.4
Yeung, D.S.5
Mar, V.6
Bass, M.B.7
Robinson, M.O.8
-
14
-
-
0025743438
-
Telomerase primer specificity and chromosome healing
-
Harrington, L. A., and C. W. Greider. 1991. Telomerase primer specificity and chromosome healing. Nature 353:451-454.
-
(1991)
Nature
, vol.353
, pp. 451-454
-
-
Harrington, L.A.1
Greider, C.W.2
-
15
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie, N. D., M. Dempster, M. G. Dunlop, A. M. Thompson, D. K. Green, and R. C. Allshire. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866-868.
-
(1990)
Nature
, vol.346
, pp. 866-868
-
-
Hastie, N.D.1
Dempster, M.2
Dunlop, M.G.3
Thompson, A.M.4
Green, D.K.5
Allshire, R.C.6
-
16
-
-
0344622606
-
The serial cultivation of human diploid strains
-
Hayflick, L., and P. Moorhead. 1961. The serial cultivation of human diploid strains. Exp. Cell Res. 25:585-621.
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.2
-
17
-
-
0030006735
-
In situ analysis of changes in telomere size during replicative aging and cell transformation
-
Henderson, S., R. C. Allsopp, D. Spector, S. Wang, and C. B. Harley. 1996. In situ analysis of changes in telomere size during replicative aging and cell transformation. J. Cell Biol. 134:1-12.
-
(1996)
J. Cell Biol.
, vol.134
, pp. 1-12
-
-
Henderson, S.1
Allsopp, R.C.2
Spector, D.3
Wang, S.4
Harley, C.B.5
-
18
-
-
0030681073
-
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
-
Kilian, A., D. L. Bowtell, H. E. Abud, G. R. Hime, D. J. Venter, P. K. Keese, E. L. Duncan, R. R. Reddel, and R. A. Jefferson. 1997. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum. Mol. Genet. 6:2011-2019.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 2011-2019
-
-
Kilian, A.1
Bowtell, D.L.2
Abud, H.E.3
Hime, G.R.4
Venter, D.J.5
Keese, P.K.6
Duncan, E.L.7
Reddel, R.R.8
Jefferson, R.A.9
-
19
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N. W., M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Coviello, W. E. Wright, S. L. Weinrich, and J. W. Shay. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
20
-
-
0030938901
-
Reverse transcriptase motifs in the catalytic subunit of telomerase
-
Lingner, J., T. R. Hughes, A. Shevchenko, M. Mann, V. Lundblad, and T. R. Cech. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276:561-567.
-
(1997)
Science
, vol.276
, pp. 561-567
-
-
Lingner, J.1
Hughes, T.R.2
Shevchenko, A.3
Mann, M.4
Lundblad, V.5
Cech, T.R.6
-
21
-
-
0030745448
-
hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization
-
Meyerson, M., C. M. Counter, E. Ng Eaton, L. W. Ellisen, P. Steiner, S. D. Caddle, L. Ziaugra, R. L. Beijersbergen, M. J. Davidoff, Q. Liu, S. Bacchetti, D. A. Haber, and R. A. Weinberg. 1997. hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 90:785-795.
-
(1997)
Cell
, vol.90
, pp. 785-795
-
-
Meyerson, M.1
Counter, C.M.2
Eaton, E.Ng.3
Ellisen, L.W.4
Steiner, P.5
Caddle, S.D.6
Ziaugra, L.7
Beijersbergen, R.L.8
Davidoff, M.J.9
Liu, Q.10
Bacchetti, S.11
Haber, D.A.12
Weinberg, R.A.13
-
22
-
-
0024325562
-
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTaGGG repeats
-
Morin, G. B. 1989. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59:521-529.
-
(1989)
Cell
, vol.59
, pp. 521-529
-
-
Morin, G.B.1
-
23
-
-
0025808098
-
Recognition of a chromosome truncation site associated with alpha-thalassaemia by human telomerase
-
Morin, G. B. 1991. Recognition of a chromosome truncation site associated with alpha-thalassaemia by human telomerase. Nature 353:454-456.
-
(1991)
Nature
, vol.353
, pp. 454-456
-
-
Morin, G.B.1
-
24
-
-
0013462065
-
A highly conserved repetitive DNA sequence. (TTAGGG)n, present at the telomeres of human chromosomes
-
Moyzis, R. K., J. M. Buckingham, L. S. Cram, M. Dani, L. L. Deaven, M. D. Jones, J. Meyne, R. L. Ratliff, and J. R. Wu. 1988. A highly conserved repetitive DNA sequence. (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85:6622-6626.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 6622-6626
-
-
Moyzis, R.K.1
Buckingham, J.M.2
Cram, L.S.3
Dani, M.4
Deaven, L.L.5
Jones, M.D.6
Meyne, J.7
Ratliff, R.L.8
Wu, J.R.9
-
25
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura, T. M., G. B. Morin, K. B. Chapman, S. L. Weinrich, W. H. Andrews, J. Lingner, C. B. Harley, and T. R. Cech. 1997. Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955-959.
-
(1997)
Science
, vol.277
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
Weinrich, S.L.4
Andrews, W.H.5
Lingner, J.6
Harley, C.B.7
Cech, T.R.8
-
26
-
-
0025270234
-
Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet assay."
-
Olive, P. L., J. P. Banath, and R. E. Durand. 1990. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet assay." Radiat. Res. 122:86-94.
-
(1990)
Radiat. Res.
, vol.122
, pp. 86-94
-
-
Olive, P.L.1
Banath, J.P.2
Durand, R.E.3
-
27
-
-
0001029496
-
A theory of marginotomy
-
Olovnikov, A. M. 1971. A theory of marginotomy. Dokl. Biochem. 201:394-397.
-
(1971)
Dokl. Biochem.
, vol.201
, pp. 394-397
-
-
Olovnikov, A.M.1
-
28
-
-
0028981380
-
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
-
Rogan, E. M., T. M. Bryan, B. Hukku, K. Maclean, A. C. Chang, E. L. Moy, A. Englezou, S. G. Warneford, L. Dalla-Pozza, and R. R. Reddel. 1995. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol. Cell. Biol. 15:4745-4753.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4745-4753
-
-
Rogan, E.M.1
Bryan, T.M.2
Hukku, B.3
Maclean, K.4
Chang, A.C.5
Moy, E.L.6
Englezou, A.7
Warneford, S.G.8
Dalla-Pozza, L.9
Reddel, R.R.10
-
29
-
-
0038214755
-
Multicolor spectral karyotyping of human chromosomes
-
Schrock, E., S. du Manoir, T. Veldman, B. Schoell, J. Weinberg, M. A. Ferguson, Y. Ning, D. H. Ledbetter, I. Bar-Am, D. Soeksen, Y. Garini, and T. Ried. 1996. Multicolor spectral karyotyping of human chromosomes. Science 273:494-497.
-
(1996)
Science
, vol.273
, pp. 494-497
-
-
Schrock, E.1
Du Manoir, S.2
Veldman, T.3
Schoell, B.4
Weinberg, J.5
Ferguson, M.A.6
Ning, Y.7
Ledbetter, D.H.8
Bar-Am, I.9
Soeksen, D.10
Garini, Y.11
Ried, T.12
-
30
-
-
0000133469
-
Defining cellular senescence in IMR-90 cells: A flow cytometric analysis
-
Sherwood, S. W., D. Rush, J. L. Ellsworth, and R. T. Schimke. 1988. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Natl. Acad. Sci. USA 85:9086-9090.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 9086-9090
-
-
Sherwood, S.W.1
Rush, D.2
Ellsworth, J.L.3
Schimke, R.T.4
-
31
-
-
0000197194
-
Extension of life span by telomerase activation: A revolution in cultural senescence
-
Vaziri, H. 1998. Extension of life span by telomerase activation: a revolution in cultural senescence. J. Anti-Aging Med. 1:125-130.
-
(1998)
J. Anti-aging Med.
, vol.1
, pp. 125-130
-
-
Vaziri, H.1
-
32
-
-
0032567967
-
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
-
Vaziri, H., and S. Benchimol. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8:279-282.
-
(1998)
Curr. Biol.
, vol.8
, pp. 279-282
-
-
Vaziri, H.1
Benchimol, S.2
-
33
-
-
0027486732
-
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
-
Vaziri, H., F. Schachter, I. Uchida, L. Wei, X. Zhu, R. Effros, D. Cohen, and C. B. Harley. 1993. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52:661-667.
-
(1993)
Am. J. Hum. Genet.
, vol.52
, pp. 661-667
-
-
Vaziri, H.1
Schachter, F.2
Uchida, I.3
Wei, L.4
Zhu, X.5
Effros, R.6
Cohen, D.7
Harley, C.B.8
-
34
-
-
0030761351
-
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the posttranslational activation of p53 protein involving poly(ADP-ribose) polymerase
-
Vaziri, H., M. D. West, R. C. Allsopp, T. S. Davison, Y. S. Wu, C. H. Arrowsmith, G. G. Poirier, and S. Benchimol. 1997. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the posttranslational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16:6018-6033.
-
(1997)
EMBO J.
, vol.16
, pp. 6018-6033
-
-
Vaziri, H.1
West, M.D.2
Allsopp, R.C.3
Davison, T.S.4
Wu, Y.S.5
Arrowsmith, C.H.6
Poirier, G.G.7
Benchimol, S.8
-
35
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich, S., L., R. Pruzan, L. Ma, M. Ouellette, V. M. Tesmer, S. E. Holt, A. G. Bodnar, S. Lichtsteiner, N. W. Kim, J. B. Trager, R. D. Taylor, R. Carlos, W. H. Andrews, W. E. Wright, J. W. Shay, C. B. Harley, and G. B. Morin. 1997. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17: 498-502.
-
(1997)
Nat. Genet.
, vol.17
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
Ouellette, M.4
Tesmer, V.M.5
Holt, S.E.6
Bodnar, A.G.7
Lichtsteiner, S.8
Kim, N.W.9
Trager, J.B.10
Taylor, R.D.11
Carlos, R.12
Andrews, W.H.13
Wright, W.E.14
Shay, J.W.15
Harley, C.B.16
Morin, G.B.17
-
36
-
-
0025007621
-
A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeats (TTAGGG)n
-
Wilkie, A. O., J. Lamb, P. C. Harris, R. D. Finney, and D. R. Higgs. 1990. A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeats (TTAGGG)n. Nature 346:868-871.
-
(1990)
Nature
, vol.346
, pp. 868-871
-
-
Wilkie, A.O.1
Lamb, J.2
Harris, P.C.3
Finney, R.D.4
Higgs, D.R.5
-
37
-
-
0003074784
-
Early chromosomal changes in SV40-infected human fibroblast cultures
-
Wolman, S. R., K. Hirschhorn, and G. J. Todaro. 1964. Early chromosomal changes in SV40-infected human fibroblast cultures. Cytogenetics 3:45-61.
-
(1964)
Cytogenetics
, vol.3
, pp. 45-61
-
-
Wolman, S.R.1
Hirschhorn, K.2
Todaro, G.J.3
|