Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization

Genes and Development

Volumn 14, Issue 23, 2000, Pages 3037-3050

  Sage, Julien ^a   Mulligan, George J ^a,c   Attardi, Laura D ^a,d   Miller, Abigail ^a   Chen, Siqi ^a   Williams, Bart ^a   Theodorou, Elias ^a   Jacks, Tyler ^a,b  

^a Center for Cancer Research   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Millenium Predictive Medicine   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

G1 control; Immortalization; Knock out; MEFs; Rb

Indexed keywords

DNA; PROTEIN P107; PROTEIN P130; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL IMMORTALIZATION; CONTROLLED STUDY; GENE DISRUPTION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DNA DAMAGE; DOXORUBICIN; G1 PHASE; GENE TARGETING; GENES, RAS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130;

ANIMALIA; MAMMALIA;

EID: 0033637086     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.843200     Document Type: Article

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