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Volumn 21, Issue 11, 2001, Pages 3642-3651

The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; KU ANTIGEN;

EID: 0035023139     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.11.3642-3651.2001     Document Type: Article
Times cited : (181)

References (54)
  • 1
    • 0001265118 scopus 로고
    • Mouse lymphoma cells with different radiosensitivities
    • Alexander, P., and Z. B. Mikulski. 1961. Mouse lymphoma cells with different radiosensitivities. Nature 192:572-573.
    • (1961) Nature , vol.192 , pp. 572-573
    • Alexander, P.1    Mikulski, Z.B.2
  • 3
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice
    • Artandi, S. E., S. Chang, S.-L. Lee, S. Alson, G. J. Gottlieb, L. Chin, and R. DePinho. 2000. Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice. Nature 406:641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.-L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    Depinho, R.7
  • 4
    • 0030272689 scopus 로고    scopus 로고
    • Telomerase and cancer: Revisiting the telomere hypothesis
    • Autexier, C., and C. W. Greider. 1996. Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem. 21:387-391.
    • (1996) Trends Biochem. , vol.21 , pp. 387-391
    • Autexier, C.1    Greider, C.W.2
  • 6
    • 0033597820 scopus 로고    scopus 로고
    • Ku binds telomeric DNA in vitro
    • Bianchi, A., and T. de Lange. 1999. Ku binds telomeric DNA in vitro. J. Biol. Chem. 274:21223-21227.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21223-21227
    • Bianchi, A.1    De Lange, T.2
  • 7
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E. H. 1991. Structure and function of telomeres. Nature 350: 569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 8
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
    • Blasco, M. A., M. Rizen, C. W. Greider, and D. Hanahan. 1996. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat. Genet. 12:200-204.
    • (1996) Nat. Genet. , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 11
    • 0029788520 scopus 로고    scopus 로고
    • Identification of a non-sense mutation in the carboxyl terminal region of DNA-dependent protein kinase catalytic subunit in the SCID mouse
    • Blunt, T., D. Gell, M. Fox, G. E. Taccioli, A. R. Lehmann, S. P. Jackson, and P. A. Jeggo. 1996. Identification of a non-sense mutation in the carboxyl terminal region of DNA-dependent protein kinase catalytic subunit in the SCID mouse. Proc. Natl. Acad. Sci. USA 93:10285-10290.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10285-10290
    • Blunt, T.1    Gell, D.2    Fox, M.3    Taccioli, G.E.4    Lehmann, A.R.5    Jackson, S.P.6    Jeggo, P.A.7
  • 12
    • 0029843408 scopus 로고    scopus 로고
    • Identification of a saccharomyces cerevisiae Ku80 homolog: Roles in DNA double strand break rejoining and in telomeric maintenance
    • Boulton, S. J., and S. P. Jackson. 1996. Identification of a Saccharomyces cerevisiae Ku80 homolog: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24:4639-4648.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4639-4648
    • Boulton, S.J.1    Jackson, S.P.2
  • 13
    • 0032536861 scopus 로고    scopus 로고
    • Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
    • Boulton, S. J., and S. P. Jackson. 1998. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1819-1828.
    • (1998) EMBO J. , vol.17 , pp. 1819-1828
    • Boulton, S.J.1    Jackson, S.P.2
  • 14
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C. M., A. A. Avilion, C. E. LeFeuvre, N. G. Stewart, C. W. Greider, C. B. Harley, and S. Bacchetti. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 15
    • 0029791450 scopus 로고    scopus 로고
    • Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes
    • Danska, J. S., D. P. Holland, S. Mariathasa, K. M. Williams, and C. J. Guidos. 1996. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol. Cell. Biol. 16:5507-5517.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5507-5517
    • Danska, J.S.1    Holland, D.P.2    Mariathasa, S.3    Williams, K.M.4    Guidos, C.J.5
  • 16
    • 0003893137 scopus 로고
    • Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
    • de Lange, T. 1995. Telomeres, p. 265-293. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
    • (1995) Telomeres , pp. 265-293
    • De Lange, T.1
  • 17
    • 0034162719 scopus 로고    scopus 로고
    • DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus
    • DiBiase, S. J., Z. C. Zeng, R. Chen, T. Hyslop, W. J. Curran, Jr., and G. Iliakis. 2000. DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res. 60:1245-1253.
    • (2000) Cancer Res. , vol.60 , pp. 1245-1253
    • DiBiase, S.J.1    Zeng, Z.C.2    Chen, R.3    Hyslop, T.4    Curran W.J., Jr.5    Iliakis, G.6
  • 18
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for Ku in V(D)J recombination
    • Gao, Y., J. Chaudhuri, C. Zhu, L. Davidson, D. T. Weaver, and F. W. Alt. 1998. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for Ku in V(D)J recombination. Immunity 9:367-376.
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1    Chaudhuri, J.2    Zhu, C.3    Davidson, L.4    Weaver, D.T.5    Alt, F.W.6
  • 21
    • 0032076127 scopus 로고    scopus 로고
    • Yeast Ku as a regulator of chromosomal DNA end structure
    • Gravel, S., M. Larrivee, P. Labrecque, and R. J. Wellinger. 1998. Yeast Ku as a regulator of chromosomal DNA end structure. Science 280:741-744.
    • (1998) Science , vol.280 , pp. 741-744
    • Gravel, S.1    Larrivee, M.2    Labrecque, P.3    Wellinger, R.J.4
  • 22
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammals
    • Grawunder, U., M. Wilm, X. Wu, P. Kulesza, T. E. Wilson, M. Mann, and M. Lieber. 1997. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammals. Nature 388:492-495.
    • (1997) Nature , vol.388 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6    Lieber, M.7
  • 23
    • 0029088371 scopus 로고
    • Tell, a gene involved in controlling telomere length in s. Cerevisiae, is homologous to the human ataxia telangiectasia gene
    • Greenwall, P. W., S. L. Kronmal, S. E. Porter, J. Gassenhuber, B. Obermaier, and T. D. Petes. 1995. Tell, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82:823-829.
    • (1995) Cell , vol.82 , pp. 823-829
    • Greenwall, P.W.1    Kronmal, S.L.2    Porter, S.E.3    Gassenhuber, J.4    Obermaier, B.5    Petes, T.D.6
  • 25
    • 0030858967 scopus 로고    scopus 로고
    • Ku70 deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end binding activity, and inability to support V(D)J recombination
    • Gu, Y. S., S. F. Jin, Y. J. Gao, D. T. Weaver, and F. W. Alt. 1997. Ku70 deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end binding activity, and inability to support V(D)J recombination. Proc. Natl. Acad. Sci. USA 94:8076-8081.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8076-8081
    • Gu, Y.S.1    Jin, S.F.2    Gao, Y.J.3    Weaver, D.T.4    Alt, F.W.5
  • 28
    • 0033569847 scopus 로고    scopus 로고
    • G-strand overhangs on telomeres in telomerase deficient mouse cells
    • Hemann, M. T., and C. W. Greider. 1999. G-strand overhangs on telomeres in telomerase deficient mouse cells. Nucleic Acids Res. 27:3964-3969.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 3964-3969
    • Hemann, M.T.1    Greider, C.W.2
  • 29
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated to telomerase deficiency appear earlier in mice with short telomeres
    • Herrera, E., E. Samper, J. Martín-Caballero, J. M. Flores, H.-W. Lee, and M. A. Blasco. 1999. Disease states associated to telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18:2950-2960.
    • (1999) EMBO J. , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martín-Caballero, J.3    Flores, J.M.4    Lee, H.-W.5    Blasco, M.A.6
  • 30
    • 0343750697 scopus 로고    scopus 로고
    • Impaired germinal center formation in telomerase-deficient mice
    • Herrera, E., C. Martinez, and M. A. Blasco. 2000. Impaired germinal center formation in telomerase-deficient mice. EMBO J. 19:472-481.
    • (2000) EMBO J. , vol.19 , pp. 472-481
    • Herrera, E.1    Martinez, C.2    Blasco, M.A.3
  • 37
    • 0029585872 scopus 로고
    • The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
    • Li, Z., T. Otevrel, Y. Gao, H.-L. Cheng, B. Seed, T. D. Stamato, G. E. Taccioli, and F. W. Alt. 1995. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83:1079-1089.
    • (1995) Cell , vol.83 , pp. 1079-1089
    • Li, Z.1    Otevrel, T.2    Gao, Y.3    Cheng, H.-L.4    Seed, B.5    Stamato, T.D.6    Taccioli, G.E.7    Alt, F.W.8
  • 38
    • 0033612287 scopus 로고    scopus 로고
    • Relocalization of telomeric Ku and SIR proteins in response to DNA double-strand breaks
    • Martin, S. G., T. Laroche, N. Suka, M. Grunstein, and S. M. Gasser. 1999. Relocalization of telomeric Ku and SIR proteins in response to DNA double-strand breaks. Cell 97:621-633.
    • (1999) Cell , vol.97 , pp. 621-633
    • Martin, S.G.1    Laroche, T.2    Suka, N.3    Grunstein, M.4    Gasser, S.M.5
  • 40
    • 0033612189 scopus 로고    scopus 로고
    • MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
    • Mills, K. D., D. A. Sinclair, and L. Guarente. 1999. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97:609-620.
    • (1999) Cell , vol.97 , pp. 609-620
    • Mills, K.D.1    Sinclair, D.A.2    Guarente, L.3
  • 41
    • 0029150855 scopus 로고
    • Tel 1, an s. Cerevisiae homolog of the human gene mutatedin ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
    • Morrow, D. M., D. A. Tagle, Y. Shiloh, F. S. Collins, and P. Hieter. 1995. Tel 1, an S. cerevisiae homolog of the human gene mutatedin ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82: 831-840.
    • (1995) Cell , vol.82 , pp. 831-840
    • Morrow, D.M.1    Tagle, D.A.2    Shiloh, Y.3    Collins, F.S.4    Hieter, P.5
  • 45
    • 0028788816 scopus 로고
    • Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases
    • Poltoratsky, V. P., X. Shi, J. D. York, M. R. Lieber, and T. H. Carter. 1995. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J. Immunol. 155:4529-4533.
    • (1995) J. Immunol. , vol.155 , pp. 4529-4533
    • Poltoratsky, V.P.1    Shi, X.2    York, J.D.3    Lieber, M.R.4    Carter, T.H.5
  • 46
    • 0031879115 scopus 로고    scopus 로고
    • Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
    • Rufer, N., W. Dragowska, G. Thornbury, E. Roosnek, and P. M. Lansdorp. 1998. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 16:743-747.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 743-747
    • Rufer, N.1    Dragowska, W.2    Thornbury, G.3    Roosnek, E.4    Lansdorp, P.M.5
  • 47
    • 0034280093 scopus 로고    scopus 로고
    • Mammalian Ku86 prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
    • Samper, E., F. Goytisolo, P. Slijepcevic, P. van Buul, and M. A. Blasco. 2000. Mammalian Ku86 prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep. 1:244-252.
    • (2000) EMBO Rep. , vol.1 , pp. 244-252
    • Samper, E.1    Goytisolo, F.2    Slijepcevic, P.3    Van Buul, P.4    Blasco, M.A.5
  • 48
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • Smith, G. C. M., and S. P. Jackson. 1999. The DNA-dependent protein kinase. Genes Dev. 13:916-934.
    • (1999) Genes Dev. , vol.13 , pp. 916-934
    • Smith, G.C.M.1    Jackson, S.P.2
  • 50
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 52
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu, C. M., M. A. Bogue, D. S. Lim, P. Hasty, and D. B. Roth. 1996. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86:379-389.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.M.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 53
    • 0342561644 scopus 로고    scopus 로고
    • Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
    • Zhu, X. D., B. Kuster, M. Mann, J. H. Petrini, and T. de Lange. 2000. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat. Genet. 25:347-352.
    • (2000) Nat. Genet. , vol.25 , pp. 347-352
    • Zhu, X.D.1    Kuster, B.2    Mann, M.3    Petrini, J.H.4    De Lange, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.