Telomere length in fibroblasts and blood cells from healthy centenarians

Experimental Cell Research

Volumn 248, Issue 1, 1999, Pages 234-242

  Mondello, Chiara ^a   Petropoulou, Chariklia ^b   Monti, Daniela ^c   Gonos, Esftathios S ^b   Franceschi, Claudio ^d,e   Nuzzo, Fiorella ^a  

^a Ist Genet Biochim ed E   (Italy)

^b INSTITUTE OF BIOLOGY   (Greece)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d Department of Experimental Biology ^*  (Italy)

^e INRCA   (Italy)

Author keywords

Aging; Cellular senescence; Chromosome anomalies; Fibroblasts; Peripheral blood cells; Telomeres

Indexed keywords

CLUSTERIN; FIBRONECTIN; PROTEIN P21;

AGE; AGED; ARTICLE; BLOOD CELL; CELL AGING; CHROMOSOME SIZE; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; RESTRICTION FRAGMENT; SOMATIC CELL GENETICS; TELOMERE;

EID: 0033541401     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4398     Document Type: Article

References (48)

1. Blackburn E. H. Structure and function of telomeres. Nature. 350:1991;569-573.
2. Zakian V. A. Telomeres: Beginning to understand the end. Science. 270:1995;1601-1607.
3. Greider C. W. Telomere length regulation. Annu. Rev. Biochem. 65:1996;337-365.
4. Smith S., de Lange T. TRF1, a mammalian telomeric protein. Trends Genet. 13:1997;21-26.
5. Brun C., Marcand S., Gilson E. Proteins that bind to double-stranded regions of telomeric DNA. Trends Cell Biol. 7:1997;317-324.
6. Moyzis R. K., Buckingham J. M., Cram L. S., Dani M., Deaven L. L., Jones M. D., Meyne J., Ratliff R.-L., Wu J. R. A highly conserved repetitive DNA sequence, (TTAGGG)n. Proc. Natl. Acad. Sci. USA. 85:1988;6622-6626.
7. Landsorp P. P. M., Verwoerd N. P., van de Rijke F. M., Dragowska V., Little M. T., Dirks R. W., Raap A. K., Tanke H. J. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5:1996;685-691.
8. Greider C. W., Blackburn E. H. Identification of a specific terminal transferase activity inTetrahymena. Cell. 43:1985;405-413.
9. Nugent C. I., Lundblad V. The telomerase reverse transcriptase: Components and regulation. Genes Dev. 12:1988;1073-1085.
10. Cooke H. J., Smith B. A. Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harbor Symp. Quant. Biol. LI:1986.
11. Counter C. M., Avilion A. A., LeFeuvre C. E., Stewart N. G., Greider C. W., Harley C. B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929.
12. Kim N. W., Piatyszek M. A., Prowse K. R., Harley C. B., West M. D., Ho P. L., Coviello G. M., Wright W. E., Weinrich S. L., Shay J. W. Specific association of human telomerase activity with immortal cells and cancer. Science. 266:1994;2011-2015.
13. Harley C. B., Futcher A. B., Greider C. W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
14. Harley C. B. Telomere loss: Mitotic clock or genetic time bomb? Mutat. Res. 256:1991;271-282.
15. Allsopp R. C., Chang E., Kashefi-Aazam M., Rogaev E. I., Piatyszek M. A., Shay J. W., Harley C. B. Telomere shortening is associated with cell divisionin vitroin vivo. Exp. Cell Res. 220:1995;194-200.
16. Smith J. R., Pereira-Smith O. M. Replicative senescence: Implication forin vivo. Science. 273:1996;63-67.
17. Campisi J. Aging and cancer: The double-edged sword of replicative senescence. J. Am. Geriatr. Soc. 45:1997;482-488.
18. Hayflick L., Moorhead P. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:1961;585-621.
19. Hayflick L. Mortality and immortality at the cellular level. A review. Biochemistry (Moscow). 62:1997;1180-1190.
20. Allsopp R. C., Harley C. B. Evidence of a critical telomere length in senescent human fibroblasts. Exp. Cell Res. 219:1995;130-136.
21. Counter C. M., Hirte H. W., Bacchetti S., Harley C. B. Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA. 91:1994;2900-2904.
22. Bryan T. M., Englezou A., Gupta J., Bacchetti S., Reddel R. R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:1995;4240-4248.
23. Bodnar A. G., Ouellette M., Frolkis M., Holt S. E., Chiu C.-P., Morin G. B., Harley C. B., Shay J. W., Lichtsteiner S., Wright W. E. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:1998;349-352.
24. Benn P. A. Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos. Am. J. Hum. Genet. 28:1976;465-473.
25. Mondello C., Riboni R., Casati A., Nardo T., Nuzzo F. Chromosomal instability and telomere length variations during the life span of human fibroblast clones. Exp. Cell Res. 236:1997;385-396.
26. Riboni R., Casati A., Nardo T., Zaccaro E., Ferretti L., Nuzzo F. Telomeric fusions in cultured human fibroblasts as a source of genomic instability. Cancer Genet. Cytogenet. 95:1997;130-136.
27. Hastie N. D., Dempster M., Dunlop M. G., Thomspon A. M., Green D. K., Allshire R. C. Telomere reduction in human colo-rectal carcinoma and with ageing. Nature. 346:1990;866-868.
28. Allsopp R. C., Vaziri H., Patterson C., Goldstein S., Younglai E. V., Futcher A. B., Greider C. W., Harley C. B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA. 89:1992;10114-10118.
29. Vaziri H., Schächter F., Uchida I., Wei L., Zhu X., Effros R., Cohen D., Harley C. B. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52:1993;661-667.
30. Vaziri H., Dragowska W., Allsopp R. C., Thomas T. E., Harley C. B., Landsorp P. M. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA. 91:1994;9857-9860.
31. Notaro R., Cimmino A., Tabarini D., Rotoli B., Luzzatto L. In vivo. Proc. Natl. Acad. Sci. USA. 94:1997;13782-13785.
32. Grassilli E., Bellesia E., Salomoni P., Croce M. A., Sikora E., Radziszewska E., Tesco G., Vergelli M., Latorraca S., Barbieri D., Fagiolo U., Santacaterina S., Amaducci L., Tiozzo R., Sorbi S., Franceschi C. C-fos/c-jun expression and AP-1 activation in skin fibroblasts from centenarians. Biochem. Biophys. Res. Commun. 226:1996;517-523.
33. Tesco G., Vergelli M., Grassilli E., Salomoni P., Bellesia E., Sikora E., Radziszewska E., Barberi D., Latorraca S., Fagiolo U., Santacaterina S., Amaducci L., Tiozzo R., Franceschi C., Sorbi S. Growth propertiers and growth factor responsiveness in skin fibroblasts from centenarians. Biochem. Biophys. Res. Commun. 244:1998;912-916.
34. Gonos E. S., Derventzi A., Kveiborg M., Agiostratidou G., Kassem M., Clark B. F. C., Jat P. S., Rattan S. I. S. Cloning and identification of genes that associate with mammalian replicative senescence. Exp. Cell Res. 240:1998;66-74.
35. Noda A., Ning Y., Venable S. F., Pereira-Smith O. M., Smith J. R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:1994;90-98.
36. Tahara H., Sato E., Noda A., Ide T. Increase in expression level of p21(sdi-1/cip-1/waf-1) with increasing division age in both normal and SV-40-transformed human fibroblasts. Oncogene. 10:1995;835-840.
37. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
38. nsequences in gene amplification and chromosome stability. Genomics. 24:1994;53-62.
39. Mondello C., Casati A., Riboni R., Nuzzo F. Structural instability of a transmissible end-to-end dicentric chromosome in a xeroderma pigmentosum fibroblast clone. Cancer Genet. Cytogenet. 79:1995;41-48.
40. Iwama H., Ohyashiki K., Ohyashiki J. H., Hayashi S., Yahata N., Ando K., Toyama K., Hoshika A., Takasaki M., Mori M., Shay J. W. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum. Genet. 102:1998;397-402.
41. Frenck R. W., Blackburn E. H., Shannon K. M. The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. USA. 95:1998;5607-5610.
42. Slagboom P. E., Droog S., Boomsma D. I. Genetic determination of telomere size in humans: A twin study of three age groups. Am. J. Hum. Genet. 55:1994;876-882.
43. Cristofalo V. J., Allen G. R., Pignolo R. J., Martin B. G., Beck J. C. Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation. Proc. Natl. Acad. Sci. USA. 95:1998;10614-10619.
44. Chang E., Harley C. B. Telomere length and replicative aging in human vascular tissues. Proc. Natl. Acad. Sci. USA. 92:1995;11190-11194.
45. Blasco M. A., Lee H.-W., Hande M. P., Samper E., Landsorp P. M., DePinho R. A., Greider C. W. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91:1997;25-34.
46. Lee H. W., Blasco M. A., Gottlieb G. J., Horner J. W. II, Greider C. W., DePinho R. A. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:1998;569-574.
47. Bacchetti S., Counter C. M. Telomeres and telomerase in human cancer. Int. J. Oncol. 7:1995;423-432.
48. Bérubé N. G., Smith J. R., Pereira-Smith O. M. The genetics of cellular senescence. Am. J. Hum. Genet. 62:1998;1015-1019.