-
3
-
-
0035793104
-
Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 113-118
-
-
Shamblott, M.J.1
Axelman, J.2
Littlefield, J.W.3
Blumenthal, P.D.4
Huggins, G.R.5
Cui, Y.6
Cheng, L.7
Gearhart, J.D.8
-
8
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.L.5
Gottlieb, G.J.6
Greider, C.W.7
DePinho, R.A.8
-
11
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
(1998)
Science
, vol.279
, pp. 334-335
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
12
-
-
0032924343
-
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
-
(1999)
Nat Genet
, vol.21
, pp. 115-118
-
-
Morales, C.P.1
Holt, S.E.2
Ouellette, M.3
Kaur, K.J.4
Yan, Y.5
Wilson, K.S.6
White, M.A.7
Wright, W.E.8
Shay, J.W.9
-
13
-
-
0032923742
-
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
-
(1999)
Nat Genet
, vol.21
, pp. 111-114
-
-
Jiang, X.R.1
Jimenez, G.2
Chang, E.3
Frolkis, M.4
Kusler, B.5
Sage, M.6
Beeche, M.7
Bodnar, A.G.8
Wahl, G.M.9
Tlsty, T.D.10
Chiu, C.P.11
-
14
-
-
0033013985
-
Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life span human fibroblasts
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2373-2379
-
-
Vaziri, H.1
Squire, J.A.2
Pandita, T.K.3
Bradley, G.4
Kuba, R.M.5
Zhang, H.6
Gulyas, S.7
Hill, R.P.8
Nolan, G.P.9
Benchimol, S.10
-
17
-
-
0033979731
-
Human keratinocytes that express hTERT and also bypass a p16INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1436-1447
-
-
Dickson, M.A.1
Hahn, W.C.2
Ino, Y.3
Ronfard, V.4
Wu, J.Y.5
Weinberg, R.A.6
Louis, D.N.7
Li, F.P.8
Rheinwald, J.G.9
-
19
-
-
0035836727
-
Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor-beta growth inhibition in p16INK4A(-) human mammary epithelial cells
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4498-4503
-
-
Stampfer, M.R.1
Garbe, J.2
Levine, G.3
Lichtsteiner, S.4
Vasserot, A.P.5
Yaswen, P.6
-
20
-
-
0035355340
-
Increased epidermal tumors and increased wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
-
(2001)
EMBO J
, vol.20
, pp. 2619-2630
-
-
González-Suárez, E.1
Samper, E.2
Ramírez, A.3
Flores, J.M.4
Martín-Caballero, J.5
Jorcano, J.L.6
Blasco, M.A.7
-
27
-
-
0033842950
-
Genetic and epigenetic changes in human epithelial cells immortalized by telomerase
-
(2000)
Am J Pathol
, vol.156
, pp. 1537-1547
-
-
Farwell, D.G.1
Shera, K.A.2
Koop, J.I.3
Bonnet, G.A.4
Matthews, C.P.5
Reuther, G.W.6
Coltrera, M.D.7
McDougall, J.K.8
Klingelhutz, A.J.9
-
28
-
-
0033941559
-
Evidence for a telomere-independent 'clock' limiting RAS oncogene-driven proliferation of human thyroid epithelial cells
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5690-5699
-
-
Jones, C.J.1
Kipling, D.2
Morris, M.3
Hepburn, P.4
Skinner, J.5
Bounacer, A.6
Wyllie, F.S.7
Ivan, M.8
Bartek, J.9
Wynford-Thomas, D.10
Bond, J.A.11
-
32
-
-
0033637086
-
Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
-
(2000)
Genes Dev
, vol.14
, pp. 3037-3050
-
-
Sage, J.1
Mulligan, G.J.2
Attardi, L.D.3
Miller, A.4
Chen, S.5
Williams, B.6
Theodorou, E.7
Jacks, T.8
-
37
-
-
0035931859
-
INK4a expression during cellular senescence
-
(2001)
Nature
, vol.409
, pp. 1067-1070
-
-
Ohtani, N.1
Zebedee, Z.2
Huot, T.J.3
Stinson, J.A.4
Sugimoto, M.5
Ohashi, Y.6
Sharrocks, A.D.7
Peters, G.8
Hara, E.9
-
41
-
-
0034661167
-
Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation and tumorigenesis
-
(2000)
Genes Dev
, vol.14
, pp. 1797-1809
-
-
Inoue, K.1
Wen, R.2
Rehg, J.E.3
Adachi, M.4
Cleveland, J.L.5
Roussel, M.F.6
Sherr, C.J.7
-
43
-
-
0033764030
-
ARF) and is amplified in a subset of human breast cancers
-
(2000)
Nat Genet
, vol.26
, pp. 291-299
-
-
Jacobs, J.J.1
Keblusek, P.2
Robanus-Maandag, E.3
Kristel, P.4
Lingbeek, M.5
Nederlof, P.M.6
Van Welsem, T.7
Van de Vijver, M.J.8
Koh, E.Y.9
Daley, G.Q.10
van Lohuizen, M.11
-
44
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
(2000)
Nature
, vol.406
, pp. 207-210
-
-
Pearson, M.1
Carbone, R.2
Sebastiani, C.3
Cioce, M.4
Fagioli, M.5
Saito, S.6
Higashimoto, Y.7
Appella, E.8
Minucci, S.9
Pandolfi, P.P.10
Pelicci, P.G.11
-
51
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
(1999)
J Biol Chem
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
Fenster, B.E.2
Ito, H.3
Takeda, K.4
Bae, N.S.5
Hirai, T.6
Yu, Z.X.7
Ferrans, V.J.8
Howard, B.H.9
Finkel, T.10
-
53
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
-
55
-
-
0034051249
-
Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia
-
(2000)
Urology
, vol.56
, pp. 160-166
-
-
Choi, J.1
Shendrik, I.2
Peacocke, M.3
Peehl, D.4
Buttyan, R.5
Ikeguchi, E.F.6
Katz, A.E.7
Benson, M.C.8
-
57
-
-
0035079864
-
Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
-
(2001)
Hum Pathol
, vol.32
, pp. 327-332
-
-
Paradis, V.1
Youssef, N.2
Dargere, D.3
Ba, N.4
Bonvoust, F.5
Deschatrette, J.6
Bedossa, P.7
-
59
-
-
0035817688
-
Arf predisposes mice to tumourigenesis
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.-H.3
Carrasco, D.4
Castrillon, D.H.5
Aguirre, A.J.6
Wu, E.A.7
Horner, J.W.8
DePinho, R.A.9
|