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Volumn 9, Issue 2, 1998, Pages 139-146

Independent Induction of Senescence by p16INK4a and p21CIP1 in Spontaneously Immortalized Human Fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 METHYLCYTOSINE; AZACITIDINE; CDKN1A PROTEIN, HUMAN; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; CYTOSINE; DRUG DERIVATIVE; PROTEIN P16INK4A;

EID: 0031992493     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (120)

References (29)
  • 1
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L., and Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res., 25: 585-621, 1961.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 2
    • 0015844590 scopus 로고
    • A theory of marginotomy
    • Olovnikov, A. M. A theory of marginotomy. J. Theor. Biol., 41: 181-190, 1973.
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 3
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • Harley, C. B. Telomere loss: mitotic clock or genetic time bomb? Mutat. Res., 256: 271-282, 1991.
    • (1991) Mutat. Res. , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 5
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., and Reddel, R. R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J., 14: 4240-4248, 1995.
    • (1995) EMBO J. , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 6
    • 0022545617 scopus 로고
    • Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts
    • Holliday, R. Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts. Exp. Cell Res., 166: 543-552, 1986.
    • (1986) Exp. Cell Res. , vol.166 , pp. 543-552
    • Holliday, R.1
  • 7
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • Washington DC
    • Wilson, V. L., and Jones, P. A. DNA methylation decreases in aging but not in immortal cells. Science (Washington DC), 220: 1055-1057, 1983.
    • (1983) Science , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 8
    • 0025650332 scopus 로고
    • Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: Aneuploidy and immortalization
    • Bischoff, F., Yim, S. O., Pathak, S., Grant, G., Siciliano, M. J., Giovanella, B. C., Strong, L. C., and Tainsky, M. A. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. Cancer Res., 50: 7979-7984, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 7979-7984
    • Bischoff, F.1    Yim, S.O.2    Pathak, S.3    Grant, G.4    Siciliano, M.J.5    Giovanella, B.C.6    Strong, L.C.7    Tainsky, M.A.8
  • 9
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin, Y., Tainsky, M. A., Bischoff, F. Z., Strong, L. C., and Wahl, G. M. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell, 70: 937-948, 1992.
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 11
    • 0023125009 scopus 로고
    • The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine induced demethylation
    • Fairweather, D. S., Fox, M., and Margison, G. P. The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine induced demethylation. Exp. Cell Res., 168: 153-159, 1987.
    • (1987) Exp. Cell Res. , vol.168 , pp. 153-159
    • Fairweather, D.S.1    Fox, M.2    Margison, G.P.3
  • 12
    • 0028080422 scopus 로고
    • Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts
    • Vertino, P. M., Issa, J-P., Pereira-Smith, O. M., and Baylin, S. B. Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts. Cell Growth Differ., 5: 1395-1402, 1994.
    • (1994) Cell Growth Differ. , vol.5 , pp. 1395-1402
    • Vertino, P.M.1    Issa, J.-P.2    Pereira-Smith, O.M.3    Baylin, S.B.4
  • 13
    • 0024453654 scopus 로고
    • Maintenance of DNA methylation level in SV40-infected human fibroblasts during their in vitro limited proliferative lifespan
    • Matsumura, T., Hunter, J. L., Farook, M., and Holliday, R. Maintenance of DNA methylation level in SV40-infected human fibroblasts during their in vitro limited proliferative lifespan. Exp. Cell Res., 184: 148-157, 1989.
    • (1989) Exp. Cell Res. , vol.184 , pp. 148-157
    • Matsumura, T.1    Hunter, J.L.2    Farook, M.3    Holliday, R.4
  • 16
    • 0029818858 scopus 로고    scopus 로고
    • Expression of p21 is not required for senescence of human fibroblasts
    • Medcalf, A. S. C., Klein-Szanto, A. J. P., and Cristofalo, V. J. Expression of p21 is not required for senescence of human fibroblasts. Cancer Res., 56: 4582-4585, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4582-4585
    • Medcalf, A.S.C.1    Klein-Szanto, A.J.P.2    Cristofalo, V.J.3
  • 17
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., and Barrett, J. C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA, 93: 13742-13747, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 19
    • 0029944622 scopus 로고    scopus 로고
    • Differential CDK-inhibitor gene expression in aging diploid fibroblasts
    • Wong, H., and Riabowol, K. Differential CDK-inhibitor gene expression in aging diploid fibroblasts. Exp. Gerontol., 31: 311-325, 1996.
    • (1996) Exp. Gerontol. , vol.31 , pp. 311-325
    • Wong, H.1    Riabowol, K.2
  • 21
    • 0029841549 scopus 로고    scopus 로고
    • Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence
    • Bond, J., Haughton, M., Blaydes, J., Gire, V., Wynford-Thomas, D., and Wyllie, F. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. Oncogene, 13: 2097-2104, 1996.
    • (1996) Oncogene , vol.13 , pp. 2097-2104
    • Bond, J.1    Haughton, M.2    Blaydes, J.3    Gire, V.4    Wynford-Thomas, D.5    Wyllie, F.6
  • 22
    • 0029955714 scopus 로고    scopus 로고
    • The pCL vector system: Rapid production of helper-free, high titer, recombinant retroviruses
    • Naviaux, R. K., Costanzi, E., Haas, M., and Verma, I. M. The pCL vector system: rapid production of helper-free, high titer, recombinant retroviruses. J. Virol., 70: 5701-5705, 1996.
    • (1996) J. Virol. , vol.70 , pp. 5701-5705
    • Naviaux, R.K.1    Costanzi, E.2    Haas, M.3    Verma, I.M.4
  • 23
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • Graham, F. L., Smiley, W., Russel, W. C., and Nairn, R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol., 36: 59-72, 1977.
    • (1977) J. Gen. Virol. , vol.36 , pp. 59-72
    • Graham, F.L.1    Smiley, W.2    Russel, W.C.3    Nairn, R.4
  • 24
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, F. L., and van der Eb, A. J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52: 456-467, 1973.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van Der Eb, A.J.2
  • 25
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., and Bacchetti, S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J., 11: 1921-1929, 1992.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 26
    • 0025808098 scopus 로고
    • Recognition of a chromosome truncation site associated with thalassaemia by human telomerase
    • Morin, G. B. Recognition of a chromosome truncation site associated with thalassaemia by human telomerase. Nature (Lond.), 353: 454-456, 1991.
    • (1991) Nature (Lond.) , vol.353 , pp. 454-456
    • Morin, G.B.1
  • 27
    • 0020712660 scopus 로고
    • Direct hybridization of labeled DNA to DNA in agarose gels
    • Purrello, M., and Balazs, I. Direct hybridization of labeled DNA to DNA in agarose gels. Analyt. Biochem., 128: 393-397, 1983.
    • (1983) Analyt. Biochem. , vol.128 , pp. 393-397
    • Purrello, M.1    Balazs, I.2
  • 28
    • 0028961759 scopus 로고
    • A bisulfite method of 5-methylcytosine mapping that minimizes template degradation
    • Raizis, A. M., Schmitt, F., and Jost, J-P. A bisulfite method of 5-methylcytosine mapping that minimizes template degradation. Analyt. Biochem., 226: 161-166, 1995.
    • (1995) Analyt. Biochem. , vol.226 , pp. 161-166
    • Raizis, A.M.1    Schmitt, F.2    Jost, J.-P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.