Human keratinocytes that express hTERT and also bypass a p16(INK4a)- enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

Molecular and Cellular Biology

Volumn 20, Issue 4, 2000, Pages 1436-1447

  Dickson, Mark A ^a   Hahn, William C ^a,b   Ino, Yasushi ^c   Ronfard, Vincent ^d   Wu, Jenny Y ^a   Weinberg, Robert A ^b   Louis, David N ^c   Li, Frederick P ^e   Rheinwald, James G ^a,f  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d ORGANOGENESIS INC   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; TELOMERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CELL IMMORTALIZATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; GENE LOCUS; GROWTH REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TELOMERE;

CELL AGING; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE DELETION; GENE EXPRESSION; GENES, P53; GENETIC COMPLEMENTATION TEST; HUMANS; KERATINOCYTES; MUTATION; RNA; TELOMERASE;

EID: 0033979731     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.4.1436-1447.2000     Document Type: Article

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