Induced p21(waf) expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin

Oncogene

Volumn 18, Issue 16, 1999, Pages 2643-2649

  Wang, Yingcai ^a   Blandino, Giovanni ^a   Givol, David ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Anti cancer drugs; Inducible p21(waf); Radiation; Senescence

Indexed keywords

DOXORUBICIN; ENZYME INHIBITOR; PACLITAXEL; PROTEIN P21; PROTEIN P53; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; DRUG DERIVATIVE; ECDYSTERONE; MURISTERONE A;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROTECTION; CELL SHAPE; COLONY FORMATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; GENE OVEREXPRESSION; GROWTH DISORDER; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RADIATION INJURY; SENESCENCE; TRANSACTIVATION; ADENOCARCINOMA; BIOSYNTHESIS; CELL AGING; CELL CULTURE; DRUG ANTAGONISM; DRUG RESISTANCE; GENE EXPRESSION REGULATION; LUNG TUMOR; METABOLISM; RADIATION DOSE;

ADENOCARCINOMA; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DOXORUBICIN; DRUG RESISTANCE; ECDYSTERONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; RADIATION TOLERANCE; TUMOR CELLS, CULTURED;

EID: 0033594245     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202632     Document Type: Article

References (34)

1. Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D and Barrett C. (1996). Proc. Natl. Acad. Sci. USA, 93, 13742-13747.
2. Bates S and Vousden KH. (1996). Curr. Opin. Genet. Dev., 6, 12-18.
3. Brown JP, Wei W and Sedivy LM. (1997). Science, 277, 831-834.
4. Brugaloras J, Chandrasekaran C, Gordon JI, Beach D, Jacks T and Hannon GJ. (1995). Nature, 377, 552-557.
5. Chedid M, Michieli P, Lengel C, Huppi K and Givol D. (1994). Oncogene, 9, 3021-3024.
6. Deng C, Zhang P, Harper JW, Elledge SJ and Leder P. (1995). Cell, 82, 675-684.
7. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M and Campisi J. (1995). Proc. Natl. Acad. Sci. USA, 92, 9363-9367.
8. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelstein B. (1993). Cell, 75, 805-816.
9. Fazeli A, Steen RG, Dickinson SL, Bautista D, Dietrich WF, Bronson RT, Bresalier RS, Lander ES, Costa J and Weinberg RA. (1997). Proc. Natl. Acad. Sci. USA, 94, 10199-10204.
10. Gorospe M, Cirielli C, Wang X, Seth P, Capogrossi MC and Holbrook NJ. (1997). Oncogene, 14, 929-935.
11. Gorospe M, Wang X, Guyton KZ and Holbrook NJ. (1996). Mol. Cell. Biol., 16, 6654-6660.
12. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D and Lassar A. (1995). Science, 267, 1018-1021.
13. Hansen R and Oren M. (1997). Curr. Opin. Genet. Dev., 7, 46-51.
14. Harper JW and Elledge SJ. (1996). Curr. Opin. Genet. Dev., 6, 56-64.
15. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ. (1993). Cell, 75, 817-825.
16. Kondo Y, Kondom S, Liu J, Haqqi T, Barnett GH and Barna BP. (1997). Exp. Cell. Res., 236, 51-56.
17. Maki CG and Howley PM. (1997). Mol. Cell. Biol., 17, 355-363.
18. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE and Givol D. (1994). Cancer Res., 54, 3391-3395.
19. No D, Yao TP and Evans RM. (1997). Proc. Natl. Acad. Sci. USA, 93, 3346-3351.
20. Noda A, Ning Y, Venable SF, Pereira-Smith OM and Smith JR. (1994). Exp. Cell. Res., 211, 90-98.
21. Poluha W, Poluha DK, Chang B, Crosbie NE and Schonhoff CM. (1996). Mol. Cell. Biol., 16, 1335-1341.
22. Polyak K, Waldman T, He TC, Kinzler KW and Vogelstein B. (1996). Genes Dev., 10, 1945-1952.
23. Sambrook J, Fritsch EF and Maniatis T. (1989). Molecular Cloning: a Laboratory Manual, Cold Spring Harbor Lab. Press, Plainview, NY 2nd Ed.
24. Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA and El-Houseini ME. (1994). Oncogene. 9, 3389-3396.
25. Sugrue MM, Shin DY, Lee SW and Aaronson SA. (1997). Proc. Natl. Acad. Sci. USA, 94, 9648-9653.
26. Takahashi T, Carbone D, Takahashi T, Nau MM, Hida T, Linnoila I, Ueda R and Minna JD. (1992). Cancer Res., 52, 2340-2343.
27. Uhrbom L, Nister M and Westermark B. (1997). Oncogene, 15, 505-514.
28. Waldman T, Lengauer C, Kinzler KW and Vogelstein B. (1996). Nature, 381, 713-716.
29. Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B and Williams J. (1997). Nature Med., 3, 1034-1036.
30. Wang YA, Elson A and Leder P. (1997). Proc. Natl. Acad. Sci. USA, 94, 14590-14595.
31. Wang Y, Blandino G, Oren M and Givol D. (1998). Oncogene, 17, 1923-1930.
32. Wouters BG, Giaccia AJ, Denko NC and Brown JM. (1997). Cancer Res., 57, 4703-4706.
33. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D. (1993). Nature (Lond)., 366, 701-704.
34. Zakut R and Givol D. (1995). Oncogene, 11, 393-395.