Loss of p16Ink4a with retention of p19 predisposes mice to tumorigenesis

Nature

Volumn 413, Issue 6851, 2001, Pages 86-91

  Sharpless, Norman E ^a   Bardeesy, Nabeel ^a   Lee, Kee Ho ^a,c   Carrasco, Daniel ^a,b   Castrillon, Diego H ^a,b   Aguirre, Andrew J ^a   Wu, Emily A ^a   Horner, James W ^a   DePinho, Ronald A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b Korea Cancer Center Hospital   (South Korea)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENS; CELLS; CYTOLOGY; MUTAGENESIS; PROTEINS; TUMORS;

TUMORIGENESIS;

BIOMEDICAL ENGINEERING;

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P16; PROTEIN P16INK4A; PROTEIN P19; PROTEIN P19 ARF; UNCLASSIFIED DRUG; 7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; PROTEIN; PROTEIN P14ARF; URETHAN;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL AGING; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FIBROBLAST; GENE DELETION; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS HYPERPLASIA; ANIMAL; CELL CULTURE; CELL DIVISION; CELL TRANSFORMATION; CYTOLOGY; EMBRYO; FEMALE; GENE TARGETING; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MALE; MOUSE MUTANT; NEOPLASM; PATHOLOGY; PHYSIOLOGY; THYMUS; TUMOR SUPPRESSOR GENE;

ANIMALIA;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EMBRYO; FEMALE; FIBROBLASTS; GENE DELETION; GENE TARGETING; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; MALE; MICE; MICE, KNOCKOUT; NEOPLASMS; PROTEINS; T-LYMPHOCYTES; THYMUS GLAND; TUMOR SUPPRESSOR PROTEIN P14ARF; URETHANE;

EID: 0035817688     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35092592     Document Type: Article

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