The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: Tryptase induces expression of mRNA for IL-1β and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1939-1946

  Compton, Steven J ^a   Cairns, Jennifer A ^a   Holgate, Stephen T ^a   Walls, Andrew F ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA; TRYPTASE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MAST CELL; PRIORITY JOURNAL; PROTEIN SECRETION;

CELL ADHESION MOLECULES; CELL DIVISION; CHYMASES; CYTOKINES; ENDOTHELIUM, VASCULAR; HUMANS; INTERLEUKIN-1; INTERLEUKIN-8; MAST CELLS; MITOSIS; RNA, MESSENGER; SERINE ENDOPEPTIDASES; THYMIDINE; TRYPTASES; UMBILICAL VEINS;

EID: 0032529228     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Tharp, M. D. 1989. The interaction between mast cells and endothelial cells. J. Invest. Dermatol. 89:107S.
2. Walls, A. F. 1998. Mast cell proteases in asthma. In Inflammatory Mechanisms in Asthma. S. T. Holgate and W. W. Busse, eds. Marcel Dekker, New York, p. 119.
3. Walls, A. F. 1995. The roles of neutral proteases in asthma and rhinitis. In Asthma and Rhinitis. W. W. Busse and S. T. Holgate, eds. Blackwell, Boston, p. 801.
4. He, S., and A. F. Walls. 1997. Human mast cell tryptase: a stimulus of microvascular leakage and mast cell activation. Eur. J. Pharmacol. 328:89.
5. He, S., Q. Peng, and A. F. Walls. 1997. Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: selective enhancement of eosinophil recruitment by histamine. J. Immunol. 159;6216.
6. Clark, J. M., W. M. Abraham, C. E. Fishman, R. Forteza, A. Ahmed, A. Cortes, R. L. Warne, W. R. Moore, and R. D. Tanaka. 1995. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. Am. J. Respir. Crit. Care Med. 152:2076.
7. Tam, E. K., and G. H. Caughey. 1990. Degradation of airway neuropeptides by human lung tryptase. Am. J. Respir. Cell Mol. Biol. 3:27.
8. Walls, A. F., S. D. Brain, A. Desai, P. J. Jose, E. Hawkings, M. K. Church, and T. J. Williams. 1992. Human mast cell tryptase attenuates the vasodilator activity of calcitonin gene-related peptide. Biochem. Pharmacol. 43:1243.
9. Lohi, J., I. Harvima, and J. Keski-Oja. 1992. Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin. J. Cell. Biochem. 50:337.
10. Gruber, B. L., M. J. Marchese, K. Suziki, L. B. Schwartz, Y. Okada, H. Nagase, and N. S. Ramamurthy. 1989. Synovial procollagenase activation by human mast cell tryptase: dependence upon matrix metalloproteinase 3 activation. J. Clin. Invest. 84:1657.
11. Walls, A. F., A. R. Bennett, J. Suieras-Diaz, and H. Olsson. 1992. The kininogenase activity of human mast cell tryptase. Biochem. Soc. Trans. 20:260S.
12. Ruoss, S. J., T. Hartmann, and G. H. Caughey. 1991. Mast cell tryptase is a mitogen for cultured fibroblasts. J. Clin. Invest. 88:493.
13. Cairns, J. A., and A. F. Walls. 1997. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J. Clin. Invest. 99:1313.
14. Cairns, J. A., and A. F. Walls. 1996. Mast cell tryptase is a mitogen for epithelial cells: stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J. Immunol. 156:275.
15. Brown, J. K., C. L. Tyler, C. A. Jones, S. J. Ruoss, T. Hartmann, and G. H. Caughey. 1995. Tryptase, the dominant secretory granular protein in human mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 13:227.
16. Blair, R. J., H. Meng, M. J. Marchese, S. Ren, L. B. Schwartz, M. G. Tonnesen, and B. L. Gruber. 1997. Human mast cells stimulate vascular tube formation: tryptase is a novel, potent angiogenic factor. J. Clin. Invest. 99:2691.
17. Gruber, B. L., R. R. Kew, A. Jelaska, M. J. Marchese, J. Garlick, S. Ren, L. B. Schwartz, and J. H. Korn. 1997. Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid and fibroblast chemotaxis. J. Immunol. 158:2310.
18. Mantovani, A., F. Bussolino, and M. Introna. 1997. Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol. Today 18:231.
19. Bevilacqua, M. P., J. S. Pober, D. L. Mendrick, R. S. Cotran, and M. A. Gimbrone, Jr. 1987. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc. Natl. Acad. Sci. USA 84:9238.
20. Dustin, M. L., R. Rothein, A. K. Bhan, C. A. Dinarello, and T. A. Springer. 1986. Induction by IL-1 and IFN-γ: tissue distribution, biochemistry, function of a natural adherence molecule (ICAM-1). J. Immunol. 137:1893.
21. Pober, J. S., M. A. Gimbrone, Jr., L. A. Lapierre, D. L. Mendrick, W. Fiers, R. Rothlein, and T. A. Springer. 1986. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune IFN. J. Immunol. 137:1893.
22. Carlos, T., N. Kovach, B. Schwartz, M. Rosa, B. Newman, E. Wayner, C. Benjamin, L. Osborn, R. Lobb, and J. Harlan 1991. Human monocytes bind to cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood 77:2277.
23. Smart, Y., and T. B. Casale. 1994. TNF-α induced transendothelial neutrophil migration is IL-8 dependent. Am. J. Physiol. 266:L238.
24. Broudy, V. C., K. Kaushansky, J. M. Harlan, and J. W. Adamson. 1987. Interleukin 1 stimulates human endothelial cells to produce granulocyte colony-stimulating factor and granulocyte colony-stimulating factor. J. Immunol. 139:464.
25. Kaplanski, G., M. Fabrigoule, V. Boulay, C. A. Dinarello, P. Bongrand, S. Kaplanski, and C. Farnarier. 1997. Thrombin induces endothelial type II activation in vitro. J. Immunol. 158:5435.
26. Walls, A. F., A. R. Bennett, H. M. McBride, M. J. Glennie, S. T. Holgate, and M. K. Church. 1990. Production and characterization of monoclonal antibodies specific for human mast cell tryptase. Clin. Exp. Allergy 20:581.
27. Schwartz, L. B., and T. R. Bradford. 1986. Regulation of tryptase from human lung mast cells by heparin. J. Biol. Chem. 261:7372.
28. Jaffe, E. A., R. L. Nachman, C. G. Becker, and C. R. Minick. 1973. Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria. J. Clin. Invest. 52:2745.
29. Miller, J. S., G. Moxley, and L. B. Schwartz. 1990. Cloning and characterization of a second complementary DNA for human tryptase. J. Clin. Invest. 86:864.
30. Bourdoulous, S., A. Bensaid, D. Martinez, C. Sheikboudou, I. Trap, A. Strosberg, and P. Couraud. 1995. Infection of bovine brain microvessel endothelial cells with Cowdria ruminantium elicits IL-1β, -6, and -8 mRNA production and expression of an unusual MHC class II Dqα transcript. J. Immunol. 154:4032.
31. Jirik, F. R., T. J. Podor, T. Hirano, T. Kishimoto, D. J. Loskutoff, D. A. Carson, and M. Lotz. 1988. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J. Immunol. 89:1421.
32. Libby, P., J. M. Ordovas, K. R. Auger, A. H. Robbins, L. K. Birinyi, and C. A. Dinarello. 1986. Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells. Am. J. Pathol. 124: 179.
33. Beitz, J. M., I. S. Kim, P. Calabresi, and A. R. Frankelton. 1991. Human microvascular cells express receptors for platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 88:2021.
34. Meyrick, B., B. Christman, and G. Jesmok. 1991. Effects of recombinant tumor necrosis factor-α on cultured pulmonary artery and lung microvascular endothelial monolayers. Am. J. Pathol. 138:93.
35. Bussolino, F., M. DeRossi, A. Sica, F. Colotta, J. M. Wang, E. Bocchietto, I. M. Padura, A. Bosia, E. Dejana, and A. Mantovani. 1991. Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines. J. Immunol. 147:2122.
36. Belloni, P. N., D. H. Carney, and G. L. Nicolson. 1992. Organ-derived microvascular endothelial cells exhibit differential responsiveness to thrombin and other growth factors. Microvasc. Res. 43:20.
37. Drach, J., M. Thomas, J. Barnett, and C. Shipman. 1981. Tritiated thymidine incorporation does not measure DNA synthesis in ribavirin-treated human cells. Science 212:549.
38. 3H]thymidine incorporation as a reliable method to estimate cell proliferation rate. Biochem. J. 270:563.
39. Norioka, K., M. Hara, A. Kitani, T. Hirose, W. Hirose, M. Harigai, K. Suzuki, M. Kawakami, H. Tabata, M. Kawagoe, and H. Nakamura. 1987. Inhibitory effect of interleukin-1α and β on growth of human vascular endothelial cells. Biochem. Biophys. Res. Commun. 145:969.
40. Friedman, D., T. Claus, S. Pilkis, and G. Pine. 1981. Hormonal regulation of DNA synthesis in primary cultures of adult rat hepatocytes. Exp. Cell Res. 135: 283.
41. Samanta, A. K., J. J. Oppenheim, and K. Matsushima. 1990. Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dramatically regulates its own receptor expression on human neutrophils. J. Biol. Chem. 265:183.
42. Detmers, P. A., S. K. Lo, E. Olsen-Egbert, A. Walz, M. Baggiolini, and Z. A. Cohn. 1990. Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J. Exp. Med. 171:1155.
43. Smith, W. B., J. R. Gamble, I. Clark-Lewis, and M. A. Vadas. 1991. Interleukin-8 induces neutrophil transendothelial migration. Immunology 72:65.
44. Erger, R. A., and T. B. Casale. 1995. Interleukin-8 is a potent mediator of eosinophil chemotaxis through endothelium and epithelium. Am. J. Physiol. 268: L117.
45. Rot, A. 1992. Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration. Immunol. Today 13:291.
46. Marceau, F., J. Grassi, Y. Frobert, C. Bergeron, and P. E. Poubelle. 1992. Effects of experimental conditions on the production of interleukin-1α and interleukin-1β by human endothelial cells in culture. Int. J. Immunopharmacol. 14:525.
47. Shingu, M., M. Nobunaga, I. Ezaki, and K. Yoshoika. 1991. Recombinant human IL-1β and TNF-α stimulate production of IL-1α and IL-1β by vascular smooth muscle cells and IL-1α by vascular endothelial cells. Life Sci. 49:241.
48. Kurt-Jones, E., W. Fiers, and J. Pober. 1987. Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts. J. Immunol. 139:2317.
49. Poubelle, P. E., J. Grassi, P. Pradelles, and F. Marceau. 1990. Pharmacological modulation of interleukin 1 production by cultured endothelial cells from human umbilical veins. Immunopharmacology 9:121.
50. Elias, J. A., M. M. Reynolds, R. M. Kotloff, and J. A. Kern. 1989. Fibroblast interleukin 1β: synergistic stimulation by recombinant interleukin 1 and tumor necrosis factor and posttranscriptional regulation. Proc. Natl. Acad. Sci. USA 86:6171.
51. Herbert, J.-M., E. Dupuy, M.-C. Claude, J.-M. Zini, R. Bar Shavit, and G. Tobelem. 1994. Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway. Biochem. J. 303:227.
52. Molino, M., E. S. Barnathan, R. Numerof, J. Clark, M. Dreyer, A. Cumashi, J. A. Hoxie, N. Schechter, M. Woolkalis, and L. F. Brass. 1997. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem. 272:4043.
53. Mirza, H., V. Yatsula, and W. Bahou. 1996. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. J. Clin. Invest. 97:1705.
54. Molino, M., M. J. Woolkalis, J. Reavey-Cantwell, D. Pratico, P. Andrade-Gordon, E. S. Barnthan, and L. F. Brass. 1997. Endothelial cell thrombin receptors and PAR-2. J. Biol. Chem. 272:11133.
55. Ishihara, H., A. J. Connolly, D. Zeng, M. L. Kahn, Y. W. Zheng, C. Timmons, T. Tram, and S. R. Coughlin. 1997. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386:502.