ROCK mediates thrombin's endothelial barrier dysfunction

American Journal of Physiology - Cell Physiology

Volumn 279, Issue 1 48-1, 2000, Pages

  Carbajal, J M ^a   Gratrix, M L ^a   Yu, C H ^a   Schaeffer R C , Jr ^a  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

Immunofluorescent digital imaging; Myosin light chain phosphorylation; Nonmuscle myosin; Paxillin; Rho associated coiled coil forming kinase; Y 27632

Indexed keywords

BETA CATENIN; F ACTIN; FOCAL ADHESION KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; PAXILLIN; RHO FACTOR; THROMBIN;

ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; CATTLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0033866449     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.279.1.c195     Document Type: Article

References (29)

1. The role of phosphorylation in regulating contractile proteins
2. Bacterial toxins block endothelial wound repair: Evidence that Rho GTPases control cytoskeletal rearrangements in migrating endothelial cells
3. Formation of actin stress fibers and focal adhesions enhanced by Rho- kinase
4. ADP ribosylation of Rho proteins reorganizes actomyosin filaments to cell-cell junctions and enhances endothelial barrier function
5. The small GTP-binding protein Rho regulates a phosphatidylinositol 4- phosphate 5-kinase in mammalian cells
6. Assembly of focal adhesions: Progress, paradigms and portents
7. Endothelial adherens junctions: Implications in the control of vascular permeability and angiogenesis
8. Inhibition of serine-threonine protein phosphatases decreased barrier function of rat pulmonary artery endothelial cells
9. Thrombin inactivates myosin light chain phosphatase via rho and its target rho kinase in human endothelial cells
10. Regulation of: Thrombin-mediated endothelial cell contraction and permeability
11. Myosin light chain kinase-regulated endothelial cell contraction: The relationship between isometric tension, actin polymerization and myosin phosphorylation
12. Regulation of contraction-relaxation in smooth muscle
13. Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function
14. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP- binding protein Rho
15. Regulation of myosin phosphatase by Rho and Rho-associated kinase (rho-kinase)
16. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins
17. Mechanisms of increased endothelial permeability
18. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
19. Regulation of myosin phosphatase through phosphorylation of the myosin binding subunit in platelet activation
20. Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial barrier dysfunction
21. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
22. Effects of human α-thrombin and 8bromo-cAMP on large and microvessel endothelial monolayer equivalent 'pore' radii
23. Cyclic AMP and KT-5926 initiate p125FAK phosphorylation and paxillin appearance at bovine pulmonary artery endothelial cell-cell junctions (Abstract)
24. Restricted diffusion of macromolecules by endothelial monolayers and small pore filters
25. Thrombin and bradykinin initiate discrete endothelial solute permeability mechanisms
26. Preparation and high-performance size-exclusion chromatographic analysis of fluorescein isothiocyanatehydroxy ethyl starch: Macromolecular probes of the blood-lymph barrier
27. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
28. Myosin II filament assembly in the active lamella of fibroblasts: Their morphogenesis and role in the formation of actin filament bundles
29. Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho