Expression of protease-activated receptor-2 by osteoblasts

Bone

Volumn 26, Issue 1, 2000, Pages 7-14

  Abraham, L A ^a   Chinni, C ^a   Jenkins, A L ^b   Lourbakos, A ^b   Ally, N ^b   Pike, R N ^b   MacKie, E J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Gingipain R; Osteoblast; Protease activated receptor (PAR); SaOS 2 cells; Thrombin; Trypsin

Indexed keywords

ALKALINE PHOSPHATASE; GINGIPAIN R; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEINASE; SYNTHETIC PEPTIDE; THROMBIN; THROMBIN RECEPTOR; TRYPSIN;

ANIMAL CELL; ARTICLE; BONE DENSITY; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADHESINS, BACTERIAL; ANIMALS; BASE SEQUENCE; CALCIUM; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; DNA PRIMERS; HEMAGGLUTININS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; OLIGOPEPTIDES; OSTEOBLASTS; RATS; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; SPECIES SPECIFICITY;

EID: 0033990327     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(99)00237-9     Document Type: Article

References (33)

1. Abraham L.A., Jenkins A.L., Stone S.R., Mackie E.J. Expression of the thrombin receptor in developing bone and associated tissues. J Bone Miner Res. 13:1998;818-827.
2. Abraham L.A., Mackie E.J. Modulation of osteoblast-like cell behaviour by activation of protease-activated receptor-1. J Bone Miner Res. 14:1999;1320-1329.
3. 3H] thymidine and harvesting on to glass fibre filter discs. J Immunol Meth. 10:1976;329-336.
4. 2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol. 73:1995;1203-1207.
5. Andrew S.M., Freemont A.J. Skeletal mastocytosis. J Clin Pathol. 46:1993;1033-1035.
6. Blackhart B.D., Emilsson K., Nguyen D., Teng W., Martelli A.J., Nystedt S., Sundelin J., Scarborough R.M. Ligand cross-reactivity within the protease-activated receptor family. J Biol Chem. 271:1996;16466-16471.
7. Bohm S.K., Khitin L.M., Grady E.F., Aponte G., Payan D.G., Bunnett N.W. Mechanisms of desensitization and resensitization ofproteinase-activated receptor-2. J Biol Chem. 271:1996;22003-22016.
8. Bohm S.K., Kong W., Bromme D., Smeekens S.P., Anderson D.C., Connolly A., Kahn M., Nelken N.A., Coughlin S.R., Payan D.G., Bunnett N.W. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J. 314:1996;1009-1016.
9. Cocks T.M., Fong B., Chow J.M., Anderson G.P., Frauman A.G., Goldie R.G., Henry P.J., Carr M.J., Hamilton J.R., Moffatt J.D. A protective role for protease-activated receptors in the airways. Nature. 398:1998;156-160.
10. Corvera C.U., Dery O., McConalogue K., Bohm S.K., Khitin L.M., Caughey G.H., Payan D.G., Bunnett N.W. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest. 100:1997;1383-1393.
11. D'Andrea M.R., Derian C.K., Leturcq D., Baker S.M., Brunmark A., Ling P., Darrow A.L., Santulli R.J., Brass L.F., Andrade-Gordon P. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem. 46:1998;157-164.
12. Hou L., Kapas S., Cruchley A.T., Macey M.G., Harriott P., Chinni C., Stone S.R., Howells G.L. Immunolocalization of protease-activated receptor-2 in skin Receptor activation stimulates interleukin-8 secretion by keratinocytes in vitro . Immunology. 94:1998;356-362.
13. Howells G.L., Macey M.G., Chinni C., Hou L., Fox M.T., Harriott P., Stone S.R. Proteinase-activated receptor-2 Expression by human neutrophils . J Cell Sci. 110:1997;881-887.
14. Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.W., Timmons C., Tram T., Coughlin S.R. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386:1997;502-506.
15. Jenkins A.L., Bootman M.D., Berridge M.J., Stone S.R. Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells. J Biol Chem. 269:1994;17104-17110.
16. Jenkins A.L., Bootman M.D., Taylor C.W., Mackie E.J., Stone S.R. Characterization of the receptor responsible for thrombin-induced intracellular calcium responses in osteoblast-like cells. J Biol Chem. 268:1993;21432-21437.
17. Johansson C., Roupe G., Lindstedt G., Mellstrom D. Bone density, bone markers and bone radiological features in mastocytosis. Age Ageing. 25:1996;1-7.
18. Kahn M.L., Zheng Y.W., Huang W., Bigornia V., Zeng D., Moff S., Farese R.V. Jr, Tam C., Coughlin S.R. A dual thrombin receptor system for platelet activation. Nature. 394:1998;690-694.
19. Kong W., McConalogue K., Khitin L.M., Hollenberg M.D., Payan D.G., Bohm S.K., Bunnett N.W. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci USA. 94:1997;8884-8889.
20. Lieberherr M. Effects of vitamin D3 metabolites on cytosolic free calcium in confluent mouse osteoblasts. J Biol Chem. 262:1987;13168-13173.
21. Lourbakos A., Chinni C., Thompson P., Potempa J., Travis J., Mackie E.J., Pike R.N. Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. Fed Eur Bone Soc Lett. 435:1998;45-48.
22. Martin T.J., Ng K.W., Partridge N.C., Livesey S.A. Hormonal influences on bone cells. Meth Enzymol. 145:1987;324-336.
23. Mirza H., Schmidt V.A., Derian C.K., Jesty J., Bahou W.F. Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases. Blood. 90:1997;3914-3922.
24. Molino M., Barnathan E.S., Numerof R., Clark J., Dreyer M., Cumashi A., Hoxie J.A., Schechter N., Woolkalis M., Brass L.F. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem. 272:1997;4043-4049.
25. Mirza H., Yatsula V., Bahou W.F. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. J Clin Invest. 97:1996;1705-1714.
26. Molino M., Woolkalis M.J., Reavey-Cantwell J., Pratico D., Andrade-Gordon P., Barnathan E.S., Brass L.F. Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment. J Biol Chem. 272:1997;11133-11141.
27. Nystedt S., Emilsson K., Wahlestedt C., Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA. 91:1994;9208-9212. [see comments].
28. Parekh A.B., Penner R. Store depletion and calcium influx. Physiol Rev. 77:1997;901-930.
29. Potempa J., Mikolajczyk-Pawlinska J., Brassell D., Nelson D., Thogersen I.B., Enghild J.J., Travis J. Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis. J Biol Chem. 273:1998;21648-21657.
30. Saifeddine M., al-Ani B., Cheng C.H., Wang L., Hollenberg M.D. Rat proteinase-activated receptor-2 (PAR-2) cDNA sequence and activity ofreceptor-derived peptides in gastric and vascular tissue . Br J Pharmacol. 118:1996;521-530.
31. Smith-Swintosky V.L., Cheo-Isaacs C.T., D'Andrea M.R., Santulli R.J., Darrow A.L., Andrade-Gordon P. Protease-activated receptor-2 (PAR-2) is present in the rat hippocampus and is associated with neurodegeneration. J Neurochem. 69:1997;1890-1896.
32. Teronen O., Hietnanen T.O., Lindqvist J., Salo T., Sorsa T., Eklund K.K., Sommerhoff C.P., Ylipaavalniemi P., Konttinen Y.T. Mast cell-derived tryptase in odontogenic cysts. J Oral Pathol. 25:1996;376-381.
33. Vu T.K., Hung D.T., Wheaton V.I., Coughlin S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 64:1991;1057-1068.