Vascular effects of proteinase-activated receptor 2 agonist peptide

Journal of Vascular Research

Volumn 34, Issue 4, 1997, Pages 267-272

  Emilsson, Kjell ^a   Wahlestedt, Claes ^b   Sun, Miao Kun ^c   Nystedt, Sverker ^a   Owman, Christer ^a   Sundelin, Johan ^a  

^a LUND UNIVERSITY   (Sweden)

^b Astra Pain Research Unit   (Canada)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Hypotension; Nitric oxide; Proteinase activated receptor 2; Vascular endothelium; Vasodilation

Indexed keywords

ARGININE; DEXTRO ARGININE; GUANINE NUCLEOTIDE BINDING PROTEIN; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PROTEINASE ACTIVATED RECEPTOR 2; SYNTHETIC PEPTIDE; THROMBIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; DOSE RESPONSE; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0030879202     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000159233     Document Type: Article

References (25)

1. Esmon CT: Cell-mediated events that control blood coagulation and vascular injury, Annu Rev Cell Biol 1993:9:1-26.
2. Williams JC, Falcone RC, Do MIT, Lindstrom DD, Howe BB: Acute blood pressure effects of selected serine proteases in normotensivc rats and dogs, Pharmacology 1991;43:199-209.
3. Chang W-C, Shi G-Y, Chow Y-H, Chang L-C, Hau J-S, Lin MT, Jen CJ, Wing L-YC, Wu H-L: Human plasmin induces a receptor-mediated arachidonate release coupled with G proteins in endothelial cells, Am J Physiol 1993;264:C271-C281.
4. Gajdusek C, Carbon S, Ross R, Nawroth P, Stern D: Activation of coagulation releases endothelial cell mitogens, J Cell Biol 1986:103: 419-428.
5. Herbert JM, Lamarche I, Prabonnaud V, Dol F, Gauthier T: Tissue-type plasminogen activator is a potent mitogen for human aortic smooth muscle cells, J Biol Chem 1994:269: 3076-3080.
6. Vu T-K.H, Hung DT, Wheaton VI, Coughlin SR: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation, Cell 1991:64:1057-1068.
7. Chao BH, Kalkunte S, Maraganorc JM, Stone SR: Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor, Biochemistry 1992;31:6175-6178.
8. Scarborough RM, Naughton M, Teng W, Hung DT, Rose J, Vu T-KH, Wheaton VI, Turck CW, Coughlin SR: Tethered ligand agonist peptides, J Biol Chem 1992:267:13146-13149.
9. Sabo T, Gurwitz D, Motola L, Brodt P, Barak R, Elhanaty E: Structurc-activity studies of the thrombin receptor activating peptide, Biochem Biophys Res Commun 1992;188:604-610.
10. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J: Molecular cloning of a potential proteinase activated receptor, Proc Natl Acad Sci USA 1994:91:9208-9212.
11. Sambrook J, Fritsch EF, Manialis T: Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 1989.
12. Nystcdt S, Emilsson K, Larsson A-K, Ström-beck B, Sundelin J: Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2, Eur J Biochem 1995;232:84-89.
13. Hwa JJ, Ghibaudi L, Williams P, Chintala M, Zhang R, Chatterjcc M, Sybertz E: Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells, Circ Res 1996:78: 581-588.
14. Palmer RM, Ashton DS, Monconada S: Vascular endothelial cells synthesize nitric oxide from Jarginine, Nature 1988:333:664-666.
15. Furchgott RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature 1980:288:373-376.
16. Needleman P, Corr PB, Johnson EM Jr.: Drugs used for the treatment of angina: Organic nitrates, calcium channel blockers and ß-adrener-gic antagonists; in Goodman Gilman A, Goodman LS, Rail TW, Murad F (eds): Goodman and Gilman’s the Pharmacological Basis of Therapeutics, ed 7, New York, Macmillan, 1985, pp 806-826.
17. Al-Ani B, Saifeddine M, Hollenbcrg MD: Detection of functional receptors for the proteinase-activated receptor-2-activating polypeptide, SLIGRL-NH;, in rat vascular and gastric-smooth muscle, Can J Physiol Pharmacol 1995;73:1203-1207.
18. Saifeddine M, Al-Ani B, Cheng C-H, Wang L, Hollenbcrg MD: Rat proteinase-activated rc-ceptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue, Br J Pharmacol 1996; 118:521-530.
19. Muramatsu I, Laniyonu A, Moore GJ, Hollen-berg MD: Vascular actions of thrombin receptor peptide, Can J Phvsiol Pharmacol 1992;70: 996-1003.
20. Nystcdt S, Ramakrishnan V, Sundelin J: The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells, J Biol Chem 1996;271:14910-14915.
21. Mirza H, Yatsula V, Bahou WF: The proteinase-activated receptor-2 (PAR-2) mediates mi-togen.c responses in human vascular endothelial cells, J Clin Invest 1996;97:1705-1714.
22. Nathan C, Xie Q-W: Nitric oxide synthases: Roles, tolls, and controls, Cell 1994:78:915-918.
23. Shepherd JT, Katusic ZS: Endothelium-derived vasoactive factors, I, Endothelium-dependent relaxation, Hypertension 1991: 18(suppl III):76-85.
24. Blackhart BD, Emilsson K, Nguyen D, Teng W, Martelli AJ, Nystedt S, Sundelin J, Scarborough RM: Ligand cross-reactivity within the protease-activated receptor family, J Biol Chem 1996:271:16466-16471.
25. Ru DD: Mechanism of thrombin-induced endothelium-dependent coronary vasodilation in dogs: Role of its proteolytic enzymatic activity, J Cardiovasc Pharmacol 1986:8:29-36.