Proteinase-activated receptors (PARs): Activation of PAR1 and PAR2 by a proteolytic fragment of the neuronal growth associated protein B-50/GAP-43

Canadian Journal of Physiology and Pharmacology

Volumn 78, Issue 1, 2000, Pages 81-85

  Hollenberg, Morley D ^a   Saifeddine, Mahmoud ^a   Zwiers, Henk ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

B 50 GAP 43; Calcium signalling; Neurones; Proteinase activated receptors

Indexed keywords

CALCIUM ION; NEUROMODULIN; PROTEINASE; THROMBIN; THROMBIN RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KIDNEY CELL; NERVE CELL GROWTH; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SYNAPTOSOME;

EID: 0033982381     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-78-1-81     Document Type: Article

References (16)

1. Blackhart, B.D., Emilsson, K., Nguyen, D., Teng, W., Martelli, A.J., Nystedt, S., Sundelin, J., and Scarborough, R.M. 1996. Ligand cross-reactivity with the protease-activated receptor family. J. Biol. Chem. 271: 16466-16471.
2. Brass, L.F., and Molino, M. 1997. Protease-activated G protein-coupled receptors on human platelets and endothelial cells. Thromb. Haemostasis, 78: 234-241.
3. Corvera, C.U., Olivier, D., McConalogue, K., Gamp, P., Thoma, M., Al-Ani, B. Caughey, G.H., Hollenberg, M.D., and Bunnett, N.W. 1999. Thrombin and mast cell tryptase regulate guinea-pig my enteric neurons through proteinase-activated receptors-1 and -2. J. Physiol. (London), 517.3: 741-756.
4. Coughlin, S.R., Vu, T.K., Hung, D.T., and Wheaton, V.I. 1992. Characterization of a functional thrombin receptor. J. Clin. Invest. 89: 351-355.
5. Dery, O., Corvera, C.U., Steinhoff, M., and Bunnett, N.W. 1998. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 274: 1429-1452.
6. Hollenberg, M.D. 1996. Protease-mediated signalling: new paradigms for cell regulation and drug development. Trends Pharmacol. Sci. 17: 3-6.
7. 4 and counting: How long is the course? Trends Pharmacol. Sci. 20: 271-273.
8. Hollenberg, M.D., Yang, S.-G., Laniyonu, A.A., Moore, G.J., and Saifeddine, M. 1992. Action of thrombin receptor polypeptide in gastric smooth muscle: identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity. Mol. Pharmacol. 42: 186-191.
9. Hollenberg, M.D., Saifeddine, M., Al-Ani, B., and Kawabata, A. 1997. Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity and receptor selectivity of receptor-activating peptides. Can. J. Physiol. Pharmacol. 75: 832-841.
10. 1-targeted ligands. J. Pharmacol. Exp. Ther. 288: 358-370.
11. McMaster, D., Zwiers, H., and Lederis, K. 1988. The growth-associated neuronal phosphoprotein B-50: improved purification, partial primary structure, and characterization and localization of proteolysis products. Brain Res. Bull. 21: 265-276.
12. Natarajan, S., Rexinger, D., Peluso, M., and Seiler, S.M. 1995. 'Tethered ligand' derived peptapeptide agonists of thrombin receptor: a study of side chain requirements for human platelet activation and GTPase stimulation. Int. J. Pept. Protein Res. 45: 145-151.
13. Vu, T.K.H., Hung, D.T., Wheaton, V.I., and Coughlin, S.R. 1991. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell, 64: 1057-1068.
14. Zwiers, H., and Coggins, P.J. 1990. Corticotrophin (ACTH) inhibits the specific proteolysis of the neuronal phosphoprotein B-50/GAP-43. Peptides, 11: 951-954.
15. Zwiers, H., and Coggins, P.J. 1991. B-50: structure, processing and interaction with ACTH. In Progress in brain research., Vol. 89. Edited by W.H. Gispen and A. Routtenberg. Elsevier Science Publishers, Amsterdam, pp. 3-16.
16. Zwiers, H., Schotman, P., and Gispen, W.H. 1980. Purification and some characteristics of an ACTH-sensitive protein kinase and its substrate protein in rat brain membranes. J. Neurochem. 34: 1689-1699.