Inhibition of melanosome transfer results in skin lightening

Journal of Investigative Dermatology

Volumn 115, Issue 2, 2000, Pages 162-167

  Seiberg, Miri ^a   Paine, Christine ^a   Sharlow, Elizabeth ^a   Andrade Gordon, Patricia ^b   Costanzo, Michael ^b   Eisinger, Magdalena ^a   Shapiro, Stanley S ^a  

^a Skin Biology Research Center   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

PAR 2; RWJ 50353

Indexed keywords

RWJ 50353; SERINE PROTEINASE INHIBITOR;

ANIMAL CELL; ARTICLE; DRUG MECHANISM; KERATINOCYTE; MELANOSOME; NONHUMAN; PRIORITY JOURNAL; SKIN DISEASE; SKIN PIGMENTATION; SWINE;

EID: 0033870562     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00035.x     Document Type: Article

References (21)

1. A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth
2. Molecular cloning, expression and potential functions of the human proteinase activated receptor 2
3. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
4. Potent thrombin inhibitors that probe the S1' subsite: Tripeptide transition state analogues based on a heterocycle-activated carbonyl group 1
5. Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors
6. Growth and differentiation of normal human melanocytes in a TPA-free, cholera toxin-free, low serum medium and influence of keratinocytes
7. Common disorders of pigmentation: When are more than cosmetic. Cover-ups required?
8. Chemical, pharmacologic and physical agents causing hypomelanoses
9. Melanosomal translocation and transfer
10. Molecular cloning of a potential proteinase activated receptor
11. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
12. The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression
13. Melanoma dynein: Evidence that dynein is a general 'motor' for microtubule-associated cell motilities
14. High molecular weight forms of tyrosinase and the tyrosinase-related proteins: Evidence for a melanogenic complex
15. Melanins and melanocytes, form and function
16. Temporal separation of rhabdom shrinkage and MVB formation in the light-adapting crayfish retina
17. Evidence for the presence of a protease-activated receptor distinct from thrombin receptor in human keratinocytes
18. PAR-2 regulates pigmentation via keratinocyte-melanocyte interactions
19. The predominant defect in dilute melanocytes is in melanosome distribution and not cell shape, supporting a role for myosin V in melanosome transport
20. Three models of melanosome transfer in caucasian facial skin: Hypothesis based on an ultrastructural study