메뉴 건너뛰기




Volumn 7, Issue 11, 1996, Pages 1679-1690

Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CARBACHOL; DIACYLGLYCEROL; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINIC RECEPTOR; PERTUSSIS TOXIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE C; THROMBIN; THROMBIN RECEPTOR; TRANSCRIPTION FACTOR AP 1;

EID: 0029990852     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.7.11.1679     Document Type: Article
Times cited : (67)

References (74)
  • 2
    • 0024362875 scopus 로고
    • Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes
    • Ashkenazi, A., Ramachandran, J., and Capon, D.J. (1989). Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes. Nature 340, 146-150.
    • (1989) Nature , vol.340 , pp. 146-150
    • Ashkenazi, A.1    Ramachandran, J.2    Capon, D.J.3
  • 3
    • 0023932998 scopus 로고
    • Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation
    • Banga, H.S., Walker, R.K., Winberry, L.K., and Rittenhouse, S.E. (1988). Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Biochem. J. 252, 297-300.
    • (1988) Biochem. J. , vol.252 , pp. 297-300
    • Banga, H.S.1    Walker, R.K.2    Winberry, L.K.3    Rittenhouse, S.E.4
  • 5
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh, E.G., and Dyer, W.J. (1959). A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 6
    • 0029059732 scopus 로고
    • q/11 by the m3 muscarinic acetylcholine receptor
    • q/11 by the m3 muscarinic acetylcholine receptor. J. Biol. Chem. 270, 17741-17748.
    • (1995) J. Biol. Chem. , vol.270 , pp. 17741-17748
    • Blin, N.1    Yun, J.2    Wess, J.3
  • 8
    • 0027501802 scopus 로고
    • ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor
    • ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12, 4211-4220.
    • (1993) EMBO J. , vol.12 , pp. 4211-4220
    • Burgering, B.M.T.1    Pronk, G.J.2    Van Weeren, P.C.3    Chardin, P.4    Bos, J.L.5
  • 9
    • 0025255579 scopus 로고
    • Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1
    • Cavanaugh, K.P., Gurwitz, D., Cunningham, D.D., and Bradshaw, R.A. (1990). Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J. Neurochem. 54, 1735-1743.
    • (1990) J. Neurochem. , vol.54 , pp. 1735-1743
    • Cavanaugh, K.P.1    Gurwitz, D.2    Cunningham, D.D.3    Bradshaw, R.A.4
  • 10
    • 0023186924 scopus 로고
    • Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin
    • Chambard, J.C., Paris, S., L'Allemain, G., and Pouyssegur, J. (1987). Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin. Nature 326, 800-803.
    • (1987) Nature , vol.326 , pp. 800-803
    • Chambard, J.C.1    Paris, S.2    L'Allemain, G.3    Pouyssegur, J.4
  • 13
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • Cook, S.J., and McCormick, F. (1993). Inhibition by cAMP of Ras-dependent activation of Raf. Science 262, 1069-1072.
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 14
    • 0028240869 scopus 로고
    • Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
    • Crespo, P., Xu, N., Simonds, W.F., and Gutkind, J.S. (1994). Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369, 418-420.
    • (1994) Nature , vol.369 , pp. 418-420
    • Crespo, P.1    Xu, N.2    Simonds, W.F.3    Gutkind, J.S.4
  • 16
    • 0028176297 scopus 로고
    • cAMP and βγ-subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
    • Faure, M., Voyno-Yasenetskaya, T.A., and Bourne, H.R. (1994). cAMP and βγ-subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem. 269, 7851-7854.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7851-7854
    • Faure, M.1    Voyno-Yasenetskaya, T.A.2    Bourne, H.R.3
  • 17
    • 0030064643 scopus 로고    scopus 로고
    • Acetylcholine as a mitogen: Muscarinic receptor mediated proliferation of rat astrocytes and human astrocytoma cells
    • Giuzzetti, M., Costa, P., Peters, J., and Costa, L.G. (1996). Acetylcholine as a mitogen: muscarinic receptor mediated proliferation of rat astrocytes and human astrocytoma cells. Eur. J. Pharmacol. 297, 265-273.
    • (1996) Eur. J. Pharmacol. , vol.297 , pp. 265-273
    • Giuzzetti, M.1    Costa, P.2    Peters, J.3    Costa, L.G.4
  • 18
    • 0030032791 scopus 로고    scopus 로고
    • Cellular consequences of thrombin-receptor activation
    • Grand, R., Turnell, A.S., and Grabham, P.W. (1996). Cellular consequences of thrombin-receptor activation. Biochem. J. 323, 353-368.
    • (1996) Biochem. J. , vol.323 , pp. 353-368
    • Grand, R.1    Turnell, A.S.2    Grabham, P.W.3
  • 19
    • 0022540899 scopus 로고
    • Evidence for two GTPases activated by thrombin in membranes of human platelets
    • Grandt, R., Aktories, K., and Jakobs, K.H. (1986). Evidence for two GTPases activated by thrombin in membranes of human platelets. Biochem. J. 237, 669-674.
    • (1986) Biochem. J. , vol.237 , pp. 669-674
    • Grandt, R.1    Aktories, K.2    Jakobs, K.H.3
  • 22
    • 0000201075 scopus 로고    scopus 로고
    • + exchange through distinct Cdc42-dependent and RhoA-dependent pathways
    • + exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J. Biol. Chem. 271, 6152-6158.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6152-6158
    • Hooley, R.1    Yu, C.-Y.2    Symons, M.3    Barber, D.L.4
  • 23
    • 0028091046 scopus 로고
    • Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat-1 fibroblasts
    • Hordijk, P.L., Verlaan, I., van Corven, E.J., and Moolenaar, W.H. (1994). Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat-1 fibroblasts. J. Biol. Chem. 269, 645-651.
    • (1994) J. Biol. Chem. , vol.269 , pp. 645-651
    • Hordijk, P.L.1    Verlaan, I.2    Van Corven, E.J.3    Moolenaar, W.H.4
  • 25
    • 1842362115 scopus 로고
    • Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors
    • Hughes, A.R., Martin, M.W., and Harden, T.K. (1984). Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. Proc. Natl. Acad. Sci. USA 81, 5680-5684.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5680-5684
    • Hughes, A.R.1    Martin, M.W.2    Harden, T.K.3
  • 26
    • 0026504693 scopus 로고
    • Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanisms established for the cloned platelet thrombin receptor
    • Hung, D.T., Vu, T.H., Nelken, N.A., and Coughlin, S.R. (1992a). Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanisms established for the cloned platelet thrombin receptor. J. Cell Biol. 116, 827-832.
    • (1992) J. Cell Biol. , vol.116 , pp. 827-832
    • Hung, D.T.1    Vu, T.H.2    Nelken, N.A.3    Coughlin, S.R.4
  • 27
    • 0026782001 scopus 로고
    • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
    • Hung, D.T., Wong, Y.H., Vu, T.H., and Coughlin, S.R. (1992b). The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J. Biol. Chem. 267, 20831-20834.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20831-20834
    • Hung, D.T.1    Wong, Y.H.2    Vu, T.H.3    Coughlin, S.R.4
  • 29
    • 0028999856 scopus 로고
    • G protein βγ-subunit activates Ras, Raf, and Map kinase in HEK293 cells
    • Ito, A., Satoh, T., Kaziro, Y., and Itoh, H. (1995). G protein βγ-subunit activates Ras, Raf, and Map kinase in HEK293 cells. FEBS Lett. 368, 183-187.
    • (1995) FEBS Lett. , vol.368 , pp. 183-187
    • Ito, A.1    Satoh, T.2    Kaziro, Y.3    Itoh, H.4
  • 31
    • 0024406827 scopus 로고
    • Thrombin and trypsin act at the same site to stimulate phosphoinositide hydrolysis and calcium mobilization
    • Jones, L.G., McDonough, P.M., and Brown, J.H. (1989). Thrombin and trypsin act at the same site to stimulate phosphoinositide hydrolysis and calcium mobilization. Mol. Pharmacol. 36, 142-149.
    • (1989) Mol. Pharmacol. , vol.36 , pp. 142-149
    • Jones, L.G.1    McDonough, P.M.2    Brown, J.H.3
  • 32
    • 0026772506 scopus 로고
    • Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition
    • Kahan, C., Seuwen, K., Melochie, S., and Pouyssegur, J. (1992). Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition. J. Biol. Chem. 267, 13369-13375.
    • (1992) J. Biol. Chem. , vol.267 , pp. 13369-13375
    • Kahan, C.1    Seuwen, K.2    Melochie, S.3    Pouyssegur, J.4
  • 33
    • 0024497989 scopus 로고
    • Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. II. Two signaling pathways distinguished by pertussis toxin and a potential role for the ras oncogene
    • Kelvin, D.J., Simard, G., Sue-A-Quan, A., and Connolly, J.A. (1989). Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. II. Two signaling pathways distinguished by pertussis toxin and a potential role for the ras oncogene. J. Cell Biol. 108, 169-176.
    • (1989) J. Cell Biol. , vol.108 , pp. 169-176
    • Kelvin, D.J.1    Simard, G.2    Sue-A-Quan, A.3    Connolly, J.A.4
  • 35
    • 0028085776 scopus 로고
    • Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling
    • Koch, W.J., Hawes, B.E., Inglese, J., Luttrell, L.M., and Lefkowitz, R.J. (1994b). Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J. Biol. Chem. 269, 6193-6197.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6193-6197
    • Koch, W.J.1    Hawes, B.E.2    Inglese, J.3    Luttrell, L.M.4    Lefkowitz, R.J.5
  • 36
    • 0026202049 scopus 로고
    • p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: Use of pertussis toxin as a discrimination factor
    • L'Allemain, G., Pouyssegur, J., and Weber, M.J. (1991). p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor. Cell Regul. 2, 675-684.
    • (1991) Cell Regul. , vol.2 , pp. 675-684
    • L'Allemain, G.1    Pouyssegur, J.2    Weber, M.J.3
  • 37
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 38
    • 0027468567 scopus 로고
    • Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2
    • LaMorte, V.J., Harootunian, A.T., Spiegel, A.M., Tsien, R.Y., and Feramisco, J.R. (1993a). Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2. J. Cell Biol. 121, 91-99.
    • (1993) J. Cell Biol. , vol.121 , pp. 91-99
    • LaMorte, V.J.1    Harootunian, A.T.2    Spiegel, A.M.3    Tsien, R.Y.4    Feramisco, J.R.5
  • 40
    • 0023010517 scopus 로고
    • Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin
    • Letterio, J.L., Coughlin, S.R., and Williams, L.T. (1986). Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin. Science 234, 1117-1119.
    • (1986) Science , vol.234 , pp. 1117-1119
    • Letterio, J.L.1    Coughlin, S.R.2    Williams, L.T.3
  • 41
    • 0029025036 scopus 로고
    • The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors
    • Malarkey, K., Belham, C.M., Paul, A., Graham, A., McLees, A., Scott, P.H., and Plevin, R. (1995). The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem. J. 309, 361-375.
    • (1995) Biochem. J. , vol.309 , pp. 361-375
    • Malarkey, K.1    Belham, C.M.2    Paul, A.3    Graham, A.4    McLees, A.5    Scott, P.H.6    Plevin, R.7
  • 42
    • 0021669271 scopus 로고
    • Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells
    • Masters, S.B., Harden, T.K., and Brown, J.H. (1984). Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells. Mol. Pharmacol. 26, 149-155.
    • (1984) Mol. Pharmacol. , vol.26 , pp. 149-155
    • Masters, S.B.1    Harden, T.K.2    Brown, J.H.3
  • 43
    • 0021809646 scopus 로고
    • Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization
    • Masters, S.B., Martin, M.W., Harden, T.K., and Brown, J.H. (1985a). Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. Biochem. J. 227, 933-937.
    • (1985) Biochem. J. , vol.227 , pp. 933-937
    • Masters, S.B.1    Martin, M.W.2    Harden, T.K.3    Brown, J.H.4
  • 44
    • 0021992991 scopus 로고
    • Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis
    • Masters, S.B., Quinn, M.T., and Brown, J.H. (1985b). Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis. Mol. Pharmacol. 27, 325-332.
    • (1985) Mol. Pharmacol. , vol.27 , pp. 325-332
    • Masters, S.B.1    Quinn, M.T.2    Brown, J.H.3
  • 45
    • 0023672372 scopus 로고
    • Desensitization and recovery of muscarinic and histaminergic calcium mobilization: Evidence for a common hormone sensitive calcium store in 1321N1 astrocytoma cells
    • McDonough, P.M., Eubanks, J.H., and Brown, J.H. (1988). Desensitization and recovery of muscarinic and histaminergic calcium mobilization: evidence for a common hormone sensitive calcium store in 1321N1 astrocytoma cells. Biochem. J. 249, 135-141.
    • (1988) Biochem. J. , vol.249 , pp. 135-141
    • McDonough, P.M.1    Eubanks, J.H.2    Brown, J.H.3
  • 46
    • 0029976573 scopus 로고    scopus 로고
    • cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition
    • McKenzie, F.R., and Pouyssegur, J. (1996). cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition. J. Biol. Chem. 271, 13476-13483.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13476-13483
    • McKenzie, F.R.1    Pouyssegur, J.2
  • 47
    • 0028040818 scopus 로고
    • Rapid heterologous desensitization of muscarinic and thrombin receptor-mediated phospholipase D activation
    • Nieto, M., Kennedy, E., Goldstein, D., and Brown, J.H. (1994). Rapid heterologous desensitization of muscarinic and thrombin receptor-mediated phospholipase D activation. Mol. Pharmacol. 46, 406-413.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 406-413
    • Nieto, M.1    Kennedy, E.2    Goldstein, D.3    Brown, J.H.4
  • 52
    • 0029900434 scopus 로고    scopus 로고
    • G protein-coupled receptors and signaling pathways regulating growth responses
    • Post, G.R., and Brown, J.H. (1996). G protein-coupled receptors and signaling pathways regulating growth responses. FASEB J. 10, 741-749.
    • (1996) FASEB J. , vol.10 , pp. 741-749
    • Post, G.R.1    Brown, J.H.2
  • 54
    • 0022970190 scopus 로고
    • Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells
    • Preiss, J., Loomis, C.R., Bishop, W.R., Stein, R., Niedel, J.E., and Bell, R.M. (1986). Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J. Biol. Chem. 261, 8597-8600.
    • (1986) J. Biol. Chem. , vol.261 , pp. 8597-8600
    • Preiss, J.1    Loomis, C.R.2    Bishop, W.R.3    Stein, R.4    Niedel, J.E.5    Bell, R.M.6
  • 55
    • 0028294622 scopus 로고
    • Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of raf activity
    • Russell, M., Winitz, S., and Johnson, G.L. (1994). Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of raf activity. Mol. Cell. Biol. 14, 2343-2351.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2343-2351
    • Russell, M.1    Winitz, S.2    Johnson, G.L.3
  • 56
    • 0025681555 scopus 로고
    • Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not G, to S phase progression in hamster fibroblasts
    • Seuwen, K., Kahan, C., Hartmann, T., and Pouyssegur, J. (1990). Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not G, to S phase progression in hamster fibroblasts. J. Biol. Chem. 265, 22292-22299.
    • (1990) J. Biol. Chem. , vol.265 , pp. 22292-22299
    • Seuwen, K.1    Kahan, C.2    Hartmann, T.3    Pouyssegur, J.4
  • 57
    • 0027194917 scopus 로고
    • Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1
    • Simonson, M.S., and Herman, W.H. (1993). Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. J. Biol. Chem. 268, 9347-9357.
    • (1993) J. Biol. Chem. , vol.268 , pp. 9347-9357
    • Simonson, M.S.1    Herman, W.H.2
  • 60
    • 0028246440 scopus 로고
    • Binding of G protein β-γ-subunits to pleckstrin homology domains
    • Touhara, K., Inglese, J., Pitcher, J.A., Shaw, G., and Lefkowitz, R.J. (1994). Binding of G protein β-γ-subunits to pleckstrin homology domains. J. Biol. Chem. 269, 10217-10220.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10217-10220
    • Touhara, K.1    Inglese, J.2    Pitcher, J.A.3    Shaw, G.4    Lefkowitz, R.J.5
  • 61
    • 0026656903 scopus 로고
    • Biphasic increase in c-jun mRNA is required for induction of AP-1 mediated gene transcription: Differential effects of muscarinic and thrombin receptor activation
    • Trejo, J., Chambard, J., Karin, M., and Brown, J.H. (1992). Biphasic increase in c-jun mRNA is required for induction of AP-1 mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol. Cell. Biol. 12, 4742-4750.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 4742-4750
    • Trejo, J.1    Chambard, J.2    Karin, M.3    Brown, J.H.4
  • 62
    • 0024476984 scopus 로고
    • 2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells
    • 2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells. J. Biol. Chem. 264, 3102-3107.
    • (1989) J. Biol. Chem. , vol.264 , pp. 3102-3107
    • Trilivas, I.1    Brown, J.H.2
  • 63
    • 0025913006 scopus 로고
    • Dissociation of protein kinase C redistribution from the phosphorylation of its substrates
    • Trilivas, I., McDonough, P.M., and Brown, J.H. (1991). Dissociation of protein kinase C redistribution from the phosphorylation of its substrates. J. Biol. Chem. 266, 8431-8438.
    • (1991) J. Biol. Chem. , vol.266 , pp. 8431-8438
    • Trilivas, I.1    McDonough, P.M.2    Brown, J.H.3
  • 65
    • 0027411213 scopus 로고
    • Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts
    • van Corven, E.J., Hordijk, P.L., Medema, R.H., Bos, J.L., and Moolenaar, W.H. (1993). Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. Proc. Natl. Acad. Sci. USA 90, 1257-1261.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1257-1261
    • Van Corven, E.J.1    Hordijk, P.L.2    Medema, R.H.3    Bos, J.L.4    Moolenaar, W.H.5
  • 69
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu, T.H., Hung, D.T., Wheaton, V., and Coughlin, S.R. (1991). Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.H.1    Hung, D.T.2    Wheaton, V.3    Coughlin, S.R.4
  • 70
    • 0025751636 scopus 로고
    • Development of an antiserum against m3 muscarinic receptors: Distribution of m3 receptors in rat tissues and clonal cell lines
    • Wall, S.J., Yasuda, R.P., Li, M., and Wolfe, B.B. (1991). Development of an antiserum against m3 muscarinic receptors: Distribution of m3 receptors in rat tissues and clonal cell lines. Mol. Pharmacol. 40, 783-789.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 783-789
    • Wall, S.J.1    Yasuda, R.P.2    Li, M.3    Wolfe, B.B.4
  • 71
    • 0026669450 scopus 로고
    • Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells
    • Weiss, R.H., and Nuccitelli, R. (1992). Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells. J. Biol. Chem. 267, 5608-5613.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5608-5613
    • Weiss, R.H.1    Nuccitelli, R.2
  • 72
    • 0027240231 scopus 로고
    • i-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase
    • i-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. J. Biol. Chem. 268, 19196-19199.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19196-19199
    • Winitz, S.1    Russell, M.2    Qian, N.3    Gardner, A.4    Dwyer, L.5    Johnson, G.L.6
  • 73
    • 0027772672 scopus 로고
    • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate
    • Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weber, M.J., and Sturgill, T.W. (1993). Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science 262, 1065-1069.
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Jelinek, T.3    Wolfman, A.4    Weber, M.J.5    Sturgill, T.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.