Cardiovascular responses mediated by protease-activated receptor-2 (PAR- 2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR- 2 or PAR-1

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 671-678

  Damiano, Bruce P ^c   Cheung, Wai Man ^d   Santulli, Rosemary J ^d   Fung Leung, Wai Ping ^a   Ngo, Karen ^a   Ye, Richard D ^b   Darrow, Andrew L ^d   Derian, Claudia K ^d   De Garavilla, Lawrence ^a,b,c   Andrade Gordon, Patricia ^d  

^a GENERAL ATOMICS   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c R W JOHNSON PHARMACEUTICAL RES I   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; RECEPTOR SUBTYPE; THROMBIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR RESPONSE; DRUG EFFECT; HEART RATE; HYPERTENSION; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; BLOOD PRESSURE; FEMALE; HEART RATE; MALE; MICE; OLIGOPEPTIDES; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; SUBSTRATE SPECIFICITY;

EID: 0032988474     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Alani B, Saifeddine M and Hollenberg MD (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide. SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol 73:1203-1207.
2. Blackhart BD, Emilsson K, Nguyen D, Teng W, Martelli AJ, Nystedt S, Sundelin J and Scarborough RM (1996) Ligand cross-reactivity within the protease-activated receptor family. J Biol Chem 271:16466-16471.
3. Bono F, Lamarche I and Herbert JM (1997) Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2). Biochem Biophys Res Commun 241:762-764.
4. Cheung W, Andrade-Gordon P, Derian CK and Damiano BP (1998) Receptor activating peptides distinguish thrombin receptor (PAR-1) and protease-activated receptor-2 (PAR-2)-mediated hemodynamic responses in vivo. Can J Physiol Pharmacol 76:16-25.
5. Connolly AJ, Ishihara H, Kahn ML, Farese RV and Coughlin SR (1996) Role of the thrombin receptor in development and evidence for a second receptor. Nature 381:516-519.
6. Corvera CU, Dery O, McConalogue K, Bohm SK, Khitin LM, Caughey GH, Payan DG and Bunnett NW (1997) Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invent 100:1383-1393.
7. Damiano BP, Cheung WM, Mitchell JA and Falotico R (1996) Cardiovascular actions of thrombin receptor activation in vivo. J Pharmacol Exp Ther 279:1365-1378.
8. D'Andrea MR, Derian CK, Leturcq D, Baker SM, Brunmark A, Ling P, Darrow AL, Santulli RJ, Brass LF and Andrade-Gordon P (1998) Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem 46:157-164.
9. Darrow AL, Fung-Leung WP, Ye RD, Santulli RJ, Cheung WM, Derian CK, Burns CL, Damiano BP, Zhou L, Keenan CM, Peterson PA and Andrade-Gordon P. (1996) Biological consequences of thrombin receptor deficiency in mice. Thromb Haemostasis 76:860-866.
10. Derian CK, Eckardt AJ and Andrade-Gordon P (1997) Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors. Cell Growth Differ 8:743-749.
11. Emilsson K, Wahlestedt C, Sun MK, Nystedt S, Owman C and Sundelin J (1997) Vascular effects of proteinase-activated receptor 2 agonist peptide. J Vasc Res 34:267-272.
12. Fox MT, Harriott P, Walker B and Stone SR (1997) Identification of potential activators of proteinase-activated receptor-2. FEBS Lett 417:267-269.
13. Haertlein BJ, Mitchell JA, Andrade-Gordon P, Falotico R and Damiano BP (1996) Protease activated receptor-2 does not mediate the actions of thrombin or SFLLRN in coronary vasculature (Abstract). FASEB J 10:41.
14. Hwa JJ, Ghibaudi L, Williams P, Chintala M, Zhang R, Chatterjee M and Sybertz E (1996) Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells. Circ Res 78:581-588.
15. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T and Coughlin SR (1997) Protease-activated receptor 3 is a second thrombin receptor in humans. Nature (London) 386:502-506.
16. Jeziorska M, McCollum C and Woolley DE (1997) Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries. J Pathol 182:115-122.
17. Kaartinen M, Penttila A and Kovanen PT (1994) Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase-and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas. Arterioscler Thromb 14:966-972.
18. Kahn ML, Zheng Y-W, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C and Coughlin SR (1998) A dual thrombin receptor system for platelet activation. Nature 394:690-694.
19. Kong W, McConalogue K, Khitin LM, Hollenberg MD, Payan DG, Bohm SK and Bunnett NW (1997) Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci USA 94:8884-8889.
20. Ku DD and Zaleski JK (1993) Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. J Cardiovasc Pharmacol 22:609-616.
21. McNamara CA, Sarembock IJ, Gimple LW, Fenton II JW, Coughlin SR and Owens GK (1993) Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 91:94-98.
22. Mirza H, Schmidt VA, Derian CK, Jesty J and Bahou WF (1997) Mitogenic responses mediated through the proteioase-activated receptor-2 are induced by expressed forms of mast cell α-or β-tryptases. Blood 90:3914-3922.
23. Mirza H, Yatsula V and Bahou WF (1996) The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells - Molecular characterization and evidence for functional coupling to the thrombin receptor. J Clin Invest 97:1705-1714.
24. Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M and Brass LF (1997a) Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 272:4043-4049.
25. Molino M, Woolkalis MJ, Reavey-Cantwell J, Praticó D, Andrade-Gordon P, Barnathan ES and Brass LF (1997b) Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment. J Biol Chem 272:11133-11141.
26. Muramatsu I, Laniyonu A, Moore GJ and Hollenberg MD (1992) Vascular actions of thrombin receptor peptide. Can J Physiol Pharmacol 70:996-1003.
27. Nystedt S, Emilsson K, Larsson AK, Strombeck B and Sundelin J (1995) Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem 232:84-89.
28. Nystedt S, Emilsson IE, Wahlestedt C and Sundelin J (1994) Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci 91:9208-9212.
29. Nystedt S, Ramakrishnan V and Sundelin J (1996) The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 271:14910-14915.
30. Saifeddine M, Alani B, Cheng CH, Wang L and Hollenberg MD (1996) Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol 118:521-530.
31. Santulli RJ, Derian CK, Darrow AL, Tomko KA, Eckardt AJ, Seiberg M, Scarborough RM and Andrade-Gordon P (1995) Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proc Natl Acad Sci USA 92:9151-9155.
32. Tesfamariam B, Allen GT, Normandin D and Antonaccio MJ (1993) Involvement of the tethered ligand receptor in thrombin-induced endothelium-mediated relaxations. Am J Physiol 265:H1744-H1749.
33. Vu T-KH, Hung DT, Wheaton VI and Coughlin SR (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068.
34. Yang SG, Laniyonu A, Saifeddine M, Moore GJ and Hollenberg MD (1992) Actions of thrombin and thrombin receptor peptide analogues in gastric and aortic smooth muscle - development of bioassays for structure-activity studies. Life Sci. 51: 1325-1332.