Proteinase-activated receptor-2 in human skin: Tissue distribution and activation of keratinocytes by mast cell tryptase

Experimental Dermatology

Volumn 8, Issue 4, 1999, Pages 282-294

  Steinhoff, M ^a,b   Corvera, C U ^a   Thoma, M S ^a   Kong, W ^a   McAlpine, B E ^c   Caughey, G H ^a   Ansel, J C ^c   Bunnett, Nigel W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial cells; G protein coupled receptors; Inflammation; Proteases

Indexed keywords

LIGAND; MESSENGER RNA; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 2; TRYPTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CELL ACTIVATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MAST CELL; MOUSE; NONHUMAN; NORMAL HUMAN; NORTHERN BLOTTING; PROTEIN LOCALIZATION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INFLAMMATION; TISSUE DISTRIBUTION;

EID: 0032814121     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0625.1999.tb00383.x     Document Type: Article

References (50)

1. Vu T K, Hung D T, Wheaton V I, Coughlin S R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991: 64: 1057-1068.
2. Ishihara H, Connolly A J, Zeng D et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997: 386: 502-506.
3. Xu W F, Andersen H, Whitmore T E et al. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci USA 1998: 95: 6642-6646.
4. Kahn M L, Zheng Y W, Huang W et al. A dual thrombin receptor system for platelet activation. Nature 1998: 394: 690-694.
5. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor [see comments]. Proc Natl Acad Sci U S A 1994: 91: 9208-9212.
6. Nystedt S, Emilsson K, Larsson A K, Strombeck B, Sundelin J. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem 1995: 232: 84-89.
7. Böhm S K, Kong W, Brömme D et al. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J 1996: 314: 1009-1016.
8. Grand R J, Turnell A S, Grabham P W. Cellular consequences of thrombin-receptor activation. Biochem J 1996: 313: 353-368.
9. Dery O, Corvera C U, Steinhoff M, Bunnett N W. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 1998: 274: C1429-C1452.
10. Connolly A J, Ishihara H, Kahn M L, Farese R V Jr, Coughlin S R. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996: 381: 516-519.
11. Darrow A L, Fung-Leung W P, Ye R D et al. Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost 1996: 76: 860-866.
12. Mirza H, Yatsula V, Bahou W F. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. J Clin Invest 1996: 97: 1705-1714.
13. Santulli R J, Derian C K, Darrow A L et al. Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proc Natl Acad Sci U S A 1995: 92: 9151-9155.
14. Kong W, McConalogue K, Khitin E M et al. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci U S A 1997: 94: 8884-8889.
15. Hwa J J, Ghibaudi E, Williams P et al. Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells. Circ Res 1996: 78: 581-588.
16. Nystedt S, Ramakrishnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 1996: 271: 14910-14915.
17. Saifeddine M, Al-Ani B, Cheng C, Wang E, Hollenberg M. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides and in gastric and vascular tissue. Br J Pharm 1996: 118: 521-530.
18. Corvera C U, Déry O, McConalogue K M et al. Mast cell tryptase regulates colonie myocytes through proteinase-activated receptor-2. J Clin Invest 1997: 100: 1383-1393.
19. Mari B, Guerin S, Far D F et al. Thrombin and trypsin-induced Ca(2 +) mobilization in human T-cell lines through interaction with different protease-activated receptors. FASEB J 1996: 10: 309-316.
20. Howells G E, Macey M G, Chinni C et al. Proteinase-activated receptor-2: expression by human neutrophils. J Cell Sci 1997: 110: 881-887.
21. Smith-Swintosky V, Cheo-Isaacs C, D'Andrea M, Santulli R, Darrow A, Andrade-Gordon P. Protease-activated receptor-2 (PAR-2) is present in the rat hippocampus and is associated with neurodegeneration. J Neurochem 1997: 69: 1890-1896.
22. Molino M, Barnathan E S, Numerof R et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 1997: 272: 4043-4049.
23. Mirza H, Schmidt V, Derian C, Jesty J, Bahou W. Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell α-or β-tryptases. Blood 1997: 90: 3914-3922.
24. Wakita H, Furukawa F, Takigawa M. Thrombin and trypsin stimulate granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes. Proc Assoc Am Phys 1997: 109: 190-207.
25. Derian C, Eckardt A, Andrade-Gordon P. Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors. Cell Growth Differ 1997: 8: 743-749.
26. D'Andrea M, Derian C, Leturcq D et al. Characterization of proteases activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem 1998: 46: 1-8.
27. Grady E F, Gamp P D, Baluk P, McDonald D M, Payan D G, Bunnett N W. Endocytosis and recycling of NK1 tachykinin receptors in enteric neurons. Neuroscience 1996: 16: 1239-1254.
28. Rock B M, Xin L, Wilcox J. Two Gq class G proteins are expressed in human keratinocytes. J Invest Derm 1997: 109: 645-649.
29. Brody I. Dermal and epidermal involvement in the evolution of acute eruptive guttate psoriasis vulgaris. J Invest Dermatol 1984: 82: 465-470.
30. Brody I. Mast cell degranulation in the evolution of acute eruptive guttate psoriasis vulgaris. J Invest Dermatol 1984: 82: 460-464.
31. Harvima I T, Naukkarinen A, Harvima R J, Horsmannheimo M. Enzyme-and immunohistochemical localization of mast cell tryptase in psoriatic skin. Arch Dermatol Res 1989: 281: 387-391.
32. Imayama S, Shibata Y, Hori Y. Epidermal mast cells in atopic dermatitis [letter]. Lancet 1995: 346: 1559.
33. Jarvikallio A, Naukkarinen A, Harvima I T, Aalto M L, Horsmanheimo M. Quantitative analysis of tryptase-and chymase-containing mast cells in atopic dermatitis and nummular eczema. Br J Dermatol 1997: 136: 871-877.
34. Damsgaard T E, Olesen A B, Sorensen F B, Thestrup-Pedersen K, Schiotz P O. Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin. Arch Dermatol Res 1997: 289: 256-260.
35. Heufler C, Koch F, Schuler G. Granulocyte/macrophage colony-stimulating factor and interleukin-1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J Exp Med 1988: 167: 700-708.
36. Kaplan G, Walsh G, Guido L S et al. Novel responses of human skin to intradermal recombinant granulocyte/ macrophage colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing. J Exp Med 1992: 175: 1717-1728.
37. Braunstein S, Kaplan G, Gottlieb A B et al. GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo. J Invest Dermatol 1994: 103: 601-604.
38. Goldstein S, Leong J, Schwartz L, Cooke D. Protease composition of exocytosed human skin mast cell protease-proteoglycan complexes. Tryptase resides in a complex distinct from chymase and carboxypeptidase. J Immunol 1992: 148: 2475-2482.
39. Schwartz L, Yunginger J, Miller J, Bokhari R, Dull D. Time course and appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J Clin Invest 1989: 83: 1551-1555.
40. Schwartz L B. Tryptase: a clinical indicator of mast cell-dependent events. Allergy Proc 1994: 15: 119-123.
41. Suzuki Y, Nomura J, Hori J, Koyama J, Takahashi M, Hori I. Detection and characterization of endogeneous protease associated with desquamation of stratum corneum. Arch Dermatol Res 1993: 285: 372-377.
42. Sondell B, Thornell L, Stigbrand T, Egelrud T. Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral mucosa with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia. J Histochem Cytochem 1994: 429: 459-465.
43. Saarialho-Kere U K, Kovacs S O, Pentland A P, Olerud J E, Welgus H G, Parks W C. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. J Clin Invest 1993: 92: 2858-2866.
44. Koshikawa N, Nagashima Y, Miyagi Y et al. Expression of trypsin in vascular endothelial cells. FEBS Lett 1997: 409: 442-448.
45. Wood G S, Mueller C, Warnke R A, Weissman I L. In situ localization of HuHF serine protease mRNA and cytotoxic cell-associated antigens in human dermatoses. A novel method for the detection of cytotoxic cells in human tissues. Am J Pathol 1988: 133: 218-225.
46. Brown J K, Tyler C L, Jones C A, Ruoss S J, Hartmann T, Caughey G H. Tryptase, the dominant secretory granular protein in human mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells. Am J Resp Cell Mol Biol 1995: 13: 227-236.
47. Ruoss S, Hartmann T, Caughey G H. Mast cell tryptase is a mitogen for cultured fibroblasts. J Clin Invest 1991: 88: 493-499.
48. Hartmann T, Ruoss S J, Raymond W W, Seuwen K, Caughey G H. Human tryptase as a potent, cell-specific mitogen: role of signaling pathways in synergistic responses. Am J Physiol 1992: 262: L528-534.
49. Cairns J A, Walls A F. Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intracellular adhesion molecule-1 expression. J Immunol 1995: 156: 275-283.
50. Fraki J E. Human skin proteases: effect of separated proteases on vascular permeability and leukocyte emigration in skin. Acta Derm Venereol 1977: 57: 393-398.