Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

Journal of Medicinal Chemistry

Volumn 40, Issue 23, 1997, Pages 3726-3733

  Feng, Dong Mei ^a   Gardell, Stephen J ^a   Lewis, S Dale ^a   Bock, Mark G ^a   Chen, Zhongguo ^a   Freidinger, Roger M ^a   Naylor Olsen, Adel M ^a   Ramjit, Harri G ^a   Woltmann, Richard ^a   Baskin, Elizabeth P ^a   Lynch, Joseph J ^a   Lucas, Robert ^a   Shafer, Jules A ^a   Dancheck, Kimberley B ^a   Chen, I Wu ^a   Mao, Shi Shan ^a   Krueger, Julie A ^a   Hare, Timothy R ^a   Mulichak, Anne M ^a   Vacca, Joseph P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBIN; THROMBIN INHIBITOR; TRYPSIN;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SYNTHESIS; HEMOSTASIS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTITHROMBINS; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; DOGS; KINETICS; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 9844234264     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970493r     Document Type: Article

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