Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: Role in mediating airway smooth muscle proliferation

Molecular Pharmacology

Volumn 54, Issue 6, 1998, Pages 1007-1015

  Walker, Trevor R ^a   Moore, Sarah M ^a   Lawson, Mark F ^a   Panettieri Jr , Reynold A ^b   Chilvers, Edwin R ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CALPHOSTIN C; CHELERYTHRINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; PROTEIN KINASE C INHIBITOR; THROMBIN; UNCLASSIFIED DRUG;

AIRWAY CONSTRICTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTHMA; CATTLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME REGULATION; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 0032407674     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.6.1007     Document Type: Article

References (14)

1. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, and Cohen P (1997a) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7:261-269.
2. Alessi DR, Kozlowski MT, Weng Q-P, Morrice N, and Avruch J (1997b) 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol 8:69-81.
3. Belham CM, Scott PH, Twomey DP, Gould GW, Wadsworth RM, and Plevin R (1997) Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves phosphatidylinositol 3-kinase-dependent p70 ribosomal S6 kinase activation. Cell Signal 9:109-116.
4. Bellacosa A, Testa JR, Staal SP, and Tsichlis PN (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science (Washington DC) 254:274-277.
5. Black J, Carlin S, Johnson P, Cook D, Carpenter L, Biden T, and Poronnik P (1998) A dominant negative mutant of PKC-ζ inhibits growth of human airway smooth muscle (HASM) cells in culture. Am J Respir Crit Care Med 157:A425.
6. Burgering BM and Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature (Lond) 376:599-602.
7. Carter AN and Downes CP (1993) Signaling by neurotrophic factors: activation of phosphoinositide 3-kinase by nerve growth factor. Neuroprotocols 3:107-118.
8. Chen YH, Pouyssegur J, Courtneidge SA, and Van Obberghen-Schilling E (1994) Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. J Biol Chum 269:27372-27377.
9. Daub H, Weiss FU, Wallasch C, and Ullrich A (1996) Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature (Lond) 379:557-560.
10. Donnelly R, Yang K, Omary MB, Azhar S, and Black JL (1995) Expression of multiple isoenzymes of protein kinase C in airway smooth muscle. Am J Respir Cell Mol Biol 13:253-256.
11. Duckworth BC and Cantley LC (1997) Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. J Biol Chem 272:27655-27670.
12. Dudley DT, Pang L, Decker SJ, Bridges AJ, and Saltiel AR (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92:7686-7689.
13. Hirst SJ, Webb BL, Giembycz MA, Barnes PJ, and Twort CH (1995) Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase. Am J Respir Cell Mol Biol 12:149-161.
14. James SR, Downes CP, Gigg R, Grove SJ, Holmes AB, and Alessi DR (1996) Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochem J 315:709-713.