Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture

Journal of Biochemistry

Volumn 125, Issue 6, 1999, Pages 1067-1076

  Miyata, Satoshi ^a   Koshikawa, Naohiko ^a   Higashi, Shouichi ^a   Miyagi, Yohei ^b   Nagashima, Yoji ^b   Yanoma, Shunsuke ^c   Kato, Yasumasa ^d   Yasumitsu, Hidetaro ^a   Miyazaki, Kaoru ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c KANAGAWA CANCER CENTER   (Japan)

^d KANAGAWA DENTAL COLLEGE   (Japan)

Author keywords

APP; Cancer; Trypsin; Tumor invasion; Zymography

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ENTEROPEPTIDASE; MESSENGER RNA; SERINE PROTEINASE; TRYPSIN; TRYPSINOGEN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER TISSUE; COLON CANCER; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; STOMACH CANCER; ZYMOGRAPHY;

MUS MUSCULUS;

EID: 0032806642     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022388     Document Type: Article

References (25)

1. Dann, B.M. (1989) Determination of protease mechanism in Proteolytic Enzymes (Beynon, R.J. and Bond, J.S., eds.) pp. 57-81, IRL Press, Oxford
2. Koivunen, E., Huhtala, M-L., and Stenman, U-H. (1989) Human ovarian tumor-associated trypsin. J. Biol. Chem. 264, 14095-14099
3. Koivunen, E., Saksela, O., Itokonen, O., Osman, S., Huhtala, M-L., and Stenman, U-H. (1991) Human colon carcinoma, fibrosarcoma and leukemia cell lines produce tumor-associated trypsinogen. Int. J. Cancer 28, 613-622
4. Koshikawa, N., Yasumitsu, H., Umeda, M., and Miyazaki, K. (1992) Multiple secretion of matrix serine proteinases by human stomach carcinoma cell lines. Cancer Res. 52, 5046-5053
5. Miyagi, E., Yasumitsu, H., Hirahara, F., Minaguchi, N., Koshikawa, N., Miyazaki, K., and Umeda, M. (1995) Characterization of matrix-degrading proteinases and their inhibitors secreted by human gynecological carcinoma cells. Jpn. J. Cancer Res. 86, 568-576
6. Hirahara, F., Miyagi, Y., Miyagi, E., Yasumitsu, H., Koshikawa, N., Nagashima, Y., Kitamura, H., Minaguchi, H., Umeda, M., and Miyazaki, K. (1995) Trypsinogen expression in human ovarian carcinomas. Int. J. Cancer 63, 176-181
7. Kawano, N., Osawa, H., Ito, T., Nagashima, Y., Hirahara, F., Inayama, Y., Nakatani, Y., Kimura, H., Kitajima, N., Koshikawa, N., Miyazaki, K., and Kitamura, H. (1997) Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemistry study. Hum. Pathol. 28, 613-622
8. Koshikawa, N., Hasegawa, S., Nagashima, Y., Mitsuhashi, K., Tsubota, Y., Miyata, S., Miyagi, Y., Yasumitsu, H., and Miyazaki, K. (1998) Expression of trypsin by epithelial cells of various tissues, leukocytes and neurons in human and mouse. Am. J. Pathol. 153, 937-944
9. Koshikawa, N., Nagashima, Y., Miyagi, Y., Yanoma, S., Yasumitsu, H., and Miyazaki, K. (1997) Expression of trypsin in vascular endothelial cells. FEBS Lett. 409, 442-448
10. Stetler-stevenson, W.G., Liotta, L.A., and David, E.K., Jr. (1993) Extracellular matrix 6: role of matrix proteinases in tumor invasion and metastasis. FASEB J. 7, 1434-1441
11. Okada, Y., Gonoji, Y., Naka, K., Tomita, K., Nakanishi, I., Iwata, K., Yamashita, K., and Hayakawa, T. (1992) Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. J. Biol. Chem. 267, 21712-21719
12. Imai, K., Yokohama, Y., Nakanishi, I., Ohuchi, E., Fujii, Y., Nakai, N., and Okada, Y. (1995) Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. J. Biol. Chem. 270, 6691-6697
13. Sorsa, T., Salo, T., Koivunen, E., Tyynela, J., Konttinen, Y.T., Bergmann, U., Tuuttila, A., Niemi, E., Teronen, O., Heikkila, P., Tschesche, H., Leinonen, J., Osman, S., and Stenman, U-H. (1997) Activation of type IV procollagenases by human tumor-associated trypsin-2. J. Biol. Chem. 272, 21067-21074
14. Miyata, S., Miyagi, Y., Koshikawa, N., Nagashima, Y., Kato, Y., Yasumitsu, H., Hirahara, F., Misugi, K., and Miyazaki, K. (1998) Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human stomach cancer cells. Clin. Exp. Metastasis 16, 613-622
15. Kato, Y., Koshikawa, N., Saito, S., Nagashima, Y., Miyagi, Y., Yasumitsu, H., and Miyazaki, K. (1998) Production of trypsins by human gastric cancer cells correlates with their malignant phenotype. Eur. J. Cancer 34, 1117-1123
16. Koshikawa, N., Nakamura, T., Tsuchiya, N., Isaji, M., Yasumitsu, H., Umeda, M., and Miyazaki, K. (1996) Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. J. Biochem. 119, 334-339
17. Uchino, S., Noguchi, M., Ochiai, A., Saito, T., Kobayashi, M., and Hirohashi, S. (1993) p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer. Int. J. Cancer. 54, 759-764
18. Koshikawa, N., Yasumitsu, H., Nagashima, Y., Umeda, M., and Miyazaki, K. (1994) Identification of one- and two-chain forms of trypsinogen 1 produced by a human stomach adenocarcinoma cell lines. Biochem. J. 303, 187-190
19. Ashall, F. and Goate, A.M. (1994) Role of the β-amyloid precursor protein in Alzheimer's disease. TIBS 19, 42-46
20. Roberts, M.R., Nagappan, M., Jodie, Y.D., and George, W.S. (1995) Regulation and regulatory role of proteinase inhibitors. Clit. Rev. Eukaryotic Gene Express. 5, 385-436
21. Miyazaki, K., Hasegawa, M., Funahashi, K., and Umeda, M. (1993) A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 362, 839-841
22. Maeta, M., Yamashiro, H., Oka, A., Tsujitani, S., Ikeguchi, M., and Kaibara, N. (1995) Stomach cancer in the young, with special reference to 14 pregnancy-associated cases: analysis based on 2,325 consecutive cases of stomach cancer. J. Surg. Oncol. 58, 191-195
23. Umenishi, F., Yasumitsu, H., Ashida, Y., Yamauchi, J., Umeda, M., and Miyazaki, K. (1990) Purification and properties of extracellular matrix-degrading metalloproteinase overproduced by rous sarcoma virus-transformed rat liver cell line and its identification as transin. J. Biochem. 108, 537-543
24. Mirza, H., Yatsula, V., and Bahou, W.F. (1996) The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. J. Clin. Invest. 97, 1705-1714
25. Bono, F., Lamarche, I., and Herbert, J.M. (1997) Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2). Biochem. Biophys. Res. Commun. 241, 762-764