Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery

Thrombosis and Haemostasis

Volumn 81, Issue 5, 1999, Pages 808-814

  Damiano, Bruce P ^a   D'Andrea, Michael R ^a   De Garavilla, Lawrence ^a   Cheung, Wai Man ^a   Andrade Gordon, Patricia ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BLOOD CLOTTING FACTOR 8; CYCLINE; MESSENGER RNA; POLYCLONAL ANTIBODY; PROTEINASE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA; ARTERY MEDIA; ARTICLE; BALLOON CATHETER; CAROTID ARTERY DISEASE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; VASCULAR ENDOTHELIUM;

EID: 0032929826     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614574     Document Type: Article

References (39)

1. Mullins DE, Rohrlich ST. The role of proteinases in cellular invasiveness. Biochim Biophys Acta 1983; 695: 177-214.
2. Hollenberg MD. Protease-mediated signalling: new paradigms for cell regulation and drug development. Trends Pharmacol Sci 1996; 17: 3-6.
3. Vu T-KH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-68.
4. 2+ mobilization. FEBS Letters 1991; 288: 123-8.
5. Nystedt S, Emilsson IE, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci 1994; 91: 9208-12.
6. Nystedt S, Emilsson K, Larsson AK, Strombeck B, Sundelin J. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem 1995; 232: 84-9.
7. Saifeddine M, Alani B, Cheng CH, Wang L, Hollenberg MD. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol 1996; 118: 521-30.
8. Mirza H, Yatsula V, Bahou WF. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells - molecular characterization and evidence for functional coupling to the thrombin receptor. J Clin Inves 1996; 97: 1705-14.
9. Nystedt S, Ramakrishnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 1996; 271: 14910-5.
10. Storck J, Kuesters B, Vahland M, Morys-Wortmann C, Zimmermann ER. Trypsin induced von Willebrand factor release from human endothelial cells is mediated by PAR-2 activation. Thromb Res 1996; 84: 463-73.
11. Magazine HI, King JM, Srivastava KD. Protease activated receptors modulate aortic vascular tone. Int J Cardiol 1996; 53: S75-S80.
12. Alani B, Saifeddine M, Hollenberg MD. Detection of functional receptors for the proteinase-activated receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol 1995; 73: 1203-7.
13. Bono F, Lamarche I, Herbert JM. Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2). Biochem Biophys Res Commun 1997; 241: 762-4.
14. Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 1997; 272: 4043-9.
15. D'Andrea MR, Derian CK, Leturcq D, Baker SM, Brunmark A, Ling P, Darrow AL, Santulli RJ, Brass LF, Andrade-Gordon P. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem 1998; 46: 157-64.
16. Kong W, McConalogue K, Khitin LM, Hollenberg MD, Payan DG, Bohm SK, Bunnett NW. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci USA 1997; 94:8884-9.
17. Koshikawa N, Nagashima Y, Miyagi Y, Mizushima H, Yanoma S, Yasumitsu H, Miyazaki K. Expression of trypsin in vascular endothelial cells. FEBS Lett 1997; 409: 442-8.
18. Jeziorska M, Mccollum C, Woolley DE. Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries. J Pathol. 1997; 182: 115-22.
19. Kaartinen M, Penttila A, Kovanen PT. Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas. Arterioscler Thromb 1994; 14: 966-72.
20. Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Invest 1983; 49: 208-15.
21. Bahou WF, Schmidt VA. Molecular characterization of proteolytically activated receptors: insights from the thrombin receptor and proteinase activated receptor-2 (PAR-2) genes. Platelets 1996; 7: 253-60.
22. Molino M, Raghunath PN, Kuo A, Ahuja M, Hoxie JA, Brass LF, Barnathan ES. Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells. Arterioscler, Thromb, Vasc Biol 1998; 18: 825-32.
23. Zeymer U, Fishbein MC, Forrester JS, Cercek B. Proliferating cell nuclear antigen immunohistochemistry in rat aorta after balloon denudation. Am J Pathol 1992; 141: 685-90.
24. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest. 1983; 49: 327-33.
25. Shi Y, Pieniek M, Fard A, O BJ, Mannion J, Zalewski A. Adventitial remodeling after coronary arterial injury. Circ 1996; 93: 340-8.
26. Andersen H, Maeng M, Thorwest M, Falk E. Remodeling rather than neointimal formation explains luminal narrowing after deep vessel wall injury: insights from a porcine coronary (re)stenosis model. Circ 1996; 93: 1716-24.
27. Scott N, Cipolla G, Ross C, Dunn B, Martin F, Simonet L, Wilcox J. Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries. Circ 1996; 93: 2178-87.
28. Shi Y, O BJ, Fard A, Mannion J, Wang D, Zalewski A. Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries. Circ 1996; 94: 1655-64.
29. Wilcox JN, Rodriguez J, Subramanian R, Ollerenshaw J, Zhong CZ, Hayzer DJ, Horaist C, Hanson SR, Lumsden A, Salam TA, Kelly AB, Harker LA, Runge M. Characterization of thrombin receptor expression during vascular lesion formation. Circ Res 1994; 75: 1029-38.
30. Nelken NA, Soifer SJ, O'Keefe J, Vu T-KH, Charo IF, Coughlin SR. Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 1992; 90: 1614-21.
31. Dechend R, Mo X, Schulz W, Gross M, Praus M, Dietz R, Gulba DC. Thrombin receptor and urokinase-type plasminogen activator are colocalized in vascular smooth muscle cells derived from human carotid atherosclerotic plaques. Fibrinolysis 1996; 10: 41-5.
32. Walters TK, Gorog DA, Wood RFM. Thrombin Generation Following Arterial Injury Is a Critical Initiating Event in the Pathogenesis of the Proliferative Stages of the Atherosclerotic Process. J Vasc Res 1994; 31: 173-7.
33. Barry WL, Gimple LW, Humphries JE, Powers ER, Mccoy KW, Sanders JM, Owens GK, Sarembock IJ. Arterial thrombin activity after angioplasty in an atherosclerotic rabbit model: time course and effect of hirudin. Circ 1996; 94: 88-93.
34. Abendschein DR, Recchia D, Meng YY, Oltrona L, Wickline SA, Eisenberg PR. Inhibition of thrombin attenuates stenosis after arterial injury in minipigs. J Amer Coll Cardiol 1996; 28: 1849-55.
35. Stouffer GA, Schmedtje JF, Gulba D, Huber K, Bode C, Aaron J, Runge MS. Restenosis following percutaneous revascularization - the potential role of thrombin and the thrombin receptor. Ann Hematol 1996; 73: S39-S41.
36. Corvera CU, Dery O, Mcconalogue K, Bohm SK, Khitin LM, Caughey GH, Payan DG, Bunnett NW. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 1997; 100: 1383-93.
37. Fox MT, Harriott P, Walker B, Stone SR. Identification of potential activators of proteinase-activated receptor-2. FEBS Lett 1997; 417: 267-9.
38. Mirza H, Schmidt VA, Derian CK, Jesty J, Bahou WF. Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell α- or β-tryptases. Blood 1997; 90: 3914-22.
39. Holm J, Hansson GK. Cellular and immunologic features of carotid artery disease in man and experimental animal models. Eur J Vasc Surg 1990; 4: 49-55.