Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor

Blood

Volumn 95, Issue 3, 2000, Pages 959-964

  Azim, A C ^a   Barkalow, K ^a   Chou, J ^a   Hartwig, J H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; GUANOSINE TRIPHOSPHATASE; THROMBIN; THROMBOCYTE RECEPTOR;

ARTICLE; CELL STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; THROMBOCYTE ACTIVATION; THROMBOCYTE STRUCTURE;

EID: 0034142240     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.3.959.003k22_959_964     Document Type: Article

References (28)

1. Hartwig J, Bokoch G, Carpenter C, et al. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 1995;82:843-653.
2. Leng L, Kashiwagi H, Ren X-D, Shattil S. RhoA and the function of platelet integrin αIIbβ3. Blood. 1998;91:4206-4215.
3. Dash D, Aepfelbacher M, Siess W. Integrin αIIbβ3-mediated translocation of CDC42Hs to the cytoskeleton in stimulated human platelets. J Biol Chem. 1995;270:17,321-17,326.
4. Fischer TH, Gatling M, Duffy CM, White GC. Incorporation of Rap 1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium. J Biol Chem. 1994;269: 17,257-17,261.
5. Fischer T. Gatling M, Laca J-C, White G. Rap1B, a cAMP-dependent protein kinase substrate, associates with the platelet cytoskeleton. J Biol Chem. 1990;265:19,405-19,408.
6. 2+-mediated activation of Rap1 in human platelets. EMBO J. 1997;16:252-259.
7. Hartwig J. Mechanism of actin rearrangements mediating platelet activation. J Cell Biol. 1992; 118:1421-1442.
8. Hartwig J, Chambers K, Stossel T. Association of gelsolin with actin filaments and cell membranes of macrophages and platelets. J Cell Biol. 1989; 108:467-479.
9. Benard V, Bohl B, Bokoch G. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem. 1999;274: 13,198-13,204.
10. Schliwa M, van Blerkom J, Porter K. Stabilization of the cytoptasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition. Proc Natl Acad Sci U S A. 1981;78:4329-4333.
11. Laemmli U. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond). 1970;227:680-685.
12. Kovacsovics T, Bachelot C, Toker A, et al. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets, but reverses platelet aggregation. J Biol Chem. 1995;270:11,358-11,365.
13. Reif K, Nobes C, Thomas G, Hall A, Cantrell D. Phosphatidylinositol 3-kinase signals activate a selective subset of rac/rho-dependent effector pathways. Curr Biol. 1996;6:1445-1455.
14. Hawkins P, Eguinoa A, Qiu R-G, et al. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol. 1995;5: 393-403.
15. Miranti C, Leng L, Maschberger P, Brugge J, Shattil S. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol. 1998;8:1289-1299.
16. Ridley A, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992;70:389-400.
17. Ridley A, Paterson H, Johnston C, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 1992;70:401-410.
18. Nobes C, Hall A. Rac, rho, and cdc42 GTPase regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 1995;81:53-62.
19. Hartwig J. An ultrastructural approach to understanding the cytoskeleton. In: Carraway K, Carraway C, eds. The Cytoskeleton: A Practical Approach. The Practical Approach Series. Oxford, UK: Oxford University Press; 1992:23-45.
20. Machesky L, Mullins R, Higgs H, et al. Scar, a WASp-related protein, activates dendritic nucleation of actin filaments by the ARP2/3 complex. Proc Natl Acad Sci U S A. 1999;96.
21. Rohatgi R, Ma L, Miki H, et al. The interaction between N-WASp and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 1999;97:221-231.
22. Zigmond S, Joyce M, Yang C, Brown K, Huang M, Pring M. Mechanism of Cdc42-induced actin polymerization in neutrophil extracts. J Cell Biol. 1998;142:1001-1012.
23. Zigmond S, Joyce M, Borleis J, Bokoch G, Devreotes P. Regulation of actin polymerization in cell-free systems by GTPγS and Cdc42. J Cell Biol. 1997;138:363-374.
24. Aspenstrom P, Lindberg U, Hall A. The two GT-Pases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr Biol. 1996;6: 70-75.
25. Kolluri R, Tolias K, Carpenter C, Rosen F, Kirchhausen T. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase, Cdc42. Proc Natl Acad Sci U S A. 1996;93:5615-5618.
26. Symons M, Derry J, Karlak B, et al. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell. 1996;84:723-734.
27. Bi E, Zigmond S. Actin polymerization: where the WASp stings. Curr Biol. 1999;9:R160-R163.
28. Miki H, Miura K, Takenawa T. N-WASp, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J. 1996;15:5326-5335.