Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo

Stroke

Volumn 29, Issue 7, 1998, Pages 1439-1444

  Sobey, Christopher G ^a   Cocks, Thomas M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Basilar artery; Endothelium; Nitric oxide; Rats; Vasodilation

Indexed keywords

ACETYLCHOLINE; GUANINE NUCLEOTIDE BINDING PROTEIN; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; QUINOXALINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTERY DILATATION; ARTICLE; BASILAR ARTERY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031807665     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.29.7.1439     Document Type: Article

References (21)

1. White RP, Shirasawa Y, Robertson JT. Comparison of responses elicited by alpha-thrombin in isolated canine basilar, coronary, mesenteric, and renal arteries. Blood Vessels. 1984;21:12-22.
2. Katusic ZS, Shepherd JT, Vanhoutte PM. Vasopressin causes endothelium-dependent relaxations of the canine basilar artery. Circ Res. 1984;55:575-579.
3. Vu T-KH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
4. Gerszten RE, Chen J, Ishii M, Wang L, Nanevicz T, Turck CW, Vu T-KH, Coughlin SR. Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature. 1994;368:648-651.
5. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci U S A. 1994;91:9208-9212.
6. Saifeddine M, Al-Ani B, Cheng C-H, Wang L, Hollenberg MD. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol. 1996;118:521-530.
7. Hollenberg MD, Saifeddine M, Al-Ani B. Proteinase-activated receptor-2 in rat aorta: structural requirements for agonist activity of receptor-activating peptides. Molec Pharmacol. 1996;49:229-233.
8. Hwa JJ, Ghibaudi L, Williams P, Chintala M, Zhang R, Chatterjee M, Sybertz E. Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells. Circ Res. 1996;78:581-588.
9. Emilsson K, Wahlestedt C, Sun M-K, Nystedt S, Owman C, Sundelin J. Vascular effects of proteinase-activated receptor-2 agonist peptide. J Vasc Res. 1997;34:267-272.
10. Faraci FM, Heistad DD, Mayhan WG. Role of large arteries in regulation of blood flow to brain stem in cats. J Physiol (Lond.). 1987;387:115-123.
11. Rapoport RM, Draznin MB, Murad F. Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circ Res. 1984;55:468-479.
12. 2, in rat vascular and gastric muscle Can J Physiol Pharmacol. 1995;73:1203-1207.
13. Mirza H, Yatsula V, Bahou WF. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. J Clin Invest. 1996;97:1705-1714.
14. Molino M, Woolkalis MJ, Reavey-Cantwell J, Pratico D, Andrade-Gordon P, Barnathan ES, Brass LF. Endothelial cell thrombin receptors and PAR-2: two protease-activated receptors located in a single cellular environment. J Biol Chem. 1997;272:11133-11141.
15. Rosenblum WI, Nelson GH, Povlishock JT. Laser-induced endothelial damage inhibits endothelium-dependent relaxation in the cerebral circulation of the mouse. Circ Res. 1987;60:169-176.
16. Faraci FM. Role of nitric oxide in regulation of basilar artery tone in vivo. Am J Physiol. 1990;259:H1216-H1221.
17. Faraci FM, Heistad DD. Role of ATP-sensitive potassium channels in the basilar artery. Am J Physiol. 1993;264:H8-H13.
18. Sobey CG, Faraci FM. Effect of nitric oxide and potassium channel agonists and inhibitors on basilar artery diameter. Am J Physiol. 1997; 272:H256-H262.
19. Sobey CG, Faraci FM. Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles. Stroke. 1997;28: 837-843.
20. Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol. 1995;48: 184-188.
21. Nystedt S, Ramaknshnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells: comparison with the thrombin receptor. J Biol Chem. 1996;271: 14910-14915.