Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): A novel role for PAR-4 as opposed to PAR-1

British Journal of Pharmacology

Volumn 131, Issue 3, 2000, Pages 578-584

  Kawabata, Atsufumi ^a   Kuroda, Ryotaro ^a   Kuroki, Naoko ^a   Nishikawa, Hiroyuki ^b   Kawai, Kenzo ^b  

^a KINKI UNIVERSITY   (Japan)

^b Fuso Pharmaceutical Industries Ltd   (Japan)

Author keywords

Motility modulation; Oesophageal muscularis mucosae; Protease (proteinase) activated receptor (PAR); Thrombin

Indexed keywords

8 BROMO CYCLIC AMP; APAMIN; CALCIUM CHANNEL; CARBACHOL; CHARYBDOTOXIN; CYCLIC AMP; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; PROPRANOLOL; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; TETRODOTOXIN; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESOPHAGUS MOTILITY; ESOPHAGUS MUSCLE; EXTRACELLULAR CALCIUM; ION PERMEABILITY; MALE; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

EID: 0033771536     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703590     Document Type: Article

References (35)

1. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
2. Thrombin functions as an inflammatory mediator through activation of its receptor
3. A protective role for protease-activated receptors in the airways
4. Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle
5. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
6. Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2
7. Protease-activated receptors and platelet function
8. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
9. Structure function analysis of protease activated receptor 4 tethered ligand peptides: Determinants of specificity and utility in assays of receptor function
10. Protease-activated receptors: PAR4 and counting: How long is the course
11. Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: Evidence for receptor subtypes
12. Proteinase-activated receptor-2 in rat aorta: Structural requirements for agonist activity of receptor-activating peptides
13. 2
14. Proteinase-activated receptors: Structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides
15. Protease-activated receptor 3 is a second thrombin receptor in humans
16. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
17. A dual thrombin receptor system for platelet activation
18. Protease-activated receptor (PAR), a novel family of G protein-coupled seven transmembrane domain receptors: Activation mechanisms and physiological roles
19. Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw
20. Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: A protective role of endogenous and exogenous nitric oxide
21. Modulation by protease-activated receptors of the rat duodenal motility in vitro: Possible mechanisms underlying the evoked contraction and relaxation
22. Proteinase-activated receptor-2 (PAR-2): Regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice
23. 1 targeted ligands
24. Modulation of airway smooth muscle tone by protease activated receptor-1,-2,-3 and -4 in trachea isolated from influenza A virus-infected mice
25. Vascular actions of thrombin receptor-derived polypeptides: Structure-activity profiles for contractile and relaxant effects in rat aorta
26. Interactions of mast cell tryptase with thrombin receptors and PAR-2
27. Trypsin activates pancreatic duct epithelial cell ion channels
28. Guinea pig platelets do not respond to GYPGKF, a protease-activated receptor-4-activating peptide: A property distinct from human platelets
29. Molecular cloning of a potential proteinase activated receptor
30. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
31. Pro- and anti-inflammatory actions of thrombin: A distinct role for proteinase-activated receptor-1 (PAR1 )
32. 2 that regulates intestinal transport
33. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanisms of receptor activation
34. Cloning and characterization of human protease-activated receptor 4
35. Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: Blockade by inhibitors of mitogen-activated protein kinase and phosphatidyl inositol-3'-kinase