Involvement of proline-rich tyrosine kinase 2 in platelet activation: Tyrosine phosphorylation mostly dependent on αIIbβ3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2

Biochemical Journal

Volumn 347, Issue 2, 2000, Pages 561-569

  Ohmori, Tsukasa ^a   Yatomi, Yutaka ^a   Asazuma, Naoki ^a   Satoh, Kaneo ^a   Ozaki, Yukio ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Adhesion; Focal adhesion kinase; Thrombin

Indexed keywords

ADAPTOR PROTEIN; BOTROCETIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FIBRINOGEN; FOCAL ADHESION KINASE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN IB; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYBRID PROTEIN; INTEGRIN; PHORBOL ESTER; PHOSPHOTYROSINE; PROLINE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN SHC; PROTEIN TYROSINE KINASE; THROMBIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; BLOOD PLATELETS; CALCIUM; CYTOSKELETON; EDETIC ACID; FIBRINOGEN; FOCAL ADHESION KINASE 1; FOCAL ADHESION KINASE 2; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GRB2 ADAPTOR PROTEIN; HUMANS; OLIGOPEPTIDES; PHOSPHORYLATION; PHOSPHOTYROSINE; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN TRANSPORT; PROTEIN-TYROSINE KINASES; PROTEINS; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; TETRADECANOYLPHORBOL ACETATE; THROMBIN;

EID: 0034656081     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470561     Document Type: Article

References (52)

1. 1 Hanks, S. K. and Polte, T. R. (1997) Signaling through focal adhesion kinase. Bioessays 19, 137-145
2. 2 Schlaepfer, D. D. and Hunter, T. (1998) Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol. 8, 151-157
3. FAK, a structurally distinctive protein-tyrosine kinase asociated with focal adhesions. Proc. Natl. Acad. Sci. U.S.A. 89, 5192-5196
4. 4 Hanks, S. K., Calalb, M. B., Harper, M. C. and Patel, S. K. (1992) Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. U.S.A. 89, 8487-8491
5. 5 Schlaepfer, D. D., Hanks, S. K., Hunter, T. and van der Geer, P. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (London) 372, 786-791
6. 6 Chen, H. C. and Guan, J. L. (1994) Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U.S A. 91, 10148-10152
7. 7 Calalb, M. B., Polte, T. R. and Hanks, S. K. (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity . a role for Src family kinases. Mol. Cell. Biol. 15, 954-963
8. FAK. Mol. Cell. Biol. 14, 147-155
9. Cas. Proc. Natl. Acad. Sci. U.S.A 92, 10678-10682
10. Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J. Biol. Chem 271, 13649-13655
11. HEF1. J. Biol Chem. 272, 19719-19724
12. 12 Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S. (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (London) 377, 539-544
13. 2+-induced regulation of ion channel and MAP kinase functions. Nature (London) 376, 737-745
14. 14 Avraham, S., London, R., Fu, Y., Ota, S., Hiregowdara, D., Li, J., Jiang, S., Pasztor, L. M., White, R. A., Groopman, J. E and Avraham, H. (1995) Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J. Biol. Chem. 270, 27742-27751
15. 15 Sasaki, H., Nagura, K., Ishino, M., Tobioka, H., Kotani, K. and Sasaki, T. (1995) Cloning and characterization of cell adhesion kinase β, a novel prctein-tyrosine kinase of the focal adhesion kinase subfamily. J. Biol. Chem 270, 21206-21219
16. 16 Yu, H., Li, X., Marchetto, G. S., Dy, R., Hunter, D., Calvo, B., Dawson, T. L., Wilm, M., Anderegg, R. J., Graves, L. M. and Earp, H. S. (1996) Activation of a novel calcium-dependent protein-tyrasine kinase. J. Biol. Chem. 271, 29993-29998
17. 17 Qian, D., Lev, S., van Oers, N. S. C., Dikic, I., Schlessinger, J. and Weiss, A. (1997) Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J. Exp. Med. 185, 1253-1259
18. 18 Berg, N N. and Ostergaard, H L. (1997) T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck. J. Immunol. 159, 1753-1757
19. 19 Li, J , Avraham, H., Rogers, R. A., Raja, S. and Avraham, S. (1996) Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes. Blood 88, 417-428
20. 20 Ganju, R. K., Hatch, W. C., Avraham, H., Ona, M. A., Druker, B., Avraham, S. and Groopman, J. E. (1997) RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes. J. Exp. Med. 185, 1055-1063
21. cas. J. Biol. Chem. 272, 228-232
22. 22 Schaller, M. D. and Sasaki, T. (1997) Differential signaling by the focal adhesion kinase and cell adhesion kinase β. J. Biol. Chem. 272, 25319-25325
23. FAK by glutamate and depolarization in rat hippocampus. J. Biol. Chem. 271, 28912-28946
24. 24 Zheng, C., Xing, Z., Bian, Z. C., Guo, C., Akbay, A., Warner, L. and Guan, J. L. (1998) Differential regulation of Pyk2 and focal adhesion kinase (FAK). J. Biol. Chem. 273, 2384-2389
25. 25 Xiong, W. C. and Parsons, J. T. (1997) Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. J. Cell Biol. 139, 529-539
26. 26 Jackson, S. P., Schoenwaelder, S. M., Yuan, Y., Salem. H. H. and Cooray, P. (1996) Non-receptor protein tyrosine kinases and phosphatases in human platelets. Thromb. Haemost. 76, 640-650
27. FAK in platelets. J. Cell Biol. 119, 905-912
28. FAK in platelets requires coordinated signaling through integrin and agonist receptors. J. Biol. Chem. 269, 14738-14745
29. FAK) cleavage and regulation by calpain. Biochem. J. 318, 41-47
30. 30 Phillips, D. R., Charo, I. F., Parise, L. V. and Fitzgerald, L. A. (1988) The platelet membrane glycoprotein IIb-IIIa complex. Blood 71, 831-843
31. 31 Shattil, S. J., Kashiwagi, H. and Pampori, N. (1998) Integrin signaling: the platelet paradigm. Blood 91, 2645-2657
32. 32 Raja, S., Avraham, S. and Avraham, H. (1997) Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism. J. Biol. Chem. 272, 10941-10947
33. 33 Asazuma, N., Ozaki, Y., Satoh, K., Yatomi, Y., Handa, M., Fujimura, Y., Miura, S. and Kume, S. (1997) Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets. Blood 90, 4789-4798
34. 34 Hato, T., Oda, A., Ozaki, Y., Minamoto, Y., Nakatani, S., Watanabe, A., Kume, S., Ikeda, Y. and Fujita, S. (1997) Outside-in signaling from integrin αIIb/β3 into platelets in the absence of agonist-induced signaling. Int. J. Hematol. 65, 385-395
35. 35 Davis, P. D., Hill, C. H., Keech, E., Lawton, G., Nixon, J. S., Sedgwick, A. D., Wadsworth, J., Westmacott, D. and Wilkinson, S. E. (1989) Potent selective inhibitors of protein kinase C. FEBS Lett. 259, 61-63
36. syk in human platelets. J. Biol. Chem. 270, 15119-15124
37. 37 Holt, J. C. and Niewiarawski, S. (1985) Biochemistry of a granule proteins. Semin. Hematol. 22, 151-63
38. 38 Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J. Biol. Chem. 258, 6701-6704
39. 39 Fox, J. E. B., Lipfert, L., Clark, E. A., Reynolds, C. C., Austin, C. D. and Brugge, J S. (1993) On the role of the platelet membrane skeleton in mediating signal transduction. J. Biol. Chem. 268, 25973-25984
40. 40 Matuoka, K., Shibata, M., Yamakawa, A. and Takenawa, T. (1992) Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. Proc. Natl. Acad. Sci. U.S.A. 89, 9015-9019
41. 41 Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Pawson, T. and Pelicci, P. G. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70, 93-104
42. 2+ mobilization in human platelet. Eur. J. Biochem. 205, 1003-1009
43. 43 Yatomi, Y., Ozaki, Y., Satoh, K. and Kume, S. (1994) Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85α subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets. Biochim. Biophys Acta 1212, 337-344
44. 44 Ohmori, T., Yatomi, Y., Asazuma, N., Satoh, K. and Ozaki, Y. (1999) Suppression of protein kinase C is associated with inhibition of PYK2 tyrosine phosphorylation and enhancement of PYK2 interaction with Src in thrombin-activated platelets. Thromb. Res. 93, 291-298
45. 45 Tamaoki, T. (1991) Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors. Methods Enzymol. 201, 340-347
46. 3. Curr. Opin. Cell Biol. 9, 725-731
47. 47 Shattil, S. J. and Brass, L. F. (1987) Induction of the fibrinogen receptor on human platelets by intracellular mediators. J. Biol. Chem. 262, 992-1000
48. 48 Nishizuka, Y. (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (London) 334, 661-665
49. 49 Clemetson, K. J. (1995) Platelet activation: signal transduction via membrane receptors. Thromb. Haemost., 74, 111-116
50. 50 Hiregowdara, D., Avraham, H., Fu, Y., London, R. and Avraham, S. (1997) Tyrosine phosphorylation of related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin. J. Biol. Chem. 272, 10804-10810
51. 51 Fox, J. E. B. (1993) The platelet cytoskeleton. Thromb. Haemost 70, 884-893
52. 52 Seger, R. and Krebs, E. G. (1995) The MAPK signaling cascade. FASEB J. 9, 726-735