Plasmin desensitization of the PAR1 thrombin receptor: Kinetics, sites of truncation, and implications for thrombolytic therapy

Biochemistry

Volumn 38, Issue 14, 1999, Pages 4572-4585

  Kuliopulos, Athan ^a   Covic, Lidija ^a   Seeley, Stacy K ^a   Sheridan, Paul J ^a   Helin, Jari ^b   Costello, Catherine E ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PLASMIN; PROTEINASE; THROMBIN; THROMBIN RECEPTOR; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BINDING SITE; FIBRINOLYTIC THERAPY; HUMAN; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY; RECEPTOR UPREGULATION; THROMBOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; BLOOD PLATELETS; CALCIUM SIGNALING; COS CELLS; FIBROBLASTS; GLYCOSYLATION; HUMANS; HYDROLYSIS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PEPTIDE FRAGMENTS; PLASMIN; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RABBITS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SOLUBILITY; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

FELIS CATUS; RICKETTSIA SP. PAR;

EID: 0033528761     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9824792     Document Type: Article

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