G-protein-coupled receptors function as oligomers in vivo

Current Biology

Volumn 10, Issue 6, 2000, Pages 341-344

  Overton, Mark C ^a   Blumer, Kendall J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SACCHAROMYCES CEREVISIAE;

EID: 0034704906     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00386-9     Document Type: Article

References (20)

1. Iiri T, Farfel Z, Bourne HR: G-protein diseases furnish a model for the turn-on switch. Nature 1998, 394:35-38.
2. Blumer KJ, Reneke JE, Thorner J: The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae. J Biol Chem 1988, 263:10836-10842.
3. Hebert TE, Moffett S, Morello JP, Loisel TP, Bichet DG, Barret C, Bouvier M: A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J Biol Chem 1996, 271:16384-16392.
4. Ng GY, O'Dowd BF, Lee SP, Chung HT, Brann MR, Seeman P, George SR: Dopamine D2 receptor dimers and receptor-blocking peptides. Biochem Biophys Res Commun 1996, 227:200-204.
5. Romano C, Yang WL, O'Malley KL: Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 1996, 271:28612-28616.
6. Cvejic S, Devi LA: Dimerization of the delta opioid receptor: implication for a role in receptor internalization. J Biol Chem 1997, 272:26959-26964.
7. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, et al.: Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 1998, 396:679-682.
8. Jones KA, Borowsky B, Tamm JA, Craig DA, Durkin MM, Dai M, et al.: GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 1998, 396:674-679.
9. Jordan BA, Devi LA: G-protein-coupled receptor heterodimerization modulates receptor function. Nature 1999, 399:697-700.
10. Hebert TE, Bouvier M: Structural and functional aspects of G protein-coupled receptor oligomerization. Biochem Cell Biol 1998, 76:1-11.
11. Wade SM, Dalman HM, Yang SZ, Neubig RR: Multisite interactions of receptors and G proteins: enhanced potency of dimeric receptor peptides in modifying G protein function. Mol Pharmacol 1994, 45:1191-1197.
12. Stefan CJ, Blumer KJ: A syntaxin homolog encoded by VAM3 mediates down-regulation of a yeast G protein-coupled receptor. J Biol Chem 1999, 274:1835-1841.
13. Weiner JL, Guttierez SC, Blumer KJ: Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway. J Biol Chem 1993, 268:8070-8077.
14. Bohm A, Gaudet R, Sigler PB: Structural aspects of heterotrimeric G-protein signaling. Curr Opin Biotechnol 1997, 8:480-487.
15. Unger VM, Hargrave PA, Baldwin JM, Schertler GF: Arrangement of rhodopsin transmembrane alpha-helices. Nature 1997, 389:203-206.
16. Schertler G, Hargrave PA: Projection structure of frog rhodopsin in two crystal forms. Proc Natl Acad Sci USA 1995, 92:11578-11582.
17. Onrust R, Herzmark P, Chi P, Garcia PD, Lichtarge O, Kingsley C, Boume HR: Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin. Science 1997, 275:381-384.
18. Grishin AG, Weiner JL, Blumer KJ: Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein γ subunit. Mol Cell Biol 1994, 14:4571-4578.
19. Kisselev OG, Ermolaeva MV, Gautam N: A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. J Biol Chem 1994, 269:21399-21402.
20. Nordstrom AL, Farde L, Eriksson L, Halldin C: No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone. Psychiatry Res 1995, 61:67-83.