Structure-function analysis of protease-activated receptor 4 thetered Ligand peptides. Determinants of specificity and utility in assays of receptor function

Journal of Biological Chemistry

Volumn 275, Issue 26, 2000, Pages 19728-19734

  Faruqi, Tatjana R ^a,b   Weiss, Ethan J ^a,b,c   Shapiro, Michael J ^a,b   Huang, Wei ^a,b   Coughlin, Shaun R ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Daiichi Research Center   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 4; RECEPTOR PROTEIN; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL CULTURE; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADENYLATE CYCLASE TOXIN; ANIMALS; CALCIUM; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; HEMOSTATICS; HUMANS; HYDROLYSIS; LIGANDS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDES; PHOSPHATIDYLINOSITOLS; PLASMA; PLATELET AGGREGATION; RATS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TIME FACTORS; TRANSFECTION; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA; RICKETTSIA SP. PAR;

EID: 0034733558     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M909960199     Document Type: Article

References (33)

1. Vu, T.-K. H., Hung, D. T., Wheaton, V. I., and Coughlin, S. R. (1991) Cell 64, 1057-1068
2. Rasmussen, U. B., Vouret-Craviari, V., Jallat, S., Schlesinger, Y., Pagers, G., Pavirani, A., Lecocq, J. P., Pouyssegur, J., and Van Obberghen-Schilling, E. (1991) FEBS Lett. 288, 123-128
3. Ishihara, H., Connolly, A. J., Zeng, D., Kahn, M. L., Zheng, Y. W., Timmons, C., Tram, T., and Coughlin, S. R. (1997) Nature 388, 502-506
4. Kahn, M. L., Zheng, Y. W., Huang, W., Bigornia, V., Zeng, D., Moff, S., Farese, R. V., Jr., Tam, C., and Coughlin, S. R. (1998) Nature 394, 690-694
5. Xu, W. F., Andersen, H., Whitmore, T. E., Presnell, S. R., Yee, D. P., Ching, A., Gilbert, T., Davie, E. W., and Foster, D. C. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6642-6646
6. Nystedt, S., Emilsson, K., Wahlestedt, C., and Sundelin, J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9208-9212
7. Kahn, M. L., Nakanishi-Matsui, M., Shapiro, M. J., Ishihara, H., and Coughlin, S. R. (1999) J. Clin. Invest. 103, 879-887
8. Connolly, A. J., Ishihara, H., Kahn, M. L., Farese, R. V., and Coughlin, S. R. (1996) Nature 381, 516-519
9. Trejo, J., Connolly, A. J., and Coughlin, S. R. (1996) J. Biol. Chem. 271, 21536-21541
10. Ishii, K., Hein, L., Kobilka, B., and Coughlin, S. R. (1993) J. Biol. Chem. 268, 9780-9786
11. Hung, D. T., Vu, T.-K. H., Nelken, N. A., and Coughlin, S. R. (1992) J. Cell Biol. 116, 827-832
12. Ishihara, H., Zeng, D., Connolly, A. J., Tam, C., and Coughlin, S. R. (1998) Blood 91, 4152-4157
13. Sage, S. O. (1996) in Platelets, A Practical Approach (Watson, S. P., and Authi, K. S., eds) pp. 67-90, IRL Press, Oxford, United Kingdom
14. Hung, D. T., Wong, Y. H., Vu, T.-K. H., and Coughlin, S. R. (1992) J. Biol. Chem. 267, 20831-20834
15. Coughlin, S. R., and Scarborough, R. M. (1995) U. S. Patent 5,759,994
16. Seiler, S. M., Peluso, M., Michel, I. M., Goldenberg, H., Fenton, J. n., Riexinger, D., and Natarajan, S. (1995) Biochem. Pharmacol. 49, 519-528
17. Scarborough, R. M., Naughton, M. A., Teng, W., Hung, D. T., Rose, J., Vu, T. K., Wheaton, V. I., Turck, C. W., and Coughlin, S. R. (1992) J. Biol. Chem. 267, 13146-13149
18. Coller, B. S., Ward, P., Ceruso, M., Scudder, L. E., Springer, K., Kutok, J., and Prestwich, G. D. (1992) Biochemistry 31, 11713-11720
19. Coughlin, S. R. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11023-11027
20. Vassallo, R. R., Jr., Kieber-Emmons, T., Cichowski, K., and Brass, L. F. (1992) J. Biol. Chem. 267, 6081-6085
21. Seiler, S. M., Peluso, M., Tuttle, J. G., Pryor, K., Klimas, C., Matsueda, G. R., and Bernatowicz, M. S. (1996) Mol. Pharmacol. 49, 190-197
22. Williams, J. A., McChesney, D. J., Calayag, M. C., Lingappa, V. R., and Logsdon, C. D. (1988) Proc. Natl. Acad. Sci. U. S. A. 86, 4939-4943
23. Offermanns, S., Laugwitz, K.-L., Spicher, K, and Schultz, G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 504-508
24. Aragay, A. M., Collins, L. R., Post, G. R., Watson, A. J., Feramisco, J. R., Brown, J. H., and Simon, M. I. (1995) J. Biol. Chem. 270, 20073-20077
25. Barr, A. J., Brass, L. F., and Manning, D. R. (1997) J. Biol. Chem. 272, 2223-2229
26. Blank, J. L., Shaw, K., Ross, A. H., and Exton, J. H. (1993) J. Biol. Chem. 268, 25184-25191
27. Bernatowicz, M. S., Klimas, C. E., Hartl, K. S., Peluso, M., Allegretto, N. J., and Seiler, S. M. (1996) J. Med. Chem. 39, 4879-4887
28. Nakanishi-Matsui, M., Zheng, Y.-W., Sulciner, D., Weiss, E. J., Ludeman, M. J., and Coughlin, S. R. (2000) Nature 404, 609-613
29. Klages, B., Brandt, U., Simon, M. I., Schultz, G., and Offermanns, S. (1999) J. Cell Biol. 144, 745-754
30. Brass, L. F., and Molino, M. (1997) Thromb. Haemostasis 78, 234-241
31. Offermanns, S., Toombs, C. F., Hu, Y. H., and Simon, M. I. (1997) Nature 389, 183-186
32. Law, D. A., Nannizzi-Alaimo, L., Ministri, K., Hughes, P. E., Forsyth, J., Turner, M., Shattil, S. J., Ginsberg, M. H., Tybulewicz, V. L., and Phillips, D. R. (1999) Blood 93, 2645-2652
33. Hodivala-Dilke, K. M., McHugh, K. P., Tsakiris, D. A., Rayburn, H., Crowley, D., Ullman-Culleré, M., Ross, F. P., Coller, B. S., Teitelbaum, S., and Hynes, R. O. (1999) J. Clin. Invest. 103, 229-238