Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits

Circulation

Volumn 93, Issue 6, 1996, Pages 1194-1200

  Ragosta, Michael ^a   Barry, William L ^a   Gimple, Lawrence W ^a   Gertz, S David ^b   McCoy, Kyle W ^a   Stouffer, George A ^a   McNamara, Coleen A ^a   Powers, Eric R ^a   Owens, Gary K ^a   Sarembock, Ian J ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

angioplasty; anticoagulants; atherosclerosis; hirudin

Indexed keywords

BROXURIDINE; CHOLESTEROL; DESULFATOHIRUDIN; HEPARIN; THROMBIN; THROMBIN INHIBITOR; THYMIDINE; TRITIUM;

ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTERIOGRAPHY; ARTICLE; ATHEROSCLEROSIS; AUTORADIOGRAPHY; CELL KINETICS; CELL LABELING; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; INTIMA; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RABBIT; RESTENOSIS; TUNICA MEDIA;

EID: 9044230920     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.93.6.1194     Document Type: Article

References (36)

1. Johnson DE, Hinohara T, Selmon MR, Braden LJ, Simpson JB. Primary peripheral arterial stenoses and restenoses excised by transluminal atherectomy: a histopathological study. J Am Coll Cardiol. 1990;15:419-425.
2. Austin GE, Ratliff NB, Hollman J, Tabei S, Phillips DF. Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty. J Am Coll Cardiol. 1985;6:369-375.
3. McBride W, Lange RA, Hillis LD. Restenosis after successful coronary angioplasty, pathophysiology and prevention. N Engl J Med. 1988;318:1734-1737.
4. Liu MW, Roubin GS, King SB. Restenosis after coronary angioplasty: potential biological determinants and role of intimal hyperplasia. Circulation. 1989;79:1374-1387.
5. Schwartz RS, Holmes DR, Topol EJ. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol. 1992;20:1284-1293.
6. Ip JH, Fuster V, Israel D, Badimon L, Badimon J, Chesebro JH. The role of platelets, thrombin and hyperplasia in restenosis after coronary angioplasty. J Am Coll Cardiol. 1991;17:77B-88B.
7. Ip JH, Fuster V, Badimon L, Badimon J, Taubman MB, Chesebro JH. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol. 1990;15:1667-1687.
8. Wilcox JN. Thrombin and other potential mechanisms underlying restenosis. Circulation. 1991;84:432-435.
9. Gasic GP, Arenas CP, Gasic TB, Gasic GJ. Coagulation factors X, Xa and protein S as potent mitogens of cultured aortic smooth muscle cells. Proc Natl Acad Sci U S A. 1992;89:2317-2320.
10. Chen LB, Buchanan JM. Mitogenic activity of blood components, I: thrombin and prothrombin. Proc Natl Acad Sci U S A. 1975;72: 131-135.
11. Bar-Shavit R, Benezra M, Eldor A, Hyram E, Fenton JW, Wilner GD, Vlodavsky I. Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action. Cell Regul. 1990;1:453-463.
12. Graham DJ, Alexander JJ. The effects of thrombin on bovine aortic endothelial and smooth muscle cells. J Vasc Surg. 1990;11:307-313.
13. McNamara CA, Sarembock IJ, Gimple LW, Fenton JW, Coughlin SR, Owens GK. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest. 1993;91:94-98.
14. Stouffer GA, Sarembock IJ, McNamara CA, Gimple LW, Owens GK. Thrombin-induced mitogenesis of vascular smooth muscle cells is partially mediated by autocrine production of platelet-derived growth factor-AA. Am J Physiol. 1993;265:C806-C811.
15. Sarembock IJ, Gertz SD, Gimple LW, Owen RM, Powers ER, Roberts WC. Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation. 1991;84:232-243.
16. Clowes AW, Clowes MM. Kinetics of cellular proliferation after arterial injury, II: inhibition of smooth muscle growth by heparin. Lab Invest. 1985;52:611-616.
17. Hanke H, Strohschneider T, Oberhoff M, Betz E, Karsch KR. Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ Res. 1990;67: 651-659.
18. Gimple LW, Gertz SD, Haber HL, Ragosta M, Powers ER, Roberts WC, Sarembock IJ. Effect of chronic subcutaneous or intramural administration of heparin on femoral artery restenosis following balloon angioplasty in hypercholesterolemic rabbits: a quantitative angiographic and histopathological study. Circulation. 1992;86:1536-1546.
19. Ragosta M, Gimple LW, Gertz SD, Dunwiddie CT, Vlasuk GP, Haber HL, Powers ER, Roberts WC, Sarembock IJ. Specific factor Xa inhibition reduces restenosis following balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation. 1994;89: 1262-1271.
20. Owen RM, Dewey JD, Bove AA. Evaluation of dimensions and steady-state hydraulic properties of coronary arteries. Proceedings of the Twentieth Annual Rocky Mountain Bioengineering Symposium, Rochester, Minn, April 18-19, 1983, 1983:43-46.
21. Mann KG, Tracy PB, Nesheim ME. Assembly and function of prothrombinase complex on synthetic and natural membranes. In: Oates JA, Harwiger J, Ross R, eds. Interaction of Platelets With the Vessel Wall. Washington, DC: American Physiological Society; 1985:47-57.
22. Eidt JF, Allison P, Noble S, Ashton J, Golino P, McNatt J, Buja LM, Willerson JT. Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury. J Clin Invest. 1989;84:18-27.
23. Heras M, Chesebro JH, Webster MWI, Mruk JS, Grill DE, Penny WJ, Bowie EJW, Badimon L, Fuster V. Hirudin, heparin, and placebo during deep arterial injury in the pig: the in vivo role of thrombin in platelet-mediated thrombosis. Circulation. 1990;82: 1476-1484.
24. Heras M, Chesebro JH, Penny WJ, Bailey KR, Badimon L, Fuster V. Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs: heparin versus recombinant hirudin, a specific thrombin inhibitor. Circulation. 1989;79:657-665.
25. Schaffer LW, Davidson JT, Vlasuk GP, Dunwiddie CT, Siegl RKS. Selective factor Xa inhibition by recombinant antistasin prevents vascular graft thrombosis in baboons. Arterioscler Thromb. 1992;12: 879-885.
26. Dunwiddie CT, Smith DE, Nutt EM, Vlasuk GP. Anticoagulant effects of the selective factor Xa inhibitors tick anticoagulant peptide and antistasin in the aPTT assay are determined by the relative rate of prothrombinase inhibition. Thromb Res. 1991;64: 787-794.
27. Bar-Shavit R, Kahn A, Wilner GD, Fenton JWI. Monocyte chemotaxis: stimulation by factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest. 1992;89:507-511.
28. Jawien A, Bowen-Pope DF, Lindner V, Schwartz SM, Clowes AW. Platelet-derived growth specific exosite region in thrombin. Science (Wash DC). 1983;220:728-731.
29. Reidy MA, Jackson J, Lindner V. Neointimal proliferation: control of vascular smooth muscle cell growth. Vasc Med Rev. 1992;3: 156-167.
30. Gordon D, Reidy MA, Benditt EP, Schwartz SM. Cell proliferation in human coronary arteries. Proc Natl Acad Sci U S A. 1990;87: 4600-4604.
31. Dartsch PC, Voisard R, Bauriedel G, Hofling B, Betz E. Growth characteristics and cytoskeletal organization of cultured smooth muscle cells from human primary stenosing and restenosing lesions. Arteriosclerosis. 1990;10:62-75.
32. Ross R, Wight TN, Strandness E, Theile B. Human atherosclerosis, I: cell constitution and characteristics of advanced lesions of the superficial femoral artery. Am J Pathol. 1984;114:79-93.
33. Pickering JG, Weir L, Jekanowski J, Kearney MA, Isner JM. Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization. J Clin Invest. 1993;91:1469-1480.
34. O'Brien ER, Alpers CE, Stewart DK, Ferguson M, Tran N, Gordon D, Benditt EP, Hinohara T, Simpson JB, Schwartz SM. Proliferation in primary and restenotic coronary atherectomy tissue: implications for antiproliferative therapy. Circ Res. 1993;73: 223-230.
35. Muller DW, Topol EJ, Abrams GD, Gallagher KP, Ellis SG. Intramural methotrexate therapy for the prevention of neointimal thickening after balloon angioplasty. J Am Coll Cardiol. 1992;20: 460-466.
36. Schwartz SM, Reidy M. Common mechanisms of proliferation of smooth muscle in atherosclerosis. Hum Pathol. 1987;18:240-248.