Endothelial protease-activated receptor-2 induces tissue factor expression and von Willebrand factor release

British Journal of Haematology

Volumn 105, Issue 2, 1999, Pages 542-550

  Langer, Florian ^a   Morys Wortmann, Corinna ^b   Küsters, Benno ^a   Storck, Josef ^a,c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c Department of Physiology ^*  (Germany)

Author keywords

Endothelium; PAR 2; SLIGKV; Tissue factor; Von Willebrand factor

Indexed keywords

CALCIUM; PEPTIDE; PROTEINASE; RECEPTOR; THROMBIN; THROMBIN RECEPTOR; THROMBOPLASTIN; TRYPSIN; TRYPTASE; VON WILLEBRAND FACTOR;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; FIBRIN CLOT; HEMOSTASIS; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; VASCULAR ENDOTHELIUM;

EID: 0032943041     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.1999.01356.x     Document Type: Article

References (51)

1. Al-Ani, B., Saifeddine, M. & Hollenberg, M.D. (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Canadian Journal of Physiology and Pharmacology, 73, 1203-1207.
2. Andrews, R.K., Lopez, J.A. & Berndt, M.C. (1947) Molecular mechanisms of platelet adhesion and activation. International Journal of Biochemistry and Cell Biology, 29, 91-105.
3. Bach, R.R. (1988) Initiation of coagulation by tissue factor. CRC Critical Reviews in Biochemistry, 23, 339-368.
4. Bartha, K., Brisson, C., Archipoff, G., de-la, S.C., Lanza, F., Cazenave. J.P. & Beretz, A. (1993) Thrombin regulates tissue factor and thrombomodulin mRNA levels and activities in human saphenous vein endothelial cells by distinct mechanisms. Journal of Biological Chemistry. 268, 421-429.
5. Bartha, K., Muller, P.R. & Van, R.L. (1989) Bradykinin and thrombin effects on polyphosphoinositide hydrolysis and prostacyclin production in endothelial cells. Biochemistry Journal, 263, 149-155.
6. Blackhart, B.D., Emilsson, K., Nguyen, D., Teng, W., Martelli, A.J., Nystedt, S., Sundelin, J. & Scarborough, R.M. (1996) Ligand cross-reactivity within the protease-activated receptor family. Journal of Biological Chemistry. 271, 16466-16471.
7. Bono, F., Lamarche, I. & Herbert, J.M. (1997) Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2). Biochemical and Biophysical Research Communications, 241, 762-764.
8. Brock, T.A. & Capasso, E.L. (1989) GTP gamma S increases thrombin-mediated inositol trisphosphate accumulation in permeabilized human endothelial cells. American Review of Respiratory Diseases, 140, 1121-1125.
9. Cheung, W.M., Andrade, G.P., Derian, C.K. & Damiano, B.P. (1998) Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemo-dynamic responses in vivo. Canadian Journal of Physiology and Pharmacology, 76, 16-25.
10. Dery, O., Corvera, C.U., Steinhoff, M. & Bunnett, N.W. (1998) Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. American Journal of Physiology. 274, C1429-C1452.
11. Emilsson, K., Wahlestedt, C., Sun, M.K., Nystedt, S., Owman, C. & Sundelin, J. (1997) Vascular effects of proteinase-activated receptor 2 agonist peptide. Journal of Vascular Research, 34, 267-272.
12. Endenburg, S.C., Hantgan, R.R., Lindeboom, B.L., Lankhof, H., Jerome, W.G., Lewis, J.C., Sixma, J.J. & de Gruchy, G.P. (1995) On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood. Blood, 86, 4158-4165.
13. Galdal, K.S., Lyberg, T., Evensen, S.A., Nilsen, E. & Prydz, H. (1985) Thrombin induces thromboplastin synthesis in cultured vascular endothelial cells. Thrombosis and Haemostasis, 54, 373-376.
14. Garcia, J.G., Fenton, J.W. & Natarajan, V. (1992) Thrombin stimulation of human endothelial cell phospholipase D activity: regulation by phospholipase C, protein kinase C, and cyclic adenosine 3′5′-monophosphate. Blood, 79, 2056-2067.
15. 2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium. Journal of Cell Physiology. 156, 541-549.
16. Garcia, J.G., Pavalko, F.M. & Patterson, C.E. (1995) Vascular endothelial cell activation and permeability responses to thrombin. Blood Coagulation and Fibrinolysis, 6, 609-626.
17. Gerszten, R.E., Chen, J., Ishii, M., Ishii, K., Wang, L., Nanevicz, T., Turek, C.W., Vu, T.K. & Coughlin, S.R. (1994) Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature, 368, 648-651.
18. Glusa, E., Saft, A., Prasa, D. & Sturzebecher, J. (1997) Trypsin-and SLIGRL-induced vascular relaxation and the inhibition by benzamidine derivatives. Thrombosis and Haemostasis, 78, 1399-1403.
19. 2+ indicators with greatly improved fluorescence properties. Journal of Biological Chemistry, 260, 3440-3450.
20. Hollenberg, M.D., Saifeddine, M. & al-Ani, B. (1996) Proteinase-activated receptor-2 in rat aorta: structural requirements for agonist activity of receptor-activating peptides. Molecular Pharmacology, 49, 229-233.
21. Hwa, J.J., Ghibaudi, L., Williams, P., Chintala, M., Zhang, R., Chatterjee, M. & Sybertz, E. (1996) Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells. Circulation Research, 78, 581-588.
22. Ikeda, Y., Murata, M. & Goto, S. (1997) Von Willebrand factor-dependent shear-induced platelet aggregation: basic mechanisms and clinical implications. Annals of the New York Academy of Science, 811.
23. Ishihara, H., Connolly, A.J., Zeng, D., Kahn, M.L., Zheng, Y.W., Timmons, C., Tram, T. & Coughlin, S.R. (1997) Protease-activated receptor 3 is a second thrombin receptor in humans. Nature, 386, 502-506.
24. Jaffe, E.A., Nachman, R.L., Becker, C.G. & Minick, C.R. (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. Journal of Clinical Investigation, 52, 2745-2756.
25. Levine, J.D., Harlan, J.M., Harker, L.A., Joseph, M.L. & Counts, R.B. (1982) Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture. Blood, 60, 531-534.
26. Magazine, H.I., King, J.M. & Srivastava, K.D. (1996) Protease activated receptors modulate aortic vascular tone. International Journal of Cardiology. 53, (Suppl.), 75-80.
27. Maier, J.A., Hla, T. & Maciag, T. (1990) Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. Journal of Biological Chemistry, 265, 10805-10808.
28. Mirza, H., Yatsula, V. & Bahou, W.F. (1996) The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. Journal of Clinical Investigation, 97, 1705-1714.
29. Molino, M., Barnathan, E.S., Numerof, R., Clark, J., Dreyer, M., Cumashi, A., Hoxie, J.A., Schechter, N., Woolkalis, M. & Brass, L.F. (1997a) Interactions of mast cell tryptase with thrombin receptors and PAR.-2. Journal of Biological Chemistry, 272, 4043-4049.
30. Molino, M., Woolkalis, M.J., Reavey, C.J., Pratico, D., Andrade, G.P., Barnathan, E.S. & Brass, L.F. (1997b) Endothelial cell thrombin receptors and PAR-2: two protease-activated receptors located in a single cellular environment. Journal of Biological Chemistry, 272, 11133-11141.
31. Muramatsu, I., Laniyonu, A., Moore, G.J. & Hollenberg, M.D. (1992) Vascular actions of thrombin receptor peptide. Canadian Journal of Physiology and Pharmacology, 70, 996-1003.
32. Nystedt, S., Emilsson, K., Larsson, A.K., Strombeck, B. & Sundelin, J. (1995a) Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. European Journal of Biochemistry, 232, 84-89.
33. Nystedt, S., Emilsson, K., Wahlestedt, C. & Sundelin, J. (1994) Molecular cloning of a potential proteinase activated receptor. Proceedings of the National Academy of Sciences of the United States of America, 91, 9208-9212.
34. Nystedt, S., Larsson, A.K., Aberg, H. & Sundelin, J. (1995b) The mouse proteinase-activated receptor-2 cDNA and gene: molecular cloning and functional expression. Journal of Biological Chemistry, 270, 5950-5955.
35. Nystedt, S., Ramakrishnan, V. & Sundelin, J. (1996) The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells: comparison with the thrombin receptor. Journal of Biological Chemistry, 271, 14910-14915.
36. + mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine. Biochemical Journal, 256, 371-376.
37. Potgens. A.J., Lubsen, N.H., van, A.G., Schoenmakers, J.G., Ruiter, D.J. & de Bruin, W.R. (1994) Measurement of tissue factor messenger RNA levels in human endothelial cells by a quantitative RT-PCR assay. Thrombosis and Haemostasis, 71, 208-213.
38. Roy, S.S., Saifeddine, M., Loutzenhiser, R., Triggle, C.R. & Hollenberg, M.D. (1998) Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity. British Journal of Pharmacology, 123, 1434-1440.
39. Saadi, S., Holzknecht, R.A., Patte, C.P., Stern, D.M. & Platt, J.L. (1995) Complement-mediated regulation of tissue factor activity in endothelium. Journal of Experimental Medicine, 182, 1807-1814.
40. Santulli, R.J., Derian, C.K., Darrow, A.L., Tomko, K.A., Eckardt, A.J., Seiberg, M., Scarborough, R.M. & Andrade, G.P. (1995) Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proceedings of the National Academy of Sciences of the United States of America. 92, 9151-9155.
41. Schini, V.B., Hendrickson, H., Heublein, D.M., Burnett, J. & Vanhoutte, P.M. (1989) Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells. European Journal of Pharmacology, 165, 333-334.
42. Schmidt, VA., Nierman, W.C., Maglott, D.R., Cupit, L.D., Moskowitz, K.A., Wainer, J.A. & Bahou, W.F. (1998) The human proteinase-activated receptor-3 (PAR-3) gene: identification within a Par gene cluster and characterization in vascular endothelial cells and platelets. Journal of Biological Chemistry, 273, 15061-15068.
43. Schmidt, V.A., Vitale, E. & Bahou, W.F. (1996) Genomic cloning and characterization of the human thrombin receptor gene: structural similarity to the proteinase activated receptor-2 gene. Journal of Biological Chemistry. 271, 9307-9312.
44. Silverberg, S.A., Nemerson, Y. & Zur, M. (1977) Kinetics of the activation of bovine coagulation factor X by components of the extrinsic pathway: kinetic behavior of two-chain factor VII in the presence and absence of tissue factor. Journal of Biological Chemistry, 252, 8481-8488.
45. Sixma, J.J., Sakariassen, K.S., Beeser. V.N., Ottenhof, R.M. & Bolhuis, P.A. (1984) Adhesion of platelets to human artery subendothelium: effect of factor VIII-von Willebrand factor of various multimeric composition. Blood, 63, 128-139.
46. Storck, J., Kusters, B. & Zimmermann, E.R. (1995) The tethered ligand receptor is the responsible receptor for the thrombin induced release of von Willebrand factor from endothelial cells (HUVEC). Thrombosis Research, 77, 249-258.
47. Sobey, C.G. & Cocks, T.M. (1998) Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo. Stroke, 29, 1439-1444.
48. Sugama, Y. & Malik, A.B. (1992) Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dopendent mechanism. Circulatory Research, 71, 1015-1019.
49. Tesfamariam, B., Allen, G.T., Normandin, D. & Antonaccio, M.J. (1993) Involvement of the 'tethered ligand' receptor in thrombin-induced endothelium-mediated relaxations. American Journal of Physiology, 265, H1744-H1749.
50. Tiruppathi, C., Lum, H., Andersen, T.T., Fenton, J.W. & Malik, A.B. (1992) Thrombin receptor 14-amino acid peptide binds to endothelial cells and stimulates calcium transients. American Journal of Physiology, 263, L595-L601.
51. Vu, T.K., Hung, D.T., Wheaton, V.I. & Coughlin, S.R. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell, 64, 1057-1068.