Medicinal plants - prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

BMC Veterinary Research

Volumn 12, Issue 1, 2016, Pages

  Ayrle, Hannah ^a,b   Mevissen, Meike ^b   Kaske, Martin ^c   Nathues, Heiko ^b   Gruetzner, Niels ^b   Melzig, Matthias ^d   Walkenhorst, Michael ^a  

^a RESEARCH INSTITUTE OF ORGANIC AGRICULTURE FIBL   (Switzerland)

^b VETSUISSE FACULTY UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Calves; Gastrointestinal diseases; Medicinal plants; Piglets; Respiratory diseases

Indexed keywords

ANTIINFLAMMATORY AGENT;

ANIMAL; BOVINE; CATTLE DISEASES; GASTROINTESTINAL DISEASES; HUMAN; IMMUNOMODULATION; LUNG DISEASES; MEDICINAL PLANT; PHYTOTHERAPY; PIG; SWINE DISEASES; VETERINARY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CATTLE; CATTLE DISEASES; GASTROINTESTINAL DISEASES; HUMANS; IMMUNOMODULATION; LUNG DISEASES; PHYTOTHERAPY; PLANTS, MEDICINAL; SWINE; SWINE DISEASES;

EID: 85007500733     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/S12917-016-0714-8     Document Type: Article

References (462)

1. Donovan GA, Dohoo IR, Montgomery DM, Bennett FL. Associations between passive immunity and morbidity and mortality in dairy heifers in Florida, USA. Prev Vet Med. 1998;34(1):31-46.
2. Meganck V, Hoflack G, Opsomer G. Advances in prevention and therapy of neonatal dairy calf diarrhoea: a systematical review with emphasis on colostrum management and fluid therapy. Acta Vet Scand. 2014;56:75.
3. Cusack PM, McMeniman N, Lean IJ. The medicine and epidemiology of bovine respiratory disease in feedlots. Aust Vet J. 2003;81(8):480-7.
4. Taylor JD, Fulton RW, Lehenbauer TW, Step DL, Confer AW. The epidemiology of bovine respiratory disease: what is the evidence for preventive measures? Can Vet J. 2010;51(12):1351-9.
5. Taylor JD, Fulton RW, Lehenbauer TW, Step DL, Confer AW. The epidemiology of bovine respiratory disease: What is the evidence for predisposing factors? Can Vet J. 2010;51(10):1095-102.
6. Fairbrother JM, Nadeau E, Gyles CL. Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Anim Health Res Rev. 2005;6(1):17-39.
7. Windeyer MC, Leslie KE, Godden SM, Hodgins DC, Lissemore KD, LeBlanc SJ. Factors associated with morbidity, mortality, and growth of dairy heifer calves up to 3 months of age. Prev Vet Med. 2014;113(2):231-40.
8. Lorenz I, Fagan J, More SJ. Calf health from birth to weaning. II. Management of diarrhoea in pre-weaned calves. Ir Vet J. 2011;64(1):9.
9. Lorenz I, Earley B, Gilmore J, Hogan I, Kennedy E, More SJ. Calf health from birth to weaning. III. housing and management of calf pneumonia. Ir Vet J. 2011;64(1):14.
10. Cho YI, Yoon KJ. An overview of calf diarrhea-infectious etiology, diagnosis, and intervention. J Vet Sci. 2014;15(1):1-17.
11. Bartels CJ, Holzhauer M, Jorritsma R, Swart WA, Lam TJ. Prevalence, prediction and risk factors of enteropathogens in normal and non-normal faeces of young Dutch dairy calves. Prev Vet Med. 2010;93(2-3):162-9.
12. Uhde FL, Kaufmann T, Sager H, Albini S, Zanoni R, Schelling E, Meylan M. Prevalence of four enteropathogens in the faeces of young diarrhoeic dairy calves in Switzerland. Vet Rec. 2008;163(12):362-6.
13. Luginbühl A, Reitt K, Metzler A, Kollbrunner M, Corboz L, Deplazes P. Field study of the prevalence and diagnosis of diarrhea-causing agents in the newborn calf in a Swiss veterinary practice area. Schweiz Arch Tierheilkd. 2005;147(6):245-52.
14. Kaske M, Leister T, Smolka K, Andresen U, Kunz H-J, Kehler W, Schuberth HJ, Koch A. Neonatal diarrhea in the calf-IV. communication: Neonatal diarrhea as a herd problem: colostrum management. Praktischer Tierarzt. 2009;90(8):756-67.
15. Thomson JR, Friendship RM. Digestive System. In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, editors. Disease of Swine. 10th ed. John Wiley & Sons; 2012.
16. Frydendahl K. Prevalence of serogroups and virulence genes in Escherichia coli associated with postweaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches. Vet Microbiol. 2002;85(2):169-82.
17. Fairbrother JM, Gyles CL: Colibacillosis. In: Diseases Of Swine. 10 edn. Edited by Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW. Ames, Chichester, Oxford: John Wiley & Sons; 2012.
18. Rossi L, Dell'Orto V, Vagni S, Sala V, Reggi S, Baldi A. Protective effect of oral administration of transgenic tobacco seeds against verocytotoxic Escherichia coli strain in piglets. Vet Res Commun. 2014;38(1):39-49.
19. Madec F, Bridoux N, Bounaix S, Jestin A. Measurement of digestive disorders in the piglet at weaning and related risk factors. Prev Vet Med. 1998;35(1):53-72.
20. Laine TM, Lyytikainen T, Yliaho M, Anttila M. Risk factors for post-weaning diarrhoea on piglet producing farms in Finland. Acta Vet Scand. 2008;50:21.
21. Rossi L, Vagni S, Polidori C, Alborali GL, Baldi A, Dell'Orto V. Experimental Induction of Escherichia coli Diarrhoea in Weaned Piglets. Open J Vet Med. 2012;2:1-8.
22. VanAlstine WG: Respiratory System. In: Diseases of Swine. 10 edn. Edited by Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW. Ames, Chichester, Oxford: John Wiley & Sons, Inc.; 2012.
23. Hilton WM. BRD in 2014: where have we been, where are we now, and where do we want to go? Anim Health Res Rev. 2014;15(2):120-2.
24. Bähler C, Steiner A, Luginbuhl A, Ewy A, Posthaus H, Strabel D, Kaufmann T, Regula G. Risk factors for death and unwanted early slaughter in Swiss veal calves kept at a specific animal welfare standard. Res Vet Sci. 2012;92(1):162-8.
25. Stöber M. Enzootische Bronchopneumonie. In: Dirksen G, Gründer H-D, Stöber M, editors. Innere Medizin und Chirurgie des Rindes. 4th ed. Berlin: Parey Buchverlag; 2002. p. 310-3.
26. Kaske M, Kunz H-J, Reinhold P. Die enzootische Bronchopneumonie des Kalbes-ein Update. Praktischer Tierarzt. 2012;93:232-45.
27. Hansen MS, Pors SE, Jensen HE, Bille-Hansen V, Bisgaard M, Flachs EM, Nielsen OL. An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. J Comp Pathol. 2010;143(2-3):120-31.
28. Harms PA, Halbur PG, Sorden SD. Three cases of porcine respiratory disease complex associated with porcine circovirus type 2 infection. J Swine Health Prod. 2002;10(1):27-30.
29. Choi YK, Goyal SM, Joo HS. Retrospective analysis of etiologic agents associated with respiratory diseases in pigs. Can Vet J. 2003;44(9):735-7.
30. Beer G, Doherr MG, Bähler C, Meylan M. Antibiotikaeinsatz in der Schweizer Kälbermast. Schweiz Arch Tierheilkd. 2015;157(1):55-7.
31. Pendl W, Jenny B, Sidler X, Spring P. Antibiotikaeinsatz beim Schwein: Erste Resultate aus dem Projekt FitPig. In: Kreuzer M, Lanzini T, Liesegang A, Bruckmaier R, Hess HD, editors. Gesunde und leistungsfähige Nutztiere: Futter an Genotyp oder Genotyp an Futter anpassen? vol. 38. Zürich: ETH-Schriftenreihe zur Tierernährung; 2015.
32. Eidgenössisches Departement des Innern, EDI, Bundesamt für Lebensmittelsicherheit und Veterinärwesen, BLV. ARCH Bericht über den Vertrieb von Antibiotika in der Veterinärmedizin und das Antibiotikaresistenzmonitoring bei Nutztieren in der Schweiz. 2013.
33. Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine. 2001;8(5):401-9.
34. Wagner H, Ulrich-Merzenich G. Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine. 2009;16(2-3):97-110.
35. Reichling J, Saller R. Herbal remedies in veterinary phytotherapy. Schweiz Arch Tierheilkd. 2001;143(8):395-403.
36. Disler M, Ivemeyer S, Hamburger M, Vogl CR, Tesic A, Klarer F, Meier B, Walkenhorst M. Ethnoveterinary herbal remedies used by farmers in four north-eastern Swiss cantons (St. Gallen, Thurgau, Appenzell Innerrhoden and Appenzell Ausserrhoden). J Ethnobiol Ethnomed. 2014;10:32.
37. Mayer M, Vogl CR, Amorena M, Hamburger M, Walkenhorst M. Treatment of organic livestock with medicinal plants: a systematic review of European ethnoveterinary research. Forschende Komplementärmedizin 2014;21(6): 375-86.
38. Schmid K, Ivemeyer S, Vogl C, Klarer F, Meier B, Hamburger M, Walkenhorst M. Traditional use of herbal remedies in livestock by farmers in 3 Swiss cantons (Aargau, Zurich, Schaffhausen). Forsch Komplementmed. 2012;19(3):125-36.
39. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration. PLoS Med. 2009;6(7):e1000100.
40. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. J Clin Epidemiol. 2009;62(10):1006-12.
41. Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, Porter AC, Tugwell P, Moher D, Bouter LM. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10.
42. Wynn SG, Fougère BJ. Veterinary herbal medicine. 1st ed. St. Louis: Mosby Elsevier; 2007.
43. Reichling J, Gachnian-Mirtscheva R, Frater-Schröder M, Saller R, Rabinovich MI, Widmaier W. Heilpflanzenkunde für die Veterinärpraxis. 2nd ed. Berlin Heidelberg: Springer Verlag; 2008.
44. Aichberger L, Graftschafter M, Fritsch F, Gansinger D, Hagmüller W, Hahn-Ramssl I, Hozzank A, Kolar V, Stöger E: Kräuter für Nutz-und Heimtiere, 2 edn. Wien: Eigenverlag Arbeitsgruppe Kräuter und Gewürze für Nutz-und Heimtiere; 2012.
45. Klarer F, Stöger E, Meier B. Jenzerwurz und Chäslichrut. Pflanzliche Hausmittel für Rinder, Schafe, Ziegen, Schweine und Pferde. 1st ed. Bern: Haupt; 2013.
46. Fintelmann V, Weiss RF. Lehrbuch der Phytotherapie. 10th ed. Stuttgart: Hippokrates Verlag; 2002.
47. Mayer M, Vogl CR, Amorena M, Hamburger M, Walkenhorst M. Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research. Forschende Komplementarmedizin 2014;21(6): 375-86.
48. Franz C, Bauer R, Carle R, Tedesco D, Tubaro A, Zitterl-Eglseer K. Assesment of plants/herbs, plant/herb extracts and their naturally or synthetically produced components as "additives" for use in animal production. CFT/EFSA/FEEDAP/2005/01 2005.
49. PubMed.gov [https://www.ncbi.nlm.nih.gov/pubmed] access date 2015-02-16 until 2015-02-19
50. Web of science TM [http://apps.webofknowledge.com] 2015-02-16 until 2015-02-19
51. Thomson Reuters TM: EndNote X7.
52. Burt SA, Reinders RD. Antibacterial activity of selected plant essential oils against Escherichia coli O157: H7. Lett Appl Microbiol. 2003;36(3):162-7.
53. Fleer H, Verspohl EJ. Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds. Phytomedicine. 2007;14(6):409-15.
54. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATCvet classification 2014. Oslo: 2013.
55. ESCOP. ESCOP Monographs. 2nd ed. Exeter, Stuttgart, New York: European Scientific Cooperative on Phytotherapy and Georg Thieme Verlag; 2003.
56. Biertuempfel A, Vetter A, Lutz J. Possibilities of influencing yield and quality of essential oils by choice of varieties and cultivation measures. Zeitschrift Fur Arznei-& Gewürzpflanzen. 2007;12(1):45-50.
57. Toselli F, Matthias A, Gillam EM. Echinacea metabolism and drug interactions: the case for standardization of a complementary medicine. Life Sci. 2009;85(3-4):97-106.
58. Tamta H, Pugh ND, Balachandran P, Moraes R, Sumiyanto J, Pasco DS. Variability in in vitro macrophage activation by commercially diverse bulk echinacea plant material is predominantly due to bacterial lipoproteins and lipopolysaccharides. J Agric Food Chem. 2008;56(22):10552-6.
59. European Pharmacopoe 8.0 [http://online6.edqm.eu/ep807/]
60. Ayrle H, Schmid K, Disler M, Bischoff T, Stucki K, ZbindenM, Vogl CR, Hamburger M, Walkenhorst M. Plant species reported from Swiss farmers to treat bovine respiratory disease. In: 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) August 23-27, 2015, vol. 81. Budapest: Planta Medica; 2015.
61. Olson EJ, Epperson WB, Zeman DH, Fayer R, Hildreth MB. Effects of an allicin-based product on cryptosporidiosis in neonatal calves. J Am Vet Med Assoc. 1998;212(7):987-90.
62. Ghosh S, Mehla RK, Sirohi SK, Roy B. The effect of dietary garlic supplementation on body weight gain, feed intake, feed conversion efficiency, faecal score, faecal coliform count and feeding cost in crossbred dairy calves. Tropl Anim Health Prod. 2010;42(5):961-8.
63. Ghosh S, Mehla RK, Sirohi SK, Tomar SK. Performance of crossbred calves with dietary supplementation of garlic extract. J Anim Physiol Anim Nutr. 2011;95(4):449-55.
64. Dudek K, Sliwa E, Tatara MR. Changes in blood leukocyte pattern in piglets from sows treated with garlic preparations. Bull Vet Inst Pulawy. 2006;50(2):263-7.
65. Yan L, Kim IH. Effects of dietary supplementation of fermented garlic powder on growth performance, apparent total tract digestibility, blood characteristics and faecal microbial concentration in weanling pigs. J Anim Physiol Anim Nutr. 2013;97(3):457-64.
66. Hanieh H, Narabara K, Piao M, Gerile C, Abe A, Kondo Y. Modulatory effects of two levels of dietary Alliums on immune response and certain immunological variables, following immunization, in White Leghorn chickens. Anim Sci J. 2010; 81(6):673-80.
67. Truchlinski J, Krauze M, Cendrowska-Pinkosz M, Modzelewska-Banachiewicz B. Influence of garlic, synthetic 1,2,4-triasole derivative and herbal preparation Echinovit C on selected indices of turkey-hens non-specific immunity. Pol J Vet Sci. 2006;9(1):51-5.
68. Ushimaru PI, Barbosa LN, Fernandes AA, Di Stasi LC, Fernandes Jr A. In vitro antibacterial activity of medicinal plant extracts against Escherichia coli strains from human clinical specimens and interactions with antimicrobial drugs. Nat Prod Res. 2012;26(16):1553-7.
69. Palaksha MN, Ahmed M, Das S. Antibacterial activity of garlic extract on streptomycin-resistant Staphylococcus aureus and Escherichia coli solely and in synergism with streptomycin. J Nat Sci Biol Med. 2010;1(1):12-5.
70. Meriga B, Mopuri R, MuraliKrishna T. Insecticidal, antimicrobial and antioxidant activities of bulb extracts of Allium sativum. Asian Pac J Trop Med. 2012;5(5):391-5.
71. Karuppiah P, Rajaram S. Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens. Asian Pac J Trop Biomed. 2012;2(8):597-601.
72. Gull I, Saeed M, Shaukat H, Aslam SM, Samra ZQ, Athar AM. Inhibitory effect of Allium sativum and Zingiber officinale extracts on clinically important drug resistant pathogenic bacteria. Ann Clin Microbiol Antimicrob 2012;11:8.
73. Eja ME, Asikong BE, Abriba C, Arikpo GE, Anwan EE, Enyi-Idoh KH. A comparative assessment of the antimicrobial effects of garlic (Allium sativum) and antibiotics on diarrheagenic organisms. Southeast Asian J Trop Med Public Health. 2007;38(2):343-8.
74. Belguith H, Kthiri F, Chati A, Abu Sofah A, Ben Hamida J, Ladoulsi A. Inhibitory effect of aqueous garlic extract (Allium sativum) on some isolated Salmonella serovars. Afr J Microbiol Res. 2010;4(5):328-38.
75. Abubakar E-MM. Efficacy of crude extracts of garlic (Allium sativum Linn.) against nosocomial Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniea and Pseudomonas aeruginosa. Journal of Medicinal Plants Research. 2009;3(4):179-85.
76. Kuo CH, Lee SH, Chen KM, Lii CK, Liu CT. Effect of garlic oil on neutrophil infiltration in the small intestine of endotoxin-injected rats and its association with levels of soluble and cellular adhesion molecules. J Agric Food Chem. 2011;59(14):7717-25.
77. Hofbauer R, Frass M, Gmeiner B, Kaye AD, Frost EA. Effects of garlic extract (Allium sativum) on neutrophil migration at the cellular level. Heart disease (Hagerstown, Md). 2001;3(1):14-7.
78. Liu C-T, Su H-M, Lii C-K, Sheen L-Y. Effect of Supplementation with Garlic Oil on Activity of Th1 and Th2 Lymphocytes from Rats. Planta Med. 2009;75(3):205-10.
79. Daneshmandi S, Hajimoradi M, Ahmadabad HN, Hassan ZM, Roudbary M, Ghazanfari T. Effect of 14-kDa and 47-kDa protein molecules of age garlic extract on peritoneal macrophages. Immunopharmacol Immunotoxicol. 2011;33(1):21-7.
80. Carter GT, Duong V, Ho S, Ngo KC, Greer CL, Weeks DL. Side effects of commonly prescribed analgesic medications. Phys Med Rehabil Clin N Am. 2014;25(2):457-70.
81. Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16(5):821-47.
82. Saller R, Pfister-Hotz G, Iten F, Melzer J, Reichling J. Iberogast (R): A modern phytotherapeutic combined herbal drug for the treatment of functional disorders of the gastrointestinal tract (dyspepsia, irritable bowel syndrome)-from phytomedicine to 'evidence based phytotherapy'. A systematic review. Forsch Komplementarmed Klass Naturheilkd. 2002;9:1-20.
83. Alqasoumi S, Khan TH, Al-Yahya M, Al-Mofleh I, Rafatullah S. Effect of Acute and Chronic Treatment of Common Spices in Swiss Albino Mice: A Safety Assessment Study. Int J Pharmacol. 2012;8(2):80-90.
84. Ungemach FR. Anhang 1, Umrechnung von Humandosierungen für Tiere. In: Löscher W, Ungemach FR, Kroker R, editors. Grundlagen der Pharmakotherapie bei Haus-und Nutztieren. 2nd ed. Berlin und Hamburg: Paul Parey; 1994. p. 400-1.
85. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytotherapy research: PTR. 2000;14(1): 20-3.
86. Asao T, Kuwano H, Ide M, Hirayama I, Nakamura JI, Fujita KI, Horiuti R. Spasmolytic effect of peppermint oil in barium during double-contrast barium enema compared with Buscopan. Clin Radiol. 2003;58(4):301-5.
87. Imagawa A, Hata H, Nakatsu M, Yoshida Y, Takeuchi K, Inokuchi T, Imada T, Kohno Y, Takahara M, Matsumoto K, et al. Peppermint oil solution is useful as an antispasmodic drug for esophagogastroduodenoscopy, especially for elderly patients. Dig Dis Sci. 2012;57(9):2379-84.
88. Amato A, Liotta R, Mule F. Effects of menthol on circular smooth muscle of human colon: analysis of the mechanism of action. Eur J Pharmacol. 2014;740:295-301.
89. de Sousa AA, Soares PM, de Almeida AN, Maia AR, de Souza EP, Assreuy AM. Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats. J Ethnopharmacol. 2010;130(2):433-6.
90. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytotherapy research: PTR. 2006;20(8):619-33.
91. Barnes J, Anderson LA, Gibbons S, Phillipson JD. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2005;57(8):929-54.
92. Bauer R. New knowledge regarding the effect and effectiveness of Echinacea purpurea extracts. Wien Med Wochenschr. 2002;152(15-16):407-11.
93. Maass N, Bauer J, Paulicks BR, Bohmer BM, Roth-Maier DA. Efficiency of Echinacea purpurea on performance and immune status in pigs. J Anim Physiol Anim Nutr. 2005;89(7-8):244-52.
94. Jawad M, Schoop R, Suter A, Klein P, Eccles R. Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Complement Altern Med: eCAM. 2012;2012:841315.
95. Goel V, Lovlin R, Barton R, Lyon MR, Bauer R, Lee TD, Basu TK. Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial. J Clin Pharm Ther. 2004;29(1):75-83.
96. Hermann JR, Honeyman MS, Zimmerman JJ, Thacker BJ, Holden PJ, Chang CC. Effect of dietary Echinacea purpurea on viremia and performance in porcine reproductive and respiratory syndrome virus-infected nursery pigs. J Anim Sci. 2003;81(9):2139-44.
97. Modaresi M. Effect of Echinacea purpura Hydro Alcoholic Extract on the Blood Parameters in Mice. Asian J Chem. 2013;25(3):1373-5.
98. O'Neill W, McKee S, Clarke AF. Immunological and haematinic consequences of feeding a standardised Echinacea (Echinacea angustifolia) extract to healthy horses. Equine Vet J. 2002;34(3):222-7.
99. Groom SN, Johns T, Oldfield PR. The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation. J Med Food. 2007;10(1):73-9.
100. Stevenson LM, Matthias A, Banbury L, Penman KG, Bone KM, Leach DL, Lehmann RP. Modulation of macrophage immune responses by Echinacea. Molecules (Basel, Switzerland). 2005;10(10):1279-85.
101. Wagner H, Jurcic K. Immunological studies of Revitonil, a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2002;9(5):390-7.
102. Cech NB, Tutor K, Doty BA, Spelman K, Sasagawa M, Raner GM, Wenner CA. Liver enzyme-mediated oxidation of Echinacea purpurea alkylamides: production of novel metabolites and changes in immunomodulatory activity. Planta Med. 2006;72(15):1372-7.
103. Vimalanathan S, Arnason JT, Hudson JB. Anti-inflammatory activities of Echinacea extracts do not correlate with traditional marker components. Pharm Biol. 2009;47(5):430-5.
104. Sharma M, Anderson SA, Schoop R, Hudson JB. Induction of multiple proinflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract. Antiviral Res. 2009;83(2):165-70.
105. Todd DA, Gulledge TV, Britton ER, Oberhofer M, Leyte-Lugo M, Moody AN, Shymanovich T, Grubbs LF, Juzumaite M, Graf TN, et al. Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria. PLoS One. 2015;10(5):e0124276.
106. ESCOP. ESCOP Monographs, Supplement 2009. 2nd ed. Exeter, Stuttgart, New York: European Scientific Cooperative on Phytotherapy and Georg Thieme Verlag; 2009.
107. Parnham MJ. Benefit-risk assessment of the squeezed sap of the purple coneflower (Echinacea purpurea) for long-term oral immunostimulation. Phytomedicine. 1996;3(1):95-102.
108. Gruenwald J, Graubaum HJ, Busch R. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. A double-blind, randomized, placebo-controlled clinical trial. Arzneimittelforschung. 2005;55(11):669-76.
109. Kemmerich B, Eberhardt R, Stammer H. Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough-A prospective, double-blind, placebo-controlled clinical trial. Arzneimittel-Forschung-Drug Research. 2006;56(9):652-60.
110. Kemmerich B. Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled multicentre clinical trial. Arzneimittelforschung. 2007;57(9):607-15.
111. Schmidt E, Wanner J, Hoeferl M, Jirovetz L, Buchbauer G, Gochev V, Girova T, Stoyanova A, Geissler M. Chemical Composition, Olfactory Analysis and Antibacterial Activity of Thymus vulgaris Chemotypes Geraniol, 4-Thujanol/Terpinen-4-ol, Thymol and Linalool Cultivated in Southern France. Nat Prod Commun. 2012;7(8):1095-8.
112. Wienkotter N, Kinzinger U, Schierstedt D, Begrow F, Verspohl EJ. Pharmacological effects of a thyme extract (Thymus vulgaris L.) on beta(2)-receptors and mucociliary clearance. Naunyn-Schmiedebergs Archives of Pharmacology. 2006;372:92.
113. Begrow F, Engelbertz J, Felstel B, Lehnfeld R, Bauer K, Verspohl EJ. Impact of Thymol in Thyme Extracts on Their Antispasmodic Action and Ciliary Clearance. Planta Med. 2010;76(4):311-8.
114. Boskabady MH, Aslani MR, Kiani S. Relaxant effect of Thymus vulgaris on guinea-pig tracheal chains and its possible mechanism(s). Phytother Res. 2006;20(1):28-33.
115. Keyhanmanesh R, Boskabady MH. Relaxant effects of different fractions from Tymus vulgaris on guinea-pig tracheal chains. Biol Res. 2012;45(1):67-73.
116. Engelbertz J, Lechtenberg M, Studt L, Hensel A, Verspohl EJ. Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. J Ethnopharmacol. 2012;141(3):848-53.
117. Vigo E, Cepeda A, Gualillo O, Perez-Fernandez R. In-vitro anti-inflammatory effect of Eucalyptus globulus and Thymus vulgaris: nitric oxide inhibition in J774A.1 murine macrophages. J Pharm Pharmacol. 2004;56(2):257-63.
118. Stojkovic D, Glamoclija J, Ciric A, Nikolic M, Ristic M, Siljegovic J, Sokovic M. Investigation on antibacterial synergism of Origanum vulgare and Thymzs vulgaris essential oils. Archives of Biological Sciences. 2013;65(2):639-43.
119. Sienkiewicz M, Lysakowska M, Denys P, Kowalczyk E. The Antimicrobial Activity of Thyme Essential Oil Against Multidrug Resistant Clinical Bacterial Strains. Microb Drug Resist. 2012;18(2):137-48.
120. Santurio DF, Kunz de Jesus FP, Zanette RA, Schlemmer KB, Fraton A, Martins Fries LL. Antimicrobial Activity of the Essential Oil of Thyme and of Thymol against Escherichia coli Strains. Acta Scientiae Veterinariae 2014;42:1234.
121. Oyewole OL, Owoseni AA, Faboro EO. Studies on medicinal and toxicological properties of Cajanus cajan, Ricinus communis and Thymus vulgaris leaf extracts. Journal of Medicinal Plants Research. 2010;4(19):2004-8.
122. Buechi S, Vogelin R, von Eiff MM, Ramos M, Melzer J. Open trial to assess aspects of safety and efficacy of a combined herbal cough syrup with ivy and thyme. Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine. 2005;12(6):328-32.
123. Hiller K, Melzig MF. Lexikon der Arzneipflanzen und Drogen. 2nd ed. Heidelberg: Spektrum akademischer Verlag; 2010.
124. Bruins MJ, Vente-Spreeuwenberg MA, Smits CH, Frenken LG. Black tea reduces diarrhoea prevalence but decreases growth performance in enterotoxigenic Escherichia coli-infected post-weaning piglets. J Anim Physiol Anim Nutr. 2011;95(3):388-98.
125. Zanchi R, Canzi E, Molteni L, Scozzoli M. Effect of Camellia sinensis L. whole plant extract on piglet intestinal ecosystem. Ann Microbiol. 2008;58(1):147-52.
126. Smee DF, Hurst BL, Wong MH. Effects of TheraMax on influenza virus infections in cell culture and in mice. Antivir Chem Chemother. 2011;21(6):231-7.
127. Lee HJ, Lee YN, Youn HN, Lee DH, Kwak JH, Seong BL, Lee JB, Park SY, Choi IS, Song CS. Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens. Poult Sci. 2012;91(1):66-73.
128. Yanagimoto K, Ochi H, Lee KG, Shibamoto T. Antioxidative activities of volatile extracts from green tea, oolong tea, and black tea. J Agric Food Chem. 2003;51(25):7396-401.
129. Sawai Y, Moon JH, Sakata K, Watanabe N. Effects of structure on radicalscavenging abilities and antioxidative activities of tea polyphenols: NMR analytical approach using 1,1-diphenyl-2-picrylhydrazyl radicals. J Agric Food Chem. 2005;53(9):3598-604.
130. Ling JX, Wei F, Li N, Li JL, Chen LJ, Liu YY, Luo F, Xiong HR, Hou W, Yang ZQ. Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea. Acta Pharmacol Sin. 2012;33(12):1533-41.
131. Chen BT, Li WX, He RR, Li YF, Tsoi B, Zhai YJ, Kurihara H. Anti-inflammatory effects of a polyphenols-rich extract from tea (Camellia sinensis) flowers in acute and chronic mice models. Oxid Med Cell Longev. 2012;2012:537923.
132. Chattopadhyay P, Besra SE, Gomes A, Das M, Sur P, Mitra S, Vedasiromoni JR. Anti-inflammatory activity of tea (Camellia sinensis) root extract. Life Sci. 2004;74(15):1839-49.
133. Monobe M, Ema K, Kato F, Maeda-Yamamoto M. Immunostimulating activity of a crude polysaccharide derived from green tea (Camellia sinensis) extract. J Agric Food Chem. 2008;56(4):1423-7.
134. Matsumoto K, Yamada H, Takuma N, Niino H, Sagesaka YM. Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial. BMC Complement Altern Med. 2011;11:15.
135. Hsu Y-W, Tsai C-F, Chen W-K, Huang C-F, Yen C-C. A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice. Food Chem Toxicol. 2011;49(10):2624-30.
136. Sarma DN, Barrett ML, Chavez ML, Gardiner P, Ko R, Mahady GB, Marles RJ, Pellicore LS, Giancaspro GI, Dog TL. Safety of green tea extracts-A systematic review by the US Pharmacopeia. Drug Saf. 2008;31(6):469-84.
137. Chan PC, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A. Fourteen-Week Toxicity Study of Green Tea Extract in Rats and Mice. Toxicol Pathol. 2010;38(7):1070-84.
138. Borsuk OS, Masnaya NV, Sherstoboev EY, Isaykina NV, Kalinkina GI, Reihart DV. Effects of drugs of plant origin on the development of the immune response. Bull Exp Biol Med. 2011;151(2):194-6.
139. Saha S, Nosal'ova G, Ghosh D, Fleskova D, Capek P, Ray B. Structural features and in vivo antitussive activity of the water extracted polymer from Glycyrrhiza glabra. Int J Biol Macromol. 2011;48(4):634-8.
140. Liu B, Yang J, Wen Q, Li Y. Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: Role of cGMP/PKG pathway. Eur J Pharmacol. 2008;587(1-3):257-66.
141. Chen G, Zhu L, Liu Y, Zhou Q, Chen H, Yang J. Isoliquiritigenin, a Flavonoid from Licorice, plays a Dual Role in regulating Gastrointestinal Motility in vitro and in vivo. Phytother Res. 2009;23(4):498-506.
142. Kim HK, Park Y, Kim HN, Choi BH, Jeong HG, Lee DG, Hahm KS. Antimicrobial mechanism of beta-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra. Biotechnol Lett. 2002;24(22):1899-902.
143. Irani M, Sarmadi M, Bernard F, Ebrahimi Pour GH, Shaker Bazarnov H. Leaves Antimicrobial Activity of Glycyrrhiza glabra L. Iranian journal of pharmaceutical research: IJPR. 2010;9(4):425-8.
144. Laconi S, Madeddu MA, Pompei R. Autophagy Activation and Antiviral Activity by a Licorice Triterpene. Phytother Res. 2014;28(12):1890-2.
145. Knipping K, Garssen J, van't Land B. An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts. Virol J 2012;9:137.
146. Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regulatory toxicology and pharmacology: RTP. 2006;46(3):167-92.
147. Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sokmen A, Akpulat HA. Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae). J Ethnopharmacol. 2003;87(2-3):215-20.
148. Tajik H, Jalali FSS, Sobhani A, Shahbazi Y, Zadeh MS. In vitro Assessment of Antimicrobial Efficacy of Alcoholic Extract of Achillea Millefolium in Comparison with Penicillin Derivatives. J Anim Vet Adv. 2008;7(4):508-11.
149. Babaei M, Abarghoei ME, Akhavan MM, Ansari R, Vafaei AA, Taherian AA, Mousavi S, Toussy J. Antimotility effect of hydroalcoholic extract of yarrow (Achillea millefolium) on the guinea-pig ileum. Pakistan journal of biological sciences: PJBS. 2007;10(20):3673-7.
150. Lemmens-Gruber R, Marchart E, Rawnduzi P, Engel N, Benedek B, Kopp B. Investigation of the spasmolytic activity of the flavonoid fraction of Achillea millefolium s.l. on isolated guinea-pig ilea. Arzneimittelforschung. 2006;56(8):582-8.
151. Moradi MT, Rafieian-Koupaei M, Imani-Rastabi R, Nasiri J, Shahrani M, Rabiei Z, Alibabaei Z. Antispasmodic effects of yarrow (Achillea millefolium L.) extract in the isolated ileum of rat. African journal of traditional, complementary, and alternative medicines: AJTCAM/African Networks on Ethnomedicines. 2013;10(6):499-503.
152. Yaeesh S, Jamal Q, Khan AU, Gilani AH. Studies on hepatoprotective, antispasmodic and calcium antagonist activities of the aqueous-methanol extract of Achillea millefolium. Phytotherapy research: PTR. 2006;20(7):546-51.
153. Cross DE, McDevitt RM, Hillman K, Acamovic T. The effect of herbs and their associated essential oils on performance, dietary digestibility and gut microflora in chickens from 7 to 28 days of age. Br Poultry Sci. 2007; 48(4):496-506.
154. Borrelli F, Romano B, Fasolino I, Tagliatatela-Scafati O, Aprea G, Capasso R, Capasso F, Bottazzi EC, Izzo AA. Prokinetic effect of a standardized yarrow (Achillea millefolium) extract and its constituent choline: studies in the mouse and human stomach. Neurogastroenterol Motil. 2012;24(2):164-71,e90.
155. Al-Mariri A, Safi M. In Vitro Antibacterial Activity of Several Plant Extracts and Oils against Some Gram-Negative Bacteria. Iranian journal of medical sciences. 2014;39(1):36-43.
156. Casella S, Leonardi M, Melai B, Fratini F, Pistelli L. The Role of Diallyl Sulfides and Dipropyl Sulfides in the In Vitro Antimicrobial Activity of the Essential Oil of Garlic, Allium sativum L., and Leek, Allium porrum L. Phytother Res. 2013;27(3):380-3.
157. Gomaa NF, Hashish MH. The inhibitory effect of garlic (Allium sativum) on growth of some microorganisms. J Egypt Public Health Assoc. 2003; 78(5-6):361-72.
158. Harris JC, Plummer S, Turner MP, Lloyd D. The microaerophilic flagellate Giardia intestinalis: Allium sativum (garlic) is an effective antigiardial. Microbiology-Uk. 2000;146:3119-27.
159. Kuda T, Iwai A, Yano T. Effect of red pepper Capsicum annuum var. conoides and garlic Allium sativum on plasma lipid levels and cecal microflora in mice fed beef tallow. Food Chem Toxicol. 2004;42(10):1695-700.
160. Sreter T, Szell Z, Varga I. Attempted chemoprophylaxis of cryptosporidiosis in chickens, using diclazuril, toltrazuril, or garlic extract. J Parasitol. 1999; 85(5):989-91.
161. Horie T, Matsumoto H, Kasagi M, Sugiyama A, Kikuchi M, Karasawa C, Awazu S, Itakura Y, Fuwa T. Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration. Planta Med. 1999;65(6):545-8.
162. Tatara MR, Sliwa E, Dudek K, Kowalik S, Gawron A, Piersiak T, Dobrowolski P, Studzinski T. Effect of aged garlic extract and allicin administration to sows during pregnancy and lactation on body weight gain and gastrointestinal tract development of piglets: Morphological properties of the small intestine. Part II. Bull Vet Inst Pulawy. 2005;49(4):455-64.
163. Valiei M, Shafaghat A, Salimi F. Chemical composition and antimicrobial activity of the flower and root hexane extracts of Althaea officinalis in Northwest Iran. Journal of Medicinal Plants Research. 2011;5(32):6972-6.
164. Watt K, Christofi N, Young R. The detection of antibacterial actions of whole herb tinctures using luminescent Escherichia coli. Phytotherapy research: PTR. 2007;21(12):1193-9.
165. Bandyopadhyay D, Chatterjee TK, Dasgupta A, Lourduraja J, Dastidar SG. In vitro and in vivo antimicrobial action of tea: The commonest beverage of Asia. Biol Pharm Bull. 2005;28(11):2125-7.
166. Ciraj AM, Sulaim J, Mamatha B, Gopalkrishna BK, Shivananda PG. Antibacterial activity of black tea (Camelia sinensis) extract against Salmonella serotypes causing enteric fever. Indian J Med Sci. 2001;55(7): 376-81.
167. Mukherjee D, Bhattacharjee PG, Samanta S. Comparative Profile of the Antimicrobial Activities of Assam, Dooars and Darjeeling Tea Leaves (Camellia sinensis L). Journal of Pure and Applied Microbiology. 2012;6(4):2011-5.
168. Neyestani TR, Khalaji N, Gharavi A. Selective microbiologic effects of tea extract on certain antibiotics against Escherichia coli in vitro. Journal of alternative and complementary medicine (New York, NY). 2007;13(10):1119-24.
169. Reygaert W, Jusufi I. Green tea as an effective antimicrobial for urinary tract infections caused by Escherichia coli. Front Microbiol 2013;4:62.
170. Tiwari RP, Bharti SK, Kaur HD, Dikshit RP, Hoondal GS. Synergistic antimicrobial activity of tea & antibiotics. Indian J Med Res. 2005;122(1):80-4.
171. Lee J-H, Shim JS, Chung M-S, Lim S-T, Kim KH. In Vitro Anti-Adhesive Activity of Green Tea Extract against Pathogen Adhesion. Phytother Res. 2009;23(4):460-6.
172. Chaudhuri L, Basu S, Seth P, Chaudhuri T, Besra SE, Vedasiromoni JR, Ganguly DK. Prokinetic effect of black tea on gastrointestinal motility. Life Sci. 2000;66(9):847-54.
173. Ratnasooriya WD, Fernando TSP. Antidiarrhoeal activity of Sri Lankan Dust grade Black Tea (Camellia sinensis L.) in mice. Pharmacogn Mag. 2009;5(18): 115-21.
174. Hawrelak JA, Cattley T, Myers SP. Essential Oils in the Treatment of Intestinal Dysbiosis: A Preliminary in vitro Study. Altern Med Rev. 2009;14(4):380-4.
175. Kacaniova M, Vukovic N, Horska E, Salamon I, Bobkova A, Hleba L, Fiskelova M, Vatlak A, Petrova J, Bobko M. Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin. J Environ Sci Health B. 2014;49(7):505-12.
176. Mohsenzadeh M. Evaluation of antibacterial activity of selected Iranian essential oils against Staphylococcus aureus and Escherichia coli in nutrient broth medium. Pakistan journal of biological sciences: PJBS. 2007;10(20):3693-7.
177. Al-Essa MK, Shafagoj YA, Mohammed FI, Afifi FU. Relaxant effect of ethanol extract of Carum carvi on dispersed intestinal smooth muscle cells of the guinea pig. Pharm Biol. 2010;48(1):76-80.
178. Keshavarz A, Minaiyan M, Ghannadi A, Mahzouni P. Effects of Carum carvi L. (Caraway) extract and essential oil on TNBS-induced colitis in rats. Research in pharmaceutical sciences. 2013;8(1):1-8.
179. Hill LL, Foote JC, Erickson BD, Cerniglia CE, Denny GS. Echinacea purpurea supplementation stimulates select groups of human gastrointestinal tract microbiota. J Clin Pharm Ther. 2006;31(6):599-604.
180. Al Akeel R, Al-Sheikh Y, Mateen A, Syed R, Janardhan K, Gupta VC. Evaluation of antibacterial activity of crude protein extracts from seeds of six different medical plants against standard bacterial strains. Saudi journal of biological sciences. 2014;21(2):147-51.
181. Aprotosoaie AC, Hancianu M, Poiata A, Tuchilus C, Spac A, Cioana O, Gille E, Stanescu U. In vitro antimicrobial activity and chemical composition of the essential oil of Foeniculum vulgare Mill. Rev Med Chir Soc Med Nat Iasi. 2008;112(3):832-6.
182. Bisht DS, Menon KRK, Singhal MK. Comparative Antimicrobial Activity of Essential oils of Cuminum cyminum L. and Foeniculum vulgare Mill. seeds against Salmonella typhimurium and Escherichia coli. Journal of Essential Oil Bearing Plants. 2014;17(4):617-22.
183. Gulfraz M, Mehmood S, Minhas N, Jabeen N, Kausar R, Jabeen K, Arshad G. Composition and antimicrobial properties of essential oil of Foeniculum vulgare. Afr J Biotechnol. 2008;7(24):4364-8.
184. Damyanova S, Stoyanova A. Antimicrobial activity of aromatic products. 14 extracts from fruits of sweet fennel (Foeniculum vulgare Mill. var. dulce Mill.) and coriander (Coriandrum salivum L.). Journal of Essential Oil Bearing Plants. 2007;10(5):440-5.
185. Bulut C, Altiok E, Bayraktar O, Ulku S. Antioxidative and Antimicrobial Screening of 19 Commercial Essential Oils in Turkey. In: Edited by Turgut K, Onus AN, Mathe A. I International Medicinal and Aromatic Plants Conference on Culinary Herbs. Volume 826, edn., 2009. 111-116.
186. Costa Brandelli CL, Giordani RB, Attilio De Carli G, Tasca T. Indigenous traditional medicine: in vitro anti-giardial activity of plants used in the treatment of diarrhea. Parasitol Res. 2009;104(6):1345-9.
187. Lee JH, Lee DU, Kim YS, Kim HP. 5-Lipoxygenase Inhibition of the Fructus of Foeniculum vulgare and Its Constituents. Biomol Ther. 2012;20(1):113-7.
188. Alexandrovich I, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov S. The effect of fennel (Foeniculum vulgare) seed oil emulsion in infantile colic: A randomized, placebo-controlled study. Altern Ther Health Med. 2003;9(4):58-61.
189. Capasso R, Savino F, Capasso F. Effects of the herbal formulation ColiMil (R) on upper gastrointestinal transit in mice in vivo. Phytother Res. 2007;21(10):999-1001.
190. Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, et al. Antimicrobial potential of Glycyrrhiza glabra roots. J Ethnopharmacol. 2008;116(2):377-80.
191. Tasdelen Fisgin N, Tanriverdi Cayci Y, Coban AY, Ozatli D, Tanyel E, Durupinar B, Tulek N. Antimicrobial activity of plant extract Ankaferd Blood Stopper. Fitoterapia. 2009;80(1):48-50.
192. Walter C, Shinwari ZK, Afzal I, Malik RN. Antibacterial activity in herbal products used in Pakistan. Pak J Bot. 2011;43:155-62.
193. Shinwari ZK, Khan I, Naz S, Hussain A. Assessment of antibacterial activity of three plants used in Pakistan to cure respiratory diseases. Afr J Biotechnol. 2009;8(24):7082-6.
194. Heinle H, Hagelauer D, Pascht U, Kelber O, Weiser D. Intestinal spasmolytic effects of STW 5 (Iberogast (R)) and its components. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2006;13:75-9.
195. Chandrasekaran CV, Deepak HB, Thiyagarajan P, Kathiresan S, Sangli GK, Deepak M, Agarwal A. Dual inhibitory effect of Glycyrrhiza glabra (GutGard (TM)) on COX and LOX products. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2011;18(4):278-84.
196. Puram S, Suh HC, Kim SU, Bethapudi B, Joseph JA, Agarwal A, Kudiganti V. Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study. Evid Based Complement Altern Med 2013.
197. Sancar M, Hantash T, Okuyan B, Apikoglu-Rabus S, Cirakli Z, Gulluoglu MG, Izzettin FV. Comparative effectiveness of Glycyrrhiza glabra vs. omeprazole and misoprostol for the treatment of aspirin-induced gastric ulcers. Afr J Pharm Pharmacol. 2009;3(12):615-20.
198. Srinivasan D, Ramaswamy S, Sengottuvelu S. Prokinetic Effect of Polyherbal Formulation on Gastrointestinal Tract. Pharmacogn Mag. 2009;5(17):37-42.
199. Palla AH, Khan NA, Bashir S, Ur-Rehman N, Iqbal J, Gilani AH. Pharmacological basis for the medicinal use of Linum usitatissimum (Flaxseed) in infectious and non-infectious diarrhea. J Ethnopharmacol. 2015;160:61-8.
200. Strzalkowski AK, Godlewski MM, Hallay N, Kulasek G, Gajewski Z, Zabielski R. The effect of supplementing sow with bioactive substances on neonatal small intestinal epithelium. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society. 2007;58 Suppl 3:115-22.
201. Holman DB, Baurhoo B, Chenier MR. Temporal analysis of the effect of extruded flaxseed on the swine gut microbiota. Can J Microbiol. 2014; 60(10):649-59.
202. Abdoul-Latif FM, Mohamed N, Edou P, Ali AA, Djama SO, Obame L-C, Bassole IHN, Dicko MH. Antimicrobial and antioxidant activities of essential oil and methanol extract of Matricaria chamomilla L. from Djibouti. Journal of Medicinal Plants Research. 2011;5(9):1512-7.
203. Munir N, Iqbal AS, Altaf I, Bashir R, Sharif N, Saleem F, Naz S. Evaluation of antioxidant and antimicrobial potential of two endangered plant species atropa belladonna and matricaria chamomilla. African journal of traditional, complementary, and alternative medicines: AJTCAM/African Networks on Ethnomedicines. 2014;11(5):111-7.
204. Silva NC, Barbosa L, Seito LN, Fernandes Jr A. Antimicrobial activity and phytochemical analysis of crude extracts and essential oils from medicinal plants. Nat Prod Res. 2012;26(16):1510-4.
205. Ammon HP, Kelber O, Okpanyi SN. Spasmolytic and tonic effect of Iberogast (STW 5) in intestinal smooth muscle. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2006;13 Suppl 5:67-74.
206. Maschi O, Cero ED, Galli GV, Caruso D, Bosisio E, Dell'Agli M. Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L. J Agric Food Chem. 2008;56(13):5015-20.
207. Schemann M, Michel K, Zeller F, Hohenester B, Ruehl A. Region-specific effects of STW 5 (Iberogast (R)) and its components in gastric fundus, corpus and antrum. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2006;13:90-9.
208. Storr M, Sibaev A, Weiser D, Kelber O, Schirra J, Goke B, Allescher HD. Herbal extracts modulate the amplitude and frequency of slow waves in circular smooth muscle of mouse small intestine. Digestion. 2004;70(4):257-64.
209. Calzada F, Arista R, Perez H. Effect of plants used in Mexico to treat gastrointestinal disorders on charcoal-gum acacia-induced hyperperistalsis in rats. J Ethnopharmacol. 2010;128(1):49-51.
210. Sebai H, Jabri MA, Souli A, Rtibi K, Selmi S, Tebourbi O, El-Benna J, Sakly M. Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats. J Ethnopharmacol. 2014;152(2):327-32.
211. Carvalho JCT, Vignoli VV, de Souza GHB, Ujikawa K, Neto JJ: Antimicrobial activity of essential oils from plants used in Brazilian popular medicine. In: Edited by Martino V, Caffini N, Lappa A, Schilcher H, Phillipson JD, Tchernitchin A, Debenedetti S, Acevedo C. Second World Congress on Medicinal and Aromatic Plants for Human Welfare Wocmap-2: Pharmacognosy, Pharmacology, Phytomedicines, Toxicology. 1999. 77-81.
212. Pattnaik S, Subramanyam VR, Rath CC. Effect of essential oils on the viability and morphology of Escherichia coli (SP-11). Microbios. 1995;84(340):195-9.
213. Saeed S, Tariq P. Antibacterial activities of Mentha piperita, Pisum sativum and Momordica charantia. Pak J Bot. 2005;37(4):997-1001.
214. Schelz Z, Molnar J, Hohmann J. Antimicrobial and antiplasmid activities of essential oils. Fitoterapia. 2006;77(4):279-85.
215. Thompson A, Meah D, Ahmed N, Conniff-Jenkins R, Chileshe E, Phillips CO, Claypole TC, Forman DW, Row PE. Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome. BMC Complement Altern Med. 2013;13:338.
216. Toroglu S. In-vitro antimicrobial activity and synergistic/antagonistic effect of interactions between antibiotics and some spice essential oils. Journal of environmental biology/Academy of Environmental Biology, India. 2011;32(1):23-9.
217. Jirovetz L, Buchbauer G, Bail S, Denkova Z, Slavchev A, Stoyanova A, Schmidt E, Geissler M. Antimicrobial Activities of Essential Oils of Mint and Peppermint as Well as Some of Their Main Compounds. J Essent Oil Res. 2009;21(4):363-6.
218. Jalilzadeh-Amin G, Maham M, Dalir-Naghadeh B, Kheiri F. Effects of Mentha longifolia essential oil on ruminal and abomasal longitudinal smooth muscle in sheep. J Essent Oil Res. 2012;24(1):61-9.
219. Sharifi SD, Khorsandi SH, Khadem AA, Salehi A, Moslehi H. The effect of four medicinal plants on the performance, blood biochemical traits and ileal microflora of broiler chicks. Veterinarski Arhiv. 2013;83(1):69-80.
220. Bruno DG, Massami Kitamura Martins SM, Parazzi LJ, Afonso ER, Del Santo TA, Novita Teixeira SM, Moreno AM, Moretti ASA. Phytogenic feed additives in piglets challenged with Salmonella Typhimurium. Revista Brasileira De Zootecnia-Brazilian Journal of Animal Science. 2013;42(2):137-43.
221. Micklefield G, Jung O, Greving I, May B. Effects of intraduodenal application of peppermint oil (WS(R) 1340) and caraway oil (WS(R) 1520) on gastroduodenal motility in healthy volunteers. Phytotherapy research: PTR. 2003;17(2):135-40.
222. Yamamoto N, Nakai Y, Sasahira N, Hirano K, Tsujino T, Isayama H, Komatsu Y, Tada M, Yoshida H, Kawabe T, et al. Efficacy of peppermint oil as an antispasmodic during endoscopic retrograde cholangiopancreatography. J Gastroenterol Hepatol. 2006;21(9):1394-8.
223. Bezerra Alves JG, Coelho Moraes de Brito RdC, Cavalcanti TS. Effectiveness of Mentha piperita in the Treatment of Infantile Colic: A Crossover Study. Evidence-Based Complementary and Alternative Medicine 2012.
224. Becerril R, Nerin C, Gomez-Lus R. Evaluation of bacterial resistance to essential oils and antibiotics after exposure to oregano and cinnamon essential oils. Foodborne Pathog Dis. 2012;9(8):699-705.
225. da Costa AC, Santos BH C d, Santos Filho L, Lima EO. Antibacterial activity of the essential oil of Origanum vulgare L. (Lamiaceae) against bacterial multiresistant strains isolated from nosocomial patients. Revista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy. 2009;19(1B):236-41.
226. Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. 2000;88(2):308-16.
227. Fabian D, Sabol M, Domaracka K, Bujnakova D. Essential oils-their antimicrobial activity against Escherichia coli and effect on intestinal cell viability. Toxicology in vitro: an international journal published in association with BIBRA. 2006; 20(8):1435-45.
228. Friedman M, Henika PR, Mandrell RE. Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. J Food Prot. 2002;65(10):1545-60.
229. Hulankova R, Borilova G. In vitro combined effect of oregano essential oil and caprylic acid against Salmonella serovars, Escherichia coli O157:H7, Staphylococcus aureus and Listeria monocytogenes. Acta Vet Brno. 2011; 80(4):343-8.
230. Marino M, Bersani C, Comi G. Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae and Compositae. Int J Food Microbiol. 2001;67(3):187-95.
231. Mathlouthi N, Bouzaienne T, Oueslati I, Recoquillay F, Hamdi M, Urdaci M, Bergaoui R. Use of rosemary, oregano, and a commercial blend of essential oils in broiler chickens: in vitro antimicrobial activities and effects on growth performance. J Anim Sci. 2012;90(3):813-23.
232. Ouwehand AC, Tiihonen K, Kettunen H, Peuranen S, Schulze H, Rautonen N. In vitro effects of essential oils on potential pathogens and beneficial members of the normal microbiota. Vet Med. 2010;55(2):71-8.
233. Pogany Simonova M, Laukova A, Haviarova M. Pseudomonads from rabbits and their sensitivity to antibiotics and natural antimicrobials. Res Vet Sci. 2010;88(2):203-7.
234. Sarac N, Ugur A. Antimicrobial activities of the essential oils of Origanum onites L., Origanum vulgare L. subspecies hirtum (Link) Ietswaart, Satureja thymbra L., and Thymus cilicicus Boiss. & Bal. growing wild in Turkey. J Med Food. 2008;11(3):568-73.
235. Si H, Hu J, Liu Z, Zeng Z-l. Antibacterial effect of oregano essential oil alone and in combination with antibiotics against extended-spectrum betalactamase-producing Escherichia coli. FEMS Immunol Med Microbiol. 2008;53(2):190-4.
236. Sokovic M, Glamoclija J, Marin PD, Brkic D, van Griensven LJ. Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model. Molecules (Basel, Switzerland). 2010;15(11):7532-46.
237. Strompfova V, Laukova A. Enterococci from piglets-probiotic properties and responsiveness to natural antibacterial substances. Folia Microbiol. 2009; 54(6):538-44.
238. Dahiya P, Purkayastha S. Phytochemical screening and antimicrobial activity of some medicinal plants against multi-drug resistant bacteria from clinical isolates. Indian journal of pharmaceutical sciences. 2012;74(5):443-50.
239. Karakaya S, El SN, Karagozlu N, Sahin S. Antioxidant and Antimicrobial Activities of Essential Oils Obtained from Oregano (Origanum vulgare ssp hirtum) by Using Different Extraction Methods. J Med Food. 2011;14(6):645-52.
240. Bimczok D, Rau H, Sewekow E, Janczyk P, Souffrant WB, Rothkotter HJ. Influence of carvacrol on proliferation and survival of porcine lymphocytes and intestinal epithelial cells in vitro. Toxicology in vitro: an international journal published in association with BIBRA. 2008;22(3):652-8.
241. Manzanilla EG, Perez JF, Martin M, Kamel C, Baucells F, Gasa J. Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs. J Anim Sci. 2004;82(11):3210-8.
242. Batungbacal MR, Hilomen GV, Luis ES, Centeno JR, Carandang NF. Comparative efficacy of oregano (Origanum vulgare) extract and amprolium in the control of coccidiosis and their effect on broiler performance. Philippine Journal of Veterinary Medicine. 2007;44(2):91-9.
243. Giannenas I, Florou-Paneri P, Papazahariadou M, Christaki E, Botsoglou NA, Spais AB. Effect of dietary supplementation with oregano essential oil on performance of broilers after experimental infection with Eimeria tenella. Arch Tierernahr. 2003;57(2):99-106.
244. Basmacioglu Malayoglu H, Baysal S, Misirlioglu Z, Polat M, Yilmaz H, Turan N. Effects of oregano essential oil with or without feed enzymes on growth performance, digestive enzyme, nutrient digestibility, lipid metabolism and immune response of broilers fed on wheat-soybean meal diets. Br Poultry Sci. 2010;51(1):67-80.
245. Henn JD, Bertol TM, de Moura NF, Coldebella A, de Brum PA R, Casagrande M. Oregano essential oil as food additive for piglets: antimicrobial and antioxidant potential. Revista Brasileira De Zootecnia-Brazilian Journal of Animal Science. 2010;39(8):1761-7.
246. Ariza-Nieto C, Bandrick M, Baidoo SK, Anil L, Molitor TW, Hathaway MR. Effect of dietary supplementation of oregano essential oils to sows on colostrum and milk composition, growth pattern and immune status of suckling pigs. J Anim Sci. 2011;89(4):1079-89.
247. Bukovska A, Cikos S, Juhas S, Il'kova G, Rehak P, Koppel J. Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice. Mediators Inflamm. 2007;2007:23296.
248. Bampidis VA, Christodoulou V, Florou-Paneri P, Christaki E. Effect of dried oregano leaves versus neomycin in treating newborn calves with colibacillosis. Journal of Veterinary Medicine Series a-Physiology Pathology Clinical Medicine. 2006;53(3):154-6.
249. Sipponen A, Laitinen K. Antimicrobial properties of natural coniferous rosin in the European Pharmacopoeia challenge test. APMIS: acta pathologica, microbiologica, et immunologica Scandinavica. 2011;119(10):720-4.
250. Al-Bayati FA. Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts. J Ethnopharmacol. 2008;116(3):403-6.
251. Gradinaru AC, Miron A, Trifan A, Spac A, Brebu M, Aprotosoaie AC. Screening of antibacterial effects of anise essential oil alone and in combination with conventional antibiotics against Streptococcus pneumoniae clinical isolates. Rev Med Chir Soc Med Nat Iasi. 2014;118(2):537-43.
252. Abu-Darwish MS, Al-Ramamneh EA, Kyslychenko VS, Karpiuk UV. The antimicrobial activity of essential oils and extracts of some medicinal plants grown in Ash-shoubak region-South of Jordan. Pak J Pharm Sci. 2012;25(1):239-46.
253. Prabuseenivasan S, Jayakumar M, Ignacimuthu S. In vitro antibacterial activity of some plant essential oils. BMC Complement Altern Med. 2006;6:39.
254. Darwish RM, Aburjai TA. Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC Complement Altern Med. 2010;10:9.
255. Tirapelli CR, de Andrade CR, Cassano AO, De Souza FA, Ambrosio SR, da Costa FB, de Oliveira AM. Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. J Ethnopharmacol. 2007;110(1):23-9.
256. Ivarsson E, Frankow-Lindberg BE, Andersson HK, Lindberg JE. Growth performance, digestibility and faecal coliform bacteria in weaned piglets fed a cereal-based diet including either chicory (Cichorium intybus L) or ribwort (Plantago lanceolata L) forage. Animal: an international journal of animal bioscience. 2011;5(4):558-64.
257. Subbotina MD, Timchenko VN, Vorobyov MM, Konunova YS, Aleksandrovih YS, Shushunov S. Effect of oral administration of tormentil root extract (Potentilla tormentilla) on rotavirus diarrhea in children: a randomized, double blind, controlled trial. Pediatr Infect Dis J. 2003;22(8):706-11.
258. Huber R, Ditfurth AV, Amann F, Guethlin C, Rostock M, Trittler R, Kuemmerer K, Merfort I. Tormentil for active ulcerative colitis: An open-label, doseescalating study. J Clin Gastroenterol. 2007;41(9):834-8.
259. Anthony JP, Fyfe L, Stewart D, McDougall GJ, Smith HV. The effect of blueberry extracts on Giardia duodenalis viability and spontaneous excystation of Cryptosporidium parvum oocysts, in vitro. Methods. 2007;42(4):339-48.
260. Alzoreky NS, Nakahara K. Antibacterial activity of extracts from some edible plants commonly consumed in Asia. Int J Food Microbiol. 2003;80(3):223-30.
261. Elzaawely AA, Xuan TD, Tawata S. Antioxidant and antibacterial activities of Rumex japonicus HOUTT. Aerial parts. Biol Pharm Bull. 2005;28(12):2225-30.
262. Humeera N, Kamili AN, Bandh SA, Amin SU, Lone BA, Gousia N. Antimicrobial and antioxidant activities of alcoholic extracts of Rumex dentatus L. Microb Pathog. 2013;57:17-20.
263. Rouf AS, Islam MS, Rahman MT. Evaluation of antidiarrhoeal activity Rumex maritimus root. J Ethnopharmacol. 2003;84(2-3):307-10.
264. Vargas R, Perez S, Zavala MA, Chimal A. Inhibitory effect of Salix taxifolia extract on rat ileum contraction. Phytother Res. 1998;12:S51-2.
265. Khalil R, Li Z-G. Antimicrobial activity of essential oil of Salvia officinalis L. collected in Syria. Afr J Biotechnol. 2011;10(42):8397-402.
266. Piesova E, Makova Z, Levkut M, Faixova Z, Pistl J, Marcin A, Levkut M. The effects of sage extract feed supplementation on biochemical parameters, weight of internal organs and Salmonella counts in chickens. Res Vet Sci. 2012;93(3):1307-8.
267. Szaboova R, Laukova A, Chrastinova L, Simonova M, Strompfova V, Haviarova M, Placha I, Faix S, Vasilkova Z, Chrenkova M, et al. Experimental Application of Sage in Rabbit Husbandry. Acta Vet Brno. 2008;77(4):581-8.
268. Szaboova R, Laukova A, Chrastinova L, Strompfova V, Simonova MP, Vasilkova Z, Cobanova K, Placha I, Chrenkova M. Effect of combined administration of enterocin 4231 and sage in rabbits. Pol J Vet Sci. 2011;14(3):359-66.
269. Khan A, Najeeb Ur R, AlKharfy KM, Gilani A-H. Antidiarrheal and antispasmodic activities of Salvia officinalis are mediated through activation of K+ channels. Bangladesh Journal of Pharmacology. 2011;6(2):111-6.
270. Marcin A, Laukova A, Mati R. Comparison of the effects of Enterococcus faecium and aromatic oils from sage and oregano on growth performance and diarrhoeal diseases of weaned pigs. Biologia. 2006;61(6):789-95.
271. Arjoon AV, Saylor CV, May M. In Vitro efficacy of antimicrobial extracts against the atypical ruminant pathogen Mycoplasma mycoides subsp. capri. BMC Complement Altern Med. 2012;12:169.
272. Zeman M, Nosal'ova V, Bobek P, Zakalova M, Cerna S. Changes of endogenous melatonin and protective effect of diet containing pleuran and extract of black elder in colonic inflammation in rats. Biologia. 2001;56(6):695-701.
273. Essawi T, Srour M. Screening of some Palestinian medicinal plants for antibacterial activity. J Ethnopharmacol. 2000;70(3):343-9.
274. Lisin G, Safiyev S, Craker LE: Antimicrobial activity of some essential oils. In: Second World Congress on Medicinal and Aromatic Plants for Human Welfare Wocmap-2: Pharmacognosy, Pharmacology, Phytomedicines, Toxicology. edn. Edited by Martino V, Caffini N, Lappa A, Schilcher H, Phillipson JD, Tchernitchin A, Debenedetti S, Acevedo C; 1999: 283-288.
275. Babaei M, Abarghoei ME, Ansari R, Vafaei AA, Taherian AA, Akhavan MM, Toussy G, Mousavi S. Antispasmodic effect of hydroalcoholic extract of Thymus vulgaris on the guinea-pig ileum. Nat Prod Res. 2008;22(13):1143-50.
276. Beer AM, Lukanov J, Sagorchev P. Effect of Thymol on the spontaneous contractile activity of the smooth muscles. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2007;14(1):65-9.
277. Hagmueller W, Jugl-Chizzola M, Zitterl-Eglseer K, Gabler C, Spergser J, Chizzola R, Franz C. The use of Thymi Herba as feed additive (0.1 %, 0.5 %, 1.0 %) in weanling piglets with assessment of the shedding of haemolysing E. coli and the detection of thymol in the blood plasma. Berl Munch Tierarztl Wochenschr. 2006;119(1-2):50-4.
278. Jugl-Chizzola M, Spergser J, Schilcher F, Novak J, Bucher A, Gabler C, Hagmuller W, Zitterl-Eglseer K. Effects of Thymus vulgaris L. as feed additive in piglets and against haemolytic E-coli in vitro. Berl Munch Tierarztl Wochenschr. 2005; 118(11-12):495-501.
279. Placha I, Takacova J, Ryzner M, Cobanova K, Laukova A, Strompfova V, Venglovska K, Faix S. Effect of thyme essential oil and selenium on intestine integrity and antioxidant status of broilers. Br Poultry Sci. 2014;55(1):105-14.
280. Kokoska L, Polesny Z, Rada V, Nepovim A, Vanek T. Screening of some Siberian medicinal plants for antimicrobial activity. J Ethnopharmacol. 2002;82(1):51-3.
281. Stanciuc AM, Gaspar A, Moldovan L, Saviuc C, Popa M, Marutescu L. In vitro antimicrobial activity of Romanian medicinal plants hydroalcoholic extracts on planktonic and adhered cells. Roum Arch Microbiol Immunol. 2011;70(1):11-4.
282. Erdogrul OT. Antibacterial activities of some plant extracts used in folk medicine. Pharm Biol. 2002;40(4):269-73.
283. Genc Z, Yarat A, Tunali-Akbay T, Sener G, Cetinel S, Pisiriciler R, Caliskan-Ak E, Altintas A, Demirci B. The effect of stinging nettle (Urtica dioica) seed oil on experimental colitis in rats. J Med Food. 2011;14(12):1554-61.
284. Konrad A, Mahler M, Arni S, Flogerzi B, Klingelhofer S, Seibold F. Ameliorative effect of IDS 30, a stinging nettle leaf extract, on chronic colitis. Int J Colorectal Dis. 2005;20(1):9-17.
285. Drozd J, Anuszewska E. Effects of bilberry fruit aqueous extract and selected antibiotics on immune response in mice. Acta Pol Pharm. 2009;66(2):181-5.
286. Graf D, Seifert S, Bub A, Frohling B, Dold S, Unger F, Rompp A, Watzl B. Anthocyanin-rich juice does not affect gut-associated immunity in Fischer rats. Mol Nutr Food Res. 2013;57(10):1753-61.
287. Jakesevic M, Xu J, Aaby K, Jeppsson B, Ahrne S, Molin G. Effects of bilberry (Vaccinium myrtillus) in combination with lactic acid bacteria on intestinal oxidative stress induced by ischemia-reperfusion in mouse. J Agric Food Chem. 2013;61(14):3468-78.
288. Feizpour A, Boskabady MH, Byrami G, Golamnezhad Z, Shafei MN. The effect of hydro-ethanolic extract of Achillea millefolium on muscarinic receptors of guinea pig tracheal smooth muscle. Indian J Pharmacol. 2013;45(1):13-7.
289. Koushyar H, Koushyar MM, Byrami G, Feizpour A, Golamnezhad Z, Boskabady MH. The Effect of Hydroethanol Extract of Achillea Millefolium on betaadrenoceptors of Guinea Pig Tracheal Smooth Muscle. Indian journal of pharmaceutical sciences. 2013;75(4):400-5.
290. Khan AU, Gilani AH. Blood pressure lowering, cardiovascular inhibitory and bronchodilatory actions of Achillea millefolium. Phytotherapy research: PTR. 2011;25(4):577-83.
291. Shin WJ, Lee KH, Park MH, Seong BL. Broad-spectrum antiviral effect of Agrimonia pilosa extract on influenza viruses. Microbiol Immunol. 2010; 54(1):11-9.
292. Fehri B, Ahmed MK, Aiache JM. The relaxant effect induced by Allium sativum L. bulb aqueous extract on rat isolated trachea. Pharmacogn Mag. 2011;7(25):14-8.
293. Nosalova G, Sutovska M, Mokry J, Kardosova A, Capek P, Khan MTH. Efficacy of herbal substances according to cough reflex. Minerva Biotecnologica. 2005;17(3):141-52.
294. Sutovska M, Nosalova G, Franova S, Kardosova A. The antitussive activity of polysaccharides from Althaea officinalis l., var. Robusta, Arctium lappa L., var. Herkules, and Prunus persica L., Batsch. Bratisl Lek Listy. 2007; 108(2):93-9.
295. Sutovska M, Nosalova G, Sutovsky J, Franova S, Prisenznakova L, Capek P. Possible mechanisms of dose-dependent cough suppressive effect of Althaea officinalis rhamnogalacturonan in guinea pigs test system. Int J Biol Macromol. 2009;45(1):27-32.
296. Sutovska M, Capek P, Franova S, Joskova M, Sutovsky J, Marcinek J, Kalman M. Antitussive activity of Althaea officinalis L. polysaccharide rhamnogalacturonan and its changes in guinea pigs with ovalbumine-induced airways inflammation. Bratisl Lek Listy. 2011;112(12):670-5.
297. Yamada H, Ohashi K, Atsumi T, Okabe H, Shimizu T, Nishio S, Li XD, Kosuge K, Watanabe H, Hara Y. Effects of tea catechin inhalation on methicillinresistant Staphylococcus aureus in elderly patients in a hospital ward. J Hosp Infect. 2003;53(3):229-31.
298. Peng Q, Huang Y, Hou B, Hua D, Yao F, Qian Y. Green Tea Extract Weakens the Antibacterial Effect of Amoxicillin in Methicillin-resistant Staphylococcus Aureus Infected Mice. Phytother Res. 2010;24(1):141-5.
299. Kempe C, Gruning H, Stasche N, Hormann K. Icelandic moss for prevention and treatment of inflammation and dryness of the oral mucosa. Laryngo-Rhino-Otologie. 1997;76(3):186-8.
300. Karimi S, Mohammadi A, Dadras H. The effect of Echinacea purpurea and Sambucus nigra L. on H9N2 avian influenza virus in infected chicken embryo. Veterinarski Arhiv. 2014;84(2):153-65.
301. Sharma M, Schoop R, Hudson JB. Echinacea as an antiinflammatory agent: the influence of physiologically relevant parameters. Phytotherapy research: PTR. 2009;23(6):863-7.
302. Bany J, Siwicki AK, Zdanowska D, Sokolnicka I, Skopinska-Rozewska E, Kowalczyk M. Echinacea purpurea stimulates cellular immunity and antibacterial defence independently of the strain of mice. Pol J Vet Sci. 2003;6(3 Suppl):3-5.
303. Fusco D, Liu X, Savage C, Taur Y, Xiao W, Kennelly E, Yuan J, Cassileth B, Salvatore M, Papanicolaou GA. Echinacea purpurea aerial extract alters course of influenza infection in mice. Vaccine. 2010;28(23):3956-62.
304. Lindenmuth GF, Lindenmuth EB. The efficacy of echinacea compound herbal tea preparation on the severity and duration of upper respiratory and flu symptoms: a randomized, double-blind placebo-controlled study. Journal of alternative and complementary medicine (New York, NY). 2000;6(4):327-34.
305. Grimm W, Muller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med. 1999;106(2):138-43.
306. Turner RB, Riker DK, Gangemi JD. Ineffectiveness of echinacea for prevention of experimental rhinovirus colds. Antimicrob Agents Chemother. 2000;44(6):1708-9.
307. Boskabady MH, Khatami A. Relaxant effect of Foeniculum vulgare on isolated guinea pig tracheal chains. Pharm Biol. 2003;41(3):211-5.
308. Boskabady MH, Khatami A, Nazari A. Possible mechanism(s) for relaxant effects of Foeniculum vulgare on guinea pig tracheal chains. Pharmazie. 2004;59(7):561-4.
309. Grienke U, Braun H, Seidel N, Kirchmair J, Richter M, Krumbholz A, von Grafenstein S, Liedl KR, Schmidtke M, Rollinger JM. Computer-Guided Approach to Access the Anti-influenza Activity of Licorice Constituents. J Nat Prod. 2014;77(3):563-70.
310. Boskabady MH, Ramazani-Assari M. Possible mechanism for the relaxant effect of Pimpinella anisum on guinea pig tracheal chains. Pharm Biol. 2004; 42(8):621-5.
311. Boskabady MH, Ramazani-Assari M. Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol. 2001;74(1):83-8.
312. Basbuelbuel G, Oezmen A, Biyik HH, Sen O. Antimitotic and antibacterial effects of the Primula veris L. flower extracts. Caryologia. 2008;61(1):88-91.
313. Rossi A, Serraino I, Dugo P, Di Paola R, Mondello L, Genovese T, Morabito D, Dugo G, Sautebin L, Caputi AP, et al. Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation. Free Radic Res. 2003; 37(8):891-900.
314. Getie M, Gebre-Mariam T, Rietz R, Hohne C, Huschka C, Schmidtke M, Abate A, Neubert RH. Evaluation of the anti-microbial and anti-inflammatory activities of the medicinal plants Dodonaea viscosa, Rumex nervosus and Rumex abyssinicus. Fitoterapia. 2003;74(1-2):139-43.
315. Orhan I, Deliorman-Orhan D, Ozcelik B. Antiviral activity and cytotoxicity of the lipophilic extracts of various edible plants and their fatty acids. Food Chem. 2009;115(2):701-5.
316. Hubbert M, Sievers H, Lehnfeld R, Kehrl W. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis-a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis. Eur J Med Res. 2006;11(1):20-6.
317. Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res. 2004;32(2):132-40.
318. Iten F, Saller R, Abel G, Reichling J. Additive Antmicrobial Effects of the Active Components of the Essential Oil of Thymus vulgaris-Chemotype Carvacrol. Planta Med. 2009;75(11):1231-6.
319. Mullen KA, Lee AR, Lyman RL, Mason SE, Washburn SP, Anderson KL. Short communication: an in vitro assessment of the antibacterial activity of plantderived oils. J Dairy Sci. 2014;97(9):5587-91.
320. Meister A, Bernhardt G, Christoffel V, Buschauer A. Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: Discrimination between drug and ethanol effects. Planta Med. 1999;65(6):512-6.
321. Wienkoetter N, Begrow F, Kinzinger U, Schierstedt D, Verspohl EJ. The effect of thyme extract on beta(2)-receptors and mucociliary clearance. Planta Med. 2007;73(7):629-35.
322. Turker AU, Usta C. Biological screening of some Turkish medicinal plant extracts for antimicrobial and toxicity activities. Nat Prod Res. 2008; 22(2):136-46.
323. Li ZY, Zhi HJ, Xue SY, Sun HF, Zhang FS, Jia JP, Xing J, Zhang LZ, Qin XM. Metabolomic profiling of the flower bud and rachis of Tussilago farfara with antitussive and expectorant effects on mice. J Ethnopharmacol. 2012;140(1):83-90.
324. Modarresi-Chahardehi A, Ibrahim D, Fariza-Sulaiman S, Mousavi L. Screening antimicrobial activity of various extracts of Urtica dioica. Rev Biol Trop. 2012; 60(4):1567-76.
325. Motamedi H, Seyyednejad SM, Bakhtiari A, Vafaei M. Introducing Urtica dioica, A Native Plant of Khuzestan, As an Antibacterial Medicinal Plant. Jundishapur journal of natural pharmaceutical products. 2014;9(4): e15904.
326. Kumaki Y, Wandersee MK, Smith AJ, Zhou Y, Simmons G, Nelson NM, Bailey KW, Vest ZG, Li JK, Chan PK, et al. Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin. Antiviral Res. 2011;90(1):22-32.
327. Sekizawa H, Ikuta K, Mizuta K, Takechi S, Suzutani T. Relationship between polyphenol content and anti-influenza viral effects of berries. J Sci Food Agric. 2013;93(9):2239-41.
328. Yassa N, Saeidnia S, Pirouzi R, Akbaripour M, Shafiee A. Three phenolic glycosides and immunological properties of Achillea millefolium from Iran, population of Golestan. Daru-Journal of Pharmaceutical Sciences. 2007;15(1):49-52.
329. Benedek B, Kopp B, Melzig MF. Achillea millefolium L. s.l.-Is the antiinflammatory activity mediated by protease inhibition? J Ethnopharmacol. 2007;113(2):312-7.
330. Toghyani M, Tohidi M, Toghyani M, Gheisari A, Tabeidian SA. Evaluation of yarrow (Achillea millefolium) as a natural growth promoter in comparison with a probiotic supplement on performance, humoral immunity and blood metabolites of broiler chicks. Journal of Medicinal Plants Research. 2011; 5(13):2748-54.
331. Pires JM, Mendes FR, Negri G, Duarte-Almeida JM, Carlini EA. Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs. Phytotherapy research: PTR. 2009;23(2):212-9.
332. Ivanova D, Vankova D, Nashar M. Agrimonia eupatoria tea consumption in relation to markers of inflammation, oxidative status and lipid metabolism in healthy subjects. Arch Physiol Biochem. 2013;119(1):32-7.
333. Colic M, Vucevic D, Kilibarda V, Radicevic N, Savic M. Modulatory effects of garlic extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2002;9(2):117-24.
334. Dorhoi A, Dobrean V, Zahan M, Virag P. Modulatory effects of several herbal extracts on avian peripheral blood cell immune responses. Phytother Res. 2006;20(5):352-8.
335. Mirabeau TY, Samson ES. Effect of Allium cepa and Allium sativum on some immunological cells in rats. Afr J Tradit Complement Altern Med. 2012; 9(3):374-9.
336. Chattopadhyay C, Chakrabarti N, Chatterjee M, Mukherjee S, Sarkar K, Chaudhuri AR. Black tea (Camellia sinensis) decoction shows immunomodulatory properties on an experimental animal model and in human peripheral mononuclear cells. Pharmacognosy research. 2012;4(1):15-21.
337. Hendricks R, Pool EJ. The in vitro effects of rooibos and black tea on immune pathways. J Immunoassay Immunochem. 2010;31(2):169-80.
338. Chatterjee P, Chandra S, Dey P, Bhattacharya S. Evaluation of antiinflammatory effects of green tea and black tea: A comparative in vitro study. Journal of advanced pharmaceutical technology & research. 2012;3(2): 136-8.
339. Wilasrusmee C, Siddiqui J, Bruch D, Wilasrusmee S, Kittur S, Kittur DS. In vitro immunomodulatory effects of herbal products. Am Surg. 2002;68(10):860-4.
340. Koeberle A, Bauer J, Verhoff M, Hoffmann M, Northoff H, Werz O. Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1. Biochem Biophys Res Commun. 2009;388(2):350-4.
341. Neyestani TR, Gharavi A, Kalayi A. Selective effects of tea extract and its phenolic compounds on human peripheral blood mononuclear cell cytokine secretions. Int J Food Sci Nutr. 2009;60 Suppl 1:79-88.
342. Nicod N, Chiva-Blanch G, Giordano E, Davalos A, Parker RS, Visioli F. Green tea, cocoa, and red wine polyphenols moderately modulate intestinal inflammation and do not increase high-density lipoprotein (HDL) production. J Agric Food Chem. 2014;62(10):2228-32.
343. Pajonk F, Riedisser A, Henke M, McBride WH, Fiebich B. The effects of tea extracts on proinflammatory signaling. BMC Med. 2006;4:28.
344. 2-induced inflammatory gene expression in macrophages. J Inflamm Res. 2014;7:103-12.
345. Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. Arthritis Rheum. 2002;46(8):2079-86.
346. Takano K, Nakaima K, Nitta M, Shibata F, Nakagawa H. Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. J Agric Food Chem. 2004;52(14):4571-6.
347. Tomita M, Irwin KI, Xie ZJ, Santoro TJ. Tea pigments inhibit the production of type 1 (T-H1) and type 2 (T-H2) helper T cell cytokines in CD4(+) T cells. Phytother Res. 2002;16(1):36-42.
348. Wang H, Shi S, Gu X, Zhu C, Wei G, Wang H, Bao B, Fan H, Zhang W, Duan J, et al. Homogalacturonans from preinfused green tea: structural characterization and anticomplementary activity of their sulfated derivatives. J Agric Food Chem. 2013;61(46):10971-80.
349. Monobe M, Ema K, Tokuda Y, Maeda-Yamamoto M. Effect on the epigallocatechin gallate/epigallocatechin ratio in a green tea (Camellia sinensis L.) extract of different extraction temperatures and its effect on IgA production in mice. Biosci, Biotechnol, Biochem. 2010;74(12):2501-3.
350. Li W, Ashok M, Li J, Yang H, Sama AE, Wang H. A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One. 2007;2(11):e1153.
351. Arzi A, Ghorbanzadeh B, Nazari Khorasgani Z. Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats. Jundishapur journal of natural pharmaceutical products. 2013;8(1):10-4.
352. Ingolfsdottir K, Jurcic K, Fischer B, Wagner H. Immunologically active polysaccharide from Cetraria islandica. Planta Med. 1994;60(6):527-31.
353. Olafsdottir ES, Ingolfsdottir K, Barsett H, Paulsen BS, Jurcic K, Wagner H. Immunologically active (1→3)-(1rarr;4)-alpha-D-glucan from Cetraria islandica. Phytomedicine 1999;6(1):33-39.
354. Freysdottir J, Omarsdottir S, Ingolfsdottir K, Vikingsson A, Olafsdottir ES. In vitro and in vivo immunomodulating effects of traditionally prepared extract and purified compounds from Cetraria islandica. Int Immunopharmacol. 2008;8(3):423-30.
355. Bauer VR, Jurcic K, Puhlmann J, Wagner H. Immunologic in vivo and in vitro studies on Echinacea extracts. Arzneimittelforschung. 1988;38(2):276-81.
356. Yin SY, Wang WH, Wang BX, Aravindaram K, Hwang PI, Wu HM, Yang NS. Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses. BMC Genomics. 2010;11:612.
357. Bodinet C, Lindequist U, Teuscher E, Freudenstein J. Influence of peroral application of a herbal immunomodulator on the antibody production of Peyer's patches cells. Arzneimittelforschung. 2004;54(2):114-8.
358. Classen B, Thude S, Blaschek W, Wack M, Bodinet C. Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2006; 13(9-10):688-94.
359. Hwang SA, Dasgupta A, Actor JK. Cytokine production by non-adherent mouse splenocyte cultures to Echinacea extracts. Clinica chimica acta; international journal of clinical chemistry. 2004;343(1-2):161-6.
360. Matthias A, Banbury L, Bone KM, Leach DN, Lehmann RP. Echinacea alkylamides modulate induced immune responses in T-cells. Fitoterapia. 2008;79(1):53-8.
361. Pugh ND, Balachandran P, Lata H, Dayan FE, Joshi V, Bedir E, Makino T, Moraes R, Khan I, Pasco DS. Melanin: dietary mucosal immune modulator from Echinacea and other botanical supplements. Int Immunopharmacol. 2005;5(4):637-47.
362. Randolph RK, Gellenbeck K, Stonebrook K, Brovelli E, Qian Y, Bankaitis-Davis D, Cheronis J. Regulation of human immune gene expression as influenced by a commercial blended Echinacea product: preliminary studies. Exp Biol Med. 2003;228(9):1051-6.
363. Rininger JA, Kickner S, Chigurupati P, McLean A, Franck Z. Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. J Leukoc Biol. 2000;68(4):503-10.
364. Senchina DS, McCann DA, Asp JM, Johnson JA, Cunnick JE, Kaiser MS, Kohut ML. Changes in immunomodulatory properties of Echinacea spp. root infusions and tinctures stored at 4 degrees C for four days. Clinica chimica acta; international journal of clinical chemistry. 2005;355(1-2):67-82.
365. Wagner H, Jurcic K. Immunological studies of Revitonil((R)), a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2002;9(5):390-7.
366. Wang CY, Chiao MT, Yen PJ, Huang WC, Hou CC, Chien SC, Yeh KC, Yang WC, Shyur LF, Yang NS. Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell-and gene-based study. Genomics. 2006; 88(6):801-8.
367. Wang CY, Staniforth V, Chiao MT, Hou CC, Wu HM, Yeh KC, Chen CH, Hwang PI, Wen TN, Shyur LF, et al. Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells. BMC Genomics. 2008;9:479.
368. Wildfeuer A, Mayerhofer D. Study of the influence of phytopreparations on the cellular function of body defense. Arzneimittel-Forschung/Drug Research. 1994;44-1(3):361-6.
369. Matthias A, Banbury L, Stevenson LM, Bone KM, Leach DN, Lehmann RP. Alkylamides from echinacea modulate induced immune responses in macrophages. Immunol Invest. 2007;36(2):117-30.
370. Cech NB, Kandhi V, Davis JM, Hamilton A, Eads D, Laster SM. Echinacea and its alkylamides: effects on the influenza A-induced secretion of cytokines, chemokines, and PGE(2) from RAW 264.7 macrophage-like cells. Int Immunopharmacol. 2010;10(10):1268-78.
371. Chicca A, Raduner S, Pellati F, Strompen T, Altmann KH, Schoop R, Gertsch J. Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int Immunopharmacol. 2009;9(7-8):850-8.
372. Dong GC, Chuang PH, Chang KC, Jan PS, Hwang PI, Wu HB, Yi M, Zhou HX, Chen HM. Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor. Pharm Res. 2009;26(2):375-81.
373. Sharma SM, Anderson M, Schoop SR, Hudson JB. Bactericidal and antiinflammatory properties of a standardized Echinacea extract (Echinaforce (R)): Dual actions against respiratory bacteria. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2010;17(8-9):563-8.
374. Zhai Z, Solco A, Wu L, Wurtele ES, Kohut ML, Murphy PA, Cunnick JE. Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells, indicative of alternative macrophage activation. J Ethnopharmacol. 2009;122(1):76-85.
375. Freier DO, Wright K, Klein K, Voll D, Dabiri K, Cosulich K, George R. Enhancement of the humoral immune response by Echinacea purpurea in female Swiss mice. Immunopharmacol Immunotoxicol. 2003;25(4):551-60.
376. Steinmüller C, Roesler J, Grottrup E, Franke G, Wagner H, Lohmann-Matthes ML. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. Int J Immunopharmacol. 1993;15(5):605-14.
377. Roesler J, Emmendorffer A, Steinmuller C, Luettig B, Wagner H, Lohmann-Matthes ML. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system. Int J Immunopharmacol. 1991;13(7):931-41.
378. Skopinska-Rozewska E, Sokolnicka I, Siwicki AK, Stankiewicz W, Dabrowski MP, Buchwald W, Krajewska-Patan A, Mielcarek S, Mscisz A, Furmanowa M. Dose-dependent in vivo effect of Rhodiola and Echinacea on the mitogeninduced lymphocyte proliferation in mice. Pol J Vet Sci. 2011;14(2):265-72.
379. Uluisik D, Keskin E. Effects of ginseng and echinacea on cytokine mRNA expression in rats. Sci World J. 2012;2012:942025.
380. Zwickey H, Brush J, Iacullo CM, Connelly E, Gregory WL, Soumyanath A, Buresh R. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study. Phytotherapy research: PTR. 2007;21(11):1109-12.
381. O'Neil J, Hughes S, Lourie A, Zweifler J. Efects of echinacea on the frequency of upper respiratory tract symptoms: a randomized, double-blind, placebocontrolled trial. Ann Allergy Asthma Immunol. 2008;100(4):384-8.
382. Schwarz E, Parlesak A, Henneicke-von Zepelin HH, Bode JC, Bode C. Effect of oral administration of freshly pressed juice of Echinacea purpurea on the number of various subpopulations of B-and T-lymphocytes in healthy volunteers: results of a double-blind, placebo-controlled cross-over study. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2005;12(9):625-31.
383. Schulten B, Bulitta M, Ballering-Bruhl B, Koster U, Schafer M. Efficacy of Echinacea purpurea in patients with a common cold-A placebo-controlled, randomised, double-blind clinical trial. Arzneimittel-Forschung-Drug Research. 2001; 51(7):563-8.
384. Taylor JA, Weber W, Standish L, Quinn H, Goesling J, McGann M, Calabrese C. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. Jama. 2003;290(21):2824-30.
385. Kaileh M, Vanden Berghe W, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol. 2007;113(3):510-6.
386. Choi EM, Hwang JK. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia. 2004;75(6):557-65.
387. Tanira MOM, Shah AH, Mohsin A, Ageel AM, Qureshi S. Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals. Phytother Res. 1996;10(1):33-6.
388. Zendehdel M, Taati M, Amoozad M, Hamidi F. Antinociceptive effect of the aqueous extract obtained from Foeniculum vulgare in mice: the role of histamine H-1 and H-2 receptors. Iranian Journal of Veterinary Research. 2012;13(2):100-6.
389. Bordbar N, Karimi MH, Amirghofran Z. The effect of glycyrrhizin on maturation and T cell stimulating activity of dendritic cells. Cell Immunol. 2012;280(1):44-9.
390. Cheel J, Van Antwerpen P, Tumova L, Onofre G, Vokurkova D, Zouaoui-Boudjeltia K, Vanhaeverbeek M, Neve J. Free radical-scavenging, antioxidant and immunostimulating effects of a licorice infusion (Glycyrrhiza glabra L.). Food Chem. 2010;122(3):508-17.
391. Chen CL, Zhang DD. Anti-inflammatory effects of 81 chinese herb extracts and their correlation with the characteristics of traditional chinese medicine. Evidence-based complementary and alternative medicine: eCAM. 2014; 2014:985176.
392. Herold A, Cremer L, Calugaru A, Tamas V, Ionescu F, Manea S, Szegli G. Hydroalcoholic plant extracts with anti-inflammatory activity. Roum Arch Microbiol Immunol. 2003;62(1-2):117-29.
393. Brush J, Mendenhall E, Guggenheim A, Chan T, Connelly E, Soumyanath A, Buresh R, Barrett R, Zwickey H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytotherapy research: PTR. 2006;20(8):687-95.
394. Mohan M, Austin A, Gulecha VS, Aurangabadkar VM, Balaraman R, Thirugnanasampathan S. Analgesic and anti-inflammatory activity of a polyherbal formulation (PHFAROGH). Orient Pharm Exp Med. 2009;9(3):232-7.
395. Kaithwas G, Majumdar DK. Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation. ISRN inflammation. 2013;2013:735158.
396. Vineyard KR, Warren LK, Kivipelto J. Effect of dietary omega-3 fatty acid source on plasma and red blood cell membrane composition and immune function in yearling horses. J Anim Sci. 2010;88(1):248-57.
397. Kaithwas G, Mukherjee A, Chaurasia AK, Majumdar DK. Anti-inflammatory, analgesic and antipyretic activities of Linum usitatissimum L. (flaxseed/linseed) fixed oil. Indian J Exp Biol. 2011;49(12):932-8.
398. Singh S, Nair V, Jain S, Gupta YK. Evaluation of anti-inflammatory activity of plant lipids containing alpha-linolenic acid. Indian J Exp Biol. 2008; 46(6):453-6.
399. Ferreira Martins CA, Weffort-Santos AM, Gasparetto JC, Leal Badaro Trindade AC, Otuki MF, Pontarolo R. Malva sylvestris L. extract suppresses desferrioxamineinduced PGE(2) and PGD(2) release in differentiated U937 cells: the development and validation of an LC-MS/MS method for prostaglandin quantification. Biomed Chromatogr. 2014;28(7):986-93.
400. El Ghaoui WB, Ghanem EB, Chedid LA, Abdelnoor AM. The effects of Alcea rosea L., Malva sylvestris L. and Salvia libanotica L. water extracts on the production of anti-egg albumin antibodies, interleukin-4, gamma interferon and interleukin-12 in BALB/c mice. Phytotherapy research: PTR. 2008; 22(12):1599-604.
401. Esteves PF, Sato A, Esquibel MA, de Campos-Buzzi F, Meira AV, Cechinel-Filho V. Antinociceptive Activity of Malva sylvestris L. Lat Am J Pharm. 2009; 28(3):454-6.
402. Prudente AS, Loddi AM, Duarte MR, Santos AR, Pochapski MT, Pizzolatti MG, Hayashi SS, Campos FR, Pontarolo R, Santos FA, et al. Pre-clinical antiinflammatory aspects of a cuisine and medicinal millennial herb: Malva sylvestris L. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2013;58:324-31.
403. Amirghofran Z, Azadbakht M, Karimi MH. Evaluation of the immunomodulatory effects of five herbal plants. J Ethnopharmacol. 2000;72(1-2):167-72.
404. Bhaskaran N, Shukla S, Srivastava JK, Gupta S. Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity. Int J Mol Med. 2010;26(6):935-40.
405. Presibella MM, Santos CAM, Weffort-Santos AM. In vitro antichemotactic activity of Chamomilla recutita hydroethanol extract. Pharm Biol. 2007; 45(2):124-30.
406. Safayhi H, Sabieraj J, Sailer ER, Ammon HP. Chamazulene: an antioxidanttype inhibitor of leukotriene B4 formation. Planta Med. 1994;60(5):410-3.
407. Srivastava JK, Pandey M, Gupta S. Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci. 2009;85(19-20):663-9.
408. Ghonime M, Eldomany R, Abdelaziz A, Soliman H. Evaluation of immunomodulatory effect of three herbal plants growing in Egypt. Immunopharmacol Immunotoxicol. 2011;33(1):141-5.
409. de Souza Reis LS, Frazatti-Gallina NM, de Lima PR, Giuffrida R, Albas A, Oba E, Pardo PE. Efficiency of Matricaria chamomilla CH12 and number of doses of rabies vaccine on the humoral immune response in cattle. J Vet Sci. 2008;9(4):433-5.
410. Rocha NF, Rios ER, Carvalho AM, Cerqueira GS, Lopes Ade A, Leal LK, Dias ML, de Sousa DP, de Sousa FC. Anti-nociceptive and anti-inflammatory activities of (-)-alpha-bisabolol in rodents. Naunyn Schmiedebergs Arch Pharmacol. 2011;384(6):525-33.
411. Smolinski AT, Pestka JJ. Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2003;41(10):1381-90.
412. Tomic M, Popovic V, Petrovic S, Stepanovic-Petrovic R, Micov A, Pavlovic-Drobac M, Couladis M. Antihyperalgesic and antiedematous activities of bisabolol-oxides-rich matricaria oil in a rat model of inflammation. Phytotherapy research: PTR. 2014;28(5):759-66.
413. Gobel H, Fresenius J, Heinze A, Dworschak M, Soyka D. Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type. Nervenarzt. 1996;67(8):672-81.
414. Ocana-Fuentes A, Arranz-Gutierrez E, Senorans FJ, Reglero G. Supercritical fluid extraction of oregano (Origanum vulgare) essentials oils: antiinflammatory properties based on cytokine response on THP-1 macrophages. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2010;48(6):1568-75.
415. Szaboova R, Laukova A, Lu C, Strompfova V, Simonova MP, Placha I, Vasilkova Z, Chrenkova M, Faix S. Beneficial effect of plant extracts in rabbit husbandry. Acta Vet Brno. 2012;81(3):245-50.
416. Walter BM, Bilkei G. Immunostimulatory effect of dietary oregano etheric oils on lymphocytes from growth-retarded, low-weight growing-finishing pigs and productivity. Tijdschr Diergeneeskd. 2004;129(6):178-81.
417. Cavalcante Melo FH, Rios ER, Rocha NF, Cito Mdo C, Fernandes ML, de Sousa DP, de Vasconcelos SM, de Sousa FC. Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice. J Pharm Pharmacol. 2012;64(12):1722-9.
418. Khaki MRA, Pahlavan Y, Sepehri G, Sheibani V, Pahlavan B. Antinociceptive Effect of Aqueous Extract of Origanum vulgare L. in Male Rats: Possible Involvement of the GABAergic System. Iranian Journal of Pharmaceutical Research. 2013;12(2):407-13.
419. Pahlavan Y, Sepehri G, Sheibani V, Khaki MA, Gojazadeh M, Pahlavan B, Pahlavan F. Study the Antinociceptive Effect of Intracerebroventricular Injection of Aqueous Extract of Origanum Vulgare Leaves in Rat: Possible Involvement of Opioid System. Iranian Journal of Basic Medical Sciences. 2013;16(10):1109-13.
420. Stelter K, Frahm J, Paulsen J, Berk A, Kleinwachter M, Selmar D, Danicke S. Effects of oregano on performance and immunmodulating factors in weaned piglets. Arch Anim Nutr. 2013;67(6):461-76.
421. Conforti F, Tundis R, Marrelli M, Menichini F, Statti GA, De Cindio B, Menichini F, Houghton PJ. Protective effect of Pimpinella anisoides ethanolic extract and its constituents on oxidative damage and its inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Med Food. 2010;13(1):137-41.
422. Mahmood MS, Hussain I, Ahmad MF, Khan A, Abbas RZ, Rafiq A. Immunomodulatory effects of Pimpinella anisum L. (Aniseed) in Broiler Chicks against Newcastle Disease and Infectious Bursal Disease Viruses. Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas. 2014;13(5):458-65.
423. Durrani FR, Sultan A, Ahmed S, Chand N, Khattak FM, Durrani Z. Efficacy of aniseed extract as immune stimulant and growth promoter in broiler chicks. Pakistan journal of biological sciences: PJBS. 2007;10(20):3718-21.
424. Marchesan M, Paper DH, Hose S, Franz G. Investigation of the antiinflammatory activity of liquid extracts of Plantago lanceolata L. Phytother Res. 1998;12:S33-4.
425. Vigo E, Cepeda A, Gualillo O, Perez-Fernandez R. In-vitro anti-inflammatory activity of Pinus sylvestris and Plantago lanceolata extracts: effect on inducible NOS, COX-1, COX-2 and their products in J774A.1 murine macrophages. J Pharm Pharmacol. 2005;57(3):383-91.
426. Tunon H, Olavsdotter C, Bohlin L. Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. J Ethnopharmacol. 1995;48(2):61-76.
427. Cuevas-Rodriguez EO, Dia VP, Yousef GG, Garcia-Saucedo PA, Lopez-Medina J, Paredes-Lopez O, Gonzalez De Mejia E, Ann Lila M. Inhibition of Proinflammatory Responses and Antioxidant Capacity of Mexican Blackberry (Rubus spp.) Extracts. J Agric Food Chem. 2010;58(17):9542-8.
428. Dai J, Patel JD, Mumper RJ. Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. J Med Food. 2007;10(2):258-65.
429. Denev P, Kratchanova M, Ciz M, Lojek A, Vasicek O, Blazheva D, Nedelcheva P, Vojtek L, Hyrsl P. Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts. Acta Biochim Pol. 2014;61(2):359-67.
430. Nasef NA, Mehta S, Murray P, Marlow G, Ferguson LR. Anti-inflammatory activity of fruit fractions in vitro, mediated through toll-like receptor 4 and 2 in the context of inflammatory bowel disease. Nutrients. 2014;6(11):5265-79.
431. Lee MJ, Song HJ, Jeong JY, Park SY, Sohn UD. Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells. The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 2013;17(1):81-7.
432. Suleyman H, Demirezer LO, Kuruuzum A, Banoglu ZN, Gocer F, Ozbakir G, Gepdiremen A. Antiinflammatory effect of the aqueous extract from Rumex patientia L. roots. J Ethnopharmacol. 1999;65(2):141-8.
433. Suleyman H, Demirezer LO, Kuruuzum-Uz A. Analgesic and antipyretic activities of Rumex patientia extract on mice and rabbits. Pharmazie. 2001;56(10):815-7.
434. Mekonnen T, Urga K, Engidawork E. Evaluation of the diuretic and analgesic activities of the rhizomes of Rumex abyssinicus Jacq in mice. J Ethnopharmacol. 2010;127(2):433-9.
435. Bonaterra GA, Heinrich EU, Kelber O, Weiser D, Metz J, Kinscherf R. Antiinflammatory effects of the willow bark extract STW 33-I (Proaktiv((R))) in LPS-activated human monocytes and differentiated macrophages. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2010;17(14):1106-13.
436. Farinacci M, Colitti M, Sgorlon S, Stefanon B. Immunomodulatory activity of plant residues on ovine neutrophils. Vet Immunol Immunopathol. 2008; 126(1-2):54-63.
437. Fiebich BL, Chrubasik S. Effects of an ethanolic Salix extract on the release of selected inflammatory mediators in vitro. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2004; 11(2-3):135-8.
438. Khayyal MT, El-Ghazaly MA, Abdallah DM, Okpanyi SN, Kelber O, Weiser D. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittel-Forschung-Drug Research. 2005;55(11):677-87.
439. Szaboova R, Chrastinova L, Laukova A, Strompfova V, Simonova MP, Vasilkova Z, Placha I, Cobanova K, Chrenkova M. Effect of combinative administration of bacteriocin-producing and probiotic strain Enterococcus faecium CCM 4231 and sage plant extract on rabbits. Afr J Microbiol Res. 2012;6(23):4868-73.
440. Ryzner M, Takacova J, Cobanova K, Placha I, Venglovska K, Faix S. Effect of dietary Salvia officinalis essential oil and sodium selenite supplementation on antioxidative status and blood phagocytic activity in broiler chickens. Acta Vet Brno. 2013;82(1):43-8.
441. Carrasco FR, Schmidt G, Romero AL, Sartoretto JL, Caparroz-Assef SM, Bersani-Amado CA, Cuman RK. Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor-and cell-mediated responses. J Pharm Pharmacol. 2009;61(7):961-7.
442. Alves Rodrigues MR, Sales Kanazawa LK, Neves TL M d, da Silva CF, Horst H, Pizzolatti MG, Soares Santos AR, Baggio CH, de Paula Werner MF. Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. J Ethnopharmacol. 2012;139(2):519-26.
443. Qnais EY, Abu-Dieyeh M, Abdulla FA, Abdalla SS. The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts. Pharm Biol. 2010;48(10):1149-56.
444. Juhas S, Cikos S, Czikkova S, Vesela J, Ilkova G, Hajek T, Domaracka K, Domaracky M, Bujnakova D, Rehak P, et al. Effects of borneol and thymoquinone on TNBSinduced colitis in mice. Folia Biol. 2008;54(1):1-7.
445. Oniga I, Parvu AE, Toiu A, Benedec D. Effects of Salvia officinalis L. extract on experimental acute inflammation. Rev Med Chir Soc Med Nat Iasi. 2007; 111(1):290-4.
446. Gorudko IV, Timoshenko AV. Effect of signaling inhibitors on the release of lysozyme from human neutrophils activated by Sambucus nigra agglutinin. Biochemistry Biokhimiia. 2000;65(8):940-5.
447. Modaresi M. A Comparative Analysis of the Effects of Garlic, Elderberry and Black Seed Extract on the Immune System in Mice. J Anim Vet Adv. 2012; 11(4):458-61.
448. Amirghofran Z, Hashemzadeh R, Javidnia K, Golmoghaddam H, Esmaeilbeig A. In vitro immunomodulatory effects of extracts from three plants of the Labiatae family and isolation of the active compound(s). J Immunotoxicol. 2011;8(4):265-73.
449. Fachini-Queiroz FC, Kummer R, Estevao-Silva CF, de Barros Carvalho MD, Cunha JM, Grespan R, Bersani-Amado CA, Nakamura Cuman RK. Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine 2012.
450. Ocana A, Reglero G. Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages. J Obes. 2012;2012: 104706.
451. Najafi P, Torki M. Performance, Blood Metabolites and Immunocompetaence of Broiler Chicks Fed Diets Included Essentioal Oils of Medicinal Herbs. J Anim Vet Adv. 2010;9(7):1164-8.
452. Taherian AA, Babaei M, Vafaei AA, Jarrahi M, Jadidi M, Sadeghi H. Antinociceptive effects of hydroalcoholic extract of Thymus vulgaris. Pak J Pharm Sci. 2009;22(1):83-9.
453. Hwangbo C, Lee HS, Park J, Choe J, Lee J-H. The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages. Int Immunopharmacol. 2009;9(13-14):1578-84.
454. Akbay P, Basaran AA, Undeger U, Basaran N. In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. Phytotherapy research: PTR. 2003;17(1):34-7.
455. Basaran AA, Ceritoglu I, Undeger U, Basaran N. Immunomodulatory activities of some Turkish medicinal plants. Phytother Res. 1997;11(8):609-11.
456. Daoudi A, Aarab L, Abdel-Sattar E. Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants. Toxicol Ind Health. 2013;29(3):245-53.
457. Johnson TA, Sohn J, Inman WD, Bjeldanes LF, Rayburn K. Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2013;20(2):143-7.
458. Bolfa P, Catoi C, Gal A, Taulescu M, Fit N, Nadas G, Niculae M, Tamas M, Cuc C, Spinu M. Screening of five alcoholic plants extracts effects on the immune status of Romanian EIAV infected horses. Romanian Biotechnological Letters. 2011;16(6):6730-9.
459. Dana SC, Spinu M, Brudasca F, Opris A, Duca G: Alcoholic nettle extraction influences phagocytosis and body mass in broiler chickens. In: Bulletin of the University of Agricultural Sciences and Veterinary Medicine, Vol 61: VETERINARY MEDICINE. Volume 61, edn. Edited by Marghitas LA; 2004: 233-236.
460. Hajhashemi V, Klooshani V. Antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. Avicenna journal of phytomedicine. 2013;3(2):193-200.
461. Sautebin L, Rossi A, Serraino I, Dugo P, Di Paola R, Mondello L, Genovese T, Britti D, Peli A, Dugo G, et al. Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. Planta Med. 2004;70(8):745-52.
462. Luo H, Lv XD, Wang GE, Li YF, Kurihara H, He RR. Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice. Int J Food Sci Nutr. 2014;65(5):594-601.