Relaxant effects of different fractions from Tymus vulgaris on guinea-pig tracheal chains

Biological Research

Volumn 45, Issue 1, 2012, Pages 67-73

  Keyhanmanesh, Rana ^a,b   Boskabady, Mohammad H ^c  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Fractions; Guinea pig; Relaxant effects; Trachea; Tymus vulgaris

Indexed keywords

BRONCHODILATING AGENT; DICHLOROMETHANE; HEXANE; METHANOL; N-HEXANE; PLANT EXTRACT; THEOPHYLLINE; VEGETABLE OIL; WATER;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; FEMALE; GUINEA PIG; MALE; MUSCLE RELAXATION; PHYTOTHERAPY; SMOOTH MUSCLE; SOLUTION AND SOLUBILITY; THYMUS (PLANT); TRACHEA;

ANIMALS; BRONCHODILATOR AGENTS; FEMALE; GUINEA PIGS; HEXANES; MALE; METHANOL; METHYLENE CHLORIDE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PHYTOTHERAPY; PLANT EXTRACTS; PLANT OILS; SOLUTIONS; THEOPHYLLINE; THYMUS PLANT; TRACHEA; WATER;

CAVIA;

EID: 84861846634     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602012000100009     Document Type: Article

References (38)

1. BABAEI M, ABARGHOEI ME, ANSARI R, VAFAEI AA, TAHERIAN AA, AKHAVAN MM, TOUSSY G, MOUSAVI S (2008) Antispasmodic effect of hydroalcoholic extract of Thymus vulgaris on the guinea-pig ileum. Nat Prod Res 22: 1143-1150.
2. BARANAUSKIENE R, VENSKUTONIS PR, VISKELIS P, DAMBRAUSKIENE E (2003). Influence of nitrogen fertilizers on the yield and composition of thyme (Thymus vulgaris). J Agri Food Chem 51: 7751-7758.
3. BOSKABADY MH, ASLANI MR, KIANI S (2006) Relaxant effects of Tymus volgari on guinea pig tracheal chains and its possible mechanism(s). Phytother Res 20: 28-33.
4. BOSKABADY MH, JANDAGHI P (2003) Relaxant effect of carvacrol on guinea pig tracheal chainsand its possible mechanisms. Pharmazie 58: 661-663.
5. BOSKABADY MH, RAKHSHANDAH H, MOETAMEDSHARIATI V (1998) Bronchodilatory and anticholinergic effects of Carum copticum on isolated guinea pig tracheal chains. Med J I R Iran 11: 329-334.
6. BUCKLE DR, ARCH JRS, BOERING NE, FOSTER KA, TAYLOR JF, TAYLOR SG, SHAW DJ (1993) Relaxation effect of potassium channel activators BRL 38227 and Pinacidil on guinea pig and human airway smooth muscle, and blockade of their effects by libenclamide and BRL 31660. Pulmon Pharmacol 6: 77-86.
7. CZYGAN C-F (1989) Thymian, Thymi Herba. In: Wichtl M. ed. Teedrogen, 2nd ed. Stuttgart, Wissenschaftliche Verlagsgesellschaft: 498-500.
8. DALY JW, JACOBSON KA, UKENA D. (1987). Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 230: 41-63.
9. ENGELBERTZ J, SCHWENK T, KINZINGER U, SCHIERSTEDT D, VERSPOHL EJ (2008) Thyme extract, but not thymol, inhibits endothelininduced contractions of isolated rat trachea. Planta Med 74: 1436-1440.
10. ESCOP (1997) "Thymi herba." Monographs on the Medicinal Uses of Plant Drugs. Exeter, U.K.: European Scientific Cooperative on Phytotherapy.
11. FREYTAG A. ber den Einflu von (1933) Thymianl, Thymol und Carvacrol auf die Flimmerbewegung. Pflügers Archiv, Eur J Physiol 232: 346-350.
12. HARAGUCHI H., SAITO T., ISHIKAWA H., DATE H., KATAOKA S., TAMURA Y, MIZUTANI K (1996) Antiperoxidative components in Thymus vulgaris. Planta Med 62: 217-221.
13. HOLROYDE MC (1986) The influence of epithelium on the responsiveness of guinea pig isolated trachea. Br J Pharmacol 87: 501-507.
14. JANSSEN AM, SCHEFFER JJC, Baerheim-Svendsen A (1987) Antimicrobial activity of essential oils: A1976-1986 literature review. Aspects of the test methods. Planta Med 53: 395-398.
15. JAVANMARDI J, KHALIGHI A, KASHI A, BAIS HP, VIVANCO JM (2002) Chemical characterization of basil (Ocimum basilicum L.) found in local accessions and used in traditional medicines in Iran. J Agri Food Chem 50: 5878-5883.
16. JUVEN BJ, KANNER J, SCHVED F, WEISSSLOWICZ H (1994) Factors that interact with the antibacterial action of thyme essential oil and its active constituents. J Appl Bacteriol 76:626-631.
17. LEMIERE C, CARTIER A, LEHRER SB, MALO JL (1996) Occupational asthma caused by aromatic herbs. Allergy 51: 647-649.
18. LEONARDS B, RAMPART M, HERMAN AG (1992) Selective M3 muscarinic receptors inhibit smooth muscle contraction in rabit trachea without increasing the release of acetylcholine. J Pharmacol Exp Ther 263: 773-770.
19. 2+ modulator in normal and albumin sensitised guinea pig trachea. Eur J Pharmacol 249: 53-63.
20. MEISTER A, BERNHARDT G, CHRISTOFFEL V, BUSCHAUER A (1999) Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects. Planta Med 65: 512-516.
21. 2+ antagonists on acetylcholine induced contraction in molluscan (Mytilus edulis) smooth muscle. Gen Pharmacol 24: 1419-1423.
22. MOSSA JS, Al-Yahya MA, Al-Meshal IA (1987) Medicinal plants of Saudi Arabia. Riyadh, Saudi Arabia, King Saud University Libraries 1.
23. Muller-Limmroth W, FROHLICH HH (1980) Effect of various phytotherapeutic expectorants on mucociliary transport. Fortschr Med 98: 95-101.
24. PASTEUR N, MENASHEROV M, RAVID U, JUVEN B (1995) Antifungal activity of oregano and thyme essential oils applied as fumigants against fungi attacking stored grain. J food protection 58: 81-85.
25. Perez-Guerrero C, SUAREZ J, HERRERA MD, MARHUNNDA E (1997) Spasmolytic effect of tetrazepam on rat duodenum and guinea pig ileum. Pharmacol Res 35: 493-494.
26. PERRUCCI S CECCHINI S, PRETTI C, VARRIALE COGNETTI AM, MACCHIONI G, FLAMINI G, CIONI PL (1995) In vitro antimycotic activity of some natural products against Saprolegnia ferax. Phytother Res 9: 147-149.
27. RABE, KF, MAGNUSSEN, H, DENT, G (1995) Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J 8: 637-642.
28. REITER M, BRANDT W (1985) Relaxant effects on tracheal and ileal smooth muscles of the guinea pig. Arzneimittelforschung 35: 408-414.
29. SCHIIF F, EINFLUSS VON (1932) Azetylcholin, Adrenalin, Histamin und Thymianextrakt auf die. Bronchialschleimhautsekretion; zugleich ein Beitrag zur Messung der Bronchialschleimhautsekretion. Naunyn-Schmiedebergs Archiv für Pharmakologie 166: 22-25.
30. SENATORE F (1996) Influence of harvesting time on yield and composition of the essential oil of a thyme (Thymus pulegioides L.) growing wild in Campania (southern Italy). J Agri Food Chem 44: 1327-1332.
31. SIMON JE, MORALES MR, PHIPPEN WB, VIEIRA RF, HAO Z (1999) A source of aroma compounds and a popular culinary and ornamental herb. In J Janick (Ed.), Perspectives on new crops and new uses (pp.499-505). Alexandria,VA: ASHS Press.
32. th ed. Rahway, N.J.: Merck & Co., Inc.
33. TANTAOUIELARAKI A, ERRIFI A (1994) Antifungal activity of essential oils when associated with sodium chloride or fatty acids. Grasas-y-aceites 45: 363-369.
34. VAN DEN BROUCKE CO, LEMLI JA (1983) Spasmolytic activity of the flavonoids from Thymus vulgaris. Pharm Weekbl 5: 9-14.
35. VAN DEN BROUCKE CO, LEMLI JA (1981) Pharmalogical and chemical investigation of thyme liquid extracts. Planta Medica 41: 129-135.
36. VAN DEN BROUCKE CO (1980) Chemical and pharmacological investigation on Thymi herba and its liquid extracts. Planta Med 39: 253-254.
37. VOLLMER H (1932) Untersuchungen über Expektorantien und den Mechanismus ihrer Wirkung. 21Klinische Wochenschrift 11: 590-595.
38. VOLLON C, CHAUMONT JP (1994) Antifungal properties of essential oils and their main components upon Cryptococcus neoformans. Mycopathol 128: 151-153.