Antinociceptive effects of hydroalcoholic extract of Thymus Vulgaris

Pakistan Journal of Pharmaceutical Sciences

Volumn 22, Issue 1, 2009, Pages 83-89

  Taherian, Abbas Ali ^a   Babaei, Mahdi ^a   Vafaei, Abbas Ali ^a   Jarrahi, Morteza ^a   Jadidi, Majid ^a   Sadeghi, Hassan ^a  

^a SEMNAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute and chronic pain; Formalin test; Hot plate; Tail flick; Thymus vulgaris

Indexed keywords

DEXAMETHASONE; FORMALDEHYDE; NALOXONE; OPIATE RECEPTOR; PLANT EXTRACT; THYMUS VULGARIS EXTRACT; UNCLASSIFIED DRUG; ANALGESIC AGENT; NARCOTIC ANTAGONIST;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; COLD STRESS; CONTROLLED STUDY; HOT PLATE TEST; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PAIN ASSESSMENT; STRESS; TAIL FLICK TEST; THYME; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; HEAT; MENTAL STRESS; PSYCHOLOGICAL ASPECT;

ANALGESICS; ANIMALS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; HOT TEMPERATURE; MALE; MICE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; PAIN MEASUREMENT; PLANT EXTRACTS; STRESS, PSYCHOLOGICAL; THYMUS PLANT;

EID: 61949280444     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Abbott FV and Melzack R (1982). Brainstem lesions dissociated neural mechanisms of morphine analgesia in different kinds of pain. J. Brain Res., 251: 149-155.
2. Abe S, Sato Y, Inoue S, Ishibashi H, Maruyama N, Takizawa T, Oshima H and Yamaguchi H (2003). Anti- Candida albicans activity of essential oils including Lemongrass (Cymbopogon citratus) oil and its component. Citral. J. Nippon Ishinkin Gakkai Zasshi., 44(4): 285-291. (Pubitemid 37442928)
3. Abdel-Fattah AM, Matsumoto K and Watanabe H (2000). Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone in mice. European Journal of Pharmacology, 400: 89-97. (Pubitemid 30412113)
4. Abu-Ghazaleh BM (2000). Inhibition of Aeromonas caviae and A. sobria by sodium choloride, citric acid, ascorbic acid, potassium sorbate and extracts of Thymus vulgaris. Jpn. J. Infect. Dis., 53(3): 111-115.
5. Astudillo A, Hong E, Bye R, Navarrete A (2004). Antispasmodic activity of extracts and compounds of Acalypha phleoides. Cav. J. Phytother. Res., 8(2): 102-106.
6. Aydin S and Seker E (2005). Effect of an aqueous distillate of Origanum onites L. on isolated rat fundus, duodenum and ileum: evidence for the role of oxygenated monoterpenes. J. Pharmazie, 60(2): 147-150.
7. Azaz AD, Irtem HA, Kurkcuoglu M and Baser KH (2004). Composition and the in vitro antimicrobial activities of the essential oils of some Thymus species. J. Z. Naturforsch., 59(1-2): 75-80. (Pubitemid 38261248)
8. Babaei M, Emami-Abarghoei M, Ansari R, Vafaei AA, Taherian AA, Akhavan MM, Tosi G and Mousavi S (2008). Antispasmodic effect of hydroalcoholic extract of Thymus vulgaris on the guinea-pig ileum. J. Natural Product Sciences, 22(13): 1143-1150.
9. Beera AM, Lukanovb J and Sagorchevb P (2007). Effect of Thymol on the spontaneous contractile activity of the smooth muscles. Phytomedicine, 14: 65-69.
10. Bittar M, DeSousa MM, Yunes R, Lento RA, Delle-Monache F and Cechinel-Filho V (2000). Antinociceptive activity of I3, II8-Binaringenin, a biflavonoid present in plants of the Guttiferae. Planta Medica, 66: 84-86. (Pubitemid 30097292)
11. Broucke VD and Lemli JA (1982). Antispasmodic activity of Origanum compactum. Part 2: Antagonistic effect of thymol and carvacrol. Planta Med., 45(3): 188-190.
12. Burt SA and Reinders RD (2003). Antibacterial activity of selected plant essential oils against Escherichia coli O157:H7. J. Lett. Appl. Microbiol., 36(3): 162-167.
13. Briseid-Jensen K and Dyrud OK (1962). The smooth muscle relaxing effect of thyme (Thymus vulgaris L). J. Acta. Pharmacol. Toxicol., 19: 345-355.
14. Carlisson KH and Jurna I (1987). Depression by flupirtine, a novel analgesic agent of motor and sensory response to nociceptive system in the rat spinal cord . Eur. J. Pharmacol., 143: 87-99.
15. Dalal A, Tata M, Allegre G, Gekiere F, Bons N and Albe-Fessard D (1999). Spontaneous activity of rat dorsal horn cells in spinal segments of sciatic projection following transections of sciatic nerve or of corresponding dorsal roots. J.Neuroscience,94:217-228. (Pubitemid 29457612)
16. D,Amour FE and Smith DI (1941). A method for determining loss of pain sensation. J. Pharmacology and Experimental Therapy, 72: 42-47.
17. Dickenson AH and Sullivian AF (1987). Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin. Pain, 30: 349-360.
18. Dubuisson D and Dennis SG (1977). The formalin test: a quantitative study of the analgesic effect of morphine, meperidine and brain stem stimulation in rats and cats. J. Pain, 4: 167-174. (Pubitemid 8234766)
19. Eihabazi K, Abofatima R, Benharref A, Zyad A, Chait A and Dalal A (2006). Study on the antinociceptive effects of Thymus broussonetii Boiss extracts in mice and rats. J. Ethnopharmacology, 107: 406-411. (Pubitemid 44344430)
20. Elisabetsky E, Amodor TA, Albuquerque RR, Numes DS and Carvolho ACT (1995). Analgesic activity of Psychotria colorata (WildexR&S) Muell Arg. Alkaloids. J. Ethnopharmacol., 48: 77-83.
21. Essawi T and Srour M (2000). Screening of some Palestinian medicinal plants for antibacterial activity. J. Ethnopharmacol. 70(3): 343-349. (Pubitemid 30317374)
22. Francesca C (2004). Anna Maria A refinement of pain evaluation techniques: the formalin test. J. Ann. Istsuper. Sanita., 40(2): 223-229.
23. Golshani S, Karamkhani F, Monsef-Esfahani HR and Abdollahi M (2004). Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test. J. Pharm. Pharmaceut. Sci., 7(1): 76-79. (Pubitemid 38628940)
24. th edition, pp.529-537.
25. Hajhashemi V, Ghannadi A and Pezeshkian SK (2002). Antinocicieptive and anti-inflammatory effects of Satureja hortensis L. extracts and essential oil. J. Ethnopharmacology, 82 : 83-87. (Pubitemid 35292035)
26. Heapy CG, Jamieson A and Russel NJW (1987). Afferent C-fibres and A-delta activity in models of inflammation. J. British Journal of Pharmacology, 90: 164.
27. Hunskaar S and Hole K (1987). The formalin test in mice: dissociation between inflammatory and noninflammatory pain. J. Pain, 30: 103-114. (Pubitemid 17094194)
28. Kurkcuoglu M, Tumenm G and Baser KHC (2001). Essential oil constituents of Satureja boissieri from Turkey J. Chemistry of Natural Compounds, 37: 329-331. (Pubitemid 33385595)
29. Lall, N., Meyer, J.J., 1999. In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by ethnobotanically selected South African plants. J Ethnopharmacol.66(3),347-354
30. Le Bars D, Gozariu M and Cadden SM (2001). Animal models of nociception. Pharmacological. Reviews, 53: 597-652.
31. Lee KG and Shibamoto T (2002). Determination of antioxidant potential of volatile extracts isolated from various herbs and spices. J. Agric. Food Chem., 11; 50(17): 4947-4952
32. Maleki-Dizaji N, Fathiazad1 F and Garjan A (2007). Antinociceptive properties of extracts and two Flavonoids isolated from leaves of Danae racemosa. J. Arch. Pharm. Res., 30(12): 1536-1542.
33. Meister A, Bernhardt G, Christoffel V and Buschauer A (1999). Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects. Planta. Med., 65(6): 512-516. (Pubitemid 29399951)
34. Meyre-Silva C, Yunes R, Santos ARS, Magro JD, Monache FD and Cechinel-Filho V (1999). Isolation of a C-Glycoside Flavonoid with antinociceptive action from Aleurites moluccana leaves. Planta Medica., 65: 263-294. (Pubitemid 29186098)
35. Mousa S (1983). Dexamethasone and stress-induced analgesia. J. Psychopharmacology, 79: 199-202.
36. Mousa S (1981). Corticosteroid modulation and stress induced analgesia in rats. J. Psychopharmacology, 33: 317-319. (Pubitemid 11012999)
37. Okazaki K, Kawazoe K and Takaishi Y (2002). Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res., 16(4): 398-399. (Pubitemid 34700284)
38. Panizzi L, Flamini G, Cioni PL and Morelli I (1993). Composition and antimicrobial properties of essential oils of four Mediterranean Lamiaceae. J. Ethnopharmacol., 39(3): 167-170. (Pubitemid 23272432)
39. Pathak D, Pathak K and Sigla AK (1991). Flavonoids as medicinal agents: recent advances. Fitoterapia, 62: 371-388.
40. Rang HP, Dale MM and Ritter JM (1998). Pharmacology, Churchill Livingston, New York, pp.614-616.
41. Segvic MS, Klaric I, Kosalec J, Mastelic E, Pieckova S and Pepeljnak A (2007). Antifungal activity of thyme (Thymus vulgaris L.) essential oil and thymol against moulds from damp dwellings. J. Letters in Applied Microbiology, 44: 36-42.
42. Shibatta M, Ohkubo T, Takashi H and Inoki R (1989). Modified formalin test, Characteristic biphasic pain response. J. Pain, 38: 347-352. (Pubitemid 19251258)
43. Soliman KM and Badeaa RI (2002). Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. J. Food Chem. Toxicol., 40(11): 1669-1675.
44. Tjolsen A, Berge OG and Hunskaar S (1992). The formalin test: an evaluation of the method. Pain, 51: 5-17.
45. USDA, ARS (2005). National Genetic Resources Program, Phytochemical and Ethnobotanical Database. [Online Database] National Germplasm Resources Laboratory, Beltsville, Meryland, 02 .
46. Van Den Broucke VD and Lemli JA (1983). Spasmolytic activity of the flavonoids from Thymus vulgaris. J. Pharm. Weekbl. Sci., 25; 5(1): 9-14.
47. Vigo E, Cepeda A, Gualillo O and Perez-Fernandez R (2004). In vitro anti-inflammatory effect of Eucalyptus globulus and Thymus vulgaris: nitric oxide inhibition in J774A.1 murine macrophages. J. Pharm. Pharmacol., 56(2): 257-263 (Pubitemid 38232756)
48. Wesolowska A, Nikiforuk A, Michalska K, Kisiel W and Chojnacka-Wojecik E (2006). Analgesic and sedative activities of Lactucin and Som lactucin like Guaianolides in mice. Ethno. Pharmacology, 107: 254-258. (Pubitemid 44247432)
49. Woolfe G and McDonald AD (1994). Evaluation of the analgesic action of pethidine hydrochloride (Demerol). J. Pharmacology and Experimental Therapy, 70: 300-307.
50. Youdim KA and Deans SG (1999). Dietary supplementation of thyme (Thymus vulgaris L.) essential oil during the lifetime of the rat: its effects on the antioxidant status in liver, kidney and heart tissues. J. Mech. Ageing Dev. 8; 109(3): 163-175.
51. Zhao CS, Tao YX, Tall JM, Donovan DM, Meyer RA and Raja SN (2003). Role of micro-opioid receptors in formalin-induced pain behavior in mice. J. Exp Neurol., 84(2): 839-845.