Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known Popularly by brand names of analgesic drugs

Phytotherapy Research

Volumn 23, Issue 2, 2009, Pages 212-219

  Pires, Julia Movilla ^a   Mendes, Fúlvio R ^a   Negri, Giuseppina ^a   Duarte Almeida, Joaquim M ^a   Carlini, Elisaldo A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Achillea millefolium; Antiinflammatory; Antinociceptive; Artemisia vulgaris; Brand name; Rutin

Indexed keywords

ACHILLEA MILLEFOLIUM EXTRACT; ANADOR; ARTEMISIA VULGARIS EXTRACT; CAFFEIC ACID DERIVATIVE; CIBALENA; HYDROXYBENZOIC ACID DERIVATIVE; MORPHINE; NOVALGINA; RUTOSIDE; UNCLASSIFIED DRUG; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; PLANT EXTRACT;

ACHILLEA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTEMISIA; ARTEMISIA VULGARIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; MALE; MOUSE; NONHUMAN; PAIN; RESPONSE TIME; ANIMAL; CHEMISTRY; GASTROINTESTINAL TRANSIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION;

ACHILLEA MILLEFOLIUM; ARTEMISIA VULGARIS; ASTERACEAE; MUS;

ACHILLEA; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTEMISIA; CAFFEIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GASTROINTESTINAL TRANSIT; HYDROXYBENZOIC ACIDS; MALE; MICE; PARASYMPATHOLYTICS; PLANT EXTRACTS; RUTIN;

EID: 59449106529     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2589     Document Type: Article

References (61)

1. Agnihotri VK, Lattoo SK, Thappa RK et al. 2005. Chemical variability in the essential oil components of Achillea millefolium agg. from different Himalayan habitats (India). Planta Med 71: 280-283.
2. Ahmad F, Khan RA, Rashid S. 1996. Pharmacological evaluation of medicinal plants for their analgesic activity in mice. Med J Islam Repub Iran 10: 149-152.
3. Alexandre-Moreira MS, Viegas Jr C, Palhares de Miranda ALP, Bolzani VS, Barreiro EJ. 2003. Antinociceptive profile of (-)- spectaline: a piperidine alkaloid from Cassia leptophylla. Planta Med 69: 795-799.
4. Almeida RN, Navarro DS, Barbosa-Filho JM. 2001. Plants with central analgesic activity. Phytomedicine 8: 310-322.
5. Archana P, Tandan SK, Chandra S, Lal J. 2005. Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract. Phytother Res 19: 376-381.
6. Benedek B, Gjoncaj N, Saukel J, Kopp B. 2007. Distribution of phenolic compounds in middle European taxa of the Achillea millefolium L. aggregate. Chem Biodivers 4: 849-857.
7. Calixto JB, Beirith A, Ferreira J, Santos ARS, Filho VC, Yunes RA. 2000. Naturally occurring antinociceptive substances from plants. Phytother Res 14: 401-418.
8. Carlini EA. 1972. 'Screening' farmacologico de plantas brasileiras. Rev Bras Biol 32: 265-274.
9. Carlini EA. 2003. Plants and central nervous system. Pharmacol Biochem Behav 75: 501-512.
10. Carlini EA, Contar JDP, Silva-Filho AR, Silveira-Filho NG, Frochtengarten ML, Bueno OFA. 1986. Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals. J Ethnopharmacol 17: 37-64.
11. Contar JD, Carlini EA. 1987. Pharmacological and toxicological profile of benzyleugenol, a phenylpropene derivative possessing anticonvulsant properties. Braz J Med Biol Res 20: 495-510.
12. da Silva KL, dos Santos AR, Mattos PE, Yunes RA, Delle- Monache F, Cechinel-Filho V. 2001. Chemical composition and analgesic activity of Calophyllum brasiliensis leaves. Therapie 56: 431-434.
13. da Silva R, de Souza GHB, da Silva AA et al. 2005. Synthesis and biological activity evaluation of lignan lactones derived from (-)-cubebin. Bioorg Med Chem Lett 15: 1033-1037.
14. Stasi LC, Hiruma-Lima CA. 2002. Plantas Medicinais na Amazônia e na Mata Atlântica. Editora Unesp: São Paulo; 464-466.
15. Ficarra R, Ficarra P, Tommasini S et al. 1995. Leaf extracts of some Cordia species - analgesic and antiinflammatory activities as well as their chromatographic analysis. Farmaco 50: 245-256.
16. Franco SL. 1990. Maytenus ilicifolia Martius ex. Reiss. Celestraceae. Proposta Tecnológica de Macerados. Master Thesis. UFRGS: Porto Alegre.
17. Fushiya S, Batkhuu J, Takano F et al. 2000. Effects of Mongolian plants on nitric oxide production in activated macrophages. Nat Med 54: 352-357.
18. Gaertner M, Muller L, Roos JF et al. 1999. Analgesic triterpenes from Sebastiania schottiana roots. Phytomedicine 6: 41-44.
19. García MD, Puerta R, Martínez S, Sáenz MT. 1997. Analgesic, antipyretic and antinflammatory effects of Achillea ageratum. Phytother Res 11: 376-379.
20. Gene RM, Cartana C, Adzet T, Mann E, Parella T, Canigueral S. 1996. Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents. Planta Med 62: 232-235.
21. Goldberg AS, Mueller EC, Eigen E, Desalva SJ. 1969. Isolation of the anti-inflammatory principles from Achillea millefolium (Compositae). J Pharm Sci 58: 938-941.
22. Guarrera M, Turbino L, Rebora A. 2001. The anti-inflammatory activity of azulene. J Eur Acad Dermatol Venereol15: 486-487.
23. Gutierrez-Venegas G, Jimenez-Estrada M, Maldonado S. 2007. The effect of flavonoids on transduction mechanisms in lipopolysaccharide-treated human gingival fibroblasts. Int Immunopharmacol 7: 1199-1210.
24. Harborne JB, Williams CA. 2000. Advances in flavonoid research since 1992. Phytochemistry 55: 481-504.
25. Heinrich M, Robles M, West JE, Ortiz de Montellano BR, Rodriguez E. 1998. Ethnopharmacology of Mexican Asteraceae (Compositae). Annu Rev Pharmacol Toxicol 38: 539-565.
26. Innocenti G, Vegeto E, Dall'Acqua S et al. 2007. In vitro estrogenic activity of Achillea millefolium L. Phytomedicine 14: 147-152.
27. Iscan G, Kirimer N, Kurkcuoglu M, Arabaci T, Kupeli E, Baser KHC. 2006. Biological activity and composition of the essential oils of Achillea schischkinii Sosn. and Achillea aleppica DC. subsp. aleppica. J Agric Food Chem 54: 170-173.
28. Jayaprakasha GK, Ohnishi-Kameyama M, Ono H, Yoshida M, Rao JL. 2006. Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity. J Agric Food Chem 54: 1672-1679.
29. Jiang Y, Li SP, Chang HT, Wang YT, Tu PF. 2006. Pressurized liquid extraction followed by high-performance liquid chromatography for determination of seven active compounds in Cortex dictamni. J Chromatogr A 1108: 268-272.
30. Kuroshima KN, de Campos F, de Souza MM, Yunes RA, Delle Monache F, Cechinel Filho V. 2001. Phytochemical and pharmacological investigations of Virola oleifera leaves. Z Naturforsch C/J Biosci 56: 703-706.
31. Leal LKAM, Ferreira AAG, Bezerra GA, Matos FJA, Viana GSB. 2000. Antinociceptive, antiinflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J Ethnopharmacol 70: 151-159.
32. Le Bars D, Gozariu M, Cadden SW. 2001. Animal models of nociception. Pharmacol Rev 53: 597-652.
33. Lee SJ, Chung HY, Maier CGA, Wood AR, Dixon RA, Mabry TJ. 1998. Estrogenic flavonoids from Artemisia vulgaris L. J Agric Food Chem 46: 3325-3329.
34. Lorenzi H, Matos A. 2002. Plantas Medicinais no Brasil. Nativas e Exóticas. Instituto Plantarum de Estudos da Flora Ltda: São Paulo; 512.
35. Lyss G, Glasl S, Jurenitsch J, Pahl HL, Merfort I. 2000. A sesquiterpene and sesquiterpene lactones from the Achillea millefolium group possess antiinflammatory properties but do not inhibit the transcription factor NF-κB. Pharm Pharmacol Lett 10: 13-15.
36. Marques LC, Galvão SMP, Espínola E et al. 2004. Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents. Phytother Res 18: 566-572.
37. Matos FJA, Machado MIL, Alencar JW, Matos MEO, Craveiro AA. 1991. Plants used in traditional medicine of China and Brazil. Mem Inst Oswaldo Cruz 86: 13-16.
38. Mendes FR, Mattei R, Carlini EA. 2002. Activity of Hypericum brasiliense and Hypericum cordatum on the central nervous system in rodents. Fitoterapia 73: 462-471.
39. Miller FM, Lee MC. 1954. Alkaloids of Achillea-millefolium L. 1. Isolation and characterization of achilleine. J Am Chem Soc 76: 1353-1354.
40. Mino J, Moscatelli V, Hnatyszyn O, Gorzalczany S, Acevedo C, Ferraro G. 2004. Antinociceptive and antiinflammatory activities of Artemisia copa extracts. Pharmacol Res 50: 59-63.
41. Mistieri MLA, Thomazo NMM, Mataqueiro MI, Queiroz-Neto A. 2001. Study of the analgesic properties of the Achillea millefolium. Rev Bras Plan Med 3: 1-6.
42. Nguyen MTT, Awale S, Tezuka Y, Le Tran Q, Watanabe H, Kadota S. 2004. Xanthine oxidase inhibitory activity of Vietnamese medicinal plants. Biol Pharm Bull 27: 1414-1421.
43. Nikolova I, Gevrenova R, Ivancheva S, Gevrenova S. 2004. High - performance liquid chromatographic separation of surface flavonoid aglycones in Artemisia annua L. and Artemisia vulgaris L. J Serbian Chem Soc 69: 571-574.
44. Otuki MF, Vieira-Lima F, Malheiros A, Yunes RA, Calixto JB. 2005. Topical antiinflammatory effects of the ether extract from Protium kleinii and alpha-amyrin pentacyclic triterpene. Eur J Pharmacol 507: 253-259.
45. Peana AT, D'Aquila PS, Chessa ML, Moretti MD, Serra G, Pippia P. 2003. (-)-Linalool produces antinociception in two experimental models of pain. Eur J Pharmacol 460: 37-41.
46. Rabelo M, Souza EP, Soares PMG, Miranda AV, Matos FJA, Criddle DN. 2003. Antinociceptive properties of the essential oil of Ocimum gratissimumL. (Labiatae) in mice. Braz J Med Biol Res 36: 521-524.
47. Reszka KJ, Britigan LH, Britigan BE. 2005. Oxidation of anthracyclines by peroxidase metabolites of salicylic acid. J Pharmacol Exp Ther 315: 283-290.
48. Rodrigues E. 2006. Plants and animals utilized as medicines in the Jaú National Park (JNP), Brazilian Amazon. Phytother Res 20: 378-391.
49. Rosland JH, Tjolsen A, Maehle B, Hole K. 1990. The formalin test in mice: effect of formalin concentration. Pain 42: 235-242.
50. Santos FA, Rao VS. 2000. Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytother Res 14: 240-244.
51. Schulz V, Hänsel R, Tyler VE. 2001. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Springer: Berlin; 294.
52. Si X-T, Zhang M-L, Shi Q-W, Kiyota H. 2006. Chemical constituents of the plants in the genus Achillea. Chem Biodivers 3: 1163-1180.
53. Sosa S, Tubaro A, Kastner U, Glasl S, Jurenitsch J, Della Loggia R. 2001. Topical anti-inflammatory activity of a new germacrene derivative from Achillea pannonica. Planta Med 67: 654-658.
54. Spessoto MA, Ferreira DS, Crotti AE, Silva ML, Cunha WR. 2003. Evaluation of the analgesic activity of extracts of Miconia rubiginosa (Melastomataceae). Phytomedicine 10: 606-609.
55. Svedström U, Vuorela H, Kostiainen R, Laakso I, Hiltunen R. 2006. Fractionation of polyphenols in hawthorn into polymeric procyanidins, phenolic acids and flavonoids prior to high-performance liquid chromatographic analysis. J Chromatogr A 1112: 103-111.
56. Szostek B, Orska-Grawrys J, Surowiec I, Trojanowicz M. 2003. Investigation of natural dyes occurring in historical Coptic textiles by high-performance liquid chromatography with UV-Vis and mass spectrometric detection. J Chromatogr A 1012: 179-192.
57. Wagner H. 1996. Plant Drug Analysis. A Thin Layer Chromatography Atlas, 2nd edn. Springer-Verlag: Berlin; 350.
58. Xu YK, Yang SP, Liao SG et al. 2006. Alkaloids from Gelsemium elegans. J Nat Prod 69: 1347-1350.
59. Yaeesh S, Jamal Q, Khan A, Gilani AH. 2006. Studies on hepato - protective, antispasmodic and calcium antagonist activities of the aqueous-methanol extract of Achillea millefolium. Phytother Res 20: 546-551.
60. Yonathan M, Asres K, Assefa A, Bucar F. 2006. In vivo anti- inflammatory and anti-nociceptive activities of Cheilanthes farinosa. J Ethnopharmacol 108: 462-470.
61. Yoshikawa M, Shimada H, Matsuda H, Yamahara J, Murakami N. 1996. Bioactive constituents of Chinese natural medicines 1. New sesquiterpene ketones with vasorelaxant effect from Chinese moxa, the processed leaves of Artemisia argyi Levl et Vant: Moxartenone and moxartenolide. Chem Pharm Bull 44: 1656-1662.