Variability in in vitro macrophage activation by commercially diverse bulk Echinacea plant material is predominantly due to bacterial lipoproteins and lipopolysaccharides

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 22, 2008, Pages 10552-10556

  Tamta, Hemlata ^a   Pugh, Nirmal D ^a   Balachandran, Premalatha ^a   Moraes, Rita ^a   Sumiyanto, Joko ^a   Pasco, David S ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Bacteria; Braun type lipoprotein; Echinacea; Immune stimulation; Lipopotysaccharide; Macrophage activation

Indexed keywords

LIPOPOLYSACCHARIDE; LIPOPROTEIN; PLANT EXTRACT;

ARTICLE; BACTERIUM; CHEMISTRY; DESICCATION; DRUG EFFECT; ECHINACEA; ESCHERICHIA COLI; MACROPHAGE ACTIVATION; METHODOLOGY; PLANT LEAF; PLANT ROOT;

BACTERIA; DESICCATION; ECHINACEA; ESCHERICHIA COLI; LIPOPOLYSACCHARIDES; LIPOPROTEINS; MACROPHAGE ACTIVATION; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS;

BACTERIA (MICROORGANISMS); ECHINACEA ANGUSTIFOLIA; ECHINACEA PURPUREA;

EID: 57849101746     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf8023722     Document Type: Article

References (7)

1. Woelkart, K.; Linde, K.; Bauer, R. Echinacea for preventing and treating the common cold. Planta Med. 2008, 74, 633-637.
2. Pugh, N. D.; Tamta, H.; Balachandran, P.; Wu, X.; Howell, J.; Dayan, F. E.; Pasco, D. S. The majority of in vitro macrophage activation exhibited by extracts of some immune enhancing botanicals is due to bacterial lipoproteins and lipopolysaccharides. Int. Immunopharmacol. 2008, 8, 1023-1032.
3. Pugh, N.; Ross, S. A.; ElSohly, M. A.; Pasco, D. S. Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J. Agric. Food Chem. 2001, 49, 1030-1034.
4. Subbaramaiah, K.; Bulic, P.; Lin, Y.; Dannenberg, A. J.; Pasco, D. S. Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription. J. Biomol. Screen 2001, 6, 101-110.
5. Ezendam, J.; van Loveren, H. Probiotics: Iimnunomodulation and evaluation of safety and efficacy. Nutr. Rev. 2006, 64, 1-14.
6. Chiang, B. L.; Sheih, Y. H.; Wang, L. H.; Liao, C. K.; Gill, H. S. Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): Optimization and definition of cellular immune responses. Eur. J. Clin. Nutr. 2000, 54, 849-855.
7. Hirose, Y.; Murosaki, S.; Yamamoto, Y.; Yoshikai, Y.; Tsuru, T. Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults. J. Nutr. 2006, 136, 3069-3073.