Impact of Thymol in thyme extracts on their antispasmodic action and ciliary clearance

Planta Medica

Volumn 76, Issue 4, 2010, Pages 311-318

  Begrow, Frank ^a   Engelbertz, Jonas ^a   Feistel, Björn ^b   Lehnfeld, Romanus ^c   Bauer, Katrin ^a   Verspohl, Eugen J ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Plantextrakt GmbH and Co KG   (Germany)

^c PhytoLab GmbH   (Germany)

Author keywords

Antispasmodic effect; Lamiaceae; Mucociliary clearance; Thyme extract; Thymol; Thymus vulgaris L.; Trachea

Indexed keywords

ACETYLCHOLINE; BARIUM; CARVACROL; PLANT EXTRACT; POTASSIUM; SPASMOLYTIC AGENT; THYME EXTRACT; THYMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ILEUM; MICRODIALYSIS; MOUSE; MUCOCILIARY CLEARANCE; MUCOCILIARY TRANSPORT; NONHUMAN; RAT; SMOOTH MUSCLE; THYME; TRACHEA;

ANIMALS; CILIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELINS; FEMALE; ILEUM; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; MONOTERPENES; MUCOCILIARY CLEARANCE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OILS, VOLATILE; PARASYMPATHOLYTICS; PLANT EXTRACTS; RATS; RATS, WISTAR; RESPIRATORY SYSTEM; THYMOL; THYMUS GLAND; TRACHEA;

LAMIACEAE; MUS; RATTUS; THYMUS VULGARIS;

EID: 77749316907     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1186179     Document Type: Article

References (20)

1. Marti D, Villagrasa V, Martinez-Solis I, Blanquer A, Castillo E, Royo L M. Histological and pharmacological study of Thymus piperella. Phytother Res 2005 19 298-302
2. Adzet T M. V. Luteolin and 6-hydroxyluteolin: taxonomically important flavones in the genus Thymus. Planta Med 1980 46 52-55
3. Adzet T, Vila R, Canigueral S. Chromatographic analysis of polyphenols of some Iberian Thymus. J Ethnopharmacol 1988 24 147-154
4. Loziene K, Vaiciuniene J, Venskutonis P R. Chemical composition of the essential oil of creeping thyme (Thymus serpyllum s.l.) growing wild in Lithuania. Planta Med 1998 64 772-773
5. Stahl-Biskup E. The essential oil from Norwegian Thymus species. I. Thymus praecox ssp. arcticus. Planta Med 1986 52 36-38
6. Stahl-Biskup E. The essential oil from Norwegian Thymus species; II. Thymus pulegioides. Planta Med 1986 52 233-235
7. Meister A, Bernhardt G, Christoffel V, Buschauer A. Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects. Planta Med 1999 65 512-516
8. Jensen K B., Dyrud O K. The smooth muscle relaxing effect of thyme (Thymus vulgaris L.). Acta Pharmacol Toxicol 1962 19 345-355
9. Wienkötter N, Begrow F, Kinzinger U, Schierstedt D, Verspohl E J. The effect of thyme extract on beta2-receptors and mucociliary clearance. Planta Med 2007 73 629-635
10. Kommission E of BfArM, Germany.
11. Van Den Broucke C O., Lemli J L. Antispasmodic activity of Origanum compactum. Part 2: antagonistic effect of thymol and carvacrol. Planta Med 1982 45 188-190
12. Astudillo A, Hong E, Bye R, Navarrete A. Antispasmodic activity of extract and compounds of Acalypha phleodies Cav. Phytother Res 2004 18 102-106
13. Beer A M., Lukanov J, Sagorchev P. Effect of thymol on the spontaneous contractile activity of the smooth muscles. Phytomedicine 2007 14 65-69
14. Haeseler G, Maue D, Grosskreutz J, Bufler J, Nentwig B, Piepenbrock S, Dengler R, Leuwert M. Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. Eur J Aneasthesiol 2002 19 571-579
15. Lee S P., Buber M T., Yang Q, Cerne R, Corts R Y., Sprous D G., Bryant R W. Thymol and related alkyl phenols activate the hTRPA1 channel. Br J Pharmacol 2008 153 1-11
16. Braun T, Voland P, Kunz L, Prinz C, Gatzl M. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology 2007 132 1890-1901
17. Grubb B R., Jones J H., Boucher R C. Mucociliary transport determined by in vivo microdialysis in the airways of normal and CF mice. Am J Physiol Lung Cell Mol Physiol 2004 286 L588-L595
18. Van Den Broucke C O., Lemli J L. Spasmolytic activity of the flavonoids from Thymus vulgaris. Pharm Weekbl Sci 1983 5 9-14
19. Van Den Broucke C O., Lemli J L. Pharmacological and chemical investigation of thyme liquid extracts. Planta Med 1981 41 129-135
20. Engelbertz J, Schwenk T, Kinzinger U, Schierstedt D, Verspohl E J. Thyme extract, but not thymol, inhibits endothelin-induced contractions of isolated rat trachea. Planta Med 2008 74 1-5