Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat

Planta Medica

Volumn 70, Issue 8, 2004, Pages 745-752

  Sautebin, Lidia ^a   Rossi, Antonietta ^a   Serraino, Ivana ^b   Dugo, Paola ^c   Di Paola, Rosanna ^b   Mondello, Luigi ^c   Genovese, Tiziana ^b   Britti, Domenico ^d   Peli, Angelo ^e   Dugo, Giovanni ^c   Caputi, Achille P ^b   Cuzzocrea, Salvatore ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

^d UNIVERSITY OF TERAMO   (Italy)

^e Alma Mater Studiorum ^*  (Italy)

Author keywords

Anthocyanins; Blackberry; COX 2; Endotoxic shock; Gicaceae; iNOS; Peroxynitrite; Vaccinium myrtillus

Indexed keywords

3 NITROTYROSINE; 6 OXOPROSTAGLANDIN F1 ALPHA; AMINOTRANSFERASE; AMYLASE; ANTHOCYANIN; BILIRUBIN; BLACKBERRY EXTRACT; CREATININE; ENDOTOXIN; GLUTAMYL OXALOACETIC TRANSAMINASE; GLUTAMYL PYRUVIC TRANSAMINASE; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATE; PLANT EXTRACT; PROSTAGLANDIN SYNTHASE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFICACY; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ESCHERICHIA COLI; HISTOLOGY; HYPOTENSION; ILEUM; IMMUNOHISTOCHEMISTRY; ISCHEMIA; KIDNEY DYSFUNCTION; LIPID PEROXIDATION; LIVER DYSFUNCTION; LUNG; MALE; MULTIPLE ORGAN FAILURE; NONHUMAN; PANCREAS INJURY; POLYMORPHONUCLEAR CELL; RAT; SEPTIC SHOCK; TISSUE INJURY;

ANIMALS; ANTHOCYANINS; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENDOTOXINS; ENZYME INHIBITORS; FRUIT; ILEUM; ISOENZYMES; LIPOPOLYSACCHARIDES; LUNG; MALE; MULTIPLE ORGAN FAILURE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANT EXTRACTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; VACCINIUM MYRTILLUS;

ANIMALIA; ESCHERICHIA COLI; RUBUS; VACCINIUM; VACCINIUM MYRTILLUS;

EID: 4444339097     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-827206     Document Type: Article

References (20)

1. Vane JR, Mitchell JA, Appelton I, Tomlinson A, Bishop-Bailey D, Croxtal J et al. Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation. Proc Natl Acad Sci USA 1994; 91: 2046-50
2. Thiemermann C. The role of arginine: nitric oxide pathway in circulatory shock. Adv Pharmacol 1994; 28: 45-79
3. Redl H, Gasser H, Schalg G, Marzi I. Involvement of oxygen radicals in shock related cell injury. Br Med Bull 1993; 49: 556-65
4. Zingarelli B, Day BJ, Crapo JD, Salzman AL, Szabo C. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 1997; 120: 259-67
5. Szabo C, Zingarelli B, O'Connor M, Salzman AL. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. P Proc Natl Acad Sci USA 1996; 93: 1753-8
6. Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA et al. Free radical and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000; 148: 187-97
7. Crespo ME, Galvez J, Cruz T, Ocete MA, Zarzuelo A. Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS. Planta Medica 1999; 65: 651-3
8. Donovan JL; Meyer AS, Waterhose AL. Phenolic composition and antioxidant activity of prunes and prune juice (Prunus domestica). J Agr Food Chem 1998; 46: 1247-52
9. Wang H, Cao G, Prior RL. Oxygen radical absorbing capacity of anthocyanins. J Agr Food Chem 1997; 45: 304-9
10. Dugo P, Mondello L, Errante G, Zappia G, Dugo G. Identification of anthocyanins in berries by narrow-bore high performance liquid chromatography with electrospray ionization detection. Journal of Agricultural and Food Chemistry 2001; 49: 3987-92
11. Caputi AP, Rossi F, Carney K, Brezenoff HE. Modulatory effect of brain acetylcholine on reflex-induced bradycardia and tachycardia in conscious rats. J Pharmacol Exp Ther 1980; 215: 309-16
12. Leach M, Hamilton LC, Olbrich A, Wray GM, Thiemermann C. Effects of inhibitors of the activity of cyclooxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: a comparison with dexamethasone. Br J Pharmacol 1998; 124: 586-92
13. Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Ciccolo A, Centorrino T et al. Protective effects of N-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat. The FASEB Journal 2001; 15: 1187-200
14. Rossi A, Longo R, Russo A, Borrelli F, Sautebin L. The role of the phenethyl ester of caffeic acid (CAPE) in the inhibition of rat lung cyclooxygenase activity by propolis. Fitoterapia 2002; 73: S30-7
15. Salter M, Knowles RG, Moncada S. Widespread tissue distribution, species distribution and changes in activity of Ca(2+)-dependent and Ca(2+)-independent nitric oxide synthases. FEBS Lett 1991; 291: 145-9
16. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54
17. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 1979; 95: 351-8
18. Crow JP, Beckman JS. Reactions between nitric oxide, superoxide, and peroxynitrite: footprints of peroxynitrite in vivo. Advances in Pharmacol 1995; 34: 17-43
19. 2+ signaling in vascular endothelial cells. The Am J Physiol 1996; 270: 954-61
20. Serraino I, Dugo L, Dugo P, Mondello L, Mazzon E, Dugo G et al. Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Life Sciences 2003; 73: 1097-114