Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor

Pharmaceutical Research

Volumn 26, Issue 2, 2009, Pages 375-381

  Dong, Guo Chung ^b,d   Chuang, Ping Hsien ^a,b   Chang, Kai Chun ^b   Jan, Pey Shynan ^a   Hwang, Pei Ing ^b   Wu, Huan Bin ^b   Yi, Myunggi ^c   Zhou, Huan Xiang ^c   Chen, Hueih Min ^a  

^a NATIONAL NANO DEVICE LABORATORIES   (Taiwan)

^b AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^c FLORIDA STATE UNIVERSITY   (United States)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Blocking efficiency; CD28; Cynarin; Immuno suppression; T cell receptor

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CYNARINE; T LYMPHOCYTE RECEPTOR;

ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ECHINACEA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD80; B-LYMPHOCYTES; BINDING SITES; CINNAMATES; COCULTURE TECHNIQUES; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHINACEA; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 58549108464     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9754-5     Document Type: Article

References (14)

1. O. Acuto F. Michel 2003 CD28-mediated co-stimulation: a quantitative support for TCR signalling Nat Rev Immunol. 3 939 951
2. J. P. Allison 1994 CD28-B7 interactions in T-cell activation Curr Opin Immunol. 6 414 419
3. C. H. June J. A. Ledbetter P. S. Linsley C. B. Thompson 1990 Role of the CD28 receptor in T-cell activation Immunol Today 11 211 216
4. A. H. Sharpe G. J. Freeman 2002 The B7-CD28 superfamily Nat Rev Immunol. 2 116 126
5. E. Akalin 2008 Immunosuppression minimization protocols: how should they be monitored? Nat Clin Pract Nephrol. 4 484 485
6. M. Veroux D. Corona G. Giuffrida M. Gagliano M. Sorbello C. Virgilio T. Tallarita D. Zerbo A. Giaquinta P. Fiamingo M. Macarone G.L. Volti P. Caglia P. Veroux 2008 New-onset diabetes mellitus after kidney transplantation: The role of immunosuppression Transplant Proc. 40 1885 1887
7. G. C. Dong P. H. Chuang M. D. Forrest Y. C. Lin H. M. Chen 2006 Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method J Med Chem. 49 1845 1854
8. A. W. Schuttelkopf D. M. van Aalten 2004 PRODRG: a tool for high-throughput crystallography of protein-ligand complexes Acta Crystallogr D Biol Crystallogr. 60 1355 1363
9. G. M. Morris D. S. Goodsell R. S. Halliday R. Huey W. E. Hart R. K. Belew A. J. Olson 1998 Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function J Comput Chem. 19 1639 1662
10. W. Humphrey A. Dalke K. Schulten 1996 VMD: visual molecular dynamics J Mol Graph. 14 33 38
11. W. DeLano. The PyMOL User's Manual. USA DeLano Scientific, San Carlos, CA, 2002.
12. C. Hetenyi D. van der Spoel 2002 Efficient docking of peptides to proteins without prior knowledge of the binding site Protein Sci. 11 1729 1737
13. E. J. Evans R. M. Esnouf R. Manso-Sancho R. J. Gilbert J. R. James C. Yu J. A. Fennelly C. Vowles T. Hanke B. Walse T. Hunig P. Sorensen D. I. Stuart S. J. Davis 2005 Crystal structure of a soluble CD28-Fab complex Nat Immunol. 6 271 279
14. F. Luhder Y. Huang K.M. Dennehy C. Guntermann I. Muller E. Winkler T. Kerkau S. Ikemizu S. J. Davis T. Hanke T. Hunig 2003 Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists J Exp Med. 197 955 966