Intestinal spasmolytic effects of STW 5 (Iberogast®) and its components

Phytomedicine

Volumn 13, Issue SUPPL. 1, 2006, Pages 75-79

  Heinle, H ^a   Hagelauer, D ^a   Pascht, U ^a   Kelber, O ^a   Weiser, D ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Angelica archangelica; Carum carvi; Chelidonium majus; Functional dyspepsia (FD); Functional intestinal syndromes; Glycyrrhiza glabra; Histamine induced contractions; Iberis amara; Irritable bowel syndrome (IBS); Matricaria recutita; Melissa officinalis; Mentha piperita; Silybum marianum; Spasmolysis

Indexed keywords

ANGELICA ARCHANGELICA EXTRACT; CARUM CARVI EXTRACT; CHELIDONINE; CHELIDONIUM EXTRACT; DIGESTIVE TRACT SPASMOLYTIC AGENT; GLYCYRRHIZA GLABRA EXTRACT; HERBACEOUS AGENT; HISTAMINE; IBERIS AMARA EXTRACT; IBEROGAST; MATRICARIA RECUTITA EXTRACT; MELISSA OFFICINALIS EXTRACT; PAPAVERINE; PEPPERMINT; PROTOPINE; SILYBUM MARIANUM EXTRACT; STW 5; UNCLASSIFIED DRUG;

ANGELICA ARCHANGELICA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARAWAY; CHELIDONIUM; CONTROLLED STUDY; DRUG EFFICACY; GLYCYRRHIZA GLABRA; GUINEA PIG; IBERIS AMARA; IN VITRO STUDY; INTESTINE CONTRACTION; INTESTINE MOTILITY; MALE; MATRICARIA; MEDICINAL PLANT; MELISSA OFFICINALIS; MENTHA PIPERITA; NONHUMAN; PERISTALSIS; PHYTOTHERAPY; PRIORITY JOURNAL; SILYBUM MARIANUM; SPASMOLYSIS;

ANIMALS; GUINEA PIGS; INTESTINES; MALE; PARASYMPATHOLYTICS; PERISTALSIS; PLANT EXTRACTS;

ANGELICA ARCHANGELICA; CARUM CARVI; CAVIA PORCELLUS; CHELIDONIUM MAJUS; GLYCYRRHIZA GLABRA; IBERIS AMARA; MATRICARIA RECUTITA; MELISSA OFFICINALIS; MENTHA X PIPERITA; SILYBUM MARIANUM;

EID: 33751350857     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.03.013     Document Type: Article

References (30)

1. Allescher, H.-D., 2006. Functional dyspepsia - a multi-causal disease and its therapy. Phytomedicine 13 (Suppl. V), 2-11.
2. Ammon H.P.T., Kelber O., and Okpanyi S.N. Spasmolytic and tonic effect of iberogast (STW 5) in intestinal smooth muscle. Phytomedicine 13 Suppl. V (2006) 67-74
3. Arul V., Miyazaki S., and Dhananjayan R. Mechanism of the contractile effect of the alcoholic extract of Aegle marmelos Corr. on isolated guinea pig ileum and tracheal chain. Phytomedicine 11 (2002) 679-683
4. Chandler R.F. Licorice, more than just a flavor. Can. Pharmaceut. J. 118 (1985) 421-424
5. Cremonini F., and Talley N.-J. Review article: the overlap between functional dyspepsia and irritable bowel syndrome-a tale of one or two disorders?. Aliment. Pharmacol. Ther. 20 (2004) 40-49
6. Di Carlo G., Autore G., Izzo A., Maiolino P., Mascolo N., Viola P., Diurno M., and Capasso F. Inhibition of intestinal motility and secretion by flavonoids in mice and rats: structure-activity relationships. J. Pharm. Pharmacol. 45 (1993) 1054-1059
7. Forster H., Niklas H., and Lutz S. Antispasmodic effects of some medicinal plants. Plant. Med. 40 (1980) 309-319
8. Germann, I., 2005. Radikalfangende Eigenschaften von pflanzlichen Entzündungshemmern. Dissertation, Fakultät für Chemie und Pharmazie, Universität Tübingen.
9. ®). Phytomedicine 13 Suppl. V (2006) 45-50
10. Gundermann K.-J., Godehardt E., and Ulbrich M. Efficacy of a herbal preparation in patients with functional dyspepsia: a meta-analysis of double-blind, randomized, clinical trials. Adv. Ther. 20 (2003) 2-7
11. Hahn R., and Nahrstedt A. Hydroxycinnamic acid derivatives, caffeoylmalic and new caffeoylaldonic acid esters from Chelidonium majus. Plant. Med. 59 (1993) 71-75
12. Härmälä P., and Vuorela H. Isolation and testing of the calcium blocking activity of Furanocoumarins from Angelica archangelica. Plant. Med. 57 (1991) A58-A59
13. Holtmann G., Adam B., and Vinson B. Evidenz-basierte Medizin und Phytotherapie bei funktioneller Dyspepsie und Reizdarmsyndrom: Eine systematische Analyse der verfügbaren Evidenz zum Präparat Iberogast. [Evidence-based medicine and phytotherapy for functional dyspepsia and irritable bowel syndrome: a systematic analysis of evidence for the herbal preparation Iberogast]. Wien. Med. Wochenschr. 154 (2004) 21-22
14. Izzo A., Capasso R., Senatore F., Seccia S., and Morrica P. Spasmolytic activity of medicinal plants used for the treatment of disorders involving smooth muscles. Ptytother. Res. 10 (1996) 107-108
15. Kleibeuker J.-H., and Thijs J.-C. Functional dispepsia. Curr. Opin. Gastroenterol. 20 (2004) 546-550
16. 2+ entry and vasoconstriction during osmotic swelling of vascular smooth muscle cells. Pflügers Arch. Eur. J. Physiol. 431 (1995) 253-258
17. ®). Aliment. Pharmacol. Ther. 20 (2004) 40-49
18. ®) reduces afferent sensitivity in the rat small intestine. Phytomedicine 13 Suppl. V (2006) 100-106
19. Okpanyi S.N., Mark M., and Wahl M.A. Gastrointestinal motility modulation with Iberogast. Acta Hortic. 332 (1993) 227-235
20. Reiter M., and Brandt W. Relaxant effects on tracheal and ileal smooth muscles of the guinea pig. Arzneimittel Forschung 35 1 (1985) 408-414
21. Rösch W., Liebregts T., Gundermann K.-J., Vinson B., and Holtmann G. Phytotherapy for functional dyspepsia: a review of the clinical evidence for the herbal preparation STW 5. Phytomedicine 13 Suppl. V (2006) 114-121
22. Seeger R. Die Wirkung von Silymarin auf die osmotische Resistenz der Erythrocyten. Arzneimittel Forschung 21 (1971) 1599-1605
23. ®) and its individual herbal components modulate intestinal electrophysiology of mice. Phytomedicine 13 Suppl. V (2006) 80-89
24. 3, and opioid receptors. Phytomedicine 13 Suppl. V (2006) 51-55
25. Tack J., and Lee K.-J. Pathophysiology and treatment of functional dyspepsia. J. Clin. Gastroenterol. 39 (2005) 211-216
26. Talley N.-J. Irritable bowel syndrome: disease definition and symptom description. Eur. J. Surg. Suppl. (1998) 24-28
27. Talley N.-J., Zinsmeister A.R., Schleck C.D., and Melton I.J. Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology 102 (1992) 1259-1268
28. Vahlensieck U., Hahn R., Winterhoff H., Gumbinger H.G., Nahrstedt A., and Kemper F.H. The effect of Chelidonium majus herb extraction choleresis in the isolated perfused rat liver. Planta Medica 61 (1995) 267-270
29. Vozeh S. Is the increasing use of evidence-based pharmacotherapy causing the renaissance of complementary medicine?. Br. J. Clin. Pharmacol. 56 (2003) 292-296
30. Wrocinski T. On some pharmacodynamic properties of chelidonine. Biuletyn Instytutu Roselin Lecznicych 9 (1963) 136-141