Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy

Progress in Polymer Science

Volumn 64, Issue , 2017, Pages 154-181

  Amjad, Muhammad Wahab ^a   Kesharwani, Prashant ^b,c   Mohd Amin, Mohd Cairul Iqbal ^a   Iyer, Arun K ^c,d  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^c WAYNE STATE UNIVERSITY   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Active targeting; Multidrug resistance; Passive targeting; Polymeric micelles; Proton sponge effect; siRNA

Indexed keywords

DISEASE CONTROL; DISEASES; GENE THERAPY; MICELLES; NUCLEIC ACIDS; RNA;

ACTIVE TARGETING; MULTIDRUG RESISTANCE; PASSIVE TARGETING; POLYMERIC MICELLE; PROTON SPONGE; SIRNA;

POLYMERS;

EID: 85005995802     PISSN: 00796700     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.progpolymsci.2016.09.008     Document Type: Review

References (244)

1. [1] Liu, G., Wong-Staal, F., Li, Q.X., Development of new RNAi therapeutics. Histol Histopathol 22 (2007), 211–217.
2. [2] Gondi, C.S., Rao, J.S., Concepts in in vivo siRNA delivery for cancer therapy. J Cell Physiol 220 (2009), 285–291.
3. [3] Lee, S.J., Kim, M.J., Kwon, I.C., Roberts, T.M., Delivery strategies and potential targets for siRNA in major cancer types. Adv Drug Deliv Rev 104 (2016), 2–15.
4. [4] Bumcrot, D., Manoharan, M., Koteliansky, V., Sah, D.W.Y., RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol 2 (2006), 711–719.
5. [5] Zhao, Y., Wang, W., Guo, S., Wang, Y., Miao, L., Xiong, Y., Huang, L., PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery. Nat Commun, 7, 2016 11822/1-9.
6. [6] Leng, Q., Woodle, M.C., Lu, P.Y., Mixson, A.J., Advances in systemic siRNA delivery. Drugs Future 34 (2009), 721–737.
7. [7] Melnikova, I., RNA-based therapies. Nat Rev Drug Discov 6 (2007), 863–864.
8. [8] Mishra, V., Kesharwani, P., Jain, N.K., siRNA nanotherapeutics: a Trojan horse approach against HIV. Drug Discov Today 19 (2014), 1913–1920.
9. [9] Oh, Y.K., Park, T.G., siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 61 (2009), 850–862.
10. [10] Amjad, M.W., Amin, M.C., Katas, H., Butt, A.M., Kesharwani, P., Iyer, A.K., In vivo antitumor activity of folate-conjugated cholic acid-polyethylenimine micelles for the codelivery of doxorubicin and siRNA to colorectal adenocarcinomas. Mol Pharm 12 (2015), 4247–4258.
11. [11] Dejneka, N.S., Wan, S., Bond, O.S., Kornbrust, D.J., Reich, S.J., Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes. Mol Vis 14 (2008), 997–1005.
12. [12] Burnett, J.C., Rossi, J.J., Tiemann, K., Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol J 6 (2011), 1130–1146.
13. [13] Davis, M.E., Zuckerman, J.E., Choi, C.H.J., Seligson, D., Tolcher, A., Alabi, C.A., Yen, Y., Heidel, J.D., Ribas, A., Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464 (2010), 1067–1070.
14. [14] Teo, J., McCarroll, J.A., Boyer, C., Youkhana, J., Sagnella, S.M., Duong, H.T.T., Liu, J., Sharbeen, G., Goldstein, D., Davis, T.P., Kavallaris, M., Phillips, P.A., A rationally optimized nanoparticle system for the delivery of RNA interference therapeutics into pancreatic tumors in vivo. Biomacromolecules 17 (2016), 2337–2351.
15. [15] Majzoub, R.N., Ewert, K.K., Safinya, C.R., Cationic liposome-nucleic acid nanoparticle assemblies with applications in gene delivery and gene silencing. Philos Trans A, 374, 2016 20150129/1-14.
16. [16] Putnam, D., Polymers for gene delivery across length scales. Nat Mater 5 (2006), 439–451.
17. [17] Lee, D.J., He, D., Kessel, E., Padari, K., Kempter, S., Lächelt, U., Rädler, J.O., Pooga, M., Wagner, E., Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes. J Control Release, 2016, 10.1016/j.jconrel.2016.06.011 [in press].
18. [18] Falamarzian, A., Xiong, X.B., Uludag, H., Lavasanifar, A., Polymeric micelles for siRNA delivery. J Drug Deliv Sci Technol 22 (2012), 43–54.
19. [19] Resnier, P., Montier, T., Mathieu, V., Benoit, J.P., Passirani, C., A review of the current status of siRNA nanomedicines in the treatment of cancer. Biomaterials 34 (2013), 6429–6443.
20. [20] Park, J., Park, J., Pei, Y., Xu, J., Yeo, Y., Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines. Adv Drug Deliv Rev 104 (2016), 93–109.
21. [21] Nimesh, S., Gupta, N., Chandra, R., Strategies and advances in nanomedicine for targeted siRNA delivery. Nanomedicine 6 (2011), 729–746.
22. [22] Kesharwani, P., Banerjee, S., Padhye, S., Sarkar, F.H., Iyer, A.K., Hyaluronic acid engineered nano-micelles loaded with 3,4-difluorobenzylidene curcumin for targeted killing of CD44+ stem-like pancreatic cancer cells. Biomacromolecules 16 (2015), 3042–3053.
23. [23] Kesharwani, P., Banerjee, S., Padhye, S., Sarkar, F.H., Iyer, A.K., Parenterally administrable nano-micelles of 3,4-difluorobenzylidene curcumin for treating pancreatic cancers. Colloids Surf B 132 (2015), 138–145.
24. [24] Yang, S.D., Zhu, W.J., Zhu, Q.L., Chen, W.L., Ren, Z.X., Li, F., Yuan, Z.Q., Li, J.Z., Liu, Y., Zhou, X.F., Liu, C., Zhang, X.N., Binary-copolymer system base on low-density lipoprotein-coupled N-succinyl chitosan lipoic acid micelles for co-delivery MDR1 siRNA and paclitaxel, enhances antitumor effects via reducing drug. J Biomed Mater Res B, 2016, 10.1002/jbm.b.33636 [in press].
25. [25] Nishida, H., Matsumoto, Y., Kawana, K., Christie, R.J., Naito, M., Kim, B.S., Toh, K., Min, H.S., Yi, Y., Matsumoto, Y., Kim, H.J., Miyata, K., Taguchi, A., Tomio, K., Yamashita, A., Inoue, T., Nakamura, H., Fujimoto, A., Sato, M., Yoshida, M., Adachi, K., Arimoto, T., WadaHiraike, O., Oda, K., Nagamatsu, T., Nishiyama, N., Kataoka, K., Osuga, Y., Fujii, T., Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. J Control Release 231 (2016), 29–37.
26. [26] Lee, S.Y., Yang, C.Y., Peng, C.L., Wei, M.F., Chen, K.C., Yao, C.J., Shieh, M.J., A theranostic micelleplex co-delivering SN-38 and VEGF siRNA for colorectal cancer therapy. Biomaterials 86 (2016), 92–105.
27. [27] Whitehead, K.A., Langer, R., Anderson, D.G., Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 8 (2009), 129–138.
28. [28] Conde, J., Ambrosone, A., Hernandez, Y., Tian, F., McCully, M., Berry, C.C., Baptista, P.V., Tortiglionec, B.C., de la Fuente, J.M., 15 years on siRNA delivery: beyond the state-of-the-art on inorganic nanoparticles for RNAi therapeutics. Nano Today 10 (2015), 421–450.
29. [29] Guo, J., Cahill, M.R., McKenna, S.L., O'Driscoll, C.M., Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia. Biotechnol Adv 32 (2014), 1396–1409.
30. [30] Tekade, R.K., Tekade, M., Kesharwani, P., D'Emanuele, A., RNAi-combined nano-chemotherapeutics to tackle resistant tumors. Drug Discov Today, 2016, 10.1016/j.drudis.2016.06.029 [in press] Epub ahead of print.
31. [31] Navarro, G., Essex, S., Torchilin, V.P., The “non-viral” approach for sirna delivery in cancer treatment: a special focus on micelles and liposomes. Erdmann, V.A., Barciszewski, J., (eds.) DNA RNA nanobiotechnologies. Medicine: diagnosis and treatment of diseases, 2013, Springer-Verlag, Berlin, 241–261.
32. [32] Xia, Y., Tian, J., Chen, X., Effect of surface properties on liposomal siRNA delivery. Biomaterials 79 (2016), 56–68.
33. [33] Kanasty, R.L., Whitehead, K.A., Vegas, A.J., Anderson, D.G., Action and reaction: the biological response to siRNA and its delivery vehicles. Mol Ther 20 (2012), 513–524.
34. [34] Gomes, M.J., Martins, S., Sarmento, B., siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery. Ageing Res Rev 21 (2015), 43–54.
35. [35] Guo, P., Coban, O., Snead, N.M., Trebley, J., Hoeprich, S., Guo, S., Shu, Y., Engineering RNA for targeted sirna delivery and medical application. Adv Drug Deliv Rev 62 (2010), 650–666.
36. [36] Pecot, C.V., Calin, G.A., Coleman, R.L., Lopez-Berestein, G., Sood, A.K., RNA interference in the clinic: challenges and future directions. Nat Rev Cancer 11 (2011), 59–67.
37. [37] Videira, M., Arranja, A., Rafael, D., Gaspar, R., Preclinical development of siRNA therapeutics: towards the match between fundamental science and engineered systems. Nanomedicine 10 (2014), 689–702.
38. [38] Koppers-Lalic, D., Hogenboom, M.M., Middeldorp, J.M., Pegtel, D.M., Virus-modified exosomes for targeted RNA delivery; a new approach in nanomedicine. Adv Drug Deliv Rev 65 (2013), 348–356.
39. [39] Kesharwani, P., Jain, K., Jain, N.K., Dendrimer as nanocarrier for drug delivery. Prog Polym Sci 39 (2014), 268–307.
40. [40] Kim, H.J., Kim, A., Miyata, K., Kataoka, K., Recent progress in development of siRNA delivery vehicles for cancer therapy. Adv Drug Deliv Rev 104 (2016), 61–77.
41. [41] Sheikhi Mehrabadi, F., Fischer, W., Haag, R., Dendritic and lipid-based carriers for gene/siRNA delivery (a review). Curr Opin Solid State Mater Sci 16 (2012), 310–322.
42. [42] Musacchio, T., Torchilin, V.P., siRNA delivery: from basics to therapeutic applications. Front Biosci 18 (2013), 58–79.
43. [43] Mitchell, E.P., Targeted therapy for metastatic colorectal cancer: role of aflibercept. Clin Colorectal Cancer 12 (2013), 73–85.
44. [44] Wan, B., Wang, Z.X., Lv, Q.Y., Dong, P.X., Zhao, L.X., Yang, Y., Guo, L.H., Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages. Toxicol Lett 221 (2013), 118–127.
45. [45] Kesharwani, P., Gajbhiye, V., Jain, N.K., A review of nanocarriers for the delivery of small interfering RNA. Biomaterials 33 (2012), 7138–7150.
46. [46] Gilmore, I.R., Fox, S.P., Hollins, A.J., Sohail, M., Akhtar, S., The design and exogenous delivery of siRNA for post-transcriptional gene silencing. J Drug Target 12 (2004), 315–340.
47. [47] Murthy, N., Campbell, J., Fausto, N., Hoffman, A.S., Stayton, P.S., Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. J Control Release 89 (2003), 365–374.
48. [48] Kesharwani, P., Banerjee, S., Gupta, U., Mohd Amin, M.C.I., Padhye, S., Sarkar, F.H., Iyer, A.K., PAMAM dendrimers as promising nanocarriers for RNAi therapeutics. Mater Today 18 (2015), 565–572.
49. [49] Keller, M., Lipidic carriers of RNA/DNA oligonucleotides and polynucleotides: what a difference a formulation makes!. J Control Release 103 (2005), 537–540.
50. [50] de Carvalho Vicentini, F.T.M., Borgheti-Cardoso, L.N., Depieri, L.V., de Macedo Mano, D., Abelha, T.F., Petrilli, R., Bentley, M.V., Delivery systems and local administration routes for therapeutic siRNA. Pharm Res 30 (2013), 915–931.
51. [51] Schiffelers, R.M., Woodle, M.C., Scaria, P., Pharmaceutical prospects for RNA interference. Pharm Res 21 (2004), 1–7.
52. [52] Xu, C.F., Liu, Y., Shen, S., Zhu, Y.H., Wang, J., Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy. Biomaterials 51 (2015), 1–11.
53. [53] Zeng, L., Li, J., Wang, Y., Qian, C., Chen, Y., Zhang, Q., Wu, W., Lin, Z., Liang, J., Shuai, X., Huang, K., Combination of siRNA-directed Kras oncogene silencing and arsenic-induced apoptosis using a nanomedicine strategy for the effective treatment of pancreatic cancer. Nanomedicine 10 (2014), 463–472.
54. [54] Shaat, H., Mostafa, A., Moustafa, M., Gamal-Eldeen, A., Emam, A., El-Hussieny, E., Elhefnawi, M., Modified gold nanoparticles for intracellular delivery of anti-liver cancer siRNA. Int J Pharm 504 (2016), 125–133.
55. [55] Lee, S.J., Yook, S., Yhee, J.Y., Yoon, H.Y., Kim, M.G., Ku, S.H., Kim, S.H., Park, J.H., Jeong, J.H., Kwon, I.C., Lee, S., Lee, H., Kim, K., Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo. J Control Release 20 (2015), 631–641.
56. [56] De Backer, L., Cerrada, A., PérezGil, J., De Smedt, S.C., Raemdonck, K., Bio-inspired materials in drug delivery: exploring the role of pulmonary surfactant in siRNA inhalation therapy. J Control Release 220 (2015), 642–650.
57. [57] Xie, Y., Kim, N.H., Nadithe, V., Schalk, D., Thakur, A., Kılıç, A., Lum, L.G., Bassett, D.J., Merkel, O.M., Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma. J Control Release 229 (2016), 120–129.
58. [58] Sato, Y., Note, Y., Maeki, M., Kaji, N., Baba, Y., Tokeshi, M., Harashima, H., Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery. J Control Release 229 (2016), 48–57.
59. [59] Sun, T.M., Du, J.Z., Yan, L.F., Mao, H.Q., Wang, J., Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery. Biomaterials 29 (2008), 4348–4355.
60. [60] Xiong, X.B., Uludağ, H., Lavasanifar, A., Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery. Biomaterials 30 (2009), 242–253.
61. [61] Li, Y., Kwon, G.S., Methotrexate esters of poly(ethylene oxide)-block-poly(2-hydroxyethyl-L-aspartamide). Part I: effects of the level of methotrexate conjugation on the stability of micelles and on drug release. Pharm Res 17 (2000), 607–611.
62. [62] Kozlov, M.Y., Melik-Nubarov, N.S., Batrakova, E.V., Kabanov, A.V., Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes. Macromolecules 33 (2000), 3305–3313.
63. [63] Batrakova, E.V., Li, S., Vinogradov, S.V., Alakhov, V.Y., Miller, D.W., Kabanov, A.V., Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization. J Pharmacol Exp Ther 299 (2001), 483–493.
64. [64] Kabanov, A.V., Batrakova, E.V., Li, S., Alakhov, V.Y., Selective energy depletion and sensitization of multiple drug-resistant cancer cells by pluronic block copolymer. Macromol Symp 172 (2001), 103–112.
65. [65] Husmann, M., Schenderlein, S., Lück, M., Lindner, H., Kleinebudde, P., Polymer erosion in PLGA microparticles produced by phase separation method. Int J Pharm 242 (2002), 277–280.
66. [66] Brannon-Peppas, L., Ghosn, B., Roy, K., Cornetta, K., Encapsulation of nucleic acids and opportunities for cancer treatment. Pharm Res 24 (2007), 618–627.
67. [67] Rösler, A., Vandermeulen, G.W., Klok, H.A., Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv Drug Deliv Rev 53 (2001), 95–108.
68. [68] O'Reilly, R.K., Hawker, C.J., Wooley, K.L., Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility. Chem Soc Rev 35 (2006), 1068–1083.
69. [69] Oishi, M., Nagasaki, Y., Itaka, K., Nishiyama, N., Kataoka, K., Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J Am Chem Soc 127 (2005), 1624–1625.
70. [70] Kim, H.J., Zheng, M., Miyata, K., Kataoka, K., Preparation of polyion complex micelles using block copolymers for sirna delivery. Methods Mol Biol 1364 (2016), 89–103.
71. [71] Dominska, M., Dykxhoorn, D.M., Breaking down the barriers: siRNA delivery and endosome escape. J Cell Sci 123 (2010), 1183–1189.
72. [72] Ebrahim Attia, A.B., Yang, C., Tan, J.P.K., Gao, S., Williams, D.F., Hedrick, J.L., Yang, Y.Y., The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles. Biomaterials 34 (2013), 3132–3140.
73. [73] Yu, Y., Qiu, L., Optimizing particle size of docetaxel-loaded micelles for enhanced treatment of oral epidermoid carcinoma. Nanomedicine 12 (2016), 1941–1949.
74. [74] Lin, W.J., Juang, L.W., Wang, C.L., Chen, Y.C., Lin, C.C., Chang, K.L., Pegylated polyester polymeric micelles as a nano-carrier: synthesis, characterization, degradation, and biodistribution. J Exp Clin Med 2 (2010), 4–10.
75. [75] Nakayama, M., Akimoto, J., Okano, T., Polymeric micelles with stimuli-triggering systems for advanced cancer drug targeting. J Drug Target 22 (2014), 584–599.
76. [76] Nagayama, S., Ogawara, K., Fukuoka, Y., Higaki, K., Kimura, T., Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics. Int J Pharm 342 (2007), 215–221.
77. [77] Hu, X., Yang, F.F., Quan, L.H., Liu, C.Y., Liu, X.M., Ehrhardt, C., Liao, Y.H., Pulmonary delivered polymeric micelles—pharmacokinetic evaluation and biodistribution studies. Eur J Pharm Biopharm 88 (2014), 1064–1075.
78. [78] Fang, C., Shi, B., Pei, Y.Y., Hong, M.H., Wu, J., Chen, H.Z., In vivo tumor targeting of tumor necrosis factor-alpha-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size. Eur J Pharm Sci 27 (2006), 27–36.
79. [79] Rijcken, C.J., Snel, C.J., Schiffelers, R.M., van Nostrum, C.F., Hennink, W.E., Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials 28 (2007), 5581–5593.
80. [80] Yamamoto, Y., Nagasaki, Y., Kato, Y., Sugiyama, Y., Kataoka, K., Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge. J Control Release 77 (2001), 27–38.
81. [81] Kommareddy, S., Amiji, M., Biodistribution and pharmacokinetic analysis of long-circulating thiolated gelatin nanoparticles following systemic administration in breast cancer-bearing mice. J Pharm Sci 96 (2007), 397–407.
82. [82] Wang, C., Mallela, J., Mohapatra, S., Pharmacokinetics of polymeric micelles for cancer treatment. Curr Drug Metab 14 (2013), 900–909.
83. [83] Yang, X., Li, L., Wang, Y., Tan, Y., Preparation, pharmacokinetics and tissue distribution of micelles made of reverse thermo-responsive polymers. Int J Pharm 370 (2009), 210–215.
84. [84] Montazeri Aliabadi, H., Brocks, D.R., Lavasanifar, A., Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution. Biomaterials 26 (2005), 7251–7259.
85. a directed to enhance intracellular gene silencing. J Am Chem Soc 126 (2004), 13612–13613.
86. [86] Liu, X.Q., Sun, C.Y., Yang, X.Z., Wang, J., Polymeric-micelle-based nanomedicine for sirna delivery. Part Part Syst Charact 30 (2013), 211–228.
87. [87] Mao, C.Q., Du, J.Z., Sun, T.M., Yao, Y.D., Zhang, P.Z., Song, E.W., Wang, J., A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy. Biomaterials 32 (2011), 3124–3133.
88. [88] Xiong, X.B., Uludağ, H., Lavasanifar, A., Virus-mimetic polymeric micelles for targeted siRNA delivery. Biomaterials 31 (2010), 5886–5893.
89. [89] Zhao, Z.X., Gao, S.Y., Wang, J.C., Chen, C.J., Zhao, E.Y., Hou, W.J., Feng, Q., Gao, L.Y., Liu, X.Y., Zhang, L.R., Zhang, Q., Self-assembly nanomicelles based on cationic mPEG-PLA-b-polyarginine(R15) triblock copolymer for siRNA delivery. Biomaterials 33 (2012), 6793–6807.
90. [90] Kim, T., Rothmund, T., Kissel, T., Kim, S.W., Bioreducible polymers with cell penetrating and endosome buffering functionality for gene delivery systems. J Control Release 152 (2011), 110–119.
91. [91] Qi, R., Liu, S., Chen, J., Xiao, H., Yan, L., Huang, Y., Jing, X., Biodegradable copolymers with identical cationic segments and their performance in siRNA delivery. J Control Release 159 (2012), 251–260.
92. [92] Lin, D., Huang, Y., Jiang, Q., Zhang, W., Yue, X., Guo, S., Xiao, P., Du, Q., Xing, J., Deng, L., Liang, Z., Dong, A., Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate) on PEGylated polycaprolactone nanoparticles in siRNA delivery. Biomaterials 32 (2011), 730–742.
93. [93] Nakanishi, M., Patil, R., Ren, Y., Shyam, R., Wong, P., Mao, H.Q., Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA micellar nanoparticles by co-condensation with sodium triphosphate. Pharm Res 28 (2011), 1723–1732.
94. [94] Philipp, A., Zhao, X., Tarcha, P., Wagner, E., Zintchenko, A., Hydrophobically modified oligoethylenimines as highly efficient transfection agents for siRNA delivery. Bioconjug Chem 20 (2009), 2055–2061.
95. [95] Mao, S., Neu, M., Germershaus, O., Merkel, O., Sitterberg, J., Bakowsky, U., Kissel, T., Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes. Bioconjug Chem 17 (2006), 1209–1218.
96. [96] Grayson, A.C.R., Doody, A.M., Putnam, D., Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro. Pharm Res 23 (2006), 1868–1876.
97. [97] Navarro, G., Sawant, R.R., Essex, S., Tros de Ilarduya, C., Torchilin, V.P., Phospholipid-polyethylenimine conjugate-based micelle-like nanoparticles for siRNA delivery. Drug Deliv Transl Res 1 (2011), 25–33.
98. [98] Navarro, G., Sawant, R.R., Biswas, S., Essex, S., Tros de Ilarduya, C., Torchilin, V.P., P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells. Nanomedicine 7 (2012), 65–78.
99. [99] Ryu, D.W., Kim, H.A., Song, H., Kim, S., Lee, M., Amphiphilic peptides with arginines and valines for the delivery of plasmid DNA. J Cell Biochem 112 (2011), 1458–1466.
100. [100] Ryu, D.W., Kim, H.A., Ryu, J.H., Lee, D.Y., Lee, M., Amphiphilic peptides with arginine and valine residues as siRNA carriers. J Cell Biochem 113 (2012), 619–628.
101. [101] Luo, Y., Ziebell, M.R., Prestwich, G.D., A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules 1 (2000), 208–218.
102. [102] Shen, Y., Li, Q., Tu, J., Zhu, J., Synthesis and characterization of low molecular weight hyaluronic acid-based cationic micelles for efficient siRNA delivery. Carbohydr Polym 77 (2009), 95–104.
103. [103] Shen, Y., Wang, B., Lu, Y., Ouahab, A., Li, Q., Tu, J., A novel tumor-targeted delivery system with hydrophobized hyaluronic acid-spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery. Int J Pharm 414 (2011), 233–243.
104. [104] Jeong, K., Kang, C.S., Kim, Y., Lee, Y.D., Kwon, I.C., Kim, S., Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy. Cancer Lett 374 (2016), 31–43.
105. [105] Iyer, A.K., Khaled, G., Fang, J., Maeda, H., Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today 11 (2006), 812–818.
106. [106] Kesharwani, P., Iyer, A.K., Recent advances in dendrimer-based nanovectors for tumor-targeted drug and gene delivery. Drug Discov Today 20 (2015), 536–547.
107. [107] Peer, D., Lieberman, J., Special delivery: targeted therapy with small RNAs. Gene Ther 18 (2011), 1127–1133.
108. [108] Maeda, H., Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity. Adv Drug Deliv Rev 91 (2015), 3–6.
109. [109] Kim, S.H., Jeong, J.H., Lee, S.H., Kim, S.W., Park, T.G., Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J Control Release 129 (2008), 107–116.
110. [110] Rettig, G.R., Behlke, M.A., Progress toward in vivo use of siRNAs-II. Mol Ther 20 (2012), 483–512.
111. [111] Zhang, C., Zhu, W., Liu, Y., Yuan, Z., Yang, S., Chen, W.L., Li, J.Z., Zhou, X.F., Liu, C., Zhang, X.N., Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy. Sci Rep, 6, 2016 23859/1-12.
112. [112] Zheng, C., Zheng, M., Gong, P., Deng, J., Yi, H., Zhang, P., Zhang, Y., Liu, P., Ma, Y., Cai, L., Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy. Biomaterials 34 (2013), 3431–3438.
113. [113] Sun, T.M., Du, J.Z., Yao, Y.D., Mao, C.Q., Dou, S., Huang, S.Y., Zhang, P.Z., Leong, K.W., Song, E.W., Wang, J., Simultaneous delivery of siRNA and paclitaxel via a “two-in-one” micelleplex promotes synergistic tumor suppression. ACS Nano 5 (2011), 1483–1494.
114. [114] Kirpotin, D.B., Drummond, D.C., Shao, Y., Shalaby, M.R., Hong, K., Nielsen, U.B., Marks, J.D., Benz, C.C., Park, J.W., Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 66 (2006), 6732–6740.
115. [115] Bartlett, D.W., Su, H., Hildebrandt, I.J., Weber, W.A., Davis, M.E., Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc Natl Acad Sci U S A 104 (2007), 15549–15554.
116. [116] Winkler, J., Martin-Killias, P., Plückthun, A., Zangemeister-Wittke, U., EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins. Mol Cancer Ther 8 (2009), 2674–2683.
117. [117] Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, A.F., Zhang, L., Pridgen, E., Wang, A.Z., Marein, S.L., Westerhof, K., Molnar, L.K., Farokhzad, O.C., HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy. ChemMedChem 3 (2008), 1839–1843.
118. [118] Karmali, P.P., Kotamraju, V.R., Kastantin, M., Black, M., Missirlis, D., Tirrell Ruoslahti, E., Targeting of albumin-embedded paclitaxel nanoparticles to tumors. Nanomedicine 5 (2009), 73–82.
119. [119] Park, J.H., von Maltzahn, G., Zhang, L., Schwartz, M.P., Ruoslahti, E., Bhatia, S.N., Sailor, M.J., Magnetic iron oxide nanoworms for tumor targeting and imaging. Adv Mater 20 (2008), 1630–1635.
120. [120] Sugahara, K.N., Teesalu, T., Karmali, P.P., Kotamraju, V.R., Agemy, L., Girard, O.M., Hanahan, D., Mattrey, R.F., Ruoslahti, E., Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 16 (2009), 510–520.
121. [121] Graf, N., Bielenberg, D.R., Kolishetti, N., Muus, C., Banyard, J., Farokhzad, O.C., Lippard, S.J., α(V)β(3) integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug. ACS Nano 6 (2012), 4530–4539.
122. [122] Kamaly, N., Fredman, G., Subramanian, M., Gadde, S., Pesic, A., Cheung, L., Fayad, Z.A., Langer, R., Tabas, I., Farokhzad, O.C., Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles. Proc Natl Acad Sci U S A 110 (2013), 6506–6511.
123. [123] Chan, J.M., Rhee, J.W., Drum, C.L., Bronson, R.T., Golomb, G., Langer, R., Farokhzad, O.C., In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl Acad Sci U S A 1008 (2011), 19347–19352.
124. [124] Chan, J.M., Zhang, L., Tong, R., Ghosh, D., Gao, W., Liao, G., Yuet, K.P., Gray, D., Rhee, J.W., Cheng, J., Golomb, G., Libby, P., Langer, R., Farokhzad, O.C., Spatiotemporal controlled delivery of nanoparticles to injured vasculature. Proc Natl Acad Sci U S A 107 (2010), 2213–2218.
125. [125] Saw, P.E., Kim, S., Lee, I., Park, J., Yu, M., Lee, J., Kimb, J.I., Jon, S., Aptide-conjugated liposome targeting tumor-associated fibronectin for glioma therapy. J Mater Chem B 1 (2013), 4723–4726.
126. [126] Cheng, J., Teply, B.A., Sherifi, I., Sung, J., Luther, G., Gu, F.X., Levy-Nissenbaum, E., Radovic-Moreno, A.F., Langer, R., Farokhzad, O.C., Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 28 (2007), 869–876.
127. [127] Kim, D., Jeong, Y.Y., Jon, S., A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 4 (2010), 3689–3696.
128. [128] Xiao, Z., Ji, C., Shi, J., Pridgen, E.M., Frieder, J., Wu, J., Farokhzad, O.C., DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed 51 (2012), 11853–11857.
129. [129] Werner, M.E., Karve, S., Sukumar, R., Cummings, N.D., Copp, J.A., Chen, R.C., Zhang, T., Wang, A.Z., Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials 32 (2011), 8548–8554.
130. [130] Marrache, S., Dhar, S., Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proc Natl Acad Sci U S A 109 (2012), 16288–16293.
131. [131] Hrkach, J., Von Hoff, D., Mukkaram Ali, M., Andrianova, E., Auer, J., Campbell, T., De Witt, D., Figa, M., Figueiredo, M., Horhota, A., Low, S., McDonnell, K., Peeke, E., Retnarajan, B., Sabnis, A., Schnipper, E., Song, J.J., Song, Y.H., Summa, J., Tompsett, D., Troiano, G., Van Geen Hoven, T., Wright, J., LoRusso, P., Kantoff, P.W., Bander, N.H., Sweeney, C., Farokhzad, O.C., Langer, R., Zale, S., Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med 4 (2012), 128–139.
132. [132] Gao, Z., Lukyanov, A.N., Singhal, A., Torchilin, V.P., Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Lett 2 (2002), 979–982.
133. [133] Torchilin, V., Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate. Adv Drug Deliv Rev 57 (2005), 95–109.
134. [134] Campbell, I.G., Jones, T.A., Foulkes, W.D., Trowsdale, J., Folate-binding protein is a marker for ovarian cancer. Cancer Res 51 (1991), 5329–5338.
135. [135] Jang, M., Kim, J.H., Nam, H.Y., Kwon, I.C., Ahn, H.J., Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription. Nat Commun, 6, 2015 7930/1-12.
136. [136] Yang, X., Iyer, A.K., Singh, A., Choy, E., Hornicek, F.J., Amiji, M.M., Duan, Z., MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. Sci Rep, 5, 2015 8509/1-9.
137. [137] Yang, X., Iyer, A.K., Singh, A., Milane, L., Choy, E., Hornicek, F.J., Amiji, M.M., Duan, Z., Cluster of differentiation 44 targeted hyaluronic acid based nanoparticles for MDR1 siRNA delivery to overcome drug resistance in ovarian cancer. Pharm Res 32 (2014), 2097–2109.
138. [138] Ganesh, S., Iyer, A.K., D.Morrissey, D.V., Amiji, M.M., Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors. Biomaterials 34 (2013), 3489–3502.
139. [139] Yin, T., Wang, L., Yin, L., Zhou, J., Huo, M., Co-delivery of hydrophobic paclitaxel and hydrophilic AURKA specific siRNA by redox-sensitive micelles for effective treatment of breast cancer. Biomaterials 61 (2015), 10–25.
140. [140] Ren, W., Chang, J., Yan, C., Qian, X., Long, L., He, B., Yuan, X.B., Kang, C.S., Betbeder, D., Sheng, J., Pu, P.Y., Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma. J Mater Sci Mater Med 21 (2010), 2673–2681.
141. [141] Kim, S.H., Jeong, J.H., Lee, S.H., Kim, S.W., Park, T.G., LHRH receptor-mediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI. Bioconjug Chem 19 (2008), 2156–2162.
142. [142] Zeng, F., Lee, H., Allen, C., Epidermal growth factor-conjugated poly(ethylene glycol)-block-poly(delta-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics. Bioconjug Chem 17 (2006), 399–409.
143. [143] Oe, Y., Christie, R.J., Naito, M., Low, S.A., Fukushima, S., Toh, K., Miura, Y., Matsumoto, Y., Nishiyama, N., Miyata, K., Kataoka, K., Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors. Biomaterials 35 (2014), 7887–7895.
144. [144] Christie, R.J., Matsumoto, Y., Miyata, K., Nomoto, T., Fukushima, S., Osada, K., Halnaut, J., Pittella, F., Kim, H.J., Nishiyama, N., Kataoka, K., Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 6 (2012), 5174–5189.
145. [145] Xiong, X.B., Lavasanifar, A., Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin. ACS Nano 5 (2011), 5202–5213.
146. [146] Son, S., Singha, K., Kim, W.J., Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier. Biomaterials 31 (2010), 6344–6354.
147. [147] Wang, X., Wang, Y., Chen, X., Wang, J., Zhang, X., Zhang, Q., NGR-modified micelles enhance their interaction with CD13-overexpressing tumor and endothelial cells. J Control Release 139 (2009), 56–62.
148. [148] Wang, L., Hao, Y., Li, H., Zhao, Y., Meng, D., Li, D., Shi, J., Zhang, H., Zhang, Z., Zhang, Y., Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles. J Drug Target 23 (2015), 832–846.
149. [149] Huo, H., Gao, Y., Wang, Y., Zhang, J., Wang, Z.Y., Jiang, T., Wang, S., Polyion complex micelles composed of pegylated polyasparthydrazide derivatives for siRNA delivery to the brain. J Colloid Interface Sci 447 (2015), 8–15.
150. [150] Kanazawa, T., Akiyama, F., Kakizaki, S., Takashima, Y., Seta, Y., Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles. Biomaterials 34 (2013), 9220–9226.
151. [151] Palanca-Wessels, M.C., Convertine, A.J., Cutler-Strom, R., Booth, G.C., Lee, F., Berguig, G.Y., Stayton, P.S., Press, O.W., Anti-CD22 antibody targeting of pH-responsive micelles enhances small interfering RNA delivery and gene silencing in lymphoma cells. Mol Ther 19 (2011), 1529–1537.
152. [152] Dou, S., Yao, Y.D., Yang, X.Z., Sun, T.M., Mao, C.Q., Song, E.W., Wang, J., Anti-Her2 single-chain antibody mediated DNMTs-siRNA delivery for targeted breast cancer therapy. J Control Release 161 (2012), 875–883.
153. [153] Zhu, L., Ye, Z., Cheng, K., Miller, D.D., Mahato, R.I., Site-specific delivery of oligonucleotides to hepatocytes after systemic administration. Bioconjug Chem 19 (2008), 290–298.
154. [154] Zhu, L., Mahato, R.I., Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation. Bioconjug Chem 21 (2010), 2119–2127.
155. [155] Wang, H.X., Xiong, M.H., Wang, Y.C., Zhu, J., Wang, J., N-Acetylgalactosamine functionalized mixed micellar nanoparticles for targeted delivery of siRNA to liver. J Control Release 166 (2013), 106–114.
156. [156] Stubbs, M., McSheehy, P.M., Griffiths, J.R., Bashford, C.L., Causes and consequences of tumour acidity and implications for treatment. Mol Med Today 6 (2000), 15–19.
157. [157] Manchun, S., Dass, C.R., Sriamornsak, P., Targeted therapy for cancer using pH-responsive nanocarrier systems. Life Sci 90 (2012), 381–387.
158. [158] Liu, Y., Wang, W., Yang, J., Zhou, C., Sun, J., pH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery. Asian J Pharm Sci 8 (2013), 159–167.
159. [159] Na, K., Lee, E.S., Bae, Y.H., Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro. J Control Release 87 (2003), 3–13.
160. [160] Licciardi, M., Giammona, G., Du, J., Armes, S.P., Tang, Y., Lewis, A.L., New folate-functionalized biocompatible block copolymer micelles as potential anti-cancer drug delivery systems. Polymer 47 (2006), 2946–2955.
161. [161] Felber, A.E., Dufresne, M.H., Leroux, J.C., pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates. Adv Drug Deliv Rev 64 (2012), 979–992.
162. [162] Yang, S.R., Lee, H.J., Kim, J.D., Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin. J Control Release 114 (2006), 60–68.
163. [163] Lee, E.S., Shin, H.J., Na, K., Bae, Y.H., Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization. J Control Release 90 (2003), 363–374.
164. [164] Kim, G.M., Bae, Y.H., Jo, W.H., pH-induced micelle formation of poly(histidine-co-phenylalanine)-block-poly(ethylene glycol) in aqueous media. Macromol Biosci 5 (2005), 1118–1124.
165. [165] Leroux, J., Roux, E., Le Garrec, D., Hong, K., Drummond, D.C., N-Isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles. J Control Release 72 (2001), 71–84.
166. [166] Akimoto, J., Nakayama, M., Sakai, K., Okano, T., Molecular design of outermost surface functionalized thermoresponsive polymeric micelles with biodegradable cores. J Polym Sci A Polym Chem 46 (2008), 7127–7137.
167. [167] Heller, J., Barr, J., Ng, S.Y., Abdellauoi, K.S., Gurny, R., Poly(ortho esters): synthesis, characterization, properties and uses. Adv Drug Deliv Rev 54 (2002), 1015–1039.
168. [168] Gillies, E.R., Goodwin, A.P., Fréchet, J.M.J., Acetals as pH-sensitive linkages for drug delivery. Bioconjug Chem 15 (2004), 1254–1263.
169. [169] Jin, Y., Song, L., Su, Y., Zhu, L., Pang, Y., Qiu, F., Tong, G., Yan, D., Zhu, B., Zhu, X., Oxime linkage: a robust tool for the design of pH-sensitive polymeric drug carriers. Biomacromolecules 12 (2011), 3460–3468.
170. [170] Gillies, E.R., Fréchet, J.M.J., A new approach towards acid sensitive copolymer micelles for drug delivery. Chem Commun, 2003, 1640–1641.
171. [171] Gillies, E.R., Jonsson, T.B., Fréchet, J.M.J., Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers. J Am Chem Soc 126 (2004), 11936–11943.
172. [172] Gillies, E.R., Fréchet, J.M.J., pH-responsive copolymer assemblies for controlled release of doxorubicin. Bioconjug Chem 16 (2005), 361–368.
173. [173] Ponce, A.M., Vujaskovic, Z., Yuan, F., Needham, D., Dewhirst, M.W., Hyperthermia mediated liposomal drug delivery. Int J Hyperthermia 22 (2006), 205–213.
174. [174] Shimada, N., Ino, H., Maie, K., Nakayama, M., Kano, A., Maruyama, A., Ureido-derivatized polymers based on both poly(allylurea) and poly(L-citrulline) exhibit UCST-type phase transition behavior under physiologically relevant conditions. Biomacromolecules 12 (2011), 3418–3422.
175. [175] Nagase, K., Kobayashi, J., Okano, T., Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering. J R Soc Interface 6 (2009), S293–S309.
176. [176] Park, J.S., Kataoka, K., Precise control of lower critical solution temperature of thermosensitive poly(2-isopropyl-2-oxazoline) via gradient copolymerization with 2-ethyl-2-oxazoline as a hydrophilic comonomer. Macromolecules 39 (2006), 6622–6630.
177. [177] Lutz, J.F., Polymerization of oligo(ethylene glycol) (meth)acrylates: toward new generations of smart biocompatible materials. J Polym Sci A Polym Chem 46 (2008), 3459–3470.
178. [178] Nakayama, M., Okano, T., Polymer terminal group effects on properties of thermoresponsive polymeric micelles with controlled outer-shell chain lengths. Biomacromolecules 6 (2005), 2320–2327.
179. [179] Duan, Q., Miura, Y., Narumi, A., Shen, X., Sato, S.I., Satoh, T., Duan, Q., Synthesis and thermoresponsive property of end-functionalized poly(N-isopropylacrylamide) with pyrenyl group. J Polym Sci Part A: Polym Chem 44 (2006), 1117–1124.
180. [180] Nakayama, M., Okano, T., Unique thermoresponsive polymeric micelle behavior via cooperative polymer corona phase transitions. Macromolecules 41 (2008), 504–507.
181. [181] Liu, S.Q., Tong, Y.W., Yang, Y.Y., Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) with varying compositions. Biomaterials 26 (2005), 5064–5074.
182. [182] Nakayama, M., Okano, T., Miyazaki, T., Kohori, F., Sakai, K., Yokoyama, M., Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. J Control Release 115 (2006), 46–56.
183. [183] Yang, M., Ding, Y., Zhang, L., Qian, X., Jiang, X., Liu, B., Novel thermosensitive polymeric micelles for docetaxel delivery. J Biomed Mater Res A 81 (2007), 847–857.
184. [184] Ercole, F., Davis, T.P., Evans, R.A., Photo-responsive systems and biomaterials: photochromic polymers, light-triggered self-assembly, surface modification, fluorescence modulation and beyond. Polym Chem 1 (2010), 37–54.
185. [185] Lee, H., Pietrasik, J., Matyjaszewski, K., Phototunable temperature-responsive molecular brushes prepared by ATRP. Macromolecules 39 (2006), 3914–3920.
186. [186] Wang, G., Tong, X., Zhao, Y., Preparation of azobenzene-containing amphiphilic diblock copolymers for light-responsive micellar aggregates. Macromolecules 37 (2004), 8911–8917.
187. [187] Sanchez, C., Lebeau, B., Chaput, F., JBoilot, J.P., Optical properties of functional hybrid organic–inorganic nanocomposites. Adv Mater 15 (2003), 1969–1994.
188. [188] Lee, H.I., Wu, W., Oh, J.K., Mueller, L., Sherwood, G., Peteanu, L., Kowalewski, T., Matyjaszewski, K., Light-induced reversible formation of polymeric micelles. Angew Chem Int Ed 46 (2007), 2453–2457.
189. [189] Zhao, Y., Rational design of light-controllable polymer micelles. Chem Rec 7 (2007), 286–294.
190. [190] Yan, B., Boyer, J.C., Branda, N.R., Zhao, Y., Near-infrared light-triggered dissociation of block copolymer micelles using upconverting nanoparticles. J Am Chem Soc 133 (2011), 19714–19717.
191. [191] Jiang, J., Tong, X., Zhao, Y., A new design for light-breakable polymer micelles. J Am Chem Soc 127 (2005), 8290–8291.
192. [192] Jiang, J., Tong, X., Morris, D., Zhao, Y., Toward photocontrolled release using light-dissociable block copolymer micelles, macromolecules. Macromolecules 39 (2006), 4633–4640.
193. [193] Babin, J., Pelletier, M., Lepage, M., Allard, J.F., Morris, D., Zhao, Y., A new two-photon-sensitive block copolymer nanocarrier. Angew Chem Int Ed 48 (2009), 3329–3332.
194. [194] Lin, Y.J., Chen, K.T., Huang, C.Y., Wei, K.C., Non-invasive focused ultrasound-based synergistic treatment of brain tumors. J Cancer Res Pract 3 (2016), 63–68.
195. [195] Kaneko, O.F., Willmann, J.K., Ultrasound for molecular imaging and therapy in cancer. Quant Imaging Med Surg 2 (2012), 87–97.
196. [196] Yin, T., Wang, P., Li, J., Zheng, R., Zheng, B., Cheng, D., Li, R., Lai, J., Shuai, X., Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. Biomaterials 34 (2013), 4532–4543.
197. [197] Rapoport, N., Marin, A.P., Timoshin, A.A., Effect of a polymeric surfactant on electron transport in HL-60 cells. Arch Biochem Biophys 384 (2000), 100–108.
198. [198] Rapoport, N., Pitt, W.G., Sun, H., Nelson, J.L., Drug delivery in polymeric micelles: from in vitro to in vivo. J Control Release 91 (2003), 85–95.
199. [199] Torchilin, V.P., Lukyanov, A.N., Gao, Z., Papahadjopoulos-Sternberg, B., Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs. Proc Natl Acad Sci U S A 100 (2003), 6039–6044.
200. [200] Torchilin, V.P., Levchenko, T.S., Lukyanov, A.N., Khaw, B.A., Klibanov, A.L., Rammohan, R., Samokhin, G.P., Whiteman, K.R., p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups. Biochim Biophys Acta 1511 (2001), 397–411.
201. [201] Davis, M.E., The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol Pharm 6 (2009), 659–668.
202. [202] Chou, L.Y.T., Ming, K., Chan, W.C.W., Strategies for the intracellular delivery of nanoparticles. Chem Soc Rev 40 (2011), 233–245.
203. [203] Choi, C.H.J., Alabi, C.A., Webster, P., Davis, M.E., Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci U S A 107 (2010), 1235–1240.
204. [204] Li, L., Wang, H., Ong, Z.Y., Xu, K., Ee, P.L.R., Zheng, S., Hedricke, J.L., Yang, Y.Y., Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases. Nano Today 5 (2010), 296–312.
205. [205] Wisse, E., Jacobs, F., Topal, B., Frederik, P., De Geest, B., The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer. Gene Ther 15 (2008), 1193–1199.
206. [206] Sato, Y., Murase, K., Kato, J., Kobune, M., Sato, T., Kawano, Y., Takimoto, R., Takada, K., Miyanishi, K., Matsunaga, T., Takayama, T., Niitsu, Y., Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 26 (2008), 431–442.
207. [207] Rozema, D.B., Lewis, D.L., Wakefield, D.H., Wong, S.C., Klein, J.J., Roesch, P.L., Bertin, S.L., Reppen, T.W., Chu, Q., Blokhin, A.V., Hagstrom, J.E., Wolff, J.A., Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc Natl Acad Sci U S A 104 (2007), 12982–12987.
208. [208] Akinc, A., Goldberg, M., Qin, J., Dorkin, J.R., Gamba-Vitalo, C., Maier, M., Jayaprakash, K.N., Jayaraman, M., Rajeev, K.G., Manoharan, M., Koteliansky, V., Röhl, I., Leshchiner, E.S., Langer, R., Anderson, D.G., Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol Ther 17 (2009), 872–879.
209. [209] Love, K.T., Mahon, K.P., Levins, C.G., Whitehead, K.A., Querbes, W., Dorkin, J.R., Qin, J., Cantley, W., Qin, L.L., Racie, T., Frank-Kamenetsky, M., Yip, K.N., Alvarez, R., Sah, D.W., de Fougerolles, A., Fitzgerald, K., Koteliansky, V., Akinc, A., Langer, R., Anderson, D.G., Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A 107 (2010), 1864–1869.
210. [210] Whitehead, K.A., Sahay, G., Li, G.Z., Love, K.T., Alabi, C.A., Ma, M., Zurenko, C., Querbes, W., Langer, R.S., Anderson, D.G., Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery. Mol Ther 19 (2011), 1688–1694.
211. [211] Siegwart, D.J., Whitehead, K.A., Nuhn, L., Sahay, G., Cheng, H., Jiang, S., Ma, M., Lytton-Jean, A., Vegas, A., Fenton, P., Levins, C.G., Love, K.T., Lee, H., Cortez, C., Collins, S.P., Li, Y.F., Jang, J., Querbes, W., Zurenko, C., Novobrantseva, T., Langer, R., Anderson, D.G., Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery. Proc Natl Acad Sci U S A 108 (2011), 12996–13001.
212. [212] Frank-Kamenetsky, M., Grefhorst, A., Anderson, N.N., Racie, T.S., Bramlage, B., Akinc, A., Butler, D., Charisse, K., Dorkin, R., Fan, Y., Gamba-Vitalo, C., Hadwiger, P., Jayaraman, M., John, M., Jayaprakash, K.N., Maier, M., Nechev, L., Rajeev, K.G., Read, T., Röhl, I., Soutschek, J., Tan, P., Wong, J., Wang, G., Zimmermann, T., de Fougerolles, A., Vornlocher, H.P., Langer, R., Anderson, D.G., Manoharan, M., Koteliansky, V., Horton, J.D., Fitzgerald, K., Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A 105 (2008), 11915–11920.
213. [213] Ren, Y., Cheung, H.W., von Maltzhan, G., Agrawal, A., Cowley, G.S., Weir, B.A., Boehm, J.S., Tamayo, P., Karst, A.M., Liu, J.F., Hirsch, M.S., Mesirov, J.P., Drapkin, R., Root, D.E., Lo, J., Fogal, V., Ruoslahti, E., Hahn, W.C., Bhatia, S.N., Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med, 4, 2012 147ra112/1-12.
214. [214] Yao, Y., Sun, T., Huang, S., Dou, S., Lin, L., Chen, J., Ruan, J.B., Mao, C.Q., Yu, F.Y., Zeng, M.S., Zang, J.Y., Liu, Q., Su, F.X., Zhang, P., Lieberman, J., Wang, J., Song, E., Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med, 4, 2012 130ra48/1-10.
215. [215] Leuschner, F., Dutta, P., Gorbatov, R., Novobrantseva, T.I., Donahoe, J.S., Courties, G., Lee, K.M., Kim, J.I., Markmann, J.F., Marinelli, B., Panizzi, P., Lee, W.W., Iwamoto, Y., Milstein, S., Epstein-Barash, H., Cantley, W., Wong, J., Cortez-Retamozo, V., Newton, A., Love, K., Libby, P., Pittet, M.J., Swirski, F.K., Koteliansky, V., Langer, R., Weissleder, R., Anderson, D.G., Nahrendorf, M., Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 29 (2011), 1005–1010.
216. [216] Liu, X.Q., Xiong, M.H., Shu, X.T., Tang, R.Z., Wang, J., Therapeutic delivery of siRNA silencing HIF-1 alpha with micellar nanoparticles inhibits hypoxic tumor growth. Mol Pharm 9 (2012), 2863–2874.
217. [217] Zhang, Y., Peng, L., Mumper, R.J., Huang, L., Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy. Biomaterials 34 (2013), 8459–8468.
218. [218] Zhang, Y., Schwerbrock, N.M., Rogers, A.B., Kim, W.Y., Huang, L., Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther 21 (2013), 1559–1569.
219. [219] Li, L., Wang, R., Wilcox, D., Zhao, X., Song, J., Lin, X., Kohlbrenner, W.M., Fesik, S.W., Shen, Y., Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery. Gene Ther 19 (2012), 775–780.
220. [220] Yin, L., Song, Z., Qu, Q., Kim, K.H., Zheng, N., Yao, C., Chaudhury, I., Tang, H., Gabrielson, N.P., Uckun, F.M., Cheng, J., Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation. Angew Chem Int Ed 52 (2013), 5757–5761.
221. [221] Zheng, D., Giljohann, D.A., Chen, D.L., Massich, M.D., Wang, X.Q., Iordanov, H., Mirkin, C.A., Paller, A.S., Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation. Proc Natl Acad Sci U S A 109 (2012), 11975–11980.
222. [222] Kanasty, R., Dorkin, J.R., Vegas, A., Anderson, A., Delivery materials for siRNA therapeutics. Nat Mater 12 (2013), 967–977.
223. [223] Kim, H.J., Miyata, K., Nomoto, T., Zheng, M., Kim, A., Liu, X., Cabral, H., Christie, R.J., Nishiyama, N., Kataoka, K., siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (2014), 4548–4556.
224. [225] Matsumoto, S., Christie, R.J., Nishiyama, N., Miyata, K., Ishii, A., Oba, M., Koyama, H., Yamasaki, Y., Kataoka, K., Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 10 (2009), 119–127.
225. [226] Christie, R.J., Miyata, K., Matsumoto, Y., Nomoto, T., Menasco, D., Lai, T.C., Pennisi, M., Osada, K., Fukushima, S., Nishiyama, N., Yamasaki, Y., Kataoka, K., Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines. Biomacromolecules 12 (2011), 3174–3185.
226. [227] Yu, H., Zou, Y., Wang, Y., Huang, X., Huang, G., Sumer, B.D., Boothman, D.A., Gao, J., Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery. ACS Nano 5 (2011), 9246–9255.
227. [228] Al-Abd, A.M., Lee, S.H., Kim, S.H., Cha, J.H., Park, T.G., Lee, S.J., Kuh, H.J., Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in-vitro. J Control Release 137 (2009), 130–135.
228. [229] Lee, S.H., Kim, S.H., Park, T.G., Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide. Biochem Biophys Res Commun 357 (2007), 511–516.
229. [230] Kanazawa, T., Sugawara, K., Tanaka, K., Horiuchi, S., Takashima, Y., Okada, H., Suppression of tumor growth by systemic delivery of anti-VEGF siRNA with cell-penetrating peptide-modified MPEG-PCL nanomicelles. Eur J Pharm Biopharm 81 (2012), 470–477.
230. [231] Qin, B., Chen, Z., Jin, W., Cheng, K., Development of cholesteryl peptide micelles for siRNA delivery. J Control Release 172 (2013), 159–168.
231. [232] Convertine, A.J., Diab, C., Prieve, M., Paschal, A., Hoffman, A.S., Johnson, P.H., Stayton, P.S., pH-responsive polymeric micelle carriers for siRNA drugs. Biomacromolecules 11 (2010), 2904–2911.
232. [233] Lundy, B.B., Convertine, A., Miteva, M., Stayton, P.S., Neutral polymeric micelles for RNA delivery. Bioconjug Chem 24 (2013), 398–407.
233. [234] Lee, Y., Lee, S.H., Kim, J.S., Maruyama, A., Chen, X., Park, T.G., Controlled synthesis of PEI-coated gold nanoparticles using reductive catechol chemistry for siRNA delivery. J Control Release 155 (2011), 3–10.
234. [235] Lee, S.H., Mok, H., Lee, Y., Park, T.G., Self-assembled siRNA-PLGA conjugate micelles for gene silencing. J Control Release 152 (2011), 152–158.
235. [236] Musacchio, T., Vaze, O., D'souza, G., Torchilin, V.P., Effective stabilization and delivery of siRNA: reversible siRNA-phospholipid conjugate in nanosized mixed polymeric micelles. Bioconjug Chem 21 (2010), 1530–1536.
236. [237] Boudier, A., Aubert-Pouëssel, A., Gérardin, C., Devoisselle, J.M., Bégu, S., Louis-Plence, P., Quentin, J., Jorgensen, C., Tripartite siRNA micelles as controlled delivery systems for primary dendritic cells. Drug Dev Ind Pharm 35 (2009), 950–958.
237. [238] Choi, S.W., Lee, S.H., Mok, H., Park, T.G., Multifunctional siRNA delivery system: polyelectrolyte complex micelles of six-arm PEG conjugate of siRNA and cell penetrating peptide with crosslinked fusogenic peptide. Biotechnol Prog 26 (2010), 57–63.
238. [239] Wang, H.X., Yang, X.Z., Sun, C.Y., Mao, C.Q., Zhu, Y.H., Wang, J., Matrix metalloproteinase 2-responsive micelle for siRNA delivery. Biomaterials 35 (2014), 7622–7634.
239. [240] Kim, H.J., Ishii, T., Zheng, M., Watanabe, S., Toh, K., Matsumoto, Y., Nishiyama, N., Miyata, K., Kataoka, K., Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer. Drug Deliv Transl Res 4 (2014), 50–60.
240. [241] Pittella, F., Cabral, H., Maeda, Y., Mi, P., Watanabe, S., Takemoto, H., Kim, H.J., Nishiyama, N., Miyata, K., Kataoka, K., Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles. J Control Release 178 (2014), 18–24.
241. [242] Maeda, Y., Pittella, F., Nomoto, T., Takemoto, H., Nishiyama, N., Miyata, K., Kataoka, K., Fine-tuning of charge-conversion polymer structure for efficient endosomal escape of siRNA-loaded calcium phosphate hybrid micelles. Macromol Rapid Commun 35 (2014), 1211–1215.
242. [243] Salzano, G., Riehle, R., Navarro, G., Perche, F., De Rosa, G., Torchilin, V.P., Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: a promising strategy to overcome drug resistance in cancer. Cancer Lett 343 (2014), 224–231.
243. [244] Omedes Pujol, M., Coleman, D.J.L., Allen, C.D., Heidenreich, O., Fulton, D.A., Determination of key structure-activity relationships in siRNA delivery with a mixed micelle system. J Control Release 172 (2013), 939–945.
244. [245] Kim, D., Hong, J., Moon, H.H., Nam, H.Y., Mok, H., Jeong, J.H., Kim, S.W., Choi, D., Kim, S.H., Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier. J Control Release 168 (2013), 125–134.