Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: Contributions of energy depletion and membrane fluidization

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 2, 2001, Pages 483-493

  Batrakova, Elena V ^a   Li, Shu ^a   Vinogradov, Sergey V ^a   Alakhov, Valery Yu ^b   Miller, Donald W ^a   Kabanov, Alexander V ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b Supratek Pharma Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DIPHENYL 1,3,5 HEXATRIENE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; LUCIFERASE; LUCIFERIN; PLURONIC P85; POLOXAMER; RHODAMINE 123; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CATTLE; CELL LEVEL; CELL MEMBRANE FLUIDITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; ENDOTHELIUM CELL; ENERGY CONSUMPTION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VISCOSITY;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALGORITHMS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CATTLE; CELL SEPARATION; CELL SURVIVAL; ENERGY TRANSFER; FLUORESCENCE POLARIZATION; KINETICS; MEMBRANES; MICROSCOPY, FLUORESCENCE; P-GLYCOPROTEIN; POLOXALENE; VISCOSITY;

EID: 0034757615     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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